{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T01:22:54Z","timestamp":1782177774142,"version":"3.54.5"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","maturitas.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Maturitas"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.maturitas.2012.11.001","type":"journal-article","created":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T21:22:25Z","timestamp":1354224145000},"page":"172-178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Effects of a continuous-combined regimen of low-dose hormone therapy (oestradiol and norethindrone acetate) and tibolone on the quality of life in symptomatic postmenopausal women: A double-blind, randomised study"],"prefix":"10.1016","volume":"74","author":[{"given":"Alvaro Fernando","family":"Polisseni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaury Teixeira Leite","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Claudio","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela Queir\u00f3s","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Brand\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Polisseni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"de Oliveira Guerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.maturitas.2012.11.001_bib0005","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1590\/S0104-42302007000500017","article-title":"Preval\u00eancia de transtornos mentais comuns e avalia\u00e7\u00e3o da qualidade de vida no climat\u00e9rio","volume":"53","author":"Galv\u00e3o","year":"2007","journal-title":"Revista da Associacao Medica Brasileira"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0010","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.maturitas.2007.01.009","article-title":"Assessing menopausal symptoms among healthy middle aged women with the menopause rating scale","volume":"57","author":"Chedraui","year":"2007","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0015","first-page":"89","article-title":"Terapia estrog\u00eanica no climat\u00e9rio: qual a melhor via? Uma resposta baseada nas melhores evid\u00eancias","volume":"28","author":"Fonseca","year":"2010","journal-title":"Femina"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0020","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1590\/S0100-72032008001100001","article-title":"Qualidade de vida","volume":"30","author":"Pinto-Neto","year":"2008","journal-title":"Revista Brasileira de Ginecologia e Obstetr\u00edcia"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0025","first-page":"899","article-title":"Climat\u00e9rio e qualidade de vida","volume":"33","author":"De Lorenzi","year":"2005","journal-title":"Femina"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0030","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.maturitas.2009.11.012","article-title":"Prescribing postmenopausal hormone therapy to women in their 50s in the post-women's health initiative era","volume":"65","author":"Rossouw","year":"2010","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0035","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1590\/S0104-42302005000300012","article-title":"Qualidade de vida em usu\u00e1rias e n\u00e3o usu\u00e1rias de Terapia de Reposi\u00e7\u00e3o Hormonal","volume":"51","author":"Zahar","year":"2005","journal-title":"Revista da Associacao Medica Brasileira"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0040","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1097\/gme.0b013e3181605494","article-title":"A randomized placebo-controlled trial of the effects of physical exercises and estrogen therapy on health-related quality of life in postmenopausal women","volume":"15","author":"Moriyama","year":"2008","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0045","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.maturitas.2009.03.017","article-title":"Patterns of hormone therapy in the Norwegian women and cancer study (NOWAC) 1996\u20132005","volume":"63","author":"Waaseth","year":"2009","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0050","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.maturitas.2008.10.009","article-title":"The EMAS update on clinical recommendations on postmenopausal hormone replacement therapy","volume":"61","author":"Gompel","year":"2008","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0055","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0378-5122(02)00327-4","article-title":"Effects of low-dose, continuous combined estradiol and noretisterone acetate on menopausal quality of life in early postmenopausal women","volume":"44","author":"Gambacciani","year":"2003","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0060","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.maturitas.2003.10.005","article-title":"Sexual function, menopause and hormone replacement therapy (HTR)","volume":"48","author":"Gonz\u00e1lez","year":"2004","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0065","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.maturitas.2007.02.014","article-title":"Androgens and female sexual function","volume":"57","author":"Palacios","year":"2007","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0070","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.maturitas.2007.03.004","article-title":"Efficacy and tolerability of estradiol 1mg and drospirenona 2mg in postmenopausal Korean women: a double-blind, randomized, placebo-controlled, multicenter study","volume":"57","author":"Lee","year":"2007","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0075","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.maturitas.2007.07.005","article-title":"Effects of tibolone and raloxifene on health-related quality of life and sexual function","volume":"58","author":"Nijland","year":"2007","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0080","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.maturitas.2007.02.025","article-title":"Rationale for use of lower estrogen doses for postmenopausal hormone therapy","volume":"57","author":"Ettinger","year":"2007","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0085","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.maturitas.2006.06.005","article-title":"The benefits of androgens combined with hormone replacement therapy regarding to patients with postmenopausal sexual symptoms","volume":"56","author":"Paula","year":"2007","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0090","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.maturitas.2009.03.021","article-title":"Menopause and sexuality: prevalence of symptoms and impact on quality of life","volume":"63","author":"Nappi","year":"2009","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0095","first-page":"1","article-title":"A randomized study of low-dose conjugated estrogens on sexual function and quality of life in postmenopausal women","volume":"16","author":"Gast","year":"2009","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0100","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.maturitas.2006.06.009","article-title":"The effect of hormone therapy on the health-related quality of life in elderly women","volume":"56","author":"Evi\u00f6","year":"2007","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0105","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/08870449208404294","article-title":"The Women's Health Questionnaire: a measure of mid-aged women's perception of their emotional and physical health","volume":"20","author":"Hunter","year":"1992","journal-title":"Psychology and Health"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0110","first-page":"181","article-title":"Adapta\u00e7\u00e3o para o portugu\u00eas do question\u00e1rio de auto-avalia\u00e7\u00e3o de percep\u00e7\u00e3o de sa\u00fade f\u00edsica e mental da mulher de meia-idade \u2013 Question\u00e1rio da Sa\u00fade da Mulher","volume":"29","author":"Dias","year":"2002","journal-title":"Revista de Psiquiatria Cl\u00ednica"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0115","first-page":"35","article-title":"The Women's Health Questionnaire (WHQ): frequently asked questions (FAQ) \u2013 review. Health and quality of life outcomes","volume":"1","author":"Hunter","year":"2004","journal-title":"Psychology and Health"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0120","series-title":"Practical nonparametric statistics","author":"Conover","year":"1999"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0125","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.maturitas.2007.08.004","article-title":"A multicenter, prospective, randomized, double-blind, placebo-controlled study to investigate the efficacy of a continuous-combined hormone therapy preparation containing 1mg estradiol valerato\/2mg dienogest on hot flushes in postmenopausal women","volume":"58","author":"Graeser","year":"2007","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0130","first-page":"41","article-title":"Effect of tibolone on sexual function in late postmenopausal women","volume":"49","author":"Kamenov","year":"2007","journal-title":"Folia Medica"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0135","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1590\/S0100-72032005000300004","article-title":"Efeitos da associa\u00e7\u00e3o estro-androg\u00eanica em mulheres na p\u00f3s-menopausa","volume":"27","author":"Mameri Filho","year":"2005","journal-title":"Revista Brasileira de Ginecologia e Obstetr\u00edcia"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0140","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/gme.0b013e31817d5372","article-title":"Transdermal estradiol gel 0.1% for the treatment of vasomotor symptoms in postmenopausal women","volume":"16","author":"Hedrick","year":"2009","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0145","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.maturitas.2008.07.013","article-title":"Quality of life in climacteric Chilean women treated with low-dose estrogen","volume":"61","author":"A\u00e9do","year":"2008","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0150","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1097\/GME.0b013e3181963ef4","article-title":"Angelic versus activelle in normotensive postmenopausal women","volume":"16","author":"Battaglia","year":"2009","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0155","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.maturitas.2008.12.010","article-title":"Do different delivery systems of hormone therapy have different effects on psychological symptoms in surgically menopausal women?","volume":"62","author":"Baksu","year":"2009","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0160","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0378-5122(00)00134-1","article-title":"The comparison of effects of tibolone and conjugated estrogen\u2013medroxyprogesterone acetate therapy on sexual performance in postmenopausal women","volume":"36","author":"K\u00f6k\u00e7\u00fc","year":"2000","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0165","first-page":"117","article-title":"Efficacy and safety of oral tibolona 1.25 or 2.5mg\/day vs. placebo in postmenopausal women","volume":"7","author":"Hudita","year":"2003","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0170","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1210\/jcem.87.1.8141","article-title":"Tibolone for postmenopausal women: review of randomized trials","volume":"87","author":"Modeska","year":"2002","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0175","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.maturitas.2004.02.012","article-title":"Tissue-selectivity: the mechanism of action of tibolone","volume":"48","author":"Kloosterboer","year":"2004","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0180","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.maturitas.2006.06.004","article-title":"The effect of tibolone versus 17 beta-estradiol on climacteric symptoms in women with surgical menopause: a randomized, cross-over study","volume":"56","author":"Somunkiran","year":"2007","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0185","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.maturitas.2011.11.002","article-title":"EMAS position statement: vitamin D and postmenopausal health","volume":"71","author":"P\u00e9res-L\u00f3pes","year":"2012","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0190","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.maturitas.2011.12.005","article-title":"Vitamin D intake and mental health-related quality of life in older women: the Iowa Women's Health Study","volume":"71","author":"Motsinger","year":"2012","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0195","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1161\/CIRCHEARTFAILURE.109.907899","article-title":"The effects of vitamin D supplementation on physical function and quality of life in older patients with heart failure: a randomized controlled trial","volume":"3","author":"Witham","year":"2010","journal-title":"Circulation. Heart Failure"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0200","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1590\/S0104-42302006000500017","article-title":"Fatores associados \u00e0 qualidade de vida ap\u00f3s menopausa","volume":"52","author":"De Lorenzi","year":"2006","journal-title":"Revista da Associacao Medica Brasileira"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0205","first-page":"103","article-title":"Avalia\u00e7\u00e3o da qualidade de vida no climat\u00e9rio","volume":"30","author":"De Lorenzi","year":"2008","journal-title":"Revista da Associacao Medica Brasileira"},{"key":"10.1016\/j.maturitas.2012.11.001_bib0210","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1097\/01.GME.0000151655.10243.48","article-title":"Menopause symptoms and quality of life in women aged 45\u201365 years with and without breast cancer","volume":"12","author":"Conde","year":"2005","journal-title":"Menopause"}],"container-title":["Maturitas"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512212003696?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512212003696?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T08:55:52Z","timestamp":1759913752000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378512212003696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0378512212003696"],"URL":"https:\/\/doi.org\/10.1016\/j.maturitas.2012.11.001","relation":{},"ISSN":["0378-5122"],"issn-type":[{"value":"0378-5122","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of a continuous-combined regimen of low-dose hormone therapy (oestradiol and norethindrone acetate) and tibolone on the quality of life in symptomatic postmenopausal women: A double-blind, randomised study","name":"articletitle","label":"Article Title"},{"value":"Maturitas","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.maturitas.2012.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}