{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:38:34Z","timestamp":1788266314391,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","maturitas.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Maturitas"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.maturitas.2014.03.010","type":"journal-article","created":{"date-parts":[[2014,4,7]],"date-time":"2014-04-07T21:45:09Z","timestamp":1396907109000},"page":"117-122","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Urine 6-sulfatoxymelatonin levels are inversely associated with arterial stiffness in post-menopausal women"],"prefix":"10.1016","volume":"78","author":[{"given":"Jee-Yon","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duk-Chul","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.maturitas.2014.03.010_bib0005","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1093\/eurheartj\/ehq030","article-title":"Novel therapeutic concepts: the epidemic of cardiovascular disease in the developing world: global implications","volume":"31","author":"Gersh","year":"2010","journal-title":"Eur Heart J"},{"key":"10.1016\/j.maturitas.2014.03.010_bib0010","series-title":"The Framingham study: the epidemiology of atherosclerotic disease","author":"Dawber","year":"1980"},{"issue":"2\u20133","key":"10.1016\/j.maturitas.2014.03.010_bib0015","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1159\/000175868","article-title":"Relationship of baseline major risk factors to coronary and all-cause mortality, and to longevity: findings from long-term follow-up of Chicago cohorts","volume":"82","author":"Stamler","year":"1993","journal-title":"Cardiology"},{"issue":"1","key":"10.1016\/j.maturitas.2014.03.010_bib0020","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1600-079X.2007.00518.x","article-title":"Cardiovascular diseases: protective effects of melatonin","volume":"44","author":"Tengattini","year":"2008","journal-title":"J Pineal Res"},{"issue":"1","key":"10.1016\/j.maturitas.2014.03.010_bib0025","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.acthis.2006.08.002","article-title":"Atherosclerosis and the protective role played by different proteins in apolipoprotein E-deficient mice","volume":"109","author":"Fabrizio Rodella","year":"2007","journal-title":"Acta Histochem"},{"issue":"1","key":"10.1016\/j.maturitas.2014.03.010_bib0030","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.atherosclerosis.2004.11.003","article-title":"Elevated levels of oxidized low-density lipoprotein and impaired nocturnal synthesis of melatonin in patients with myocardial infarction","volume":"180","author":"Dominguez-Rodriguez","year":"2005","journal-title":"Atherosclerosis"},{"issue":"2","key":"10.1016\/j.maturitas.2014.03.010_bib0035","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2174\/1568026023394443","article-title":"Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavenger","volume":"2","author":"Tan","year":"2002","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.maturitas.2014.03.010_bib0040","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1046\/j.1365-2249.1998.00493.x","article-title":"Regulation of secretion of IL-4 and IgG1 isotype by melatonin-stimulated ovalbumin-specific T cells","volume":"111","author":"Shaji","year":"1998","journal-title":"Clin Exp Immunol"},{"issue":"2","key":"10.1016\/j.maturitas.2014.03.010_bib0045","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1530\/eje.0.1350188","article-title":"Decrease in melatonin precedes follicle-stimulating hormone increase during perimenopause","volume":"135","author":"Vakkuri","year":"1996","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.maturitas.2014.03.010_bib0050","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0079-6123(08)81008-4","article-title":"Melatonin: a multitasking molecule","volume":"181","author":"Reiter","year":"2010","journal-title":"Prog Brain Res"},{"issue":"4","key":"10.1016\/j.maturitas.2014.03.010_bib0055","doi-asserted-by":"crossref","DOI":"10.1615\/CritRevOncog.v13.i4.30","article-title":"Light at night, chronodisruption, melatonin suppression, and cancer risk: a review","volume":"13","author":"Reiter","year":"2007","journal-title":"Crit Rev Oncog"},{"issue":"5","key":"10.1016\/j.maturitas.2014.03.010_bib0060","article-title":"Melatonin secretion and the incidence of type 2 diabetes","volume":"31","author":"Farham","year":"2013","journal-title":"Contin Med Educ"},{"issue":"3","key":"10.1016\/j.maturitas.2014.03.010_bib0065","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1097\/HJH.0b013e3283340c16","article-title":"Urinary melatonin and risk of incident hypertension among young women","volume":"28","author":"Forman","year":"2010","journal-title":"J Hypertens"},{"issue":"3","key":"10.1016\/j.maturitas.2014.03.010_bib0070","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1034\/j.1600-079X.2000.290302.x","article-title":"Low urinary 6-sulphatoxymelatonin levels in patients with coronary artery disease","volume":"29","author":"Girotti","year":"2000","journal-title":"J Pineal Res"},{"issue":"12","key":"10.1016\/j.maturitas.2014.03.010_bib0075","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/j.amjhyper.2005.05.008","article-title":"Prolonged melatonin administration decreases nocturnal blood pressure in women","volume":"18","author":"Cagnacci","year":"2005","journal-title":"Am J Hypertens"},{"issue":"2","key":"10.1016\/j.maturitas.2014.03.010_bib0080","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1161\/01.HYP.0000113293.15186.3b","article-title":"Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension","volume":"43","author":"Scheer","year":"2004","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.maturitas.2014.03.010_bib0085","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.atherosclerosis.2007.10.019","article-title":"Association of ischemia-modified albumin and melatonin in patients with ST-elevation myocardial infarction","volume":"199","author":"Dominguez-Rodriguez","year":"2008","journal-title":"Atherosclerosis"},{"issue":"2","key":"10.1016\/j.maturitas.2014.03.010_bib0090","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.coph.2013.01.005","article-title":"Menopause, atherosclerosis, and coronary artery disease","volume":"13","author":"Barrett-Connor","year":"2013","journal-title":"Curr Opin Pharmacol"},{"issue":"1","key":"10.1016\/j.maturitas.2014.03.010_bib0095","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.maturitas.2013.06.007","article-title":"Muscle strength and quality are associated with severity of menopausal symptoms in peri-and post-menopausal women","volume":"76","author":"Lee","year":"2013","journal-title":"Maturitas"},{"issue":"2","key":"10.1016\/j.maturitas.2014.03.010_bib0100","doi-asserted-by":"crossref","first-page":"101","DOI":"10.5551\/jat.13.101","article-title":"A novel blood pressure-independent arterial wall stiffness parameter; cardio-ankle vascular index (CAVI)","volume":"13","author":"Shirai","year":"2006","journal-title":"J Atheroscler Thromb"},{"issue":"4","key":"10.1016\/j.maturitas.2014.03.010_bib0105","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1365-2265.1987.tb01172.x","article-title":"The correlation between serum and salivary melatonin concentrations and urinary 6-hydroxymelatonin sulphate excretion rates: two non-invasive techniques for monitoring human circadian rhythmicity","volume":"27","author":"Nowak","year":"1987","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"3","key":"10.1016\/j.maturitas.2014.03.010_bib0110","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1210\/jcem-53-3-645","article-title":"Radioimmunological determination of urinary melatonin in humans: correlation with plasma levels and typical 24-hour rhythmicity","volume":"53","author":"Lang","year":"1981","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.maturitas.2014.03.010_bib0115","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1600-079X.1998.tb00538.x","article-title":"Prediction of nocturnal plasma melatonin from morning urinary measures","volume":"24","author":"Graham","year":"1998","journal-title":"J Pineal Res"},{"issue":"1","key":"10.1016\/j.maturitas.2014.03.010_bib0120","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1600-079X.1998.tb00366.x","article-title":"Sulphatoxymelatonin excretion in older people: relationship to plasma melatonin and renal function","volume":"24","author":"Basket","year":"1998","journal-title":"J Pineal Res"},{"issue":"2","key":"10.1016\/j.maturitas.2014.03.010_bib0125","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1136\/hrt.26.2.261","article-title":"The effect of blood pressure alteration on the pulse wave velocity","volume":"26","author":"Nye","year":"1964","journal-title":"Br Heart J"},{"issue":"11","key":"10.1016\/j.maturitas.2014.03.010_bib0130","doi-asserted-by":"crossref","first-page":"924","DOI":"10.5551\/jat.7716","article-title":"Cardio-ankle vascular index (CAVI) as a novel indicator of arterial stiffness: theory, evidence and perspectives","volume":"18","author":"Shirai","year":"2011","journal-title":"J Atheroscler Thromb"},{"issue":"4","key":"10.1016\/j.maturitas.2014.03.010_bib0135","doi-asserted-by":"crossref","first-page":"328","DOI":"10.5551\/jat.5983","article-title":"Associations between cardio-ankle vascular index and microvascular complications in type 2 diabetes mellitus patients","volume":"18","author":"Kim","year":"2010","journal-title":"J Atheroscler Thromb"},{"issue":"1","key":"10.1016\/j.maturitas.2014.03.010_bib0140","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1471-2261-11-51","article-title":"Establishing baseline criteria of cardio-ankle vascular index as a new indicator of arteriosclerosis: a cross-sectional study","volume":"11","author":"Namekata","year":"2011","journal-title":"BMC Cardiovasc Disord"},{"issue":"4","key":"10.1016\/j.maturitas.2014.03.010_bib0145","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1177\/0003319708325443","article-title":"Comparison of atherosclerotic indicators between cardio ankle vascular index and brachial ankle pulse wave velocity","volume":"60","author":"Horinaka","year":"2009","journal-title":"Angiology"},{"issue":"7","key":"10.1016\/j.maturitas.2014.03.010_bib0150","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1291\/hypres.31.1347","article-title":"Cardio-ankle vascular index is superior to brachial-ankle pulse wave velocity as an index of arterial stiffness","volume":"31","author":"Takaki","year":"2008","journal-title":"Hypertens Res"},{"issue":"1","key":"10.1016\/j.maturitas.2014.03.010_bib0155","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.artres.2007.03.003","article-title":"Abridged version of the expert consensus document on arterial stiffness","volume":"1","author":"Laurent","year":"2007","journal-title":"Artery Res"},{"issue":"3","key":"10.1016\/j.maturitas.2014.03.010_bib0160","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2012-002483","article-title":"Descriptive study of possible link between cardioankle vascular index and homocysteine in vascular-related diseases","volume":"3","author":"Wang","year":"2013","journal-title":"BMJ Open"},{"issue":"3","key":"10.1016\/j.maturitas.2014.03.010_bib0165","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/01.fjc.0000175232.11079.7e","article-title":"Increased susceptibility of low-density lipoprotein to ex vivo oxidation in mice transgenic for human apolipoprotein B treated with 1 melatonin-related compound is not associated with atherosclerosis progression","volume":"46","author":"Tailleux","year":"2005","journal-title":"J Cardiovasc Pharmacol"},{"issue":"10","key":"10.1016\/j.maturitas.2014.03.010_bib0170","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1161\/01.RES.87.10.840","article-title":"Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress","volume":"87","author":"Cai","year":"2000","journal-title":"Circ Res"},{"issue":"1","key":"10.1016\/j.maturitas.2014.03.010_bib0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-079X.2011.00916.x","article-title":"Melatonin as a natural ally against oxidative stress: a physicochemical examination","volume":"51","author":"Galano","year":"2011","journal-title":"J Pineal Res"},{"issue":"4","key":"10.1016\/j.maturitas.2014.03.010_bib0180","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/10409230903044914","article-title":"Reducing oxidative\/nitrosative stress: a newly-discovered genre for melatonin","volume":"44","author":"Reiter","year":"2009","journal-title":"Crit Rev Biochem Mol Biol"},{"issue":"2","key":"10.1016\/j.maturitas.2014.03.010_bib0185","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1006\/bbrc.1996.0731","article-title":"Melatonin protects LDL from oxidation but does not prevent the apolipoprotein derivatization","volume":"222","author":"Pieri","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"issue":"10","key":"10.1016\/j.maturitas.2014.03.010_bib0190","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1161\/CIRCULATIONAHA.106.652859","article-title":"Endothelial function and dysfunction testing and clinical relevance","volume":"115","author":"Deanfield","year":"2007","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.maturitas.2014.03.010_bib0195","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1056\/NEJM199701163360306","article-title":"Melatonin in humans","volume":"336","author":"Brzezinski","year":"1997","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.maturitas.2014.03.010_bib0200","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0165-5728(98)00179-9","article-title":"Involvement of nuclear binding sites for melatonin in the regulation of IL-2 and IL-6 production by human blood mononuclear cells","volume":"92","author":"Garcia-Mauri\u00f1o","year":"1998","journal-title":"J Neuroimmunol"},{"issue":"13","key":"10.1016\/j.maturitas.2014.03.010_bib0205","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1111\/j.1742-4658.2006.05322.x","article-title":"Melatonin","volume":"273","author":"Pandi-Perumal","year":"2006","journal-title":"FEBS J"},{"issue":"3","key":"10.1016\/j.maturitas.2014.03.010_bib0210","doi-asserted-by":"crossref","first-page":"F447","DOI":"10.1152\/ajprenal.00264.2002","article-title":"Melatonin reduces renal interstitial inflammation and improves hypertension in spontaneously hypertensive rats","volume":"284","author":"Nava","year":"2003","journal-title":"Am J Physiol Renal Physiol"},{"issue":"7","key":"10.1016\/j.maturitas.2014.03.010_bib0215","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1136\/jcp.32.7.639","article-title":"Plasma lipoproteins, lipid transport, and atherosclerosis: recent developments","volume":"32","author":"Miller","year":"1979","journal-title":"J Clin Pathol"},{"issue":"3","key":"10.1016\/j.maturitas.2014.03.010_bib0220","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1161\/ATVBAHA.109.196105","article-title":"Pathways by which reconstituted high-density lipoprotein mobilizes free cholesterol from whole body and from macrophages","volume":"30","author":"Cuchel","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"10.1016\/j.maturitas.2014.03.010_bib0225","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1006\/bbrc.1994.2198","article-title":"Melatonin inhibits LDL receptor activity and cholesterol-synthesis in freshly isolated human mononuclear leukocytes","volume":"203","author":"Mullerwieland","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"issue":"11","key":"10.1016\/j.maturitas.2014.03.010_bib0230","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/S0024-3205(97)00613-9","article-title":"Effect of melatonin on serum cholesterol and phospholipid levels, and on prolactin, thyroid-stimulating hormone and thyroid hormone levels, in hyperprolactinemic rats","volume":"61","author":"Esquifino","year":"1997","journal-title":"Life Sci"},{"issue":"1","key":"10.1016\/j.maturitas.2014.03.010_bib0235","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1600-079X.2008.00561.x","article-title":"Melatonin treatment in peri- and postmenopausal women elevates serum high-density lipoprotein cholesterol levels without influencing total cholesterol levels","volume":"45","author":"Tamura","year":"2008","journal-title":"J Pineal Res"}],"container-title":["Maturitas"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512214001182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512214001182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T08:58:56Z","timestamp":1759913936000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378512214001182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["S0378512214001182"],"URL":"https:\/\/doi.org\/10.1016\/j.maturitas.2014.03.010","relation":{},"ISSN":["0378-5122"],"issn-type":[{"value":"0378-5122","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Urine 6-sulfatoxymelatonin levels are inversely associated with arterial stiffness in post-menopausal women","name":"articletitle","label":"Article Title"},{"value":"Maturitas","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.maturitas.2014.03.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}