{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T01:22:33Z","timestamp":1782177753004,"version":"3.54.5"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","maturitas.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Maturitas"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1016\/j.maturitas.2005.02.009","type":"journal-article","created":{"date-parts":[[2005,10,28]],"date-time":"2005-10-28T07:22:50Z","timestamp":1130484170000},"page":"49-58","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"title":["Randomized clinical trial comparing conjugated equine estrogens and isoflavones in postmenopausal women: a pilot study"],"prefix":"10.1016","volume":"53","author":[{"given":"Cristina","family":"Kaari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro Abi","family":"Haidar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Maria Soares","family":"J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia Gaspar","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Gerk de Azevedo","family":"Quadros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udio","family":"Kemp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Noberto","family":"Stavale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund C.","family":"Baracat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.maturitas.2005.02.009_bib1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.7326\/0003-4819-98-2-195","article-title":"Estrogen replacement therapy: indications and complications","volume":"98","author":"Judd","year":"1983","journal-title":"Ann Int Med"},{"key":"10.1016\/j.maturitas.2005.02.009_bib2","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1001\/jama.1981.03310420031025","article-title":"Association of waking episodes with menopausal hot flushes","volume":"245","author":"Erlite","year":"1981","journal-title":"JAMA"},{"key":"10.1016\/j.maturitas.2005.02.009_bib3","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1001\/jama.1982.03330040033027","article-title":"Estrogen reproduction and vaginal function in postmenopausal women","volume":"248","author":"Semmens","year":"1982","journal-title":"JAMA"},{"key":"10.1016\/j.maturitas.2005.02.009_bib4","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/S0002-9378(13)90437-3","article-title":"Incidence ofendometrial hyperplasia in postmenopausal women taking conjugated estrogens (Premarin) with medroxyproesterone acetate or conjugated estrogens alone","volume":"170","author":"Woodruf","year":"1994","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.maturitas.2005.02.009_bib5","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/S0140-6736(97)08233-0","article-title":"Breast cancer and hormone therapy: collaborative reanalysis of data from 51 epidemiological studies of 52705 women with breast cancer and 108411 women without breast cancer","volume":"350","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.maturitas.2005.02.009_bib6","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1001\/jama.288.3.321","article-title":"Risk and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial","volume":"288","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.maturitas.2005.02.009_bib7","first-page":"8","article-title":"Isoflavones in the management of menopause","volume":"S1","author":"Nachtigall","year":"2001","journal-title":"J Br Menopause Soc"},{"key":"10.1016\/j.maturitas.2005.02.009_bib8","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0378-5122(94)90068-X","article-title":"Climacteric and menopausein seven South-east Asian countries","volume":"19","author":"Boulet","year":"1994","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2005.02.009_bib9","series-title":"Encounters with aging: mythologies of menopause in Japan and North America","author":"Lock","year":"1993"},{"key":"10.1016\/j.maturitas.2005.02.009_bib10","first-page":"8","article-title":"Estrogen replacement therapy indications, contraindications and agent selection","volume":"167","author":"Notelovitz","year":"1989","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.maturitas.2005.02.009_bib11","series-title":"A portrait of the menopause","first-page":"23","article-title":"Mastering the menopause","author":"Rekers","year":"1991"},{"key":"10.1016\/j.maturitas.2005.02.009_bib12","first-page":"103","article-title":"Phytoestrogens: epidemiology and a possible role in cancer protection","volume":"103","author":"Adlercreutz","year":"1995","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.maturitas.2005.02.009_bib13","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.7326\/0003-4819-117-12-1016","article-title":"Hormone therapy to prevent disease and prolong life in postmenopausal women","volume":"117","author":"Grady","year":"1992","journal-title":"Ann Int Med"},{"key":"10.1016\/j.maturitas.2005.02.009_bib14","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.4065\/75.11.1174","article-title":"Soy isoflavones: are they useful in menopause?","volume":"75","author":"Vincent","year":"2000","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.maturitas.2005.02.009_bib15","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1210\/endo.139.10.6216","article-title":"Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta","volume":"130","author":"Kuiper","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.maturitas.2005.02.009_bib16","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/00042192-200007040-00003","article-title":"The role of isoflavones in menopausal health","volume":"7","year":"2000","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2005.02.009_bib17","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1210\/endo.138.3.4979","article-title":"Comparison of the lig and binding specificity and transcript tissue distribution of estrogen receptors alpha and beta","volume":"138","author":"Kuiper","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.maturitas.2005.02.009_bib18","first-page":"2223","article-title":"Potencial health benefits of dietary phytoestrogens: a review of the clinical, epidemiological and mechanistic evidence","volume":"83","author":"Tham","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.maturitas.2005.02.009_bib19","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1289\/ehp.94102572","article-title":"Dietary estrogens act through estrogen receptor-mediated processes and show no antiestrogenicity in cultured breast cancer cells","volume":"102","author":"Makela","year":"1994","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.maturitas.2005.02.009_bib20","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/jn\/127.2.263","article-title":"Dietary genistein exerts estrogenic effects upon the uterus, mammary gland and the hypothalamic\/pituitary axis in rats","volume":"127","author":"Santell","year":"1997","journal-title":"J Nutr"},{"key":"10.1016\/j.maturitas.2005.02.009_bib21","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0960-0760(94)90005-1","article-title":"Interaction of naturally occurring nonsteroidal estrogens with expressed recombinant human estrogen receptor","volume":"49","author":"Mikisicek","year":"1994","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.maturitas.2005.02.009_bib22","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1006\/abbi.1996.9854","article-title":"Genistein selectively inhibits platelet derived growth factor-stimulated versican biosynthesis in monkey arterial smooth muscle cells","volume":"339","author":"Schonherr","year":"1997","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.maturitas.2005.02.009_bib23","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/00042192-199704020-00005","article-title":"Short-term effects of phytoestrogen-rich diet on postmenopausal women","volume":"4","author":"Brzezinski","year":"1997","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2005.02.009_bib24","first-page":"389","article-title":"Benefits of soy isoflavone therapeutic regimen on menopausal symptoms","volume":"99","author":"Han","year":"2002","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.maturitas.2005.02.009_bib25","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0378-5122(95)00899-V","article-title":"Dietary flour supplementation decreases post-memnopausal hot flushes: effect of soy and wheat","volume":"21","author":"Murkies","year":"1995","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2005.02.009_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/109662003765184697","article-title":"Efficacy of soyfoods and soybean isoflavone supplements for alleviating menopausal symptoms is positively related to initial hot flush frequency","volume":"6","author":"Messina","year":"2003","journal-title":"J Med Food"},{"key":"10.1016\/j.maturitas.2005.02.009_bib27","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1097\/00042192-200007040-00005","article-title":"Vasomotor symptom relief by soy isoflavone extract tablets in postmenopausal women: a multicenter, double-blind, randomized, placebo-controlled study","volume":"7","author":"Upmalis","year":"2000","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2005.02.009_bib28","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/00042192-200209000-00005","article-title":"Effects of a standardized soy extract on hot flushes: a multicenter, double-blind, randomized, placebo-controlled study","volume":"9","author":"Faure","year":"2002","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2005.02.009_bib29","first-page":"686","article-title":"Comparative clinical evolution of estrogenic preparations by the menopausal and amenorrheal indices","volume":"13","author":"Kupperman","year":"1953","journal-title":"Endocrinology"},{"key":"10.1016\/j.maturitas.2005.02.009_bib30","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1136\/jcp.55.6.446","article-title":"The effect of Replens\u00ae on vaginal cytology in the treatment of postmenopausal atrophy: cytomorphology versus computerised cytometry","volume":"55","author":"van der Laak","year":"2002","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.maturitas.2005.02.009_bib31","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0020-7292(97)00111-2","article-title":"Transvaginal ultrasonography and the progestogen challenge test in postmenopausal endometrial evaluation","volume":"58","author":"Bortoletto","year":"1997","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.maturitas.2005.02.009_bib32","doi-asserted-by":"crossref","first-page":"1362S","DOI":"10.1093\/jn\/131.4.1362S","article-title":"Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements","volume":"131","author":"Setchell KDR","year":"2001","journal-title":"J Nutr"},{"key":"10.1016\/j.maturitas.2005.02.009_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1301\/nr.2003.janr.1-33","article-title":"Soy isoflavones: a safety review","volume":"61","author":"Munro","year":"2003","journal-title":"Nutr Rev"},{"key":"10.1016\/j.maturitas.2005.02.009_bib34","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/00042192-200310020-00006","article-title":"Soy protein and isoflavone effects on vasomotor symptoms in peri- and postmenopausal women: the soy estrogen alternative study","volume":"10","author":"Burke","year":"2003","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2005.02.009_bib35","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/00042192-200101000-00005","article-title":"Isoflavone-rich or isoflavone-poor soy protein does not reduce menopausal symptoms during 24 week of treatment","volume":"8","author":"St. Germain","year":"2001","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2005.02.009_bib36","first-page":"1685","article-title":"Effects of dietary phytoestrogens in postmenopausal women. Climacteric. 1998 estrogenicity of dietary soy among postmenopausal women","volume":"80","author":"Dalais","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.maturitas.2005.02.009_bib37","first-page":"1685","article-title":"Dietary intervention study to assess estrogenicity of dietary soy among postmenopausal women","volume":"80","author":"Baird","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.maturitas.2005.02.009_bib38","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/00042192-200007020-00006","article-title":"Clinical effects of a standardized soy extract in postmenopausal women: a pilot study","volume":"7","author":"Scambia","year":"2000","journal-title":"Menopause"},{"issue":"6 Suppl","key":"10.1016\/j.maturitas.2005.02.009_bib39","first-page":"1413S","article-title":"Effects of mammalian and plant estrogens on mammary glands and uteri of macaques","volume":"68","author":"Foth","year":"1998","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.maturitas.2005.02.009_bib40","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.fertnstert.2003.11.041","article-title":"Endometrial effects of long-term treatment with phytoestrogens: a randomized, double-blind, placebo-controlled study","volume":"82","author":"Unfer","year":"2004","journal-title":"Fertil Steril"},{"key":"10.1016\/j.maturitas.2005.02.009_bib41","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1248\/bpb.24.351","article-title":"Interaction of phytoestrogens with estrogen receptors alpha and beta","volume":"24","author":"Morito","year":"2001","journal-title":"Biol Pharm Bull"}],"container-title":["Maturitas"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512205000277?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512205000277?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T08:40:53Z","timestamp":1759912853000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378512205000277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S0378512205000277"],"URL":"https:\/\/doi.org\/10.1016\/j.maturitas.2005.02.009","relation":{},"ISSN":["0378-5122"],"issn-type":[{"value":"0378-5122","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Randomized clinical trial comparing conjugated equine estrogens and isoflavones in postmenopausal women: a pilot study","name":"articletitle","label":"Article Title"},{"value":"Maturitas","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.maturitas.2005.02.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}