{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:39:46Z","timestamp":1790008786414,"version":"4.0.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Maturitas"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.maturitas.2010.10.005","type":"journal-article","created":{"date-parts":[[2010,12,15]],"date-time":"2010-12-15T09:30:45Z","timestamp":1292405445000},"page":"94-97","source":"Crossref","is-referenced-by-count":45,"title":["EMAS position statement: Managing the menopause in the context of coronary heart disease"],"prefix":"10.1016","volume":"68","author":[{"given":"Karin","family":"Schenck-Gustafsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Brincat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Tamer","family":"Erel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Gambacciani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Lambrinoudaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette H.","family":"Moen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Tremollieres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana Vujovic Serge","family":"Rozenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Rees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.maturitas.2010.10.005_bib0005","unstructured":"World Health Organization Statistical Information System; 2008. www.who.int\/whosis (accessed 14 October 2010)."},{"key":"10.1016\/j.maturitas.2010.10.005_bib0010","unstructured":"Swedish Board of Health and Welfare. Open comparisons; 2009 http:\/\/www.fhi.se\/en\/Publications\/All-publications-in-english\/Open-Comparisons-2009 Public-Health-including-the-indicator-Smoking-habits\/ (accessed 14 October 2010)."},{"issue":"Suppl. 1","key":"10.1016\/j.maturitas.2010.10.005_bib0015","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1186\/1472-6874-4-S1-S9","article-title":"Mortality: life and health expectancy of Canadian women, Women's Health Surveillance Report","volume":"4","author":"DesMeules","year":"2004","journal-title":"BMC Women's Health"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0020","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1093\/eurheartj\/ehq094","article-title":"European Heart Health Strategy. Women and research on cardiovascular diseases in Europe: a report from the European Heart Health Strategy (EuroHeart) project","volume":"31","author":"Stramba-Badiale","year":"2010","journal-title":"Eur Heart J"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0025","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1161\/CIRCOUTCOMES.110.868307","article-title":"Representation of women in randomized clinical trials of cardiovascular disease prevention","volume":"3","author":"Melloni","year":"2010","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0030","unstructured":"WHO Statistical Information System (WHOSIS); 1960. www.who.int\/whosis (accessed 14 October 2010)"},{"issue":"9438","key":"10.1016\/j.maturitas.2010.10.005_bib0035","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0140-6736(04)17018-9","article-title":"INTERHEART Study Investigators Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study","volume":"364","author":"Yusuf","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0040","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1093\/eurheartj\/ehn018","article-title":"INTERHEART Investigators. Risk factors for myocardial infarction in women and men: insights from the INTERHEART study","volume":"29","author":"Anand","year":"2008","journal-title":"Eur Heart J"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0045","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.maturitas.2009.02.014","article-title":"Risk factors for cardiovascular disease in women","volume":"63","author":"Schenck-Gustafsson","year":"2009","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0050","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.maturitas.2010.04.011","article-title":"EMAS position statement: Managing women with premature ovarian failure","volume":"67","author":"Vujovic","year":"2010","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0055","doi-asserted-by":"crossref","unstructured":"Drost JT, Maas AHEM, van Eyck J, van der Schouw YT. Preeclampsia as a female-specific risk factor for chronic hypertension Maturitas; 2010 sep 10. (Epub ahead of print) PMID 20833489-as supplied by publisher.","DOI":"10.1016\/j.maturitas.2010.08.002"},{"issue":"4","key":"10.1016\/j.maturitas.2010.10.005_bib0060","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1210\/jc.2007-0425","volume":"93","author":"Shaw","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0065","unstructured":"Alternatives to HRT for the Management of Symptoms of the Menopause (SAC Opinion Paper 6). RCOG; 2010. http:\/\/www.rcog.org.uk\/womens-health\/clinical-guidance\/alternatives-hrt-management-symptoms-menopause (accessed 14 October 2010)."},{"key":"10.1016\/j.maturitas.2010.10.005_bib0070","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1097\/AOG.0b013e3181d41191","article-title":"Role of hormone therapy in the management of menopause","volume":"115","author":"Shifren","year":"2010","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0075","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1056\/NEJMoa0800743","article-title":"LIFT Trial Investigators: the effects of tibolone in older postmenopausal women","volume":"359","author":"Cummings","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0080","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1056\/NEJMoa062462","article-title":"Raloxifene use for The Heart (RUTH) Trial Investigators: effects of raloxifene on cardiovascular events and breast cancer in postmenopausal women","volume":"355","author":"Barrett-Connor","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0085","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1161\/hc2901.092200","article-title":"Hormone replacement therapy and cardiovascular disease a statement for healthcare professionals from the American Heart Association","volume":"104","author":"Mosca","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0090","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1093\/eurheartj\/ehm296","article-title":"Management of the cardiovascular risk in the peri-menopausal woman: a consensus statement of European cardiologists and gynecologists","volume":"28","author":"Collins","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0095","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1056\/NEJM199109123251102","article-title":"Postmenopausal estrogen therapy and cardiovascular disease Ten-year follow-up from the nurses\u2019 health study","volume":"325","author":"Stampfer","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0100","doi-asserted-by":"crossref","first-page":"2660","DOI":"10.1093\/eurheartj\/ehn408","article-title":"Hormone therapy and risk of myocardial infarction: a national register study","volume":"29","author":"L\u00f6kkegaard","year":"2008","journal-title":"Eur Heart J"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0105","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1056\/NEJM199906103402306","article-title":"The protective effects of estrogen on the cardiovascular system","volume":"340","author":"Mendelsohn","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0110","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1001\/jama.288.3.321","article-title":"Writing Group for the Women's Health Initiative Investigators Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial","volume":"288","author":"Rossouw","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0115","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1001\/jama.291.14.1701","article-title":"Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial","volume":"291","author":"The Women's Health Initiative Steering Committee","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0120","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1056\/NEJMoa030808","article-title":"Women's Health Initiative Investigators Estrogen plus progestin and the risk of coronary heart disease","volume":"349","author":"Manson","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0125","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.maturitas.2009.01.004","article-title":"Cardiovascular risk markers during treatment with estradiol and trimegestone or dydrogesterone","volume":"62","author":"Hellgren","year":"2009","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0130","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1001\/archinte.166.3.357","article-title":"Conjugated equine estrogens and coronary heart disease","volume":"166","author":"Hsia","year":"2006","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0135","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1056\/NEJMoa071513","article-title":"For the WHI and WHI-CACS investigators estrogen therapy and coronary-artery calcification","volume":"356","author":"Manson","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0140","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1001\/jama.297.13.1465","article-title":"Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause","volume":"297","author":"Rossouw","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0145","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/aje\/kwp115","article-title":"Benefits and risks of postmenopausal hormone therapy when it is initiated soon after menopause","volume":"170","author":"Prentice","year":"2009","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0150","doi-asserted-by":"crossref","first-page":"211","DOI":"10.7326\/0003-4819-152-4-201002160-00005","article-title":"Coronary heart disease in postmenopausal recipientsof estrogens plus progestin therapy: does the increased risk ever disappear?","volume":"152","author":"Sengwee","year":"2010","journal-title":"Ann Intern Med"},{"issue":"7655","key":"10.1016\/j.maturitas.2010.10.005_bib0155","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1136\/bmj.39555.441944.BE","article-title":"Hormone replacement therapy and risk of venous thromboembolism in postmenopausal women: systematic review and meta-analysis","volume":"336","author":"Canonico","year":"2008","journal-title":"BMJ"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0160","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s12265-009-9104-y","article-title":"Using basic science to design a clinical trial: baseline characteristics of women enrolled in the Kronos Early Estrogen Prevention Study (KEEPS)","volume":"2","author":"Miller","year":"2009","journal-title":"J Cardiovasc Transl Res"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0165","unstructured":"Early Versus Late Intervention Trial With Estradiol (ELITE) study. http:\/\/clinicaltrials.gov\/ct2\/show\/NCT00114517 (accessed 14 October 2010)."},{"key":"10.1016\/j.maturitas.2010.10.005_bib0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-135-1-200107030-00003","article-title":"Postmenopausal hormone use and secondary prevention of coronary events in the nurses\u2019 health study. A prospective, observational study","volume":"135","author":"Grodstein","year":"2001","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0175","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1001\/jama.273.3.199","article-title":"Effects of estrogen or estrogen\/progestin regimens on heart disease risk factors in postmenopausal women. The Postmenopausal Estrogen\/Progestin Interventions (PEPI) Trial","volume":"273","author":"The Writing Group for the PEPI Trial","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0180","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1097\/00004872-199917100-00004","article-title":"A randomized trial on effects of hormone therapy on ambulatory blood pressure and lipoprotein levels in women with coronary artery disease","volume":"17","author":"Pripp","year":"1999","journal-title":"J Hypertension"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0185","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1053\/euhj.1998.0975","article-title":"Does sublingual 17 beta-oestradiol have any effects on exercise capacity and myocardial ischaemia in post-menopausal women with stable coronary artery disease?","volume":"19","author":"Al-Khalili","year":"1998","journal-title":"Eur Heart J"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0190","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1016\/S0140-6736(05)61121-X","article-title":"Oestrogen improves exercise induced myocardial ischemia in women","volume":"351","author":"Webb","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0195","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0002-9149(98)00314-2","article-title":"Effect of conjugated estrogen on peripheral flow-mediated vasodilation in postmenopausal women","volume":"82","author":"Al-Khalili","year":"1998","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0200","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1016\/S0140-6736(02)12001-0","article-title":"Oestrogen therapy for prevention of reinfarction in postmenopausal women: a randomised placebo controlled trial","volume":"360","author":"Cherry","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0205","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1111\/j.1471-0528.2002.01544.x","article-title":"A study of hormone replacement therapy in postmenopausal women with ischaemic heart disease: the Papworth HRT atherosclerosis study","volume":"109","author":"Clarke","year":"2002","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0210","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1093\/eurheartj\/ehl183","article-title":"WHISP (Women's Hormone Intervention Secondary Prevention Study) Pilot Study Investigators; randomized trial of effects of continuous combined HRT on markers of lipids and coagulation in women with acute coronary syndromes: WHISP Pilot Study","volume":"27","author":"Collins","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0215","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1001\/jama.280.7.605","article-title":"Vittinghoff E Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women Heart and Estrogen\/progestin Replacement Study (HERS) Research Group","volume":"280","author":"Hulley","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0220","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1001\/jama.288.1.49","article-title":"HERSResearch Group. Cardiovascular disease outcomes during 6. 8 years of hormonetherapy: Heart and Estrogen\/progestin Replacement Study follow-up (HERS II)","volume":"288","author":"Grady","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.maturitas.2010.10.005_bib0225","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1161\/CIRCULATIONAHA.106.642280","article-title":"Estrogen and Thromboembolism Risk (ESTHER) Study Group Hormone therapy and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration and progestogens: the ESTHER study","volume":"115","author":"Canonico","year":"2007","journal-title":"Circulation"},{"issue":"Suppl. 1","key":"10.1016\/j.maturitas.2010.10.005_bib0230","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1080\/13697130903006837","article-title":"Hormone therapy and risk of venous thromboembolism among postmenopausal women","volume":"12","author":"Canonico","year":"2009","journal-title":"Climacteric"}],"updated-by":[{"DOI":"10.1016\/j.maturitas.2011.03.006","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000}}],"container-title":["Maturitas"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037851221000383X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037851221000383X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T02:52:13Z","timestamp":1559875933000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037851221000383X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S037851221000383X"],"URL":"https:\/\/doi.org\/10.1016\/j.maturitas.2010.10.005","relation":{},"ISSN":["0378-5122"],"issn-type":[{"value":"0378-5122","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}