{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:08:19Z","timestamp":1790773699953,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","maturitas.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Maturitas"],"published-print":{"date-parts":[[2006,10]]},"DOI":"10.1016\/j.maturitas.2006.03.008","type":"journal-article","created":{"date-parts":[[2006,5,6]],"date-time":"2006-05-06T06:24:57Z","timestamp":1146896697000},"page":"203-211","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":121,"title":["Isoflavone therapy for menopausal flushes: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"55","author":[{"given":"Laurence G.","family":"Howes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan B.","family":"Howes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Knight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.maturitas.2006.03.008_bib1","doi-asserted-by":"crossref","first-page":"805","DOI":"10.7326\/0003-4819-137-10-200211190-00009","article-title":"Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials","volume":"137","author":"Kronenberg","year":"2002","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.maturitas.2006.03.008_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5122(03)00221-4","article-title":"Soy for the treatment of perimenopausal symptoms\u2014a systematic review","volume":"47","author":"Huntley","year":"2004","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2006.03.008_bib3","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1097\/01.GME.0000058147.24036.B0","article-title":"A systematic review of herbal medicinal products for the treatment of menopausal symptoms","volume":"10","author":"Huntley","year":"2003","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2006.03.008_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/109662003765184697","article-title":"Efficacy of soyfoods and soybean isoflavone supplements for alleviating menopausal symptoms is positively related to initial hot flush frequency","volume":"6","author":"Messina","year":"2003","journal-title":"J Med Food"},{"key":"10.1016\/j.maturitas.2006.03.008_bib5","series-title":"Meta-analytic procedures for social research","author":"Rosenthal","year":"1984"},{"key":"10.1016\/j.maturitas.2006.03.008_bib6","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0378-5122(02)00080-4","article-title":"Isoflavones from red clover (Promensil) significantly reduce menopausal hot flush symptoms compared with placebo","volume":"42","author":"van de Weijer","year":"2002","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2006.03.008_bib7","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3109\/13697139909025570","article-title":"The effect of Promensil, an isoflavone extract, on menopausal symptoms","volume":"2","author":"Knight","year":"1999","journal-title":"Climacteric"},{"key":"10.1016\/j.maturitas.2006.03.008_bib8","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1001\/jama.290.2.207","article-title":"Phytoestrogen supplements for the treatment of hot flashes: the isoflavone clover extract (ICE) study: a randomized controlled trial","volume":"290","author":"Tice","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.maturitas.2006.03.008_bib9","first-page":"47","article-title":"The use of an isoflavone supplement to relieve hot flushes","volume":"27","author":"Jeri","year":"2002","journal-title":"Female Patient"},{"key":"10.1016\/j.maturitas.2006.03.008_bib10","doi-asserted-by":"crossref","first-page":"R170","DOI":"10.1186\/bcr773","article-title":"Red-clover-derived isoflavones and mammographic breast density: a double-blind, randomized, placebo-controlled trial","volume":"6","author":"Atkinson","year":"2004","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.maturitas.2006.03.008_bib11","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0029-7844(97)00597-8","article-title":"The effect of dietary soy supplementation on hot flushes","volume":"91","author":"Albertazzi","year":"1998","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.maturitas.2006.03.008_bib12","first-page":"389","article-title":"Benefits of soy isoflavone therapeutic regimen on menopausal symptoms","volume":"99","author":"Han","year":"2002","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.maturitas.2006.03.008_bib13","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/00042192-200209000-00005","article-title":"Effects of a standardized soy extract on hot flushes: a multicenter, double-blind, randomized, placebo-controlled study","volume":"9","author":"Faure","year":"2002","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2006.03.008_bib14","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/S0015-0282(03)00158-4","article-title":"Effect of soy-derived isoflavones on hot flushes, endometrial thickness, and the pulsatility index of the uterine and cerebral arteries","volume":"79","author":"Penotti","year":"2003","journal-title":"Fertil Steril"},{"key":"10.1016\/j.maturitas.2006.03.008_bib15","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1097\/00042192-200007040-00005","article-title":"Vasomotor symptom relief by soy isoflavone extract tablets in postmenopausal women: a multicenter, double-blind, randomized, placebo-controlled study","volume":"7","author":"Upmalis","year":"2000","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2006.03.008_bib16","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/cmt.4.1.13.18","article-title":"Effects on menopausal symptoms and acceptability of isoflavone-containing soy powder dietary supplementation","volume":"4","author":"Knight","year":"2001","journal-title":"Climacteric"},{"key":"10.1016\/j.maturitas.2006.03.008_bib17","first-page":"407","article-title":"Effects of soy isoflavones on menopausal neurovegetative symptoms","volume":"56","author":"Colacurci","year":"2004","journal-title":"Minerva Ginecol"},{"key":"10.1016\/j.maturitas.2006.03.008_bib18","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0378-5122(95)00899-V","article-title":"Dietary flour supplementation decreases post-menopausal hot flushes: effect of soy and wheat","volume":"21","author":"Murkies","year":"1995","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2006.03.008_bib19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/00042192-200101000-00005","article-title":"Isoflavone-rich or isoflavone-poor soy protein does not reduce menopausal symptoms during 24 weeks of treatment","volume":"8","author":"St Germain","year":"2001","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2006.03.008_bib20","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/00042192-200007020-00006","article-title":"Clinical effects of a standardized soy extract in postmenopausal women: a pilot study","volume":"7","author":"Scambia","year":"2000","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2006.03.008_bib21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/00042192-200310020-00006","article-title":"Soy protein and isoflavone effects on vasomotor symptoms in peri- and postmenopausal women: the Soy Estrogen Alternative Study","volume":"10","author":"Burke","year":"2003","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2006.03.008_bib22","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1200\/JCO.2002.20.6.1449","article-title":"Effect of soy phytoestrogens on hot flashes in postmenopausal women with breast cancer: a randomized, controlled clinical trial","volume":"20","author":"Van Patten","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.maturitas.2006.03.008_bib23","first-page":"1685","article-title":"Dietary intervention study to assess estrogenicity of dietary soy among postmenopausal women","volume":"80","author":"Baird","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.maturitas.2006.03.008_bib24","first-page":"137","article-title":"The clinical use of a preparation based on phyto-oestrogens in the treatment of menopausal disorders","volume":"74","author":"Russo","year":"2003","journal-title":"Acta Bio Med Ateneo Parmense"},{"key":"10.1016\/j.maturitas.2006.03.008_bib25","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1177\/107155760200900410","article-title":"A pilot study of the effects of phytoestrogen supplementation on postmenopausal endometrium","volume":"9","author":"Balk","year":"2002","journal-title":"J Soc Gynecol Invest"},{"key":"10.1016\/j.maturitas.2006.03.008_bib26","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/13697130008500108","article-title":"The effects of soy protein containing phytoestrogens on menopausal symptoms in postmenopausal women","volume":"3","author":"Kotsopoulos","year":"2000","journal-title":"Climacteric"},{"key":"10.1016\/j.maturitas.2006.03.008_bib27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0378-5122(03)00219-6","article-title":"Soy isoflavones and melatonin for the relief of climacteric symptoms: a multicenter, double-blind, randomized study","volume":"47","author":"Secreto","year":"2004","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2006.03.008_bib28","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.maturitas.2003.09.026","article-title":"Benefits of soy germ isoflavones in postmenopausal women with contraindication for conventional hormone replacement therapy","volume":"48","author":"Nahas","year":"2004","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2006.03.008_bib29","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3109\/13697139809085527","article-title":"Effects of dietary phytoestrogens in postmenopausal women","volume":"1","author":"Dalais","year":"1998","journal-title":"Climacteric"},{"key":"10.1016\/j.maturitas.2006.03.008_bib30","first-page":"7","article-title":"Effect of soy protein supplementation on serum lipoproteins, blood pressure, and menopausal symptoms in perimenopausal women","volume":"6","author":"Washburn","year":"1999","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2006.03.008_bib31","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3109\/13697139909025571","article-title":"Randomized placebo-controlled trial of an isoflavone supplement and menopausal symptoms in women","volume":"2","author":"Baber","year":"1999","journal-title":"Climacteric"},{"key":"10.1016\/j.maturitas.2006.03.008_bib32","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/biof.5520220145","article-title":"Effects of isoflavone supplements on bone metabolic markers and climacteric symptoms in Japanese women","volume":"22","author":"Uesugi","year":"2004","journal-title":"Biofactors"},{"key":"10.1016\/j.maturitas.2006.03.008_bib33","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.ejca.2005.01.005","article-title":"A randomised double-blind controlled trial of oral soy supplements verses placebo for treatment of menopausal symptoms in patients with early breast cancer","volume":"41","author":"MacGregor","year":"2005","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.maturitas.2006.03.008_bib34","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1200\/JCO.2000.18.5.1068","article-title":"Evaluation of soy phytoestrogens for the treatment of hot flashes in breast cancer survivors: A North Central Cancer Treatment Group Trial","volume":"18","author":"Quella","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.maturitas.2006.03.008_bib35","first-page":"60","article-title":"Clinical effects of a proprietary combination isoflavone nutritional supplement in menopausal women: a pilot trial","volume":"11","author":"Lukaczer","year":"2005","journal-title":"Altern Ther Health Med"},{"key":"10.1016\/j.maturitas.2006.03.008_bib36","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/01.GME.0000108177.85442.71","article-title":"Treatment of menopause-associated vasomotor symptoms: position statement of the North American Menopause Society","volume":"11","author":"Anonymous","year":"2004","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2006.03.008_bib37","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.7326\/0003-4819-142-12_Part_1-200506210-00117","article-title":"National Institutes of Health State-of-the-Science Conference statement: management of menopause-related symptoms","volume":"142","author":"National Institutes of Health","year":"2005","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.maturitas.2006.03.008_bib38","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1097\/01.AOG.0000140688.71638.d3","article-title":"Phytoestrogens for treatment of menopausal symptoms: a systematic review","volume":"104","author":"Krebs","year":"2004","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.maturitas.2006.03.008_bib39","first-page":"CD002978","article-title":"Oral oestrogen replacement therapy verses placebo for hot flushes (Cochrane Review)","volume":"1","author":"MacLennan","year":"2001","journal-title":"Cochrane Database Sys Rev"}],"container-title":["Maturitas"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512206000995?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512206000995?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T08:41:52Z","timestamp":1759912912000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378512206000995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["S0378512206000995"],"URL":"https:\/\/doi.org\/10.1016\/j.maturitas.2006.03.008","relation":{},"ISSN":["0378-5122"],"issn-type":[{"value":"0378-5122","type":"print"}],"subject":[],"published":{"date-parts":[[2006,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isoflavone therapy for menopausal flushes: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Maturitas","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.maturitas.2006.03.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}