{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:56:36Z","timestamp":1789826196408,"version":"4.0.1"},"reference-count":129,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","maturitas.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Maturitas"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.maturitas.2018.12.003","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T12:27:00Z","timestamp":1544012820000},"page":"13-21","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"special_numbering":"C","title":["Methamphetamine and its immune-modulating effects"],"prefix":"10.1016","volume":"121","author":[{"given":"Marco","family":"Papageorgiou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Raza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kulmira","family":"Nurgali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasso","family":"Apostolopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.maturitas.2018.12.003_bib0005","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1111\/j.1360-0443.2009.02564.x","article-title":"A review of the clinical pharmacology of methamphetamine","volume":"104","author":"Cruickshank","year":"2009","journal-title":"Addiction"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0010","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1111\/add.12474","article-title":"Does methamphetamine use increase violent behaviour? Evidence from a prospective longitudinal study","volume":"109","author":"McKetin","year":"2014","journal-title":"Addiction"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0015","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/dar.12414","article-title":"A potential role for N-acetylcysteine in the management of methamphetamine dependence","volume":"36","author":"McKetin","year":"2017","journal-title":"Drug Alcohol Rev."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0020","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/09595230801950572","article-title":"The epidemiology of methamphetamine use and harm in Australia","volume":"27","author":"Degenhardt","year":"2008","journal-title":"Drug Alcohol Rev."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0025","series-title":"Research into Methamphetamine Use in the Australian Capital Territory","author":"Rebecca McKetin","year":"2017"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0030","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s11481-011-9288-1","article-title":"Methamphetamine-associated psychosis","volume":"7","author":"Grant","year":"2012","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0035","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/ajr.12331","article-title":"Ice and the outback: patterns and prevalence of methamphetamine use in rural Australia","volume":"25","author":"Roche","year":"2017","journal-title":"Aust. J. Rural Health"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0040","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3109\/00952990.2015.1114625","article-title":"The impact of age, HIV serostatus and seroconversion on methamphetamine use","volume":"42","author":"Montoya","year":"2016","journal-title":"Am. J. Drug Alcohol Abuse"},{"issue":"12","key":"10.1016\/j.maturitas.2018.12.003_bib0045","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1007\/s11136-018-1957-6","article-title":"Methamphetamine use and oral health-related quality of life","volume":"27","author":"Mukherjee","year":"2018","journal-title":"Qual. Life Res."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0050","first-page":"1","article-title":"Concerns about heroin, cocaine and methamphetamine: prevalence and correlates of at-risk users from 2015 National Survey on Drug Use and Health","author":"Larson","year":"2018","journal-title":"J. Subst. Use"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0055","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1139\/jpn.0635","article-title":"The need for speed: an update on methamphetamine addiction","volume":"31","author":"Barr","year":"2006","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0060","first-page":"6","article-title":"Methamphetamine mediates immune dysregulation in a murine model of chronic viral infection","author":"Sriram","year":"2015","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0065","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s11481-006-9023-5","article-title":"Drugs of abuse, immune modulation, and AIDS","volume":"1","author":"Cabral","year":"2006","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0070","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s12640-010-9223-x","article-title":"Methamphetamine causes persistent immune dysregulation: a cross-species, translational report","volume":"20","author":"Loftis","year":"2010","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0075","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.imbio.2013.02.001","article-title":"Methamphetamine administration modifies leukocyte proliferation and cytokine production in murine tissues","volume":"218","author":"Peerzada","year":"2013","journal-title":"Immunobiology."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0080","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/BF03256465","article-title":"Methamphetamine modulates gene expression patterns in monocyte derived mature dendritic cells","volume":"10","author":"Mahajan","year":"2006","journal-title":"Mo. Diagn. Ther."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0085","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.imbio.2015.09.006","article-title":"Acute exposure to methamphetamine alters TLR9-mediated cytokine expression in human macrophage","volume":"221","author":"Burns","year":"2016","journal-title":"Immunobiology"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0090","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1038\/jcbfm.2015.59","article-title":"The TNF-\u03b1\/Nf-\u03baB signaling pathway has a key role in methamphetamine\u2013induced blood\u2013brain barrier dysfunction","volume":"35","author":"Coelho-Santos","year":"2015","journal-title":"J. Cereb. Blood Flow Metabol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0095","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1196\/annals.1432.043","article-title":"Methamphetamine-induced early increase of IL-6 and TNF-\u03b1 mRNA expression in the mouse brain","volume":"1139","author":"Gon\u00e7alves","year":"2008","journal-title":"Ann. New York Acad. Sci."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0049897","article-title":"Methamphetamine administration targets multiple immune subsets and induces phenotypic alterations suggestive of immunosuppression","volume":"7","author":"Harms","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0105","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.pnpbp.2014.01.013","article-title":"Inflamed moods: a review of the interactions between inflammation and mood disorders","volume":"53","author":"Rosenblat","year":"2014","journal-title":"Progress Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0110","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1126\/science.1178331","article-title":"Development of monocytes, macrophages, and dendritic cells","volume":"327","author":"Geissmann","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0115","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s11481-013-9443-y","article-title":"Drug induced increases in CNS dopamine alter monocyte, macrophage and t cell functions: implications for HAND","volume":"8","author":"Gaskill","year":"2013","journal-title":"J. Neuroimm. Pharmacol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0120","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.phrs.2017.03.009","article-title":"Methamphetamine: effects on the brain, gut and immune system","volume":"120","author":"Prakash","year":"2017","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0125","article-title":"Methamphetamine increases LPS-mediated expression of IL-8, TNF-alpha and IL-1beta in human macrophages through common signaling pathways","volume":"7","author":"Liu","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0130","doi-asserted-by":"crossref","DOI":"10.1186\/1742-2094-7-82","article-title":"A neurotoxic regimen of methamphetamine exacerbates the febrile and neuroinflammatory response to a subsequent peripheral immune stimulus","volume":"7","author":"Buchanan","year":"2010","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0135","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s11481-012-9379-7","article-title":"Nanoparticle based galectin-1 gene silencing, implications in methamphetamine regulation of HIV-1 infection in monocyte derived macrophages","volume":"7","author":"Reynolds","year":"2012","journal-title":"J. Neuroimm. Pharmacol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0140","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2013.00438","article-title":"Immature, semi-mature, and fully mature dendritic cells: toward a DC-Cancer cells interface that augments anticancer immunity","volume":"4","author":"Dudek","year":"2013","journal-title":"Front. Immunol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0145","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s11481-008-9128-0","article-title":"Methamphetamine enhances HIV-1 infectivity in monocyte derived dendritic cells","volume":"4","author":"Nair","year":"2008","journal-title":"J. Neuroimm. Pharmacol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0150","article-title":"Methamphetamine-mediated endoplasmic reticulum (ER) stress induces type-1 programmed cell death in astrocytes via ATF6, IRE1a and PERK pathways","volume":"7","author":"Ankit Shah","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0155","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.immuni.2012.08.016","article-title":"CXCR3 chemokine receptor-ligand interactions in the lymph node optimize CD4+ t helper 1 cell differentiation","volume":"37","author":"Groom Joanna","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0160","doi-asserted-by":"crossref","DOI":"10.1038\/s41420-018-0045-6","article-title":"Methamphetamine alters T cell cycle entry and progression: role in immune dysfunction","volume":"4","author":"Potula","year":"2018","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0165","article-title":"Toll-like receptor 4 mediates methamphetamine-induced neuroinflammation through Caspase-11 signaling pathway in astrocytes","volume":"10","author":"Du S-H","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0170","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.4049\/jimmunol.0903691","article-title":"Methamphetamine causes mitrochondrial oxidative damage in human t lymphocytes leading to functional impairment","volume":"185","author":"Potula","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0175","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1097\/QAD.0b013e32833dfc20","article-title":"Increased plasmacytoid dendritic cell maturation and natural killer cell activation in HIV-1 exposed, uninfected intravenous drug users","volume":"24","author":"Tomescu","year":"2010","journal-title":"Aids"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0180","doi-asserted-by":"crossref","first-page":"355","DOI":"10.2353\/ajpath.2010.090953","article-title":"Methamphetamine increases brain viral load and activates natural killer cells in simian immunodeficiency virus-infected monkeys","volume":"177","author":"Marcondes","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0185","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cellimm.2008.08.007","article-title":"Relationship between CD107a expression and cytotoxic activity","volume":"254","author":"Aktas","year":"2009","journal-title":"Cell Immunol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0190","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1365-2567.1996.tb00017.x","article-title":"CD27\/CD70 interaction directly induces natural killer cell killing activity","volume":"88","author":"YANG","year":"1996","journal-title":"Immunology"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0195","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12974-017-0825-6","article-title":"Astrocyte-specific overexpressed gene signatures in response to methamphetamine exposure in vitro","volume":"14","author":"Bortell","year":"2017","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0200","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.bbadis.2016.12.005","article-title":"GPR4 deficiency alleviates intestinal inflammation in a mouse model of acute experimental colitis","volume":"1863","author":"Sanderlin","year":"2017","journal-title":"Biochim. Biophys. Acta (BBA) \u2013 Mol. Basis Dis."},{"issue":"5","key":"10.1016\/j.maturitas.2018.12.003_bib0205","first-page":"4136","article-title":"Protein kinase C\u03b4 gene depletion protects against methamphetamine-induced impairments in recognition memory and ERK1\/2 signaling via upregulation of glutathione Peroxidase-1 gene","volume":"55","author":"Tran","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0210","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s11481-016-9699-0","article-title":"Effects of HIV and methamphetamine on brain and behavior: evidence from human studies and animal models","volume":"11","author":"Soontornniyomkij","year":"2016","journal-title":"J. Neuroimm. Pharmacol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0215","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/npp.2016.143","article-title":"Inflammation effects on motivation and motor activity: role of dopamine","volume":"42","author":"Treadway JCFaMT","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0220","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/rheumatology\/keq031","article-title":"Transmembrane TNF-: structure, function and interaction with anti-TNF agents","volume":"49","author":"Horiuchi","year":"2010","journal-title":"Rheumatology"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0225","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.canlet.2012.10.014","article-title":"Tumor necrosis factor","volume":"328","author":"Chu","year":"2013","journal-title":"Cancer Lett."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0230","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/imr.12621","article-title":"Overview of the IL-1 family in innate inflammation and acquired immunity","volume":"281","author":"Dinarello","year":"2018","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0235","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.molmed.2007.09.002","article-title":"Signaling to NF-\u03baB by toll-like receptors","volume":"13","author":"Kawai","year":"2007","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0240","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.joca.2006.04.008","article-title":"NF-kappaB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis","volume":"14","author":"Roman-Blas","year":"2006","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0245","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2174\/138945010791011938","article-title":"Goldring. NF-\u03baB signaling: multiple angles to target OA","volume":"11","author":"Marcu","year":"2010","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0250","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1615\/CritRevImmunol.v32.i1.30","article-title":"Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease","volume":"32","author":"SSIaG","year":"2012","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0255","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1056\/NEJMoa0907206","article-title":"Inflammatory bowel disease and mutations affecting the interleukin-10 receptor","volume":"361","author":"Glocker","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0260","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-016-0553-3","article-title":"Methamphetamine alters microglial immune function through P2X7R signaling","volume":"13","author":"Fernandes","year":"2016","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0265","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a028530","article-title":"Interleukin (IL)-12 and IL-23 and their conflicting roles in Cancer","volume":"10","author":"Yan","year":"2018","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0270","doi-asserted-by":"crossref","first-page":"40","DOI":"10.2174\/187152809787582507","article-title":"The IL-12 family of cytokines in infection, inflammation and autoimmune disorders","volume":"8","author":"Katrina Gee","year":"2009","journal-title":"Inflamm. Allergy - Drug Targets"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0275","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.imlet.2016.11.010","article-title":"IL-6 roles - molecular pathway and clinical implication in pancreatic cancer - a systemic review","volume":"181","author":"Pop","year":"2017","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0280","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1080\/09273948.2016.1277247","article-title":"Roles of IL-6 in ocular inflammation: a review","volume":"26","author":"Ghasemi","year":"2017","journal-title":"Ocular Immunol. Inflamm."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0285","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1136\/jnnp-2017-316201","article-title":"Peripheral inflammatory markers in Alzheimer\u2019s disease: a systematic review and meta-analysis of 175 studies","volume":"88","author":"Lai","year":"2017","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0290","article-title":"Prevention of methamphetamine-induced microglial cell death by TNF-\u03b1 and IL-6 through activation of the JAK-STAT pathway","volume":"9","author":"Vanessa Coelho-Santos","year":"2012","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0295","doi-asserted-by":"crossref","first-page":"e295","DOI":"10.1038\/emm.2016.148","article-title":"NF-kappaB signaling regulates cell-autonomous regulation of CXCL10 in breast cancer 4T1 cells","volume":"49","author":"Jin","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0300","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.fct.2017.03.030","article-title":"Methamphetamine induces hepatotoxicity via inhibiting cell division, arresting cell cycle and activating apoptosis: in vivo and in vitro studies","volume":"105","author":"Wang","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0305","doi-asserted-by":"crossref","first-page":"900","DOI":"10.3389\/fmicb.2015.00900","article-title":"Phenotypic changes in the brain of SIV-infected macaques exposed to methamphetamine parallel macrophage activation patterns induced by the common gamma-chain cytokine system","volume":"6","author":"Bortell","year":"2015","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0310","article-title":"Involvement of metabotropic glutamate receptor 5, AKT\/PI3K Signaling and NF- B pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes","volume":"9","author":"Ankit Shah","year":"2012","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0315","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3389\/fpsyt.2015.00178","article-title":"Plasma inflammatory factors are associated with anxiety, depression, and cognitive problems in adults with and without methamphetamine dependence: an exploratory protein array study","volume":"6","author":"Huckans","year":"2015","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0320","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.neuropharm.2013.04.040","article-title":"Cyclooxygenase activity contributes to the monoaminergic damage caused by serial exposure to stress and methamphetamine","volume":"72","author":"Northrop","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0325","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.brainres.2005.05.049","article-title":"MK-801 and dextromethorphan block microglial activation and protect against methamphetamine-induced neurotoxicity","volume":"1050","author":"Thomas","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0330","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s12640-012-9350-7","article-title":"The anti-inflammatory effect of melatonin on methamphetamine-induced proinflammatory mediators in human neuroblastoma dopamine SH-SY5Y cell lines","volume":"23","author":"Permpoonputtana","year":"2013","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2003.08.015","article-title":"Methamphetamine-induced neurotoxicity in mouse brain is attenuated by ketoprofen, a non-steroidal anti-inflammatory drug","author":"Asanuma","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0340","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s13365-011-0043-4","article-title":"Methamphetamine toxicity and its implications during HIV-1 infection","volume":"17","author":"Silverstein","year":"2011","journal-title":"J. NeuroVirol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0345","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0109603","article-title":"Methamphetamine alters the normal progression by inducing cell cycle arrest in astrocytes","volume":"9","author":"Jackson","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0350","article-title":"The effect of chronic methamphetamine exposure on the hippocampal and olfactory bulb neuroproteomes of rats","volume":"11","author":"Pendyala","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0355","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0093228","article-title":"Solution structure of CXCL5--a novel chemokine and adipokine implicated in inflammation and obesity","volume":"9","author":"Sepuru","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0360","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.bbapap.2007.02.001","article-title":"Proteomic analyses of methamphetamine (METH)-induced differential protein expression by immature dendritic cells (IDC)","volume":"1774","author":"Reynolds","year":"2007","journal-title":"Biochim. Biophys. Acta (BBA) - Proteins Proteom."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0365","article-title":"Function of nuclear factor kappa B (NF-kB) in human diseases-a review","volume":"2","author":"Serasanambati","year":"2016","journal-title":"South Indian J. Biolog. Sci."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0370","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nri.2017.52","article-title":"The non-canonical NF-\u03baB pathway in immunity and inflammation","volume":"17","author":"Sun","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0375","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1080\/00207454.2016.1212854","article-title":"Neuroinflammation pathways: a general review","volume":"127","author":"Shabab","year":"2016","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0380","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cmet.2010.12.008","article-title":"NF-\u03baB, inflammation, and metabolic disease","volume":"13","author":"Baker","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0385","article-title":"Bioenergetics failure and oxidative stress in brain stem mediates cardiovascular collapse associated with fatal methamphetamine intoxication","volume":"7","author":"Li","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0390","doi-asserted-by":"crossref","DOI":"10.1093\/alcalc\/agw098","article-title":"The role of NFkB in drug addiction: beyond inflammation","author":"Nennig","year":"2017","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0395","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/jnr.1248","article-title":"Methamphetamine induces AP-1 and NF- B binding and transactivation in human brain endothelial cells","volume":"66","author":"Yong Woo Lee","year":"2001","journal-title":"J. of Neurosci. Res."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0400","doi-asserted-by":"crossref","DOI":"10.1007\/s11011-018-0265-8","article-title":"Effect of methamphetamine on the fasting blood glucose in methamphetamine abusers","author":"Zhang","year":"2018","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0405","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/sj.npp.1300891","article-title":"Methamphetamine causes alterations in the MAP kinase-related pathways in the brains of mice that display increased aggressiveness","volume":"31","author":"Sokolov","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0410","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-017-1009-0","article-title":"Asiatic acid attenuates methamphetamine-induced neuroinflammation and neurotoxicity through blocking of NF-kB\/STAT3\/ERK and mitochondria-mediated apoptosis pathway","volume":"14","author":"Park","year":"2017","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0415","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.brainres.2012.11.038","article-title":"Amphetamine increases phosphorylation of MAPK\/ERK at synaptic sites in the rat striatum and medial prefrontal cortex","volume":"1494","author":"Mao","year":"2013","journal-title":"Brain Res."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0420","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.taap.2009.06.021","article-title":"Methamphetamine induces heme oxygenase-1 expression in cortical neurons and glia to prevent its toxicity","volume":"240","author":"Huang","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0425","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ejphar.2008.05.028","article-title":"Differential regional effects of methamphetamine on dopamine transport","volume":"590","author":"Chu","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0430","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1471-2202-7-20","article-title":"Role of the ERK pathway in psychostimulant-induced locomotor sensitization","volume":"7","author":"Valjent","year":"2006","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0435","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.redox.2015.09.005","article-title":"Reactive oxygen species and mitochondria: a nexus of cellular homeostasis","volume":"6","author":"Dan Dunn","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0440","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ceb.2007.02.001","article-title":"The JNK signal transduction pathway","volume":"19","author":"Weston","year":"2007","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0445","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/S0026-895X(24)12208-0","article-title":"Methamphetamine causes coordinate regulation of Src, Cas, Crk, and the jun N-terminal kinase\u2013Jun pathway","volume":"61","author":"Jayanthi","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0450","article-title":"Luteolin inhibits behavioral sensitization by blocking methamphetamine-induced MAPK pathway activation in the caudate putamen in mice","volume":"9","author":"Yan","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0455","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1600-079X.2010.00761.x","article-title":"Melatonin attenuates methamphetamine-induced overexpression of pro-inflammatory cytokines in microglial cell lines","volume":"48","author":"Tocharus","year":"2010","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0460","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/nrd1902","article-title":"Exploiting the PI3K\/AKT pathway for cancer drug discovery","volume":"4","author":"Hennessy","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0465","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.neuropharm.2011.05.010","article-title":"Low dose methamphetamine mediates neuroprotection through a PI3K-AKT pathway","volume":"61","author":"Rau","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0470","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2017.00271","article-title":"Identification of novel signal transduction, immune function, and oxidative stress genes and pathways by topiramate for treatment of methamphetamine dependence based on secondary outcomes","volume":"8","author":"Niu","year":"2017","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0475","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.4049\/jimmunol.178.5.2623","article-title":"The JAK-STAT signaling pathway: input and output integration","volume":"178","author":"Murray","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0480","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.23","article-title":"The anti-apoptotic Bcl-2 family protein A1\/Bfl-1 regulates neutrophil survival and homeostasis and is controlled via PI3K and JAK\/STAT signaling","volume":"7","author":"Vier","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0485","article-title":"Study of serum malondialdehyde level in opioid and methamphetamine dependent patients","volume":"55","author":"Najafi Khadije","year":"2017","journal-title":"Acta Med. Iran."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0490","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.neuro.2012.03.002","article-title":"Methamphetamine mimics the neurochemical profile of aging in rats and impairs recognition memory","volume":"33","author":"Melo","year":"2012","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0495","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neuro.2016.06.014","article-title":"Comparative effects of amphetamine-like psychostimulants on rat hippocampal cell genesis at different developmental ages","volume":"56","author":"Garc\u00eda-Cabrerizo","year":"2016","journal-title":"NeuroToxicology"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0500","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.drugalcdep.2014.02.021","article-title":"Long-term effects of exposure to methamphetamine in adolescent rats","volume":"138","author":"Ye","year":"2014","journal-title":"Drug Alcohol Depend."},{"issue":"Suppl. 1","key":"10.1016\/j.maturitas.2018.12.003_bib0505","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1093\/gerona\/glu057","article-title":"Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases","volume":"69","author":"Franceschi","year":"2014","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0510","first-page":"1169","article-title":"Methamphetamine abuse","volume":"76","author":"Winslow","year":"2007","journal-title":"Am. Family Phys."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0515","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1124\/jpet.301.1.152","article-title":"Cardiovascular responses elicited by the \"binge\" administration of methamphetamine","volume":"301","author":"Varner","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0520","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/j.1369-1600.2010.00270.x","article-title":"Effect of methamphetamine dependence on heart rate variability","volume":"17","author":"Henry","year":"2012","journal-title":"Addict. Biol."},{"issue":"18","key":"10.1016\/j.maturitas.2018.12.003_bib0525","first-page":"31925","article-title":"Heart rate variability as a marker of healthy ageing","volume":"5273","author":"Tan","year":"2018","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0530","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jchf.2017.02.017","article-title":"Clinical characteristics, histopathological features, and clinical outcome of methamphetamine-associated cardiomyopathy","volume":"5","author":"Schurer","year":"2017","journal-title":"JACC Heart Fail."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0535","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ijcard.2016.02.039","article-title":"Healthy aging and myocardium: a complicated process with various effects in cardiac structure and physiology","volume":"209","author":"Nakou","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0540","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.tiv.2018.10.012","article-title":"Methamphetamine exposure induces neuropathic protein beta-Amyloid expression","volume":"54","author":"Chen","year":"2018","journal-title":"Toxicol. Vitro: Int. J. Publ. Assoc. BIBRA"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0545","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3233\/JAD-180340","article-title":"Role of noradrenergic brain nuclei in the regulation of carotid artery blood flow: pharmacological evidence from anesthetized pigs with Alpha-2 adrenergic receptor modulator drugs","volume":"66","author":"Wirth","year":"2018","journal-title":"J. Alzheimer\u2019s Dis.: JAD"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0550","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2174\/1871524918666180531083944","article-title":"Recent findings in melatonin research and their relevance to the CNS","volume":"18","author":"Hardeland","year":"2018","journal-title":"Centr. Nerv. Syst. Agents Med. Chem."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0555","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.pbb.2010.12.004","article-title":"Methamphetamine-induced locomotor changes are dependent on age, dose and genotype","volume":"98","author":"Good","year":"2011","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0560","article-title":"Chronic methamphetamine increases alpha-synuclein protein levels in the striatum and Hippocampus but not in the cortex of juvenile mice","volume":"2","author":"JG-G","year":"2014","journal-title":"J. Addict. Prev."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0565","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/S1734-1140(09)70158-6","article-title":"Methamphetamine-induced neurotoxicity: the road to Parkinson\u2019s disease","volume":"61","author":"Thrash","year":"2009","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0570","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5350\/DAJPN20183101001","article-title":"Update on methamphetamine: an old problem that we have recently encountered","volume":"31","author":"Evren","year":"2018","journal-title":"Dusunen Adam: J. Psychiatry Neurol. Sci."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0575","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.drugalcdep.2012.11.016","article-title":"Methamphetamine use: a comprehensive review of molecular, preclinical and clinical findings","volume":"129","author":"Panenka","year":"2013","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0580","article-title":"Major depression among methamphetamine users entering drug treatment programs","volume":"195","author":"McKetin","year":"2011","journal-title":"MJA"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0585","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1111\/j.1360-0443.2011.03433.x","article-title":"Methamphetamine users show greater than normal age-related cortical gray matter loss","volume":"106","author":"Nakama","year":"2011","journal-title":"Addiction"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0590","doi-asserted-by":"crossref","first-page":"300","DOI":"10.2174\/1570159X14666160428110329","article-title":"The role of oxidative stress in methamphetamine-induced toxicity and sources of variation in the design of animal studies","volume":"15","author":"McDonnell-Dowling","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0595","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1093\/gerona\/59.9.M924","article-title":"Cytokine-related aging process","volume":"59A","author":"Morley","year":"2004","journal-title":"J. Gerontol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0600","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2010\/475139","article-title":"Interleukin-6 contributes to age-related alteration of cytokine production by macrophages","volume":"2010","author":"Gomez","year":"2010","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0605","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/8426874","article-title":"An update on inflamm-aging: mechanisms, prevention, and treatment","volume":"2016","author":"Xia","year":"2016","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0610","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0116961","article-title":"Methamphetamine accelerates cellular senescence through stimulation of de novo ceramide biosynthesis","volume":"10","author":"Astarita","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0615","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.cobeha.2016.09.007","article-title":"Is biological aging accelerated in drug addiction?","volume":"13","author":"Bachi","year":"2017","journal-title":"Curr. Opin. Behav. Sci."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0620","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1038\/srep01542","article-title":"Drug addiction is associated with leukocyte telomere length","volume":"3","author":"Yang","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0625","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.tiv.2009.11.015","article-title":"Methamphetamine cytotoxicity and effect on LPS-stimulated IL-1\u03b2 production by human monocytes","volume":"24","author":"Tipton","year":"2010","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.maturitas.2018.12.003_bib0630","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ejphar.2015.02.002","article-title":"Methamphetamine decreases CD4 T cell frequency and alters pro-inflammatory cytokine production in a model of drug abuse","volume":"752","author":"Mata","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0635","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1538\/expanim.57.35","article-title":"Effects of single or repeated administrations of methamphetamine on immune response in mice","volume":"57","author":"Saito","year":"2008","journal-title":"Exp. Anim."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0640","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1124\/mol.65.5.1293","article-title":"Regulations of methamphetamine reward by extracellular signal-regulated kinase 1\/2\/ets-Like Gene-1 signaling pathway via the activation of dopamine receptors","volume":"65","author":"Hiroyuki Mizoguchi","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.maturitas.2018.12.003_bib0645","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s12035-014-9040-y","article-title":"Epigenetics of stress, addiction, and resilience: therapeutic implications","volume":"53","author":"Cadet","year":"2014","journal-title":"Mol. Neurobiol."}],"container-title":["Maturitas"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512218307400?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512218307400?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T09:13:19Z","timestamp":1759914799000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378512218307400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":129,"alternative-id":["S0378512218307400"],"URL":"https:\/\/doi.org\/10.1016\/j.maturitas.2018.12.003","relation":{},"ISSN":["0378-5122"],"issn-type":[{"value":"0378-5122","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methamphetamine and its immune-modulating effects","name":"articletitle","label":"Article Title"},{"value":"Maturitas","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.maturitas.2018.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}