{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T21:10:24Z","timestamp":1766869824869,"version":"build-2065373602"},"reference-count":78,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","maturitas.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Maturitas"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1016\/j.maturitas.2011.06.007","type":"journal-article","created":{"date-parts":[[2011,8,6]],"date-time":"2011-08-06T16:16:22Z","timestamp":1312647382000},"page":"26-33","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Therapeutic targets for premature ejaculation"],"prefix":"10.1016","volume":"70","author":[{"given":"Karl-Erik","family":"Andersson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim A.","family":"Abdel-Hamid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"December","key":"10.1016\/j.maturitas.2011.06.007_bib0005","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1007\/BF03344077","article-title":"Disorders of ejaculation","volume":"25","author":"Jannini","year":"2002","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.maturitas.2011.06.007_bib0010","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.ucl.2007.08.011","article-title":"Premature ejaculation: state of the art","volume":"34","author":"Waldinger","year":"2007","journal-title":"Urol Clin N Am"},{"issue":"March (3)","key":"10.1016\/j.maturitas.2011.06.007_bib0015","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.eururo.2006.07.004","article-title":"The premature ejaculation prevalence and attitudes (PEPA) survey: prevalence, comorbidities, and professional help-seeking","volume":"51","author":"Porst","year":"2007","journal-title":"Eur Urol"},{"issue":"May (5)","key":"10.1016\/j.maturitas.2011.06.007_bib0020","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.eururo.2007.10.015","article-title":"3004 Study Group Premature ejaculation: results from a five-country European observational study","volume":"53","author":"Giuliano","year":"2008","journal-title":"Eur Urol"},{"issue":"September (9)","key":"10.1016\/j.maturitas.2011.06.007_bib0025","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1111\/j.1743-6109.2010.01975.x","article-title":"International society for sexual medicine international society for sexual medicine's guidelines for the diagnosis and treatment of premature ejaculation","volume":"7","author":"Althof","year":"2010","journal-title":"J Sex Med"},{"issue":"February (2)","key":"10.1016\/j.maturitas.2011.06.007_bib0030","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1517\/14728220802663549","article-title":"Premature ejaculation: focus on therapeutic targets","volume":"13","author":"Abdel-Hamid","year":"2009","journal-title":"Expert Opin Ther Targets"},{"issue":"May (3)","key":"10.1016\/j.maturitas.2011.06.007_bib0035","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1111\/j.1743-6109.2007.00501.x","article-title":"The DSM-IV-TR is an inadequate diagnostic tool for premature ejaculation","volume":"4","author":"Waldinger","year":"2007","journal-title":"J Sex Med"},{"issue":"May (2)","key":"10.1016\/j.maturitas.2011.06.007_bib0040","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0166-4328(97)00183-6","article-title":"Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: the involvement of the serotonergic system","volume":"92","author":"Waldinger","year":"1998","journal-title":"Behav Brain Res"},{"issue":"August (3)","key":"10.1016\/j.maturitas.2011.06.007_bib0045","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/j.1460-9568.2005.04252.x","article-title":"Individual differences in male rat ejaculatory behaviour: searching for models to study ejaculation disorders","volume":"22","author":"Pattij","year":"2005","journal-title":"Eur J Neurosci"},{"issue":"August (8)","key":"10.1016\/j.maturitas.2011.06.007_bib0050","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1111\/j.1743-6109.2009.01308.x","article-title":"Differences in the spinal command of ejaculation in rapid ejaculating rats","volume":"6","author":"Borgdorff","year":"2009","journal-title":"J Sex Med"},{"issue":"August (5586)","key":"10.1016\/j.maturitas.2011.06.007_bib0055","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1126\/science.1073885","article-title":"Identification of a potential ejaculation generator in the spinal cord","volume":"297","author":"Truitt","year":"2002","journal-title":"Science"},{"issue":"June (1\u20132)","key":"10.1016\/j.maturitas.2011.06.007_bib0060","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0006-8993(03)02686-6","article-title":"Evidence for the involvement of a spinal pattern generator in the control of the genital motor pattern of ejaculation","volume":"975","author":"Carro-Ju\u00e1rez","year":"2003","journal-title":"Brain Res"},{"issue":"June (1)","key":"10.1016\/j.maturitas.2011.06.007_bib0065","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.brainresrev.2007.12.002","article-title":"The spinal pattern generator for ejaculation","volume":"58","author":"Carro-Ju\u00e1rez","year":"2008","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.maturitas.2011.06.007_bib0070","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.physbeh.2004.08.023","article-title":"Central regulation of ejaculation","volume":"83","author":"Coolen","year":"2004","journal-title":"Physiol Behav"},{"key":"10.1016\/j.maturitas.2011.06.007_bib0075","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1080\/10532528.2005.10559833","article-title":"Neuroanatomy and physiology of ejaculation","volume":"16","author":"Giuliano","year":"2005","journal-title":"Annu Rev Sex Res"},{"issue":"April (4)","key":"10.1016\/j.maturitas.2011.06.007_bib0080","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1111\/j.1743-6109.2010.02168.x","article-title":"Activation of NMDA receptors in lumbar spinothalamic cells is required for ejaculation","volume":"8","author":"Staudt","year":"2011","journal-title":"J Sex Med"},{"issue":"March\u2013April (2)","key":"10.1016\/j.maturitas.2011.06.007_bib0085","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/sj.ijir.3901277","article-title":"Role of genital sensory information in the control of the functioning of the spinal generator for ejaculation","volume":"17","author":"Carro-Ju\u00e1rez","year":"2005","journal-title":"Int J Impot Res"},{"issue":"September (9)","key":"10.1016\/j.maturitas.2011.06.007_bib0090","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1111\/j.1743-6109.2008.00914.x","article-title":"Regulation of epididymal contractility during semen emission, the first part of the ejaculatory process: a role for estrogen","volume":"5","author":"Vignozzi","year":"2008","journal-title":"J Sex Med"},{"issue":"March (3)","key":"10.1016\/j.maturitas.2011.06.007_bib0095","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1017\/S1092852900024445","article-title":"Neurochemical aspects of the sexual response cycle","volume":"8","author":"Halaris","year":"2003","journal-title":"CNS Spectr"},{"issue":"June (2)","key":"10.1016\/j.maturitas.2011.06.007_bib0100","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s00345-004-0496-7","article-title":"Prolactinergic and dopaminergic mechanisms underlying sexual arousal and orgasm in humans","volume":"23","author":"Kr\u00fcger","year":"2005","journal-title":"World J Urol"},{"issue":"June (1)","key":"10.1016\/j.maturitas.2011.06.007_bib0105","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.yhbeh.2007.03.030","article-title":"Sexual behavior in male rodents","volume":"52","author":"Hull","year":"2007","journal-title":"Horm Behav"},{"issue":"June (2)","key":"10.1016\/j.maturitas.2011.06.007_bib0110","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s00345-004-0486-9","article-title":"Ejaculatory disorders: epidemiology and current approaches to definition, classification and subtyping","volume":"23","author":"Jannini","year":"2005","journal-title":"World J Urol"},{"issue":"September\u2013October (18 Suppl.)","key":"10.1016\/j.maturitas.2011.06.007_bib0115","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1038\/sj.ijir.3901330","article-title":"Psychopharmacology of male rat sexual behavior: modeling human sexual dysfunctions?","volume":"1","author":"Olivier","year":"2006","journal-title":"Int J Impot Res"},{"issue":"September (3)","key":"10.1016\/j.maturitas.2011.06.007_bib0120","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.eururo.2006.05.055","article-title":"Serotonin and premature ejaculation: from physiology to patient management","volume":"50","author":"Giuliano","year":"2006","journal-title":"Eur Urol"},{"issue":"February (2)","key":"10.1016\/j.maturitas.2011.06.007_bib0125","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.tins.2006.12.002","article-title":"5-Hydroxytryptamine in premature ejaculation: opportunities for therapeutic intervention","volume":"30","author":"Giuliano","year":"2007","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.maturitas.2011.06.007_bib0130","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0028-3908(99)00010-6","article-title":"A review of central 5-HT receptors and their function","volume":"38","author":"Barnes","year":"1999","journal-title":"Neuropharmacology"},{"issue":"July (7)","key":"10.1016\/j.maturitas.2011.06.007_bib0135","first-page":"743","article-title":"Utility of selective serotonin reuptake inhibitors in premature ejaculation","volume":"5","author":"Waldinger","year":"2004","journal-title":"Curr Opin Investig Drugs"},{"issue":"September (6)","key":"10.1016\/j.maturitas.2011.06.007_bib0140","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/j.1464-410X.2008.07719.x","article-title":"The pharmacological treatment of premature ejaculation","volume":"102","author":"Giuliano","year":"2008","journal-title":"BJU Int"},{"issue":"September (9539)","key":"10.1016\/j.maturitas.2011.06.007_bib0145","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0140-6736(06)69373-2","article-title":"Dapoxetine Study Group. Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind randomised controlled trials","volume":"368","author":"Pryor","year":"2006","journal-title":"Lancet"},{"issue":"January (1)","key":"10.1016\/j.maturitas.2011.06.007_bib0150","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/clpt.2010.215","article-title":"Dapoxetine for premature ejaculation","volume":"89","author":"Feige","year":"2011","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.maturitas.2011.06.007_bib0155","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0091-3057(91)90543-B","article-title":"Sex behavior of male and female Wistar rats affected by the serotonin agonist 8-OH-DPAT","volume":"40","author":"Haensel","year":"1991","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.maturitas.2011.06.007_bib0160","doi-asserted-by":"crossref","first-page":"313","DOI":"10.5326\/15473317-37-4-313","article-title":"Clomipramine-beyond separation anxiety","volume":"37","author":"Landsberg","year":"2001","journal-title":"J Am Anim Hosp Assoc"},{"key":"10.1016\/j.maturitas.2011.06.007_bib0165","doi-asserted-by":"crossref","first-page":"547","DOI":"10.2165\/00003495-200767040-00005","article-title":"Premature ejaculation: definition and drug treatment","volume":"67","author":"Waldinger","year":"2007","journal-title":"Drugs"},{"issue":"February (1)","key":"10.1016\/j.maturitas.2011.06.007_bib0170","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ejphar.2004.12.024","article-title":"Citalopram combined with WAY 100635 inhibits ejaculation and ejaculation-related Fos immunoreactivity","volume":"509","author":"de Jong","year":"2005","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"10.1016\/j.maturitas.2011.06.007_bib0175","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.neubiorev.2007.07.013","article-title":"Central neurophysiology and dopaminergic control of ejaculation","volume":"32","author":"Peeters","year":"2008","journal-title":"Neurosci Biobehav Rev"},{"issue":"March (1)","key":"10.1016\/j.maturitas.2011.06.007_bib0180","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1124\/pr.110.002642","article-title":"The physiology, signaling, and pharmacology of dopamine receptors","volume":"63","author":"Beaulieu","year":"2011","journal-title":"Pharmacol Rev."},{"issue":"November (3)","key":"10.1016\/j.maturitas.2011.06.007_bib0185","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.neuroscience.2007.06.051","article-title":"Microinjection of the preferential dopamine receptor D3 agonist 7-hydroxy-N,N-di-n-propylaminotetralin hydrobromide into the hypothalamic medial preoptic area induced ejaculation in anesthetized rats","volume":"149","author":"Kitrey","year":"2007","journal-title":"Neuroscience"},{"issue":"March (2)","key":"10.1016\/j.maturitas.2011.06.007_bib0190","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.neuroscience.2006.12.003","article-title":"Ejaculation induced by i.c.v. injection of the preferential dopamine D(3) receptor agonist 7-hydroxy-2-(di-N-propylamino)tetralin in anesthetized rats","volume":"145","author":"Cl\u00e9ment","year":"2007","journal-title":"Neuroscience"},{"issue":"April (4)","key":"10.1016\/j.maturitas.2011.06.007_bib0195","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1111\/j.1743-6109.2008.01173.x","article-title":"Delay of ejaculation induced by SB-277011, a selective dopamine D3 receptor antagonist, in the rat","volume":"6","author":"Cl\u00e9ment","year":"2009","journal-title":"J Sex Med"},{"issue":"January (3)","key":"10.1016\/j.maturitas.2011.06.007_bib0200","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.neubiorev.2010.10.014","article-title":"Central control of penile erection: a re-visitation of the role of oxytocin and its interaction with dopamine and glutamic acid in male rats","volume":"35","author":"Melis","year":"2011","journal-title":"Neurosci Biobehav Rev"},{"issue":"March (1)","key":"10.1016\/j.maturitas.2011.06.007_bib0205","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/0018-506X(85)90002-9","article-title":"Oxytocin improves male copulatory performance in rats","volume":"19","author":"Arletti","year":"1985","journal-title":"Horm Behav"},{"issue":"October (1)","key":"10.1016\/j.maturitas.2011.06.007_bib0210","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1677\/joe.0.1070097","article-title":"Oxytocin and sexual behaviour in the male rat and rabbit","volume":"107","author":"Stoneham","year":"1985","journal-title":"J Endocrinol"},{"issue":"May (3)","key":"10.1016\/j.maturitas.2011.06.007_bib0215","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0014-2999(88)90675-9","article-title":"The oxytocin antagonist d(CH2)5Tyr(Me)-Orn8-vasotocin inhibits male copulatory behaviour in rats","volume":"149","author":"Argiolas","year":"1988","journal-title":"Eur J Pharmacol"},{"issue":"July (5)","key":"10.1016\/j.maturitas.2011.06.007_bib0220","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1038\/bjp.2008.176","article-title":"Brain oxytocin receptors mediate ejaculation elicited by 7-hydroxy-2-(di-N-propylamino) tetralin (7-OH-DPAT) in anaesthetized rats","volume":"154","author":"Cl\u00e9ment","year":"2008","journal-title":"Br J Pharmacol"},{"issue":"November (11)","key":"10.1016\/j.maturitas.2011.06.007_bib0225","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1111\/j.1743-6109.2009.01470.x","article-title":"Participation of endogenous opioids in the inhibition of the spinal generator for ejaculation in rats","volume":"6","author":"Carro-Ju\u00e1rez","year":"2009","journal-title":"J Sex Med"},{"issue":"13","key":"10.1016\/j.maturitas.2011.06.007_bib0230","doi-asserted-by":"crossref","first-page":"879","DOI":"10.2165\/00003088-200443130-00004","article-title":"Clinical pharmacology of tramadol","volume":"43","author":"Grond","year":"2004","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.maturitas.2011.06.007_bib0235","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/01.jcp.0000195110.79027.3f","article-title":"Safety and efficacy of tramadol in the treatment of premature ejaculation: a double-blind, placebo-controlled, fixed-dose, randomized study","volume":"26","author":"Safarinejad","year":"2006","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.maturitas.2011.06.007_bib0240","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1743-6109.2006.00424.x","article-title":"Tramadol HCl has promise in on-demand use to treat premature ejaculation","volume":"5","author":"Salem","year":"2008","journal-title":"J Sex Med"},{"issue":"Mar (6 Suppl.)","key":"10.1016\/j.maturitas.2011.06.007_bib0245","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1743-6109.2008.01181.x","article-title":"Neural regulation of ejaculation","volume":"3","author":"Young","year":"2009","journal-title":"J Sex Med"},{"issue":"January (1)","key":"10.1016\/j.maturitas.2011.06.007_bib0250","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1743-6109.2008.01061.x","article-title":"Role of the neurokinin-1 receptors in ejaculation in anesthetized rats","volume":"6","author":"Clement","year":"2009","journal-title":"J Sex Med"},{"issue":"February (2\u20133)","key":"10.1016\/j.maturitas.2011.06.007_bib0255","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0014-2999(98)00989-3","article-title":"Functional characterization of alpha1-adrenoceptor subtypes in longitudinal and circular muscle of human vas deferens","volume":"367","author":"Amobi","year":"1999","journal-title":"Eur J Pharmacol"},{"issue":"July (7)","key":"10.1016\/j.maturitas.2011.06.007_bib0260","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/ncpuro0836","article-title":"Pharmacology of alpha1-adrenoceptor antagonists in the lower urinary tract and central nervous system","volume":"4","author":"Andersson","year":"2007","journal-title":"Nat Clin Pract Urol"},{"issue":"March (3)","key":"10.1016\/j.maturitas.2011.06.007_bib0265","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.eururo.2010.10.046","article-title":"European Silodosin Study Group. Silodosin therapy for lower urinary tract symptoms in men with suspected benign prostatic hyperplasia: results of an international, randomized, double-blind, placebo- and active-controlled clinical trial performed in Europe","volume":"59","author":"Chapple","year":"2011","journal-title":"Eur Urol"},{"key":"10.1016\/j.maturitas.2011.06.007_bib0270","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1159\/000475036","article-title":"Alpha-1 blockade pharmacotherapy in primitive psychogenic premature ejaculation resistant to psychotherapy","volume":"28","author":"Cavallini","year":"1995","journal-title":"Eur Urol"},{"issue":"4","key":"10.1016\/j.maturitas.2011.06.007_bib0275","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s11255-005-3616-4","article-title":"Terazosin in the treatment of premature ejaculation: a short-term follow-up","volume":"37","author":"Ba\u015far","year":"2005","journal-title":"Int Urol Nephrol"},{"key":"10.1016\/j.maturitas.2011.06.007_bib0280","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0015-0282(16)48157-4","article-title":"The use of phenoxybenzamine treatment in premature ejaculation","volume":"42","author":"Shilon","year":"1984","journal-title":"Fertil Steril"},{"issue":"January\u2013February (1)","key":"10.1016\/j.maturitas.2011.06.007_bib0285","first-page":"43","article-title":"Effect of an alpha-blocking agent (phenoxybenzamine) in the management of premature ejaculation","volume":"17","author":"Beretta","year":"1986","journal-title":"Acta Eur Fertil"},{"key":"10.1016\/j.maturitas.2011.06.007_bib0290","first-page":"101","article-title":"Absorption, distribution and excretion of 14C-amsulosin hydrochloride in rats and dogs","volume":"40","author":"Soeishi","year":"1990","journal-title":"Oyo Yakuri\/Pharmacomet"},{"issue":"February (2)","key":"10.1016\/j.maturitas.2011.06.007_bib0295","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/molehr\/gah143","article-title":"Expression and functional activity of phosphodiesterase type 5 in human and rabbit vas deferens","volume":"11","author":"Mancina","year":"2005","journal-title":"Mol Hum Reprod"},{"issue":"April (4)","key":"10.1016\/j.maturitas.2011.06.007_bib0300","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.eururo.2005.12.050","article-title":"Immunohistochemical distribution of cAMP- and cGMP-phosphodiesterase (PDE) isoenzymes in the human prostate","volume":"49","author":"Uckert","year":"2006","journal-title":"Eur Urol"},{"issue":"November (5)","key":"10.1016\/j.maturitas.2011.06.007_bib0305","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/sj.bjp.0703657","article-title":"Inhibition of neuroeffector transmission in human vas deferens by sildenafil","volume":"131","author":"Medina","year":"2000","journal-title":"Br J Pharmacol"},{"issue":"July (1)","key":"10.1016\/j.maturitas.2011.06.007_bib0310","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.urology.2007.02.049","article-title":"Functional responses of isolated human seminal vesicle tissue to selective phosphodiesterase inhibitors","volume":"70","author":"Uckert","year":"2007","journal-title":"Urology"},{"key":"10.1016\/j.maturitas.2011.06.007_bib0315","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0031-9384(99)00100-6","article-title":"Ejaculatory abnormalities in mice lacking the gene for endothelial nitric oxide synthase (eNOS\u2013\/\u2013)","volume":"67","author":"Kriegsfeld","year":"1999","journal-title":"Physiol Behav"},{"key":"10.1016\/j.maturitas.2011.06.007_bib0320","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/0028-3908(94)90054-X","article-title":"The roles of nitric oxide in sexual function of male rats","volume":"33","author":"Hull","year":"1994","journal-title":"Neuropharmacology"},{"issue":"January\u2013February (1)","key":"10.1016\/j.maturitas.2011.06.007_bib0325","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ijir.2010.34","article-title":"Is there a role for phosphodiesterase type-5 inhibitors in the treatment of premature ejaculation?","volume":"23","author":"Aversa","year":"2011","journal-title":"Int J Impot Res"},{"issue":"October (4)","key":"10.1016\/j.maturitas.2011.06.007_bib0330","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/sj.bjp.0705479","article-title":"Expression of Rho-kinase and its functional role in the contractile activity of the mouse vas deferens","volume":"140","author":"B\u00fcy\u00fckaf\u015far","year":"2003","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.maturitas.2011.06.007_bib0335","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1097\/01.ju.0000085024.47406.6c","article-title":"Y-27632, A Rho-kinase inhibitor, inhibits proliferation and adrenergic contraction of prostatic smooth muscle cells","volume":"170","author":"Rees","year":"2003","journal-title":"J Urol"},{"issue":"April (2)","key":"10.1016\/j.maturitas.2011.06.007_bib0340","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1474-8673.2006.00367.x","article-title":"Attenuation of contractility in rat epididymal vas deferens by Rho kinase inhibitors","volume":"26","author":"Amobi","year":"2006","journal-title":"Auton Autacoid Pharmacol"},{"issue":"January (1)","key":"10.1016\/j.maturitas.2011.06.007_bib0345","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/83258","article-title":"Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway","volume":"7","author":"Chitaley","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.maturitas.2011.06.007_bib0350","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1095\/biolreprod.105.044602","article-title":"Smooth muscle and purinergic contraction of the human, rabbit, rat, and mouse testicular capsule","volume":"74","author":"Banks","year":"2006","journal-title":"Biol Reprod"},{"issue":"October (6807)","key":"10.1016\/j.maturitas.2011.06.007_bib0355","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/35039519","article-title":"Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice","volume":"407","author":"Cockayne","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.maturitas.2011.06.007_bib0360","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/j.1439-0272.1986.tb01834.x","article-title":"Evoked sacral potentials in subjects with true premature ejaculation","volume":"18","author":"Colpi","year":"1986","journal-title":"Andrologia"},{"key":"10.1016\/j.maturitas.2011.06.007_bib0365","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1439-0272.1988.tb00695.x","article-title":"Cortical evoked potentials in subjects with true premature ejaculation","volume":"20","author":"Fanciullacci","year":"1988","journal-title":"Andrologia"},{"key":"10.1016\/j.maturitas.2011.06.007_bib0370","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0022-5347(01)64499-9","article-title":"Somatosensory evoked potentials in patients with primary premature ejaculation","volume":"158","author":"Xin","year":"1997","journal-title":"J Urol"},{"key":"10.1016\/j.maturitas.2011.06.007_bib0375","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0090-4295(02)02284-7","article-title":"Neurophysiologic evaluation of central-peripheral sensory and motor pudendal pathways in primary premature ejaculation","volume":"61","author":"Perretti","year":"2003","journal-title":"Urology"},{"key":"10.1016\/j.maturitas.2011.06.007_bib0380","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/sj.ijir.3900368","article-title":"Penile sensitivity in men with premature ejaculation","volume":"10","author":"Paick","year":"1998","journal-title":"Int J Impot Res"},{"key":"10.1016\/j.maturitas.2011.06.007_bib0385","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1111\/j.1743-6109.2009.01276.x","article-title":"Quantitative sensory testing of peripheral thresholds in patients with lifelong premature ejaculation: a case-controlled study","volume":"6","author":"Salonia","year":"2009","journal-title":"J Sex Med"},{"key":"10.1016\/j.maturitas.2011.06.007_bib0390","doi-asserted-by":"crossref","unstructured":"Xin ZC, Zhu YC, Yuan YM, et al. Current therapeutic strategies for premature ejaculation and future perspectives. Asian J Androl; 2011 May 2 [Epub ahead of print].","DOI":"10.1038\/aja.2010.130"}],"container-title":["Maturitas"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512211002064?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512211002064?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T08:52:47Z","timestamp":1759913567000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378512211002064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":78,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0378512211002064"],"URL":"https:\/\/doi.org\/10.1016\/j.maturitas.2011.06.007","relation":{},"ISSN":["0378-5122"],"issn-type":[{"type":"print","value":"0378-5122"}],"subject":[],"published":{"date-parts":[[2011,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic targets for premature ejaculation","name":"articletitle","label":"Article Title"},{"value":"Maturitas","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.maturitas.2011.06.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}