{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T05:29:32Z","timestamp":1794029372019,"version":"4.8.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","maturitas.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Maturitas"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.maturitas.2010.08.003","type":"journal-article","created":{"date-parts":[[2010,9,2]],"date-time":"2010-09-02T04:59:45Z","timestamp":1283403585000},"page":"316-320","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":255,"title":["Menopause and aging: Changes in the immune system\u2014A review"],"prefix":"10.1016","volume":"67","author":[{"given":"C\u00e1tia Morgado","family":"Gameiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Rom\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camil","family":"Castelo-Branco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.maturitas.2010.08.003_bib0005","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0378-5122(95)00970-1","article-title":"Well-being, symptoms and the menopausal transition","volume":"23","author":"Dennerstein","year":"1996","journal-title":"Maturitas"},{"issue":"3","key":"10.1016\/j.maturitas.2010.08.003_bib0010","first-page":"351","article-title":"A prospective population-based study of menopausal symptoms","volume":"96","author":"Dennerstein","year":"2000","journal-title":"Obstet Gynecol Obstet"},{"key":"10.1016\/j.maturitas.2010.08.003_bib0015","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/0960-0760(91)90287-F","article-title":"Sex steroid regulation of autoimmunity","volume":"40","author":"Grossman","year":"1991","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"November (11)","key":"10.1016\/j.maturitas.2010.08.003_bib0020","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1111\/j.1432-2277.2009.00927.x","article-title":"Theaging of the immune system","volume":"22","author":"Weiskopf","year":"2009","journal-title":"Transpl Int"},{"issue":"5","key":"10.1016\/j.maturitas.2010.08.003_bib0025","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.exger.2004.01.009","article-title":"Inflammatory mediators in the elderly","volume":"39","author":"Krabbe","year":"2004","journal-title":"Exp Gerontol"},{"issue":"4","key":"10.1016\/j.maturitas.2010.08.003_bib0030","first-page":"369","article-title":"Gonadal steroids and immunity","volume":"17","author":"Olsen","year":"1996","journal-title":"Endocr Rev"},{"issue":"1","key":"10.1016\/j.maturitas.2010.08.003_bib0035","first-page":"79","article-title":"Epidemiologia cl\u00ednica do climat\u00e9rio","volume":"18","author":"Medeiros","year":"2003","journal-title":"Reprod Clim"},{"issue":"1","key":"10.1016\/j.maturitas.2010.08.003_bib0040","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1210\/edrv-17-1-64","article-title":"Immune\u2013neuro\u2013endocrine interactions: facts and hypotheses","volume":"17","author":"Basedovsky","year":"1996","journal-title":"Endocr Rev"},{"issue":"11","key":"10.1016\/j.maturitas.2010.08.003_bib0045","first-page":"593","article-title":"Efeitos da terapia hormonal na menopausa sobre o sistema imune","volume":"29","author":"Medeiros","year":"2007","journal-title":"Rev Br\u00e1s Ginecol Obestet"},{"key":"10.1016\/j.maturitas.2010.08.003_bib0050","series-title":"Kuby immunology","first-page":"508","author":"Goldsby","year":"2000"},{"issue":"1","key":"10.1016\/j.maturitas.2010.08.003_bib0055","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1600-0897.1995.tb01150.x","article-title":"In vivo CD3+CD25+ lymphocyte subpopulation is down-regulated without increased serum-soluble interleukin-2 receptor (sIL-2R) by gonadotropin releasing hormone agonist (GnRH-a)","volume":"33","author":"Ho","year":"1995","journal-title":"Am J Reprod Immunol"},{"issue":"November","key":"10.1016\/j.maturitas.2010.08.003_bib0060","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1196\/annals.1386.043","article-title":"Estrogens and autoimmune diseases","volume":"1089","author":"Cutolo","year":"2006","journal-title":"Ann N Y Acad Sci"},{"issue":"5","key":"10.1016\/j.maturitas.2010.08.003_bib0065","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/S0015-0282(00)01553-3","article-title":"The immune response during the luteal phase of the ovarian cycle: a Th2-type response?","volume":"74","author":"Faas","year":"2000","journal-title":"Fertil Steril"},{"issue":"12","key":"10.1016\/j.maturitas.2010.08.003_bib0070","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1054\/bjoc.2000.1490","article-title":"Timing within the menstrual cycle, sex, and the use of oral contraceptives determine adrenergic suppression of NK cell activity","volume":"83","author":"Shakhar","year":"2000","journal-title":"Br J Cancer"},{"issue":"6","key":"10.1016\/j.maturitas.2010.08.003_bib0075","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.4049\/jimmunol.158.6.3017","article-title":"CD3+CD8+CTL activity within the human female reproductive tract: influence of stage of menstrual cycle and menopause","volume":"158","author":"White","year":"1997","journal-title":"J Immunol"},{"issue":"2","key":"10.1016\/j.maturitas.2010.08.003_bib0080","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1590\/1809-9823.2008.110210","article-title":"Immunosenescence: the association between leukocytes, cytokines and chronic diseases","volume":"11","author":"Tonet","year":"2008","journal-title":"Rev Bras Geriatr Gerontol"},{"issue":"November (11)","key":"10.1016\/j.maturitas.2010.08.003_bib0085","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1111\/j.1432-2277.2009.00927.x","article-title":"The aging of the immune system","volume":"22","author":"Weiskopf","year":"2009","journal-title":"Transpl Int"},{"issue":"August (1)","key":"10.1016\/j.maturitas.2010.08.003_bib0090","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s12016-009-8169-3","article-title":"The role of epigenetics in agin and autoimmunity","volume":"39","author":"Grolleau- Julius","year":"2010","journal-title":"Clin Rev Allergy Immunol"},{"issue":"1","key":"10.1016\/j.maturitas.2010.08.003_bib0095","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2174\/187221309787158371","article-title":"Chronic inflammation and oxidative stress as a major cause of age-related disease and cancer","volume":"3","author":"Khansari","year":"2009","journal-title":"Recent Pat Inflamm Allergy Drug Discov"},{"issue":"18","key":"10.1016\/j.maturitas.2010.08.003_bib0100","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/0024-3205(94)00508-7","article-title":"Immune cell circulating subsets are affected by gonadal function","volume":"54","author":"Giglio","year":"1994","journal-title":"Life Sci"},{"issue":"3","key":"10.1016\/j.maturitas.2010.08.003_bib0105","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1067\/mob.2001.109940","article-title":"Postmenopausal changes in serum cytokine levels and hormone replacement therapy","volume":"184","author":"Kamada","year":"2001","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"10.1016\/j.maturitas.2010.08.003_bib0110","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.maturitas.2006.11.002","article-title":"Changes in serum cytokine concentrations during the menopausal transition","volume":"56","author":"Yasui","year":"2007","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2010.08.003_bib0115","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0378-5122(01)00286-9","article-title":"Cytocine patern in postmenopauce","volume":"41","author":"Cioffi","year":"2002","journal-title":"Maturitas"},{"issue":"4","key":"10.1016\/j.maturitas.2010.08.003_bib0120","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1600-0897.1991.tb01089.x","article-title":"Immunology of ovarian failure","volume":"25","author":"Coulam","year":"1991","journal-title":"Am J Reprod Immunol"},{"issue":"1","key":"10.1016\/j.maturitas.2010.08.003_bib0125","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1210\/edrv.23.1.0456","article-title":"Changes in proinflammatory cytokine activity after menopause","volume":"23","author":"Pfeilschifter","year":"2002","journal-title":"Endocr Rev"},{"key":"10.1016\/j.maturitas.2010.08.003_bib0130","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.cyto.2007.12.001","article-title":"Associations of interleukin-6 with interleukin 1Beta, interleukin-8 and macrophage inflammatory protein 1Beta in midlife women","volume":"41","author":"Toshiyuki","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.maturitas.2010.08.003_bib0135","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0145-305X(97)00029-3","article-title":"Immunologic aspects of osteoporosis","volume":"21","author":"William","year":"1997","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.maturitas.2010.08.003_bib0140","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1002\/jbmr.5650110802","article-title":"Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis","volume":"11","author":"Pacifici","year":"1996","journal-title":"J Bone Miner Res"},{"issue":"3","key":"10.1016\/j.maturitas.2010.08.003_bib0145","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1210\/jcem.85.3.6355","article-title":"Hormone replacement therapy and interrelation between serum interleukin-6 and body mass index in postmenopausal women: a population-based study","volume":"85","author":"Straub","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.maturitas.2010.08.003_bib0150","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1006\/cyto.2002.1963","article-title":"Hormonal modulation of interleukin-6, tumor necrosis factor and associated receptor secretion in postmenopausal women","volume":"19","author":"Brooks-Asplund","year":"2002","journal-title":"Cytokine"},{"issue":"4","key":"10.1016\/j.maturitas.2010.08.003_bib0155","first-page":"207","article-title":"Lowering effect of estrogen replacement treatment on immunoglobolins in menopausal women","volume":"85","author":"Blum","year":"1990","journal-title":"Rev Fr Gynecol Obstet"},{"issue":"1","key":"10.1016\/j.maturitas.2010.08.003_bib0160","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jri.2005.07.006","article-title":"Effect of estrogen\/progesterone hormone replacement therapy on natural killer cell cytotoxicity and immunoregulatory cytokine release by peripheral blood mononuclear cells of postmenopausal womem","volume":"69","author":"Stopinska-Gluszack","year":"2006","journal-title":"J Reprod Immunol"},{"issue":"5","key":"10.1016\/j.maturitas.2010.08.003_bib0165","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1093\/ajcn\/83.5.1118","article-title":"Soy isoflavones modulate immune function in helthy postmenopausal women","volume":"83","author":"Ryan-Borchers","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.maturitas.2010.08.003_bib0170","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1161\/01.CIR.0000013837.81710.DA","article-title":"Statin attenuates increase in C-reactive protein during estrogen replacement therapy in postmenopausal women","volume":"105","author":"Koh","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.maturitas.2010.08.003_bib0175","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1161\/01.CIR.100.7.717","article-title":"Effect of postmenopausal hormones on inflammation-sensitive proteins. The postmenopausal estrogen\/progestin interventions (PEPI) study","volume":"100","author":"Cushman","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.maturitas.2010.08.003_bib0180","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1055\/s-0037-1615643","article-title":"Effects of oral and transdermal estrogen replacement therapy on markers of coagulation, fibrinolysis, inflammation and serum lipids and lipoproteins in postmenopausal women","volume":"85","author":"Vehkavaara","year":"2001","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.maturitas.2010.08.003_bib0185","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.1210\/jcem.86.9.7799","article-title":"Differential effects of estrogen and droloxifene on C-reactive protein and other markers of inflammation in healthy postmenopausal women","volume":"86","author":"Herrington","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.maturitas.2010.08.003_bib0190","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1161\/01.ATV.19.4.893","article-title":"Hormone replacement therapy, inflammation, and hemostasis in elderly women","volume":"19","author":"Cushman","year":"1999","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.maturitas.2010.08.003_bib0195","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0002-9149(01)01865-3","article-title":"Role of tumor necrosis factor-\u03b1 and interleukin-6 in the effects of hormone replacement therapy and raloxifene on C-reactive protein in postmenopausal women","volume":"88","author":"Walsh","year":"2001","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.maturitas.2010.08.003_bib0200","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1161\/01.CIR.0000074208.02226.5E","article-title":"Increased levels of C-reactive protein after oral hormone replacement therapy may not be related to an increased inflammatory response","volume":"107","author":"Silvestri","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.maturitas.2010.08.003_bib0205","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1161\/01.CIR.0000028463.74880.EA","article-title":"Effect of transdermal estradiol and oral conjugated estrogen on C-reactive protein in retinoid-placebo trial in healthy women","volume":"106","author":"Decensi","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.maturitas.2010.08.003_bib0210","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0140-6736(99)02079-6","article-title":"Hormone replacement therapy and sensitive C-reactive protein concentrations in women with type-2 diabetes","volume":"354","author":"Sattar","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.maturitas.2010.08.003_bib0215","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1210\/jc.2005-0231","article-title":"Low-grade inflammation and estimates of insulin resistance during the menstrual cycle in lean and overweight women","volume":"90","author":"Modena","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.maturitas.2010.08.003_bib0220","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1172\/JCI118774","article-title":"Effects of 17\u03b2-estradiol on cytokine-induced endothelial cell adhesion molecule expression","volume":"98","author":"Caulin-Glaser","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1016\/j.maturitas.2010.08.003_bib0225","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1161\/01.CIR.0000142050.19488.C7","article-title":"Estrogen modulates inflammatory mediator expression and neutrophil chemotaxis in injured arteries","volume":"110","author":"Miller","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.maturitas.2010.08.003_bib0230","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1161\/hc1202.105945","article-title":"Effect of medroxyprogesterone acetate on vascular inflammatory markers in postmenopausal women receiving estrogen","volume":"105","author":"Wakatsuki","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.maturitas.2010.08.003_bib0235","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0002-9149(02)03121-1","article-title":"Effect of hormonal replacement therapy on C-reactive protein and cell-adhesion molecules in postmenopausal women","volume":"91","author":"Lamon-Fava","year":"2003","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.maturitas.2010.08.003_bib0240","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/S0002-9149(97)00732-7","article-title":"Effects of hormone therapy on inflammatory cell adhesion molecules in postmenopausal healthy women","volume":"80","author":"Koh","year":"1997","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.maturitas.2010.08.003_bib0245","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1161\/01.CIR.100.18.1851","article-title":"Vascular effects of estrogen and vitamin E therapies in postmenopausal women","volume":"100","author":"Koh","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.maturitas.2010.08.003_bib0250","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1161\/01.CIR.103.15.1961","article-title":"Vascular effects of synthetic or natural progestagen combined with conjugated equine estrogen in healthy postmenopausal women","volume":"103","author":"Koh","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.maturitas.2010.08.003_bib0255","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1161\/01.ATV.18.10.1575","article-title":"Estradiol suppresses MCP-1 expression in vivo: implications for atherosclerosis","volume":"18","author":"Pervin","year":"1998","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.maturitas.2010.08.003_bib0260","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/S0008-6363(01)00461-8","article-title":"The effect of 17 beta-estradiol on MCP-1 serum levels in postmenopausal women","volume":"53","author":"Stork","year":"2002","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.maturitas.2010.08.003_bib0265","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0167-5273(01)00527-7","article-title":"Effect of hormone replacement therapy on nitric oxide bioactivity and monocyte chemoattractant protein-1 levels","volume":"81","author":"Koh","year":"2001","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.maturitas.2010.08.003_bib0270","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1172\/JCI7094","article-title":"Estrogen decreases TNF gene expression by blocking JNK activity and the resulting production of c-Jun and JunD","volume":"104","author":"Srivastava","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.maturitas.2010.08.003_bib0275","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1161\/01.ATV.0000029226.45915.A7","article-title":"Effects of continuous combined hormone replacement therapy on inflammation in hypertensive and\/or overweight postmenopausal women","volume":"22","author":"Koh","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.maturitas.2010.08.003_bib0280","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1161\/01.ATV.18.9.1498","article-title":"Expression of interleukin-6 in atherosclerotic lesions of male apoE-knockout mice","volume":"18","author":"Sukovich","year":"1998","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["Maturitas"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512210003166?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512210003166?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T08:50:24Z","timestamp":1759913424000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378512210003166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0378512210003166"],"URL":"https:\/\/doi.org\/10.1016\/j.maturitas.2010.08.003","relation":{},"ISSN":["0378-5122"],"issn-type":[{"value":"0378-5122","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Menopause and aging: Changes in the immune system\u2014A review","name":"articletitle","label":"Article Title"},{"value":"Maturitas","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.maturitas.2010.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}