{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:18:43Z","timestamp":1791134323992,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","maturitas.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Maturitas"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.maturitas.2010.03.015","type":"journal-article","created":{"date-parts":[[2010,4,19]],"date-time":"2010-04-19T04:58:09Z","timestamp":1271653089000},"page":"285-290","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"title":["Vasomotor symptoms, estradiol levels and cardiovascular risk profile in women"],"prefix":"10.1016","volume":"66","author":[{"given":"Gerrie-Cor M.","family":"Gast","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran N.","family":"Samsioe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diederick E.","family":"Grobbee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne T.","family":"van der Schouw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.maturitas.2010.03.015_bib1","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1093\/eurheartj\/ehi297","article-title":"Menopausal complaints, oestrogens, and heart disease risk: an explanation for discrepant findings on the benefits of post-menopausal hormone therapy","volume":"26","author":"van der Schouw","year":"2005","journal-title":"Eur Heart J"},{"key":"10.1016\/j.maturitas.2010.03.015_bib2","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1161\/HYPERTENSIONAHA.107.106526","article-title":"Menopausal complaints are associated with cardiovascular risk factors","volume":"51","author":"Gast","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.maturitas.2010.03.015_bib3","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1161\/CIRCULATIONAHA.108.776823","article-title":"Hot flashes and subclinical cardiovascular disease: findings from the Study of Women's Health Across the Nation Heart Study","volume":"118","author":"Thurston","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.maturitas.2010.03.015_bib4","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1001\/archinte.168.8.840","article-title":"Persistent hot flushes in older postmenopausal women","volume":"168","author":"Huang","year":"2008","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.maturitas.2010.03.015_bib5","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1001\/jama.291.13.1610","article-title":"Commonly used types of postmenopausal estrogen for treatment of hot flashes: scientific review","volume":"291","author":"Nelson","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.maturitas.2010.03.015_bib6","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/01.gme.0000218683.97338.ea","article-title":"Postmenopausal status and early menopause as independent risk factors for cardiovascular disease: a meta-analysis","volume":"13","author":"Atsma","year":"2006","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2010.03.015_bib7","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.maturitas.2009.11.009","article-title":"The women's health in the Lund area (WHILA) study\u2014an overview","volume":"65","author":"Samsioe","year":"2010","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2010.03.015_bib8","first-page":"399","article-title":"Anthropometric factors and risk of endometrial cancer: the European prospective investigation into cancer and nutrition","volume":"18","author":"Friedenreich","year":"2007","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.maturitas.2010.03.015_bib9","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1093\/humrep\/17.5.1379","article-title":"Health profile of middle-aged women: the Women's Health in the Lund Area (WHILA) study","volume":"17","author":"Li","year":"2002","journal-title":"Hum Reprod"},{"key":"10.1016\/j.maturitas.2010.03.015_bib10","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/S0140-6736(02)11911-8","article-title":"Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies","volume":"360","author":"Lewington","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.maturitas.2010.03.015_bib11","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1136\/bmj.308.6925.367","article-title":"By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease?","volume":"308","author":"Law","year":"1994","journal-title":"BMJ"},{"key":"10.1016\/j.maturitas.2010.03.015_bib12","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.amjmed.2007.06.021","article-title":"Predictors of significant short-term increases in blood pressure in a community-based population","volume":"120","author":"Aiyer","year":"2007","journal-title":"Am J Med"},{"key":"10.1016\/j.maturitas.2010.03.015_bib13","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S0015-0282(98)00137-X","article-title":"Biochemical, metabolic, and vascular mechanisms in menopausal hot flashes","volume":"70","author":"Freedman","year":"1998","journal-title":"Fertil Steril"},{"key":"10.1016\/j.maturitas.2010.03.015_bib14","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1152\/jappl.1975.38.3.499","article-title":"Body temperatures during menopausal hot flashes","volume":"38","author":"Molnar","year":"1975","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.maturitas.2010.03.015_bib15","series-title":"Treatment of the postmenopausal woman. Basic and clinical aspects","first-page":"187","article-title":"Menopausal hot flashes","author":"Freedman","year":"2007"},{"key":"10.1016\/j.maturitas.2010.03.015_bib16","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0002-9378(99)70437-0","article-title":"Reduced thermoregulatory null zone in postmenopausal women with hot flashes","volume":"181","author":"Freedman","year":"1999","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.maturitas.2010.03.015_bib17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/00005082-199510000-00005","article-title":"Assessment of the cardiovascular effects of stress","volume":"10","author":"Engler","year":"1995","journal-title":"J Cardiovasc Nurs"},{"key":"10.1016\/j.maturitas.2010.03.015_bib18","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0021-9150(81)90139-8","article-title":"Catecholamine-induced aggravation of aortic and coronary atherosclerosis in monkeys","volume":"40","author":"Kukreja","year":"1981","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.maturitas.2010.03.015_bib19","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1161\/01.HYP.5.1.86","article-title":"Plasma catecholamines and essential hypertension. An analytical review","volume":"5","author":"Goldstein","year":"1983","journal-title":"Hypertension"},{"key":"10.1016\/j.maturitas.2010.03.015_bib20","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1749-6632.1990.tb42281.x","article-title":"Adrenaline and noradrenaline as possible chemical mediators in the pathogenesis of arteriosclerosis","volume":"598","author":"Hauss","year":"1990","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.maturitas.2010.03.015_bib21","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1016\/S0140-6736(02)11774-0","article-title":"Hot flushes","volume":"360","author":"Stearns","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.maturitas.2010.03.015_bib22","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1126\/science.462193","article-title":"Menopausal flushes: a neuroendocrine link with pulsatile luteninizing hormone secreation","volume":"205","author":"Casper","year":"1979","journal-title":"Science"},{"key":"10.1016\/j.maturitas.2010.03.015_bib23","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/01.AOG.0000270153.59102.40","article-title":"Symptoms associated with menopausal transition and reproductive hormones in midlife women","volume":"110","author":"Freeman","year":"2007","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.maturitas.2010.03.015_bib24","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0378-5122(81)90035-9","article-title":"Climacteric symptoms according to body weight in women of different socio-economic groups","volume":"3","author":"Campagnoli","year":"1981","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2010.03.015_bib25","first-page":"403","article-title":"Estrogen levels in postmenopausal women with hot flashes","volume":"59","author":"Erlik","year":"1982","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.maturitas.2010.03.015_bib26","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/gme.0b013e31815879cf","article-title":"Abdominal adiposity and hot flashes among midlife women","volume":"15","author":"Thurston","year":"2008","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2010.03.015_bib27","first-page":"264","article-title":"Smoking, body mass, and hot flashes in midlife women","volume":"101","author":"Whiteman","year":"2003","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.maturitas.2010.03.015_bib28","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/00042192-200205000-00001","article-title":"Hot flash trends and mechanisms","volume":"9","author":"Freedman","year":"2002","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2010.03.015_bib29","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/GME.0b013e3181acefd5","article-title":"Biochemical markers for cardiovascular disease in recently postmenopausal women with or without hot flashes","volume":"17","author":"Tuomikoski","year":"2010","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2010.03.015_bib30","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1097\/gme.0b013e3181a4866b","article-title":"Vasomotor symptoms and mortality: the Rancho Bernardo Study","volume":"16","author":"Svartberg","year":"2009","journal-title":"Menopause"}],"container-title":["Maturitas"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512210001246?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512210001246?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T08:49:47Z","timestamp":1759913387000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378512210001246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S0378512210001246"],"URL":"https:\/\/doi.org\/10.1016\/j.maturitas.2010.03.015","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.4671962.4550065","asserted-by":"object"}]},"ISSN":["0378-5122"],"issn-type":[{"value":"0378-5122","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vasomotor symptoms, estradiol levels and cardiovascular risk profile in women","name":"articletitle","label":"Article Title"},{"value":"Maturitas","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.maturitas.2010.03.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}