{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T09:09:03Z","timestamp":1773392943388,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","maturitas.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Maturitas"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1016\/j.maturitas.2010.04.014","type":"journal-article","created":{"date-parts":[[2010,5,18]],"date-time":"2010-05-18T01:20:50Z","timestamp":1274145650000},"page":"54-59","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cardiovascular risk factors are associated with subclinical atherosclerosis in high functioning older adults"],"prefix":"10.1016","volume":"67","author":[{"given":"Pedro","family":"Abizanda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Atienzar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Casado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Romero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Manuel","family":"S\u00e1nchez-Jurado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matilde","family":"Le\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Mart\u00edn-Sebasti\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"L\u00f3pez-Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gema","family":"Paterna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Mart\u00ednez-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.maturitas.2010.04.014_bib1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/35025203","article-title":"Atherosclerosis","volume":"407","author":"Lusis","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.maturitas.2010.04.014_bib2","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1111\/j.1742-1241.2008.01804.x","article-title":"Subclinical atherosclerosis: what it is, what it means and what we can do about it","volume":"62","author":"Toth","year":"2008","journal-title":"Int J Clin Pract"},{"key":"10.1016\/j.maturitas.2010.04.014_bib3","doi-asserted-by":"crossref","first-page":"E16","DOI":"10.1161\/01.CIR.101.1.e16","article-title":"Prevention conference V: beyond secondary prevention: identifying the high-risk patient for primary prevention, noninvasive tests of atherosclerotic burden, Writing Group III","volume":"101","author":"Greenland","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.maturitas.2010.04.014_bib4","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1056\/NEJM199906033402213","article-title":"Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group","volume":"340","author":"O\u2019Leary","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.maturitas.2010.04.014_bib5","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.atherosclerosis.2003.10.012","article-title":"Prevalence and correlates of carothid atherosclerosis among elderly Japanese men","volume":"172","author":"Kitamura","year":"2004","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.maturitas.2010.04.014_bib6","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1161\/01.STR.0000196964.24024.ea","article-title":"Carotid intima-media thickening indicates a higher vascular risk across a wide age range: prospective data from the carotid atherosclerosis progression study (CAPS)","volume":"37","author":"Lorenz","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.maturitas.2010.04.014_bib7","doi-asserted-by":"crossref","first-page":"e197","DOI":"10.1016\/j.atherosclerosis.2007.03.044","article-title":"Presence of calcified carotid plaque predicts vascular events: the Northern Manhattan Study","volume":"195","author":"Prabhakaran","year":"2007","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.maturitas.2010.04.014_bib8","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1212\/01.wnl.0000303969.63165.34","article-title":"Carotid plaque, a subclinical precursor of vascular events: the Northern Manhattan Study","volume":"70","author":"Rundek","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.maturitas.2010.04.014_bib9","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1093\/eurheartj\/ehm487","article-title":"Comparative performance of subclinical atherosclerosis tests in predicting coronary heart disease in asymptomatic individuals","volume":"28","author":"Simon","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.maturitas.2010.04.014_bib10","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.echo.2007.11.011","volume":"21","author":"Stein","year":"2008","journal-title":"J Am Soc Echocardiogr"},{"key":"10.1016\/j.maturitas.2010.04.014_bib11","first-page":"2605","article-title":"Atherosclerotic vascular disease conference: Writing Group I","volume":"109","author":"Pasternak","year":"2004","journal-title":"Epidemiol Circ"},{"key":"10.1016\/j.maturitas.2010.04.014_bib12","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1161\/01.ATV.0000255310.47940.3b","article-title":"The prevalence and quantification of atherosclerosis in an elderly population assessed by whole-body magnetic resonance angiography","volume":"27","author":"Hansen","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.maturitas.2010.04.014_bib13","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1161\/01.STR.30.4.841","article-title":"Carotid plaque, intima-media thickness, cardiovascular risk factors, and prevalent cardiovascular disease in men and women: the British Regional Heart Study","volume":"30","author":"Ebrahim","year":"1999","journal-title":"Stroke"},{"key":"10.1016\/j.maturitas.2010.04.014_bib14","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1161\/01.STR.28.2.348","article-title":"Relationship between carotid intima-media thickness and symptomatic and asymptomatic peripheral arterial disease. The Edinburgh Artery Study","volume":"28","author":"Allan","year":"1997","journal-title":"Stroke"},{"key":"10.1016\/j.maturitas.2010.04.014_bib15","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.atherosclerosis.2007.06.020","article-title":"Prevalence and predictors of subclinical atherosclerosis among asymptomatic \u201clow risk\u201d individuals in a multiethnic population","volume":"197","author":"Grewal","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.maturitas.2010.04.014_bib16","doi-asserted-by":"crossref","first-page":"859","DOI":"10.2165\/00002512-200522100-00005","article-title":"Prevention of cardiovascular events in elderly people","volume":"22","author":"Adrawes","year":"2005","journal-title":"Drugs Aging"},{"key":"10.1016\/j.maturitas.2010.04.014_bib17","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1161\/01.HYP.0000075790.33892.AE","article-title":"Seventh report of the Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7): resetting the hypertension sails","volume":"41","author":"Lenfant","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.maturitas.2010.04.014_bib18","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.2337\/diacare.20.7.1183","article-title":"Report of the expert committe on the diagnosis and classification of diabetes mellitus","volume":"20","author":"American Diabetes Association","year":"1997","journal-title":"Diabetes Care"},{"key":"10.1016\/j.maturitas.2010.04.014_bib19","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","volume":"285","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.maturitas.2010.04.014_bib20","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000097034","article-title":"Mannheim carotid intima-media thickness consensus (2004\u20132006)","volume":"23","author":"Touboul","year":"2007","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.maturitas.2010.04.014_bib21","doi-asserted-by":"crossref","first-page":"M158","DOI":"10.1093\/gerona\/56.3.M158","article-title":"Associations of subclinical cardiovascular disease with frailty","volume":"56","author":"Newman","year":"2001","journal-title":"J Gerontol A: Biol Sci Med Sci"},{"key":"10.1016\/j.maturitas.2010.04.014_bib22","series-title":"Active ageing: a policy framework. WHO\/NMH\/HPH\/02.8","author":"WHO","year":"2002"},{"key":"10.1016\/j.maturitas.2010.04.014_bib23","first-page":"477","article-title":"Associations between carotid intima-media thickness, plaque and cardiovascular risk factors","volume":"39","author":"Lee","year":"2006","journal-title":"J Prev Med Public Health"},{"key":"10.1016\/j.maturitas.2010.04.014_bib24","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/S0025-7753(05)72186-2","article-title":"Carotid ultrasound in the assessment of preclinical atherosclerosis. Distribution of intima-media thickness values and plaque frequency in a Spanish community cohort","volume":"125","author":"Junyent","year":"2005","journal-title":"Med Clin (Barc)"},{"key":"10.1016\/j.maturitas.2010.04.014_bib25","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1161\/01.ATV.0000072273.67342.6D","article-title":"Diabetes and progression of carotid atherosclerosis: the Insulin Resistance Atherosclerosis Study","volume":"23","author":"Wagenknecht","year":"2003","journal-title":"Arteroscler Thromb Vasc Biol"},{"key":"10.1016\/j.maturitas.2010.04.014_bib26","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/01.hjh.0000198028.84353.86","article-title":"Prevalence, awareness, treatment, and control of hypertension in the elderly: the Three City study","volume":"24","author":"Brindel","year":"2006","journal-title":"J Hypertens"},{"key":"10.1016\/j.maturitas.2010.04.014_bib27","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/gerona\/gln016","article-title":"Prevalence, awareness, and management of hypertension, dyslipidemia, and diabetes among United States adults aged 65 and older","volume":"64","author":"McDonald","year":"2009","journal-title":"J Gerontol A: Biol Sci Med Sci"},{"key":"10.1016\/j.maturitas.2010.04.014_bib28","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/j.1747-4949.2006.00068.x","article-title":"Measurement of intima-media thickness vs. carotid plaque: uses in patient care, genetic research and evaluation of new therapies","volume":"1","author":"Spence","year":"2006","journal-title":"Int J Stroke"},{"key":"10.1016\/j.maturitas.2010.04.014_bib29","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1053\/euhj.1999.2006","article-title":"Prognostic implications of intima-media thickness and plaques in the carotid and femoral arteries in patients with stable angina pectoris","volume":"22","author":"Held","year":"2001","journal-title":"Eur Heart J"},{"key":"10.1016\/j.maturitas.2010.04.014_bib30","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1161\/01.STR.0000136720.21095.f3","article-title":"Rates and determinants of site-specific progression of carotid artery intima-media thickness: The Carotid Atherosclerosis Progression Study","volume":"35","author":"Mackinnon","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.maturitas.2010.04.014_bib31","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1161\/01.STR.0000244780.82190.a4","article-title":"Carotid plaque surface irregularity predicts ischemic stroke: The Northern Manhattan Study","volume":"37","author":"Prabhakaran","year":"2006","journal-title":"Stroke"}],"container-title":["Maturitas"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037851221000201X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037851221000201X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T08:50:06Z","timestamp":1759913406000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037851221000201X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S037851221000201X"],"URL":"https:\/\/doi.org\/10.1016\/j.maturitas.2010.04.014","relation":{},"ISSN":["0378-5122"],"issn-type":[{"value":"0378-5122","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiovascular risk factors are associated with subclinical atherosclerosis in high functioning older adults","name":"articletitle","label":"Article Title"},{"value":"Maturitas","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.maturitas.2010.04.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}