{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:14:07Z","timestamp":1791893647790,"version":"4.3.4"},"reference-count":159,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","maturitas.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Maturitas"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.maturitas.2013.02.002","type":"journal-article","created":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T00:00:56Z","timestamp":1362441656000},"page":"7-21","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":273,"title":["The impact of coffee on health"],"prefix":"10.1016","volume":"75","author":[{"given":"A.","family":"Cano-Marquina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.J.","family":"Tar\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Cano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.maturitas.2013.02.002_bib0005","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S0140-6736(12)60816-2","article-title":"Evidence-based intervention in physical activity: lessons from around the world","volume":"380","author":"Heath","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0010","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.thromres.2011.10.018","article-title":"The Mediterranean diet: the reasons for a success","volume":"129","author":"Bonaccio","year":"2012","journal-title":"Thrombosis Research"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0015","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.maturitas.2011.05.011","article-title":"The impact of chocolate on cardiovascular health","volume":"69","author":"Fern\u00e1ndez-Murga","year":"2011","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0020","series-title":"Caffeine","first-page":"97","article-title":"The chemical components of coffee","author":"Spiller","year":"1998"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0025","doi-asserted-by":"crossref","first-page":"6962","DOI":"10.1021\/jf0710985","article-title":"In vitro antioxidant activity of coffee compounds and their metabolites","volume":"55","author":"G\u00f3mez-Ruiz","year":"2007","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0030","unstructured":"http:\/\/www.fao.org\/docrep\/006\/y5143e\/y5143e0v.htm [accessed 06.12.12]."},{"key":"10.1016\/j.maturitas.2013.02.002_bib0035","unstructured":"http:\/\/www.britishmuseum.org\/explore\/highlights\/highlight_objects\/aoa\/c\/coffee_cups.aspx [accessed 06.12.12]."},{"key":"10.1016\/j.maturitas.2013.02.002_bib0040","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1467-789X.2007.00389.x","article-title":"A short history of beverages and how our body treats them","volume":"9","author":"Wolf","year":"2008","journal-title":"Obesity Reviews"},{"issue":"204","key":"10.1016\/j.maturitas.2013.02.002_bib0045","first-page":"1","article-title":"Phosphodiesterase inhibitors: history of pharmacology","author":"Schudt","year":"2011","journal-title":"Handbook of Experimental Pharmacology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0050","first-page":"205","article-title":"Caffeine content of beverages as consumed","volume":"114","author":"Gilbert","year":"1976","journal-title":"Canadian Medical Association Journal"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0055","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0278-6915(95)00093-3","article-title":"Caffeine consumption","volume":"34","author":"Barone","year":"1996","journal-title":"Food and Chemical Toxicology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0060","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1039\/C1FO10240K","article-title":"Espresso coffees, caffeine and chlorogenic acid intake: potential health implications","volume":"3","author":"Crozier","year":"2012","journal-title":"Food and Function"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0065","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0031-6997(24)01511-4","article-title":"International union of pharmacology, XXV. Nomenclature and classification of adenosine receptors","volume":"53","author":"Fredholm","year":"2001","journal-title":"Pharmacological Reviews"},{"issue":"200","key":"10.1016\/j.maturitas.2013.02.002_bib0070","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/978-3-642-13443-2_16","article-title":"The cardiovascular effects of methylxanthines","author":"Riksen","year":"2011","journal-title":"Handbook of Experimental Pharmacology"},{"issue":"200","key":"10.1016\/j.maturitas.2013.02.002_bib0075","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/978-3-642-13443-2_19","article-title":"Methylxanthines, inflammation, and cancer: fundamental mechanisms","author":"Ohta","year":"2011","journal-title":"Handbook of Experimental Pharmacology"},{"issue":"200","key":"10.1016\/j.maturitas.2013.02.002_bib0080","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/978-3-642-13443-2_21","article-title":"Methylxanthines and human health: epidemiological and experimental evidence","author":"Beaudoin","year":"2011","journal-title":"Handbook of Experimental Pharmacology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0085","doi-asserted-by":"crossref","first-page":"8109","DOI":"10.1021\/jf804025c","article-title":"Polyphenolic chemistry of tea and coffee: a century of progress","volume":"57","author":"Wang","year":"2009","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0090","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1590\/S1677-04202006000100018","article-title":"On-line HPLC analysis of the antioxidant activity of phenolic compounds in brewed, paper-filtered coffee","volume":"18","author":"Stalmach","year":"2006","journal-title":"Brazilian Journal of Plant Physiology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0095","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/(SICI)1097-0010(19990301)79:3<362::AID-JSFA256>3.0.CO;2-D","article-title":"Chlorogenic acids and other cinnamates \u2013 nature, occurrence and dietary burden","volume":"79","author":"Clifford","year":"1999","journal-title":"Journal of the Science of Food and Agriculture"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0100","doi-asserted-by":"crossref","first-page":"820","DOI":"10.3390\/nu2080820","article-title":"Bioavailability of coffee chlorogenic acids and green tea flavan-3-ols","volume":"2","author":"Del Rio","year":"2010","journal-title":"Nutrients"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0105","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1124\/dmd.109.028019","article-title":"Metabolite profiling of hydroxycinnamate derivatives in plasma and urine after the ingestion of coffee by humans: identification of biomarkers of coffee consumption","volume":"37","author":"Stalmach","year":"2009","journal-title":"Drug Metabolism and Disposition: The Biological Fate of Chemicals"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0110","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1475-2891-10-48","article-title":"Cholesterol-raising diterpenes in types of coffee commonly consumed in Singapore. Indonesia and India and associations with blood lipids: a survey and cross sectional study","volume":"10","author":"Naidoo","year":"2011","journal-title":"Nutrition Journal"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0115","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1172\/JCI110124","article-title":"Tolerance to the humoral and hemodynamic effects of caffeine in man","volume":"67","author":"Robertson","year":"1981","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0120","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1111\/j.1365-2125.1983.tb01553.x","article-title":"Adaptation of blood pressure to continuous heavy coffee drinking in young volunteers. A double-blind crossover study","volume":"15","author":"Ammon","year":"1983","journal-title":"British Journal of Clinical Pharmacology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0125","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/0002-9149(85)90412-6","article-title":"Circulatory effects of coffee in relation to the pharmacokinetics of caffeine","volume":"56","author":"Smits","year":"1985","journal-title":"American Journal of Cardiology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0130","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1161\/01.HYP.0000120965.63962.93","article-title":"Blood pressure response to caffeine shows incomplete tolerance after short-term regular consumption","volume":"43","author":"Lovallo","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0135","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1176\/ajp.156.2.223","article-title":"Caffeine intake, tolerance, and withdrawal in women: a population-based twin study","volume":"156","author":"Kendler","year":"1999","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0140","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1161\/01.CIR.0000046228.97025.3A","article-title":"Coffee acutely increases sympathetic nerve activity and blood pressure independently of caffeine content: role of habitual versus nonhabitual drinking","volume":"106","author":"Corti","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0145","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.amjcard.2006.06.058","article-title":"Effects of acute administration of caffeine on vascular function","volume":"98","author":"Umemura","year":"2006","journal-title":"American Journal of Cardiology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0150","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/ejcn.2010.9","article-title":"Acute effects of coffee on endothelial function in healthy subjects","volume":"64","author":"Buscemi","year":"2010","journal-title":"European Journal of Clinical Nutrition"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0155","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1038\/ejcn.2009.51","article-title":"Dose-dependent effects of decaffeinated coffee on endothelial function in healthy subjects","volume":"63","author":"Buscemi","year":"2009","journal-title":"European Journal of Clinical Nutrition"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0160","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1042\/CS20040358","article-title":"Effect of coffee on endothelial function in healthy subjects: the role of caffeine","volume":"109","author":"Papamichael","year":"2005","journal-title":"Clinical Science (London)"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0165","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/hr.2009.132","article-title":"Effects of hydroxyhydroquinone-reduced coffee on vasoreactivity and blood pressure","volume":"32","author":"Ochiai","year":"2009","journal-title":"Hypertension Research"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0170","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0895-7061(00)01232-2","article-title":"Pulse pressure and aortic pulse wave are markers of cardiovascular risk in hypertensive populations","volume":"2","author":"Asmar","year":"2001","journal-title":"American Journal of Hypertension"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0175","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1161\/01.HYP.38.2.227","article-title":"Acute effect of caffeine on arterial stiffness and aortic pressure waveform","volume":"38","author":"Mahmud","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0180","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ijcard.2003.11.013","article-title":"Acute effects of caffeine on blood pressure and wave reflections in healthy subjects: should we consider monitoring central blood pressure?","volume":"98","author":"Karatzis","year":"2005","journal-title":"International Journal of Cardiology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0185","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1016\/j.jacc.2004.07.049","article-title":"Smoking and caffeine have a synergistic detrimental effect on aortic stiffness and wave reflections","volume":"44","author":"Vlachopoulos","year":"2004","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0190","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1056\/NEJM197801262980403","article-title":"Effects of caffeine on plasma renin activity, catecholamines and blood pressure","volume":"298","author":"Robertson","year":"1978","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0195","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0002-9149(85)90578-8","article-title":"Effects of caffeine on vascular resistance, cardiac output and myocardial contractility in young men","volume":"56","author":"Pincomb","year":"1985","journal-title":"American Journal of Cardiology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0200","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.amjcard.2003.12.057","article-title":"Cardiovascular effects of caffeine in men and women","volume":"93","author":"Hartley","year":"2004","journal-title":"American Journal of Cardiology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0205","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.3945\/ajcn.111.016667","article-title":"The effect of coffee on blood pressure and cardiovascular disease in hypertensive individuals: a systematic review and meta-analysis","volume":"94","author":"Mesas","year":"2011","journal-title":"American Journal of Clinical Nutrition"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0210","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.amjcard.2005.01.093","article-title":"Hemodynamic mechanisms underlying the incomplete tolerance to caffeine's pressor effects","volume":"95","author":"Farag","year":"2005","journal-title":"American Journal of Cardiology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0215","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3945\/ajcn.111.018267","article-title":"Genetic determinants of blood pressure responses to caffeine drinking","volume":"95","author":"Renda","year":"2012","journal-title":"American Journal of Clinical Nutrition"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0220","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/hr.2011.195","article-title":"Antihypertensive effects and mechanisms of chlorogenic acids","volume":"35","author":"Zhao","year":"2012","journal-title":"Hypertension Research"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0225","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1111\/j.1365-2125.1985.tb02729.x","article-title":"The cardiovascular effects of regular and decaffeinated coffee","volume":"19","author":"Smits","year":"1985","journal-title":"British Journal of Clinical Pharmacology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0230","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1097\/HJH.0b013e3283588d73","article-title":"The effect of coffee consumption on blood pressure and the development of hypertension: a systematic review and meta-analysis","volume":"30","author":"Steffen","year":"2012","journal-title":"Journal of Hypertension"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0235","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1161\/ATVB.15v11.1793","article-title":"Coffee consumption, alcohol use, and cigarette smoking as determinants of serum total and HDL cholesterol in two Serbian cohorts of the Seven Countries Study","volume":"15","author":"Jansen","year":"1995","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0240","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/ejcn.2012.68","article-title":"The effect of coffee consumption on serum lipids: a meta-analysis of randomized controlled trials","volume":"66","author":"Cai","year":"2012","journal-title":"European Journal of Clinical Nutrition"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0245","doi-asserted-by":"crossref","first-page":"950","DOI":"10.3945\/ajcn.2009.28548","article-title":"Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial","volume":"91","author":"Kempf","year":"2010","journal-title":"American Journal of Clinical Nutrition"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0250","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1038\/sj.ejcn.1601668","article-title":"Filtered coffee raises serum cholesterol: results from a controlled study","volume":"57","author":"Strandhagen","year":"2003","journal-title":"European Journal of Clinical Nutrition"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0255","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1023\/B:BIRY.0000016354.05438.0f","article-title":"Effects of coffee consumption on oxidative susceptibility of low-density lipoproteins and serum lipid levels in humans","volume":"69","author":"Yukawa","year":"2004","journal-title":"Biochemistry. Biokhimiia"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0260","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.freeradbiomed.2004.11.025","article-title":"The effects of coffee consumption on lipid peroxidation and plasma total homocysteine concentrations: a clinical trial","volume":"38","author":"Mursu","year":"2005","journal-title":"Free Radical Biology and Medicine"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0265","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0140-6736(05)70152-5","article-title":"Homocysteine and stroke: evidence on a causal link from mendelian randomisation","volume":"365","author":"Casas","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0270","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1001\/jama.288.16.2015","article-title":"Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis","volume":"288","author":"Homocysteine Studies Collaboration","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0275","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1001\/jama.2010.840","article-title":"Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors: a randomized trial","volume":"303","author":"Armitage","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0280","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1093\/ajcn\/71.2.480","article-title":"Unfiltered coffee increases plasma homocysteine concentrations in healthy volunteers: a randomized trial","volume":"71","author":"Grubben","year":"2000","journal-title":"American Journal of Clinical Nutrition"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0285","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/ajcn\/72.5.1107","article-title":"Heavy coffee consumption and plasma homocysteine: a randomized controlled trial in healthy volunteers","volume":"72","author":"Urgert","year":"2000","journal-title":"American Journal of Clinical Nutrition"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0290","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1093\/ajcn\/76.6.1244","article-title":"Contribution of caffeine to the homocysteine-raising effect of coffee: a randomized controlled trial in humans","volume":"76","author":"Verhoef","year":"2002","journal-title":"American Journal of Clinical Nutrition"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0295","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.ijcard.2003.12.036","article-title":"The association between lifestyle-related factors and plasma homocysteine levels in healthy individuals from the \u201cATTICA\u201d Study","volume":"98","author":"Panagiotakos","year":"2005","journal-title":"International Journal of Cardiology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0300","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1038\/sj.ejcn.1601703","article-title":"Folic acid supplement decreases the homocysteine increasing effect of filtered coffee. A randomised placebo-controlled study","volume":"57","author":"Strandhagen","year":"2003","journal-title":"European Journal of Clinical Nutrition"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0305","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1016\/j.metabol.2007.07.013","article-title":"Metabolic and hormonal effects of caffeine: randomized, double-blind, placebo-controlled crossover trial","volume":"56","author":"MacKenzie","year":"2007","journal-title":"Metabolism: Clinical and Experimental"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0310","doi-asserted-by":"crossref","first-page":"239","DOI":"10.4158\/EP.13.3.239","article-title":"Exaggeration of postprandial hyperglycemia in patients with type 2 diabetes by administration of caffeine in coffee","volume":"13","author":"Lane","year":"2007","journal-title":"Endocrine Practice"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0315","doi-asserted-by":"crossref","first-page":"221","DOI":"10.2337\/dc07-1112","article-title":"Caffeine increases ambulatory glucose and postprandial responses in coffee drinkers with type 2 diabetes","volume":"31","author":"Lane","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0320","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1093\/jn\/136.5.1276","article-title":"The glucose intolerance induced by caffeinated coffee ingestion is less pronounced than that due to alkaloid caffeine in men","volume":"136","author":"Battram","year":"2006","journal-title":"Journal of Nutrition"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0325","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1093\/ajcn\/78.4.728","article-title":"Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine","volume":"78","author":"Johnston","year":"2003","journal-title":"American Journal of Clinical Nutrition"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0330","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.2337\/dc09-0207","article-title":"Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance","volume":"32","author":"van Dijk","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0335","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.metabol.2012.01.021","article-title":"A cross-over study of the acute effects of espresso coffee on glucose tolerance and insulin sensitivity in people with type 2 diabetes mellitus","volume":"61","author":"Krebs","year":"2012","journal-title":"Metabolism: Clinical and Experimental"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0340","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.2337\/diabetes.54.10.2932","article-title":"Elevated levels of interleukin-18 predict the development of type 2 diabetes: results from the MONICA\/KORA Augsburg Study, 1984\u20132002","volume":"54","author":"Thorand","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0345","doi-asserted-by":"crossref","first-page":"5973","DOI":"10.1021\/cr200160h","article-title":"Isoprostane generation and function","volume":"111","author":"Milne","year":"2011","journal-title":"Chemical Reviews"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0350","doi-asserted-by":"crossref","first-page":"118","DOI":"10.2174\/187153012800493468","article-title":"Molecular mechanisms of diabetes and atherosclerosis: role of adiponectin","volume":"12","author":"Kishida","year":"2012","journal-title":"Endocrine, Metabolic & Immune Disorders \u2013 Drug Targets"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0355","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/1475-2891-10-93","article-title":"Effects of caffeinated and decaffeinated coffee on biological risk factors for type 2 diabetes: a randomized controlled trial","volume":"10","author":"Wedick","year":"2011","journal-title":"Nutrition Journal"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0360","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s00125-010-1957-8","article-title":"Associations between the intake of caffeinated and decaffeinated coffee and measures of insulin sensitivity and beta cell function","volume":"54","author":"Loopstra-Masters","year":"2011","journal-title":"Diabetologia"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0365","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1007\/s00125-004-1573-6","article-title":"Coffee consumption and incidence of impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes: the Hoorn Study","volume":"47","author":"van Dam","year":"2004","journal-title":"Diabetologia"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0370","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1055\/s-2006-924982","article-title":"Effects of coffee consumption on glucose tolerance, serum glucose and insulin levels\u2014a cross-sectional analysis","volume":"38","author":"Bidel","year":"2006","journal-title":"Hormone and Metabolic Research"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0375","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1007\/s00125-004-1590-5","article-title":"Coffee consumption and glucose tolerance status in middle-aged Japanese men","volume":"47","author":"Yamaji","year":"2004","journal-title":"Diabetologia"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0380","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1056\/NEJMoa0804381","article-title":"Sex hormone-binding globulin and risk of type 2 diabetes in women and men","volume":"361","author":"Ding","year":"2009","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0385","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1002\/cncr.24328","article-title":"Relationship between caffeine intake and plasma sex hormone concentrations in premenopausal and postmenopausal women","volume":"115","author":"Kotsopoulos","year":"2009","journal-title":"Cancer"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0390","doi-asserted-by":"crossref","first-page":"269","DOI":"10.2337\/db10-1193","article-title":"Coffee and caffeine consumption in relation to sex hormone-binding globulin and risk of type 2 diabetes in postmenopausal women","volume":"60","author":"Goto","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0395","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1097\/00001648-199307000-00013","article-title":"A meta-analysis of coffee, myocardial infarction, and coronary death","volume":"4","author":"Greenland","year":"1993","journal-title":"Epidemiology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0400","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1136\/hrt.72.3.269","article-title":"Does coffee drinking increase the risk of coronary heart disease? Results from a meta-analysis","volume":"72","author":"Kawachi","year":"1994","journal-title":"British Heart Journal"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0405","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.ijcard.2008.06.051","article-title":"Coffee consumption and risk of coronary heart diseases: a meta-analysis of 21 prospective cohort studies","volume":"137","author":"Wu","year":"2009","journal-title":"International Journal of Cardiology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0410","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.ahj.2008.11.009","article-title":"Coffee consumption and mortality after acute myocardial infarction: the Stockholm Heart Epidemiology Program","volume":"157","author":"Mukamal","year":"2009","journal-title":"American Heart Journal"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0415","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1097\/01.ede.0000229444.55718.96","article-title":"Transient exposure to coffee as a trigger of a first nonfatal myocardial infarction","volume":"17","author":"Baylin","year":"2006","journal-title":"Epidemiology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0420","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/aje\/kwr226","article-title":"Coffee consumption and risk of stroke: a dose\u2013response meta-analysis of prospective studies","volume":"174","author":"Larsson","year":"2011","journal-title":"American Journal of Epidemiology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0425","doi-asserted-by":"crossref","first-page":"356","DOI":"10.4082\/kjfm.2012.33.6.356","article-title":"Coffee consumption and stroke risk: a meta-analysis of epidemiologic studies","volume":"33","author":"Kim","year":"2012","journal-title":"Korean Journal of Family Medicine"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0430","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1212\/WNL.0b013e3181fb443d","article-title":"Coffee and acute ischemic stroke onset: the Stroke Onset Study","volume":"75","author":"Mostofsky","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0435","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.amjmed.2010.10.017","article-title":"Caffeine and cardiac arrhythmias: a review of the evidence","volume":"124","author":"Pelchovitz","year":"2011","journal-title":"American Journal of Medicine"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0440","doi-asserted-by":"crossref","first-page":"19","DOI":"10.7812\/TPP\/11-020","article-title":"Coffee, caffeine, and risk of hospitalization for arrhythmias","volume":"15","author":"Klatsky","year":"2011","journal-title":"Permanente Journal"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0445","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3945\/ajcn.110.001305","article-title":"Dietary factors and incident atrial fibrillation: the Framingham Heart Study","volume":"93","author":"Shen","year":"2011","journal-title":"American Journal of Clinical Nutrition"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0450","doi-asserted-by":"crossref","first-page":"e17584","DOI":"10.1371\/journal.pone.0017584","article-title":"Coffee, alcohol, smoking, physical activity and QT interval duration: results from the Third National Health and Nutrition Examination Survey","volume":"6","author":"Zhang","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0455","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1161\/CIR.0b013e3182456d46","article-title":"Executive summary: heart disease and stroke statistics\u20142012 update: a report from the American Heart Association","volume":"125","author":"Roger","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0460","first-page":"401","article-title":"Habitual coffee consumption and risk of heart failure: a dose\u2013response meta-analysis","volume":"5","author":"Mostofsky","year":"2012","journal-title":"Circulation: Heart Failure"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0465","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1001\/jama.294.1.97","article-title":"Coffee consumption and risk of type 2 diabetes: a systematic review","volume":"294","author":"van Dam","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0470","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1001\/archinternmed.2009.439","article-title":"Coffee, decaffeinated coffee, and tea consumption in relation to incident type 2 diabetes mellitus: a systematic review with meta-analysis","volume":"169","author":"Huxley","year":"2009","journal-title":"Archives of Internal Medicine"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0475","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.numecd.2009.10.020","article-title":"Coffee consumption and the incidence of type 2 diabetes in men and women with normal glucose tolerance: the Strong Heart Study","volume":"21","author":"Zhang","year":"2011","journal-title":"Nutrition, Metabolism & Cardiovascular Diseases"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0480","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1017\/S1368980008003303","article-title":"Coffee intake and risk of incident diabetes in Puerto Rican men: results from the Puerto Rico Heart Health Program","volume":"12","author":"Fuhrman","year":"2009","journal-title":"Public Health Nutrition"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0485","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1097\/MEG.0b013e32833cca96","article-title":"Coffee and the liver: a potential treatment for liver disease?","volume":"22","author":"Masterton","year":"2010","journal-title":"European Journal of Gastroenterology and Hepatology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0490","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/1471-230X-12-145","article-title":"Effects of coffee, smoking, and alcohol on liver function tests: a comprehensive cross-sectional study","volume":"12","author":"Jang","year":"2012","journal-title":"BMC Gastroenterology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0495","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1023\/A:1007683626665","article-title":"Coffee consumption and decreased serum gamma-glutamyltransferase: a study of middle-aged Japanese men","volume":"16","author":"Nakanishi","year":"2000","journal-title":"European Journal of Epidemiology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0500","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1053\/j.gastro.2004.09.075","article-title":"Coffee and caffeine consumption reduce the risk of elevated serum alanine aminotransferase activity in the United States","volume":"128","author":"Ruhl","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0505","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/ana.23687","article-title":"Meta-analysis of early nonmotor features and risk factors for Parkinson disease","volume":"72","author":"Noyce","year":"2012","journal-title":"Annals of Neurology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0510","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1093\/aje\/kwr451","article-title":"Caffeine intake, smoking, and risk of Parkinson disease in men and women","volume":"175","author":"Liu","year":"2012","journal-title":"American Journal of Epidemiology"},{"issue":"8","key":"10.1016\/j.maturitas.2013.02.002_bib0515","doi-asserted-by":"crossref","first-page":"e1002237","DOI":"10.1371\/journal.pgen.1002237","article-title":"Genome-wide gene-environment study identifies glutamate receptor gene GRIN2A as a Parkinson's disease modifier gene via interaction with coffee","volume":"7","author":"Hamza","year":"2011","journal-title":"PLoS Genetics"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0520","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1093\/aje\/kwh312","article-title":"Coffee consumption, gender, and Parkinson's disease mortality in the cancer prevention study II cohort: the modifying effects of estrogen","volume":"160","author":"Ascherio","year":"2004","journal-title":"American Journal of Epidemiology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0525","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1212\/01.WNL.0000046523.05125.87","article-title":"Caffeine, postmenopausal estrogen, and risk of Parkinson's disease","volume":"60","author":"Ascherio","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0530","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1002\/mds.25076","article-title":"Caffeine and risk of Parkinson's disease in a large cohort of men and women","volume":"27","author":"Palacios","year":"2012","journal-title":"Movement Disorders"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0535","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.neuroscience.2006.07.021","article-title":"Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain beta-amyloid production","volume":"142","author":"Arendash","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0540","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3233\/JAD-2009-1087","article-title":"Caffeine reverses cognitive impairment and decreases brain amyloid-beta levels in aged Alzheimer's disease mice","volume":"17","author":"Arendash","year":"2009","journal-title":"Journal of Alzheimer's Disease"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0545","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ejphar.2010.09.001","article-title":"Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholinesterase and anti-oxidative activities in mice","volume":"649","author":"Kwon","year":"2010","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0550","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3233\/JAD-2011-110110","article-title":"Caffeine synergizes with another coffee component to increase plasma GCSF: linkage to cognitive benefits in Alzheimer's mice","volume":"25","author":"Cao","year":"2011","journal-title":"Journal of Alzheimer's Disease"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0555","doi-asserted-by":"crossref","first-page":"S167","DOI":"10.3233\/JAD-2010-1404","article-title":"Caffeine as a protective factor in dementia and Alzheimer's disease","volume":"Suppl. 1","author":"Eskelinen","year":"2010","journal-title":"Journal of Alzheimer's Disease"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0560","doi-asserted-by":"crossref","first-page":"607","DOI":"10.3233\/JAD-2010-101428","article-title":"Coffee intake in midlife and risk of dementia and its neuropathologic correlates","volume":"23","author":"Gelber","year":"2011","journal-title":"Journal of Alzheimer's Disease"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0565","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3233\/JAD-2012-111781","article-title":"High Blood caffeine levels in MCI linked to lack of progression to dementia","volume":"30","author":"Cao","year":"2012","journal-title":"Journal of Alzheimer's Disease"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0570","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1172\/JCI105467","article-title":"The effects of chronic acid loads in normal man: further evidence for the participation of bone mineral in the defense against chronic metabolic acidosis","volume":"45","author":"Lemann","year":"1966","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0575","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1093\/ajcn\/85.4.1134","article-title":"More acidic dietary acid\u2013base load is associated with reduced calcaneal broadband ultrasound attenuation in women but not in men: results from the EPIC-Norfolk cohort study","volume":"85","author":"Welch","year":"2007","journal-title":"American Journal of Clinical Nutrition"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0580","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1093\/oxfordjournals.aje.a115709","article-title":"Caffeine and the risk of hip fracture: the Framingham Study","volume":"132","author":"Kiel","year":"1990","journal-title":"American Journal of Epidemiology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0585","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1093\/ajcn\/54.1.157","article-title":"Caffeine, moderate alcohol intake, and risk of fractures of the hip and forearm in middle-aged women","volume":"54","author":"Hernandez-Avila","year":"1991","journal-title":"American Journal of Clinical Nutrition"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0590","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/jbmr.5650070415","article-title":"Is caffeine consumption a risk factor for osteoporosis?","volume":"7","author":"Cooper","year":"1992","journal-title":"Journal of Bone and Mineral Research"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0595","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/ageing\/21.1.20","article-title":"Coffee drinking: a minor risk factor for bone loss and fractures","volume":"21","author":"Johansson","year":"1992","journal-title":"Age and Ageing"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0600","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1093\/jn\/122.5.1119","article-title":"Calcium metabolism in postmenopausal osteoporotic women is determined by dietary calcium and coffee intake","volume":"122","author":"Hasling","year":"1992","journal-title":"Journal of Nutrition"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0605","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/ajcn\/60.4.573","article-title":"Caffeine and bone loss in healthy postmenopausal women","volume":"60","author":"Harris","year":"1994","journal-title":"American Journal of Clinical Nutrition"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0610","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1002\/jbmr.5650101125","article-title":"Risk factors for hip fracture in European women: the MEDOS Study. Mediterranean Osteoporosis Study","volume":"10","author":"Johnell","year":"1995","journal-title":"Journal of Bone and Mineral Research"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0615","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/00001648-199607000-00012","article-title":"The influence of body size, smoking, and diet on bone density in pre- and postmenopausal women","volume":"7","author":"Franceschi","year":"1996","journal-title":"Epidemiology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0620","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1093\/ajcn\/65.6.1826","article-title":"Dietary caffeine intake and bone status of postmenopausal women","volume":"65","author":"Lloyd","year":"1997","journal-title":"American Journal of Clinical Nutrition"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0625","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1093\/ajcn\/74.5.694","article-title":"Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes","volume":"74","author":"Rapuri","year":"2001","journal-title":"American Journal of Clinical Nutrition"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0630","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s00198-002-1319-6","article-title":"Lifestyle factors are associated with osteoporosis in lean women but not in normal and overweight women: a population-based cohort study of 1222 women","volume":"14","author":"Korpelainen","year":"2003","journal-title":"Osteoporosis International"},{"issue":"Suppl.","key":"10.1016\/j.maturitas.2013.02.002_bib0635","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/BF03026328","article-title":"Epidemiology of hip fracture in Japan: incidence and risk factors","volume":"23","author":"Yoshimura","year":"2005","journal-title":"Journal of Bone and Mineral Metabolism"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0640","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/s00198-006-0109-y","article-title":"Coffee, tea and caffeine consumption in relation to osteoporotic fracture risk in a cohort of Swedish women","volume":"17","author":"Hallstr\u00f6m","year":"2006","journal-title":"Osteoporosis International"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0645","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s001980050260","article-title":"Factors affecting broadband ultrasound attenuation results of the calcaneus using a gel-coupled quantitative ultrasound scanning system","volume":"10","author":"Cheng","year":"1999","journal-title":"Osteoporosis International"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0650","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1046\/j.1365-2796.2000.00642.x","article-title":"Calcaneal ultrasound measurements are determined by age and physical activity. Studies in two Swedish random population samples","volume":"247","author":"Landin-Wilhelmsen","year":"2000","journal-title":"Journal of Internal Medicine"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0655","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s001980050284","article-title":"Risk factors for perimenopausal fractures: a prospective study","volume":"11","author":"Huopio","year":"2000","journal-title":"Osteoporosis International"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0660","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S8756-3282(00)00444-0","article-title":"Effect of coffee consumption on bone metabolism","volume":"28","author":"Sakamoto","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0665","unstructured":"http:\/\/www.shef.ac.uk\/FRAX\/ [accessed 06.12.12]."},{"key":"10.1016\/j.maturitas.2013.02.002_bib0670","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1038\/sj.bjc.6604008","article-title":"Tea and coffee drinking and ovarian cancer risk: results from the Netherlands Cohort Study and a meta-analysis","volume":"97","author":"Steevens","year":"2007","journal-title":"British Journal of Cancer"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0675","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.3945\/ajcn.111.026393","article-title":"Coffee and tea consumption and the risk of ovarian cancer: a prospective cohort study and updated meta-analysis","volume":"95","author":"Braem","year":"2012","journal-title":"American Journal of Clinical Nutrition"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0680","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/annonc\/mdr331","article-title":"A meta-analysis of coffee consumption and pancreatic cancer","volume":"23","author":"Turati","year":"2012","journal-title":"Annals of Oncology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0685","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.3748\/wjg.v17.i9.1204","article-title":"Coffee drinking and pancreatic cancer risk: a meta-analysis of cohort studies","volume":"17","author":"Dong","year":"2011","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0690","first-page":"925","article-title":"Coffee consumption and bladder cancer in nonsmokers: a pooled analysis of case\u2013control studies in European countries","volume":"11","author":"Sala","year":"2000","journal-title":"Cancer Causes and Control"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0695","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/ije\/30.2.353","article-title":"Are coffee and tea consumption associated with urinary tract cancer risk? A systematic review and meta-analysis","volume":"30","author":"Zeegers","year":"2001","journal-title":"International Journal of Epidemiology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0700","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ypmed.2012.04.020","article-title":"A dose\u2013response meta-analysis of coffee consumption and bladder cancer","volume":"55","author":"Zhou","year":"2012","journal-title":"Preventive Medicine"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0705","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/j.1464-410X.2010.09493.x","article-title":"Coffee consumption and risk of prostate cancer: a meta-analysis of epidemiological studies","volume":"106","author":"Park","year":"2010","journal-title":"BJU International"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0710","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1093\/oxfordjournals.aje.a009398","article-title":"Meta-analysis of coffee consumption and risk of colorectal cancer","volume":"147","author":"Giovannucci","year":"1998","journal-title":"American Journal of Epidemiology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0715","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/jnci\/djq107","article-title":"Risk of colon cancer and coffee, tea, and sugar-sweetened soft drink intake: pooled analysis of prospective cohort studies","volume":"102","author":"Zhang","year":"2010","journal-title":"Journal of the National Cancer Institute"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0720","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1002\/ijc.24124","article-title":"Coffee consumption and risk of colorectal cancer: a systematic review and meta-analysis of prospective cohort studies","volume":"124","author":"Je","year":"2009","journal-title":"International Journal of Cancer"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0725","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.lungcan.2009.03.012","article-title":"Coffee consumption and risk of lung cancer: a meta-analysis","volume":"67","author":"Tang","year":"2010","journal-title":"Lung Cancer"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0730","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1590\/S0102-311X2006000500002","article-title":"Coffee and gastric cancer: systematic review and meta-analysis","volume":"22","author":"Botelho","year":"2006","journal-title":"Cadernos de Saude Publica"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0735","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2008.10.019","article-title":"Coffee consumption and risk of breast cancer: a metaanalysis","volume":"200","author":"Tang","year":"2009","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0740","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/hep.21708","article-title":"Coffee drinking and hepatocellular carcinoma risk: a meta-analysis","volume":"46","author":"Bravi","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0745","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1053\/j.gastro.2007.03.044","article-title":"Coffee consumption and risk of liver cancer: a meta-analysis","volume":"132","author":"Larsson","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0750","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1158\/1055-9965.EPI-08-0923","article-title":"Effect of coffee and green tea consumption on the risk of liver cancer: cohort analysis by hepatitis virus infection status","volume":"18","author":"Inoue","year":"2009","journal-title":"Cancer Epidemiology, Biomarkers and Prevention"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0755","first-page":"503","article-title":"Coffee consumption and reduced risk of hepatocellular carcinoma: findings from the Singapore Chinese Health Study","volume":"22","author":"Johnson","year":"2011","journal-title":"Cancer Causes and Control"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0760","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1136\/jech.2009.104125","article-title":"Moderate coffee consumption reduces the risk of hepatocellular carcinoma in hepatitis B chronic carriers: a case\u2013control study","volume":"65","author":"Leung","year":"2011","journal-title":"Journal of Epidemiology and Community Health"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0765","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1093\/annonc\/mdq603","article-title":"Coffee and cancers of the upper digestive and respiratory tracts: meta-analyses of observational studies","volume":"22","author":"Turati","year":"2011","journal-title":"Annals of Oncology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0770","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1093\/aje\/kws222","article-title":"Coffee, tea, and fatal oral\/pharyngeal cancer in a large prospective US cohort","volume":"177","author":"Hildebrand","year":"2013","journal-title":"American Journal of Epidemiology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0775","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ajog.2008.10.032","article-title":"Coffee drinking and endometrial cancer risk: a metaanalysis of observational studies","volume":"200","author":"Bravi","year":"2009","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0780","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1002\/ijc.27408","article-title":"Coffee consumption and risk of endometrial cancer: findings from a large up-to-date meta-analysis","volume":"131","author":"Je","year":"2012","journal-title":"International Journal of Cancer"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0785","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/1471-2407-11-96","article-title":"Coffee consumption and risk of cancers: a meta-analysis of cohort studies","volume":"11","author":"Yu","year":"2011","journal-title":"BMC Cancer"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0790","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1007\/s00125-006-0435-9","article-title":"Coffee consumption and risk of total and cardiovascular mortality among patients with type 2 diabetes","volume":"49","author":"Bidel","year":"2006","journal-title":"Diabetologia"},{"key":"10.1016\/j.maturitas.2013.02.002_bib0795","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1056\/NEJMoa1112010","article-title":"Association of coffee drinking with total and cause-specific mortality","volume":"366","author":"Freedman","year":"2012","journal-title":"New England Journal of Medicine"}],"container-title":["Maturitas"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512213000479?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512213000479?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T08:57:27Z","timestamp":1759913847000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378512213000479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":159,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S0378512213000479"],"URL":"https:\/\/doi.org\/10.1016\/j.maturitas.2013.02.002","relation":{},"ISSN":["0378-5122"],"issn-type":[{"value":"0378-5122","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of coffee on health","name":"articletitle","label":"Article Title"},{"value":"Maturitas","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.maturitas.2013.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}