{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:20:04Z","timestamp":1785547204748,"version":"3.56.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","maturitas.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Maturitas"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.maturitas.2020.06.005","type":"journal-article","created":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T16:03:26Z","timestamp":1592064206000},"page":"49-54","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Comparison of the effects of Pueraria mirifica gel and of placebo gel on the vaginal microenvironment of postmenopausal women with Genitourinary Syndrome of Menopause (GSM)"],"prefix":"10.1016","volume":"140","author":[{"given":"Chuleekorn","family":"Sritonchai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jittima","family":"Manonai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areepan","family":"Sophonsritsuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wichai","family":"Cherdshewasart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.maturitas.2020.06.005_bib0005","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.maturitas.2014.07.013","article-title":"Genitourinary syndrome of menopause: new terminology for vulvovaginal atrophy from the International Society for the Study of Women\u2019s Sexual Health and the North American Menopause Society","volume":"79","author":"Portman","year":"2014","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2020.06.005_bib0010","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/GME.0000000000000549","article-title":"Vulvovaginal symptoms prevalence in postmenopausal women and relationship to other menopausal symptoms and pelvic floor disorders","volume":"23","author":"Erekson","year":"2016","journal-title":"Menopause."},{"key":"10.1016\/j.maturitas.2020.06.005_bib0015","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3109\/13697137.2014.978754","article-title":"Vasomotor symptoms and urogenital atrophy in older women: a systematic review","volume":"18","author":"Zeleke","year":"2015","journal-title":"Climacteric."},{"key":"10.1016\/j.maturitas.2020.06.005_bib0020","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.maturitas.2016.06.010","article-title":"The REVIVE (REal Women\u2019s VIews of Treatment Options for Menopausal Vaginal ChangEs) survey in Europe: country-specific comparisons of postmenopausal women\u2019s perceptions, experiences and needs","volume":"91","author":"Nappi","year":"2016","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2020.06.005_bib0025","first-page":"451","article-title":"The vaginal microbiota, host defense and reproductive physiology","volume":"595","author":"Smith","year":"2017","journal-title":"J. Physiol. (Paris)"},{"key":"10.1016\/j.maturitas.2020.06.005_bib0030","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1097\/GME.0b013e3182a4690b","article-title":"Association between the vaginal microbiota, menopause status, and signs of vulvovaginal atrophy","volume":"21","author":"Brotman","year":"2014","journal-title":"Menopause."},{"key":"10.1016\/j.maturitas.2020.06.005_bib0035","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.UTI-0025-2016","article-title":"The vaginal microbiota and urinary tract infection","volume":"4","author":"Stapleton","year":"2016","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.maturitas.2020.06.005_bib0040","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1159\/000321042","article-title":"Morphology and physiological changes of genital skin and mucosa","volume":"40","author":"Farage","year":"2011","journal-title":"Curr. Probl. Dermatol."},{"key":"10.1016\/j.maturitas.2020.06.005_bib0045","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.ogc.2018.07.010","article-title":"Genitourinary changes with aging","volume":"45","author":"Mitchell","year":"2018","journal-title":"Obstet. Gynecol. Clin. North Am."},{"key":"10.1016\/j.maturitas.2020.06.005_bib0050","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.maturitas.2015.09.001","article-title":"Vaginal atrophy of women in postmenopause. Results from a multicentric observational study: the AGATA study","volume":"83","author":"Palma","year":"2016","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2020.06.005_bib0055","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1080\/13697137.2018.1446930","article-title":"The European Vulvovaginal Epidemiological Survey (EVES): prevalence, symptoms and impact of vulvovaginal atrophy of menopause","volume":"21","author":"Palacios","year":"2018","journal-title":"Climacteric"},{"issue":"8","key":"10.1016\/j.maturitas.2020.06.005_bib0060","article-title":"Local oestrogen for vaginal atrophy in postmenopausal women","author":"Lethaby","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.maturitas.2020.06.005_bib0065","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1097\/GME.0000000000001241","article-title":"The 2017 hormone therapy position statement of the North American Menopause Society","volume":"25","author":"The North American Menopause Society","year":"2018","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2020.06.005_bib0070","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3109\/13697137.2015.1078206","article-title":"The urogenital system and the menopause","volume":"18","author":"Calleja-Agius","year":"2015","journal-title":"Climacteric"},{"key":"10.1016\/j.maturitas.2020.06.005_bib0075","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3109\/13697137.2015.1079100","article-title":"Treatment of the genitourinary syndrome of menopause","volume":"18","author":"Palacios","year":"2015","journal-title":"Climacteric."},{"key":"10.1016\/j.maturitas.2020.06.005_bib0080","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/GME.0000000000000742","article-title":"Comparison of Pueraria mirifica gel and conjugated equine estrogen cream effects on vaginal health in menopausal women","volume":"24","author":"Suwanvesh","year":"2017","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2020.06.005_bib0085","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s11684-012-0184-8","article-title":"Medical application of phytoestrogens from the Thai herb Pueraria mirifica","volume":"6","author":"Malaivijitnond","year":"2012","journal-title":"Front. Med. (Lausanne)"},{"key":"10.1016\/j.maturitas.2020.06.005_bib0090","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1262\/jrd.18065","article-title":"Evaluation of the estrogenic activity of the wild Pueraria mirifica by vaginal cornification assay","volume":"53","author":"Cherdshewasart","year":"2007","journal-title":"J. Reprod. Dev."},{"key":"10.1016\/j.maturitas.2020.06.005_bib0095","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1262\/jrd.2013-144","article-title":"Improvements of vaginal atrophy without systemic side effects after topical application of Pueraria mirifica, a phytoestrogen-rich herb, in postmenopausal cynomolgus macaques","volume":"60","author":"Jaroenporn","year":"2014","journal-title":"J. Reprod. Dev."},{"key":"10.1016\/j.maturitas.2020.06.005_bib0100","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1097\/gme.0b013e3180399486","article-title":"Effect of Peuraria mirifica on vaginal health","volume":"14","author":"Manonai","year":"2007","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2020.06.005_bib0105","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1097\/gme.0b013e31815c5fd8","article-title":"Effects and safety of Pueraria mirifica on lipid profiles and biochemical markers of bone turnover rates in healthy postmenopausal women","volume":"15","author":"Manonai","year":"2008","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2020.06.005_bib0110","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1128\/JCM.40.6.2147-2152.2002","article-title":"Prevalence of bacterial vaginosis and vaginal flora changes in peri- and postmenopausal women","volume":"40","author":"Cauci","year":"2002","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.maturitas.2020.06.005_bib0115","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3855\/jidc.1625","article-title":"Development of modified diagnostic criteria for bacterial vaginosis at peripheral health centres in developing countries","volume":"6","author":"Mittal","year":"2012","journal-title":"J. Infect. Dev."},{"key":"10.1016\/j.maturitas.2020.06.005_bib0120","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/365194","article-title":"Comparison of Hay\u2019s criteria with Nugent\u2019s scoring system for diagnosis of bacterial vaginosis","volume":"2013","author":"Chawla","year":"2013","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.maturitas.2020.06.005_bib0125","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1067\/mob.2003.23","article-title":"Are women with urogenital atrophy symptomatic?","volume":"188","author":"Davila","year":"2003","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.maturitas.2020.06.005_bib0130","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/geronb\/gbu105","article-title":"Prevalence of bacterial vaginosis and Candida among postmenopausal women in United States","volume":"69","author":"Hoffmann","year":"2014","journal-title":"J. Gerontol. B Psychol. Sci. Soc. Sci."},{"key":"10.1016\/j.maturitas.2020.06.005_bib0135","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00192-014-2464-0","article-title":"Assessment of vaginal atrophy: a review","volume":"26","author":"Weber","year":"2015","journal-title":"Int. Urogynecol. J."},{"key":"10.1016\/j.maturitas.2020.06.005_bib0140","doi-asserted-by":"crossref","first-page":"316","DOI":"10.5489\/cuaj.687","article-title":"Guidelines for the diagnosis and management of recurrent urinary tract infection in women","volume":"5","author":"Dason","year":"2011","journal-title":"Can. Urol. Assoc. J."},{"key":"10.1016\/j.maturitas.2020.06.005_bib0145","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/S1701-2163(16)34717-X","article-title":"Recurrent urinary tract infection","volume":"32","author":"Epp","year":"2010","journal-title":"J. Obstet. Gynaecol. Can."}],"container-title":["Maturitas"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512220302942?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512220302942?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T09:16:33Z","timestamp":1759914993000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378512220302942"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":29,"alternative-id":["S0378512220302942"],"URL":"https:\/\/doi.org\/10.1016\/j.maturitas.2020.06.005","relation":{},"ISSN":["0378-5122"],"issn-type":[{"value":"0378-5122","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of the effects of Pueraria mirifica gel and of placebo gel on the vaginal microenvironment of postmenopausal women with Genitourinary Syndrome of Menopause (GSM)","name":"articletitle","label":"Article Title"},{"value":"Maturitas","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.maturitas.2020.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}