{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T02:12:58Z","timestamp":1782958378189,"version":"3.54.5"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","maturitas.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Maturitas"],"published-print":{"date-parts":[[2004,8]]},"DOI":"10.1016\/j.maturitas.2004.02.012","type":"journal-article","created":{"date-parts":[[2004,5,29]],"date-time":"2004-05-29T10:09:57Z","timestamp":1085825397000},"page":"30-40","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":122,"special_numbering":"S1","title":["Tissue-selectivity: the mechanism of action of tibolone"],"prefix":"10.1016","volume":"48","author":[{"given":"Helenius J.","family":"Kloosterboer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.maturitas.2004.02.012_BIB1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1210\/jcem.87.1.8141","article-title":"Tibolone for post-menopausal women: systematic review of randomized trials","volume":"87","author":"Modelska","year":"2002","journal-title":"J. Clin Endocrinol. Metab."},{"key":"10.1016\/j.maturitas.2004.02.012_BIB2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0378-5122(98)00059-0","article-title":"Tibolone: a review","volume":"30","author":"Albertazzi","year":"1998","journal-title":"Maturitas"},{"issue":"Suppl 19","key":"10.1016\/j.maturitas.2004.02.012_BIB3","first-page":"1","article-title":"Livial: a review of clinical studies","volume":"106","author":"Moore","year":"1999","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"10.1016\/j.maturitas.2004.02.012_BIB4","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1136\/bmj.280.6225.1207","article-title":"Prospective double-blind trial of synthetic steroid (org OD 14) for preventing post-menopausal osteoporosis","volume":"280","author":"Lindsay","year":"1980","journal-title":"BMJ"},{"key":"10.1016\/j.maturitas.2004.02.012_BIB5","unstructured":"Blom MJ, Groot-Wassink M, Ederveen AGH, Kloosterboer HJ, Lambert JGD, Goos HJT. The metabolism of Org OD14 and its derivatives in rat and human target tissues for hormone replacement therapy. In: Blom MJ, editor. Thesis. Steroids and steroid analogues for hormone replacement therapy; metabolism in target tissues. ISBN 90-393-2680-0; 2001; chapter 5, p. 63\u201380."},{"key":"10.1016\/j.maturitas.2004.02.012_BIB6","first-page":"3669","article-title":"3\u00df-Hydroxysteroid dehydrogenase\/\u03945 \u2192 4-isomerase activity associated with the human 17\u00df-hydroxysteroid dehydrogenase type II isoform","volume":"85","author":"Suzuki","year":"2000","journal-title":"J. Clin Endocrinol. Metab."},{"key":"10.1016\/j.maturitas.2004.02.012_BIB7","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1592\/phco.22.1.6.33495","article-title":"Dose proportionality of three different doses of tibolone","volume":"22","author":"Timmer","year":"2002","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.maturitas.2004.02.012_BIB8","doi-asserted-by":"crossref","first-page":"41","DOI":"10.5414\/CPP39041","article-title":"Bioequivalence and relative bioavailability of three estradiol and norethisterone acetate-containing hormone replacement therapy tablets","volume":"39","author":"Zdravkovic","year":"2001","journal-title":"Int. J. Clin. Pharmacol. Ther."},{"key":"10.1016\/j.maturitas.2004.02.012_BIB9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0303-7207(01)00606-2","article-title":"Tibolone: a compound with tissue specific inhibitory effects on sulfatase","volume":"183","author":"de Gooyer","year":"2001","journal-title":"Mol Cell Endocrinol."},{"key":"10.1016\/j.maturitas.2004.02.012_BIB10","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/00042192-200207000-00011","article-title":"Formation of 7\u03b1-methyl-ethinyl estradiol during treatment with tibolone","volume":"9","author":"Wiegratz","year":"2002","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2004.02.012_BIB11","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3109\/00498259409043228","article-title":"Metabolism of three pharmacologically active drugs in isolated human and rat hepatocytes: analysis of interspecies variability and comparison with metabolism in vivo","volume":"24","author":"Sandker","year":"1994","journal-title":"Xenobiotica"},{"key":"10.1016\/j.maturitas.2004.02.012_BIB12","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0039-128X(02)00184-8","article-title":"Tibolone is not converted by human aromatase to 7\u03b1-methyl-17\u03b1-ethynylestradiol (7\u03b1-MEE); analyses with sensitive bioassays for estrogens and androgens and LC-MSMS","volume":"68","author":"de Gooyer","year":"2003","journal-title":"Steroids"},{"key":"10.1016\/j.maturitas.2004.02.012_BIB13","unstructured":"Jones MEE, Reutens AT, Boon WC, Erderveen AG, Kloosterboer HJ, Simpson ER. The aromatase knockout (Arko) mouse as a model to study the oestrogenic action of tibolone. In: Proceedings of the 46th Annual Scientific Meeting of the Endocrine Society of Australia (Abstract 157), Melbourne, 2003, p. 112."},{"key":"10.1016\/j.maturitas.2004.02.012_BIB14","first-page":"16","article-title":"Tibolone-its tissue specificity and bone-preserving effects","volume":"1","author":"Kloosterboer","year":"2002","journal-title":"J. Menopause"},{"key":"10.1016\/j.maturitas.2004.02.012_BIB15","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1146\/annurev.physiol.64.081601.142703","article-title":"Aromatase: a brief overview","volume":"64","author":"Simpson","year":"2002","journal-title":"Ann. Rev. Physiol."},{"key":"10.1016\/j.maturitas.2004.02.012_BIB16","first-page":"133","article-title":"Preparation and reactions of norethynodrel epoxide. A possible mechanism for A-ring aromatization of 19-norsteroids","volume":"5","author":"Thompson","year":"1974","journal-title":"Steroids Lipids Res."},{"key":"10.1016\/j.maturitas.2004.02.012_BIB17","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0039-128X(02)00112-5","article-title":"Receptor profiling and endocrine interactions of tibolone","volume":"68","author":"de Gooyer","year":"2003","journal-title":"Steroids"},{"key":"10.1016\/j.maturitas.2004.02.012_BIB18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0960-0760(00)00125-4","article-title":"Hormonal properties of norethisterone, 7alpha-methyl-norethisterone and their derivatives","volume":"74","author":"Schoonen","year":"2000","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.maturitas.2004.02.012_BIB19","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1359\/jbmr.2001.16.9.1651","article-title":"Tibolone exerts its protective effect on trabecular bone loss through the estrogen receptor","volume":"16","author":"Ederveen","year":"2001","journal-title":"J. Bone Miner Res."},{"key":"10.1016\/j.maturitas.2004.02.012_BIB20","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1359\/jbmr.2001.16.9.1674","article-title":"Effect of 16 months of treatment with tibolone on bone mass, turnover, and biomechanical quality in mature ovariectomized rats","volume":"16","author":"Ederveen","year":"2001","journal-title":"J. Bone Miner Res."},{"key":"10.1016\/j.maturitas.2004.02.012_BIB21","doi-asserted-by":"crossref","first-page":"5396","DOI":"10.1210\/jcem.86.11.8021","article-title":"A comparison of tibolone and conjugated equine estrogens effects on coronary artery atherosclerosis and bone density of post-menopausal monkeys","volume":"86","author":"Clarkson","year":"2001","journal-title":"J. Clin Endocrinol Metab."},{"key":"10.1016\/j.maturitas.2004.02.012_BIB22","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0303-7207(00)00206-9","article-title":"Tibolone inhibits leukocyte adhesion molecule expression in human endothelial cells","volume":"162","author":"Simoncini","year":"2000","journal-title":"Mol Cell Endocrinol."},{"key":"10.1016\/j.maturitas.2004.02.012_BIB23","unstructured":"Dubey RK, Gillespie DG, D\u00e4ster C, Keller PJ, Imthurn B. Tibolone and its endogenous metabolites induce anti-mitogenesis in human coronary artery smooth muscle cells: potential role of estrogen-dependent and -independent mechanisms. In: Proceedings of the North American Menopause Society 13th Annual Meeting 2002 (Abstract 62)."},{"key":"10.1016\/j.maturitas.2004.02.012_BIB24","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0960-0760(94)90273-9","article-title":"Effects of progestogens and Org OD14 in in vitro and in vivo tumour models","volume":"49","author":"Kloosterboer","year":"1994","journal-title":"J. Steroid Biochem Mol. Biol."},{"key":"10.1016\/j.maturitas.2004.02.012_BIB25","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00404-002-0291-x","article-title":"Effects of tibolone on human breast cancer cells and human vascular coronary cells","volume":"267","author":"Mueck","year":"2003","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.maturitas.2004.02.012_BIB26","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1016\/j.maturitas.2003.09.019","article-title":"Differential effects of progestogens on breast cancer cell line","volume":"46S1","author":"Franke","year":"2003","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2004.02.012_BIB27","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0959-8049(01)00391-4","article-title":"Tibolone and 5-alpha-dihydrotestosterone alone or in combination with an anti-androgen in a rat breast tumour model","volume":"38","author":"Deckers","year":"2002","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.maturitas.2004.02.012_BIB28","first-page":"135","article-title":"Effect of tibolone (Org OD14) and its metabolites on estrone sulphatase activity in MCF-7 and T-47D mammary cancer cells","volume":"17","author":"Chetrite","year":"1997","journal-title":"Anticancer Res."},{"key":"10.1016\/j.maturitas.2004.02.012_BIB29","first-page":"261","article-title":"Effects of Org OD14 (Livial) and its metabolites on 17 beta-hydroxysteroid dehydrogenase activity in hormone-dependent MCF-7 and T-47D breast cancer cells","volume":"19","author":"Chetrite","year":"1999","journal-title":"Anticancer Res."},{"key":"10.1016\/j.maturitas.2004.02.012_BIB30","first-page":"269","article-title":"Effect of Org OD14 (LIVIAL) and its metabolites on human estrogen sulphotransferase activity in the hormone-dependent MCF-7 and T-47D, and the hormone-independent MDA-MB-231, breast cancer cell lines","volume":"19","author":"Chetrite","year":"1999","journal-title":"Anticancer Res."},{"key":"10.1016\/j.maturitas.2004.02.012_BIB31","first-page":"368","article-title":"Action of SERM and SAS (tibolone) on breast tissue","volume":"27","author":"Gompel","year":"1999","journal-title":"Contracept Fertil. Sex"},{"key":"10.1016\/j.maturitas.2004.02.012_BIB32","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0015-0282(02)03203-X","article-title":"In vitro studies of tibolone in breast cells","volume":"78","author":"Gompel","year":"2002","journal-title":"Fertil Steril"},{"issue":"Suppl 4","key":"10.1016\/j.maturitas.2004.02.012_BIB33","doi-asserted-by":"crossref","first-page":"S76","DOI":"10.1016\/S0959-8049(00)00236-7","article-title":"Tibolone actions on normal and breast cancer cells","volume":"36","author":"Gompel","year":"2000","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.maturitas.2004.02.012_BIB34","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0960-0760(99)00069-2","article-title":"Proapoptotic effects of antiestrogens, progestins and androgen in breast cancer cells","volume":"69","author":"Kandouz","year":"1999","journal-title":"J. Steroid Biochem. Mol Biol."},{"issue":"Suppl. 1","key":"10.1016\/j.maturitas.2004.02.012_BIB35","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3109\/09513599709152586","article-title":"The effect of tibolone on proliferation","volume":"11","author":"Gompel","year":"1997","journal-title":"Gynecol. Endocrinol"},{"key":"10.1016\/j.maturitas.2004.02.012_BIB36","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1111\/j.1471-0528.2002.01338.x","article-title":"The effect of tibolone compared with conjugated equine oestrogens continuously combined with medroxyprogesterone acetate on bleeding rates, quality of life and tolerability in post-menopausal women","volume":"109","author":"Huber","year":"2002","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"10.1016\/j.maturitas.2004.02.012_BIB37","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1067\/mob.2002.121896","article-title":"Effects of tibolone and a continuous combined hormone replacement therapy on mammographic breast density","volume":"186","author":"Lundstr\u00f6m","year":"2002","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.maturitas.2004.02.012_BIB38","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0378-5122(03)00086-0","article-title":"Effects of estrdiol, cyproterone acetate, tibolone and raloxifene on the uterus and atherosclerosis in oophorectomized cholesterol-fed rabbits","volume":"45","author":"Sanjuan","year":"2003","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2004.02.012_BIB39","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1210\/jc.2002-021737","article-title":"Progestagenic effects of tibolone on human endometrial cancer cells","volume":"88","author":"Blok","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.maturitas.2004.02.012_BIB40","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0960-0760(93)90003-F","article-title":"Human endometrial 3 beta-hydroxysteroid dehydrogenase\/isomerase can locally reduce intrinsic estrogenic\/progestagenic activity ratios of a steroidal drug (Org OD 14)","volume":"45","author":"Tang","year":"1993","journal-title":"J. Steroid Biochem. Mol Biol."},{"key":"10.1016\/j.maturitas.2004.02.012_BIB41","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/00042192-199906040-00005","article-title":"Impact on uterine bleeding and endometrial thickness: tibolone compared with continuous combined estradiol and norethisterone acetate replacement therapy","volume":"6","author":"Doren","year":"1999","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2004.02.012_BIB42","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1080\/cmt.4.3.203.208","article-title":"Effects of tibolone on the endometrium","volume":"4","author":"V\u00f6lker","year":"2001","journal-title":"Climacteric"},{"key":"10.1016\/j.maturitas.2004.02.012_BIB43","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1046\/j.1365-2362.2003.01163.x","article-title":"Treatment with hormone replacement therapy lowers remnant lipoprotein particles in healthy post-menopausal women: results from a randomized trial","volume":"33","author":"Ossewaarde","year":"2003","journal-title":"Eur. J. Clin Invest."},{"key":"10.1016\/j.maturitas.2004.02.012_BIB44","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1161\/01.ATV.18.12.1844","article-title":"Tibolone prevents atherosclerotic lesion formation in cholesterol-fed, ovariectomized rabbits","volume":"18","author":"Zandberg","year":"1998","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"10.1016\/j.maturitas.2004.02.012_BIB45","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1097\/00042192-200103000-00004","article-title":"Comparison of the antiatherosclerotic effect of tibolone with that of estradiol and ethinyl estradiol in cholesterol-fed, ovariectomized rabbits","volume":"8","author":"Zandberg","year":"2001","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2004.02.012_BIB46","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1046\/j.1365-2265.2003.01666.x","article-title":"Tibolone lowers high density lipoprotein cholesterol concentrations by increasing hepatic lipase activity but does not impair cholesterol efflux","volume":"58","author":"von Eckardstein","year":"2003","journal-title":"Clin Endocrinol."}],"container-title":["Maturitas"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512204001069?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512204001069?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T08:37:55Z","timestamp":1759912675000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378512204001069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8]]},"references-count":46,"alternative-id":["S0378512204001069"],"URL":"https:\/\/doi.org\/10.1016\/j.maturitas.2004.02.012","relation":{},"ISSN":["0378-5122"],"issn-type":[{"value":"0378-5122","type":"print"}],"subject":[],"published":{"date-parts":[[2004,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tissue-selectivity: the mechanism of action of tibolone","name":"articletitle","label":"Article Title"},{"value":"Maturitas","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.maturitas.2004.02.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}