{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:21:18Z","timestamp":1791462078761,"version":"4.3.4"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","maturitas.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Maturitas"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.maturitas.2021.06.012","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T04:42:23Z","timestamp":1625028143000},"page":"22-30","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["The interplay between metabolic dysregulations and non-alcoholic fatty liver disease in women after menopause"],"prefix":"10.1016","volume":"151","author":[{"given":"Ralitsa","family":"Robeva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du\u0161an","family":"Mladenovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Veskovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragan","family":"Hrn\u010di\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelica","family":"Bjeki\u0107-Macut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivera","family":"Stanojlovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarantis","family":"Livadas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bulent O.","family":"Yildiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djuro","family":"Macut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.maturitas.2021.06.012_bib0001","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.jhep.2015.11.004","article-title":"European Association for the Study of Diabetes (EASD); European Association for the Study of Obesity (EASO), EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease","volume":"64","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0002","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.3748\/wjg.v24.i30.3361","article-title":"Current guidelines for the management of non-alcoholic fatty liver disease: A systematic review with comparative analysis","volume":"24","author":"Leoni","year":"2018","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.maturitas.2021.06.012_bib0003","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of non-alcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.maturitas.2021.06.012_bib0004","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-036663","article-title":"Prevalence trends in non-alcoholic fatty liver disease at the global, regional and national levels, 1990-2017: a population-based observational study","volume":"10","author":"Ge","year":"2020","journal-title":"BMJ Open"},{"key":"10.1016\/j.maturitas.2021.06.012_bib0005","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1007\/s12325-017-0556-1","article-title":"NAFLD as a Sexual Dimorphic Disease: Role of Gender and Reproductive Status in the Development and Progression of Non-alcoholic Fatty Liver Disease and Inherent Cardiovascular Risk","volume":"34","author":"S.Ballestri","year":"2017","journal-title":"Adv. Ther."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0006","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cgh.2020.04.067","article-title":"Women Have a Lower Risk of Non-alcoholic Fatty Liver Disease but a Higher Risk of Progression vs Men: A Systematic Review and Meta-analysis","volume":"19","author":"Balakrishnan","year":"2021","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0007","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.3390\/jcm9051278","article-title":"Sexual Dimorphism of NAFLD in Adults. Focus on Clinical Aspects and Implications for Practice and Translational Research","volume":"9","author":"Lonardo","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0008","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41574-020-00431-8","article-title":"Sexual dimorphism in cardiometabolic health: the role of adipose tissue, muscle and liver","volume":"17","author":"Goossens","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0009","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/978-3-319-70178-3_20","article-title":"G-Protein-Coupled Estrogen Receptor (GPER) and Sex-Specific Metabolic Homeostasis","volume":"1043","author":"Sharma","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0010","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/978-3-319-70178-3_12","article-title":"Role of Estrogens in the Regulation of Liver Lipid Metabolism","volume":"1043","author":"Palmisano","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0011","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.mce.2019.04.005","article-title":"Disruption of ESR1 alters the expression of genes regulating hepatic lipid and carbohydrate metabolism in male rats","volume":"490","author":"Khristi","year":"2019","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0012","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1093\/nar\/25.12.2424","article-title":"Estrogen receptor impairs interleukin-6 expression by preventing protein binding on the NF-\u03baB site","volume":"25","author":"Galien","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.maturitas.2021.06.012_bib0013","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.tem.2009.06.009","article-title":"Plasma membrane estrogen receptors","volume":"20","author":"Levin","year":"2009","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0014","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jsbmb.2017.02.012","article-title":"Roles of G protein-coupled estrogen receptor GPER in metabolic regulation","volume":"176","author":"Sharma","year":"2018","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0015","first-page":"7564","article-title":"G Protein-coupled Estrogen Receptor Protects from","volume":"4","author":"Meyer","year":"2014","journal-title":"Atherosclerosis. Sci. Rep."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0016","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.1210\/en.2013-1357","article-title":"GPER deficiency in male mice results in insulin resistance, dyslipidemia, and a proinflammatory state","volume":"154","author":"Sharma","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.maturitas.2021.06.012_bib0017","doi-asserted-by":"crossref","first-page":"bqaa134","DOI":"10.1210\/endocr\/bqaa134","article-title":"NAFLD and NASH in Postmenopausal Women: Implications for Diagnosis and Treatment","volume":"161","author":"DiStefano","year":"2020","journal-title":"Endocrinology"},{"key":"10.1016\/j.maturitas.2021.06.012_bib0018","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1097\/GME.0000000000001403","article-title":"Lipid profile differences during menopause: a review with meta-analysis","volume":"26","author":"Ambikairajah","year":"2019","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2021.06.012_bib0019","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.molmet.2018.05.008","article-title":"Sex differences in lipid and lipoprotein metabolism","volume":"15","author":"Palmisano","year":"2018","journal-title":"Mol. Metab."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.acc.2015.07.001","article-title":"Metabolic Syndrome and Menopause: Pathophysiology, Clinical and Diagnostic Significance","volume":"72","author":"Stefanska","year":"2015","journal-title":"Adv. Clin. Chem."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0021","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1093\/humrep\/dew076","article-title":"Non-alcoholic fatty liver disease is associated with insulin resistance and lipid accumulation product in women with polycystic ovary syndrome","volume":"31","author":"Macut","year":"2016","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0022","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1172\/JCI9575","article-title":"Altered expression of fatty acid-metabolizing enzymes in aromatase-deficient mice","volume":"105","author":"Nemoto","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0023","doi-asserted-by":"crossref","first-page":"594","DOI":"10.3109\/13697137.2011.637650","article-title":"Liver fat accumulation may be dissociated from adiposity gain in ovariectomized rats","volume":"15","author":"C\u00f4t\u00e9","year":"2012","journal-title":"Climacteric"},{"key":"10.1016\/j.maturitas.2021.06.012_bib0024","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.lfs.2016.05.044","article-title":"Melatonin protects female rats against steatosis and liver oxidative stress induced by oestrogen deficiency","volume":"157","author":"Hermoso","year":"2016","journal-title":"Life Sci"},{"key":"10.1016\/j.maturitas.2021.06.012_bib0025","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3892\/mmr.2016.5236","article-title":"Treatment with estrogen protects against ovariectomy-induced hepatic steatosis by increasing AQP7 expression","volume":"14","author":"Fu","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0026","doi-asserted-by":"crossref","first-page":"7613","DOI":"10.3748\/wjg.v21.i25.7613","article-title":"Liver disease in menopause","volume":"21","author":"Brady","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0027","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/TP.0000000000002480","article-title":"Non-alcoholic Fatty Liver Disease: Basic Pathogenetic Mechanisms in the Progression From NAFLD to NASH","volume":"103","author":"Pierantonelli","year":"2019","journal-title":"Transplantation"},{"key":"10.1016\/j.maturitas.2021.06.012_bib0028","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1002\/hep.31599","article-title":"American Association for the Study of Liver Diseases NASH Task Force, NAFLD: Reporting Histologic Findings in Clinical Practice","volume":"73","author":"Brunt","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.maturitas.2021.06.012_bib0029","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.arcmed.2013.12.010","article-title":"Time-dependent changes and association between liver free fatty acids, serum lipid profile and histological features in mice model of non-alcoholic fatty liver disease","volume":"45","author":"Stankovi\u0107","year":"2014","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0030","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1017\/S1431927620024265","article-title":"Effect of Betaine Supplementation on Liver Tissue and Ultrastructural Changes in Methionine-Choline-Deficient Diet-Induced NAFLD","volume":"26","author":"Veskovi\u0107","year":"2020","journal-title":"Microsc. Microanal."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0031","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/17474124.2018.1415756","article-title":"Clinical relevance of liver histopathology and different histological classifications of NASH in adults","volume":"12","author":"Nascimbeni","year":"2018","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0032","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3390\/ijms17010097","article-title":"Nonalcoholic Fatty Liver Disease: Pros and Cons of Histologic Systems of Evaluation","volume":"17","author":"Brunt","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0033","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1002\/hep.25889","article-title":"Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients","volume":"56","author":"Bedossa","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.maturitas.2021.06.012_bib0034","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s12325-016-0306-9","article-title":"The role of nuclear receptors in the pathophysiology, natural course, and drug treatment of NAFLD in humans","volume":"33","author":"Ballestri","year":"2016","journal-title":"Adv. Ther."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0035","doi-asserted-by":"crossref","first-page":"3501","DOI":"10.1172\/JCI74438","article-title":"Periostin promotes liver steatosis and hypertriglyceridemia through downregulation of PPAR\u03b1","volume":"124","author":"Lu","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0036","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.2337\/db14-1213","article-title":"Short-Chain Fatty Acids Protect Against High-Fat Diet-Induced Obesity via a PPAR\u03b3-Dependent Switch From Lipogenesis to Fat Oxidation","volume":"64","author":"G","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.maturitas.2021.06.012_bib0037","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.fct.2018.05.006","article-title":"Effects of high fructose intake on liver injury progression in high fat diet induced fatty liver disease in ovariectomized female mice","volume":"118","author":"Ohashi","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0038","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1538\/expanim.20-0028","article-title":"Gender difference in development of steatohepatitis in p62\/Sqstm1 and Nrf2 double-knockout mice","volume":"69","author":"Watahiki","year":"2020","journal-title":"Exp. Anim."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0039","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0239659","article-title":"Estrogen protects against liver damage in sepsis through inhibiting oxidative stress mediated activation of pyroptosis signaling pathway","volume":"15","author":"Xu","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.maturitas.2021.06.012_bib0040","first-page":"140","article-title":"The role of oxidative stress in menopause","volume":"4","author":"Doshi","year":"2013","journal-title":"J. Midlife Health."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0041","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s12906-020-02962-z","article-title":"Genistein and exercise modulated lipid peroxidation and improved steatohepatitis in ovariectomized rats","volume":"20","author":"Witayavanitkul","year":"2020","journal-title":"BMC Complement Med. Ther."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0042","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.yjmcc.2006.06.001","article-title":"Upregulation of mitochondrial respiratory complex IV by estrogen receptor-beta is critical for inhibiting mitochondrial apoptotic signaling and restoring cardiac functions following trauma-hemorrhage","volume":"41","author":"Hsieh","year":"2006","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0043","doi-asserted-by":"crossref","first-page":"14069","DOI":"10.1523\/JNEUROSCI.4391-07.2007","article-title":"Estradiol in vivo regulation of brain mitochondrial proteome","volume":"27","author":"Nilsen","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0044","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1053\/j.gastro.2016.09.017","article-title":"Estrogen Signals Through Peroxisome Proliferator-Activated Receptor-\u03b3 Coactivator 1\u03b1 to Reduce Oxidative Damage Associated With Diet-Induced Fatty Liver Disease","volume":"152","author":"Besse-Patin","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.maturitas.2021.06.012_bib0045","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1073\/pnas.91.4.1309","article-title":"Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: a potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis","volume":"91","author":"Virbasius","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0046","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s10654-019-00526-1","article-title":"Oophorectomy and risk of non-alcoholic fatty liver disease and primary liver cancer in the Clinical Practice Research Datalink","volume":"34","author":"Florio","year":"2019","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0047","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejogrb.2015.04.017","article-title":"Menopausal stages and non-alcoholic fatty liver disease in middle-aged women","volume":"190","author":"Ryu","year":"2015","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0048","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/hep.28514","article-title":"Non-alcoholic Steatohepatitis Clinical Research Network, A longer duration of estrogen deficiency increases fibrosis risk among postmenopausal women with non-alcoholic fatty liver disease","volume":"64","author":"Klair","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.maturitas.2021.06.012_bib0049","doi-asserted-by":"crossref","first-page":"513","DOI":"10.2174\/1871530318666180423101755","article-title":"Menopause Does Not Affect Fatty Liver Severity In Women: A Population Study in a Mediterranean Area","volume":"18","author":"Veronese","year":"2018","journal-title":"Endocr. Metab. Immune Disord. Drug Targets."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0050","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/BF03401306","article-title":"Sex steroids and sex hormone-binding globulin in postmenopausal women with non-alcoholic fatty liver disease","volume":"12","author":"Polyzos","year":"2013","journal-title":"Hormones (Athens)"},{"key":"10.1016\/j.maturitas.2021.06.012_bib0051","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.maturitas.2010.08.003","article-title":"Menopause and aging: changes in the immune system\u2013a review","volume":"67","author":"Gameiro","year":"2010","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2021.06.012_bib0052","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1016\/j.cgh.2014.12.033","article-title":"Association Between Endogenous Sex Hormones and Liver Fat in a Multiethnic Study of Atherosclerosis","volume":"13","author":"Lazo","year":"2015","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0053","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1089\/jwh.2018.7263","article-title":"Serum Testosterone Level Within Normal Range Is Positively Associated with Non-alcoholic Fatty Liver Disease in Premenopausal but Not Postmenopausal Women","volume":"282","author":"Park","year":"2019","journal-title":"J. Womens Health (Larchmt)."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0054","doi-asserted-by":"crossref","first-page":"R145","DOI":"10.1530\/EJE-16-1063","article-title":"Polycystic ovary syndrome and non-alcoholic fatty liver disease","volume":"177","author":"Macut","year":"2017","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0055","doi-asserted-by":"crossref","first-page":"382","DOI":"10.5604\/01.3001.0009.8593","article-title":"Testosterone, Sex Hormone-Binding Globulin and Non-alcoholic Fatty Liver Disease: a Systematic Review and Meta-Analysis","volume":"16","author":"Jaruvongvanich","year":"2017","journal-title":"Ann. Hepatol."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0056","first-page":"545","article-title":"Sex Hormone-Binding Globulin Reduction in Metabolic Disorders May Play a Role in NAFLD Development","volume":"158","author":"Saez-Lopez","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.maturitas.2021.06.012_bib0057","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3390\/ijms17030367","article-title":"Bidirectional Relationships and Disconnects between NAFLD and Features of the Metabolic Syndrome","volume":"17","author":"Wainwright","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0058","doi-asserted-by":"crossref","first-page":"5888","DOI":"10.3390\/ijms21165888","article-title":"History of Non-alcoholic Fatty Liver Disease","volume":"21","author":"Lonardo","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0059","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-008204","article-title":"Identification of reciprocal causality between non-alcoholic fatty liver disease and metabolic syndrome by a simplified Bayesian network in a Chinese population","volume":"5","author":"Zhang","year":"2015","journal-title":"BMJ. Open."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0060","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13098-020-00570-y","article-title":"NAFLD as a continuum: from obesity to metabolic syndrome and diabetes","volume":"12","author":"Godoy-Matos","year":"2020","journal-title":"Diabetol. Metab. Syndr."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0061","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1872-034X.2012.01031.x","article-title":"Liver and diabetes. A vicious circle","volume":"43","author":"Loria","year":"2013","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0062","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.maturitas.2015.02.262","article-title":"Effects of menopause, gender and age on lipids and high-density lipoprotein cholesterol subfractions","volume":"81","author":"Anagnostis","year":"2015","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2021.06.012_bib0063","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/131528","article-title":"The influence of metabolic factors for non-alcoholic Fatty liver disease in women","volume":"2015","author":"Chung","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0064","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s12902-019-0427-7","article-title":"Prevalence of cardiovascular risk factors in non-menopausal and postmenopausal inpatients with type 2 diabetes mellitus in China","volume":"19","author":"Zhou","year":"2019","journal-title":"BMC Endocr. Disord."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0065","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1530\/EJE-18-0602","article-title":"Early menopause and premature ovarian insufficiency are associated with increased risk of type 2 diabetes: a systematic review and meta-analysis","volume":"180","author":"Anagnostis","year":"2019","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0066","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/GME.0000000000000500","article-title":"Surgical menopause and increased risk of non-alcoholic fatty liver disease in endometrial cancer","volume":"23","author":"Matsuo","year":"2016","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2021.06.012_bib0067","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.diabet.2019.12.007","article-title":"Efficacy and safety of anti-hyperglycaemic drugs in patients with non-alcoholic fatty liver disease with or without diabetes: An updated systematic review of randomized controlled trials","volume":"46","author":"Mantovani","year":"2020","journal-title":"Diabetes Metab"},{"key":"10.1016\/j.maturitas.2021.06.012_bib0068","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/ijo.2016.4","article-title":"Strong and persistent effect on liver fat with a Paleolithic diet during a two-year intervention","volume":"40","author":"Otten","year":"2016","journal-title":"Int. J. Obes. (Lond)."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0069","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.3390\/nu12092748","article-title":"Very Low-Carbohydrate Ketogenic Diet for the Treatment of Severe Obesity and Associated Non-Alcoholic Fatty Liver Disease: The Role of Sex Differences","volume":"12","author":"D'Abbondanza","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.maturitas.2021.06.012_bib0070","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1093\/ajcn\/85.5.1275","article-title":"Sex and menopausal status influence human dietary requirements for the nutrient choline","volume":"85","author":"Fischer","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0071","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.3945\/jn.114.197533","article-title":"Higher dietary choline intake is associated with lower risk of nonalcoholic fatty liver in normal-weight Chinese women","volume":"144","author":"Yu","year":"2014","journal-title":"J. Nutr."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0072","doi-asserted-by":"crossref","first-page":"15952","DOI":"10.1038\/s41598-017-16159-x","article-title":"Effect of aerobic exercise and diet on liver fat in pre-diabetic patients with non-alcoholic-fatty-liver-disease: A randomized controlled trial","volume":"7","author":"Cheng","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0073","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1053\/gast.2002.33573","article-title":"Non-alcoholic fatty liver disease","volume":"122","author":"Clark","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.maturitas.2021.06.012_bib0074","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1590\/S0004-28032013000200032","article-title":"Non-alcoholic fatty liver disease in menopausal women","volume":"50","author":"Florentino","year":"2013","journal-title":"Arq. Gastroenterol."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0075","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1002\/hep.26761","article-title":"Gender and menopause impact severity of fibrosis among patients with non-alcoholic steatohepatitis","volume":"59","author":"Yang","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.maturitas.2021.06.012_bib0076","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cgh.2016.07.034","article-title":"Non-alcoholic Steatohepatitis Clinical Research Network, Patient Sex, Reproductive Status, and Synthetic Hormone Use Associate With Histologic Severity of Non-alcoholic Steatohepatitis","volume":"15","author":"Yang","year":"2017","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0077","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1097\/GME.0000000000000921","article-title":"The 2017 hormone therapy position statement of The North American Menopause Society","volume":"24","year":"2017","journal-title":"Menopause"},{"key":"10.1016\/j.maturitas.2021.06.012_bib0078","doi-asserted-by":"crossref","first-page":"546","DOI":"10.2174\/1570161116666180711121949","article-title":"Menopause and Non-Alcoholic Fatty Liver Disease: A Review Focusing on Therapeutic Perspectives","volume":"17","author":"Venetsanaki","year":"2019","journal-title":"Curr. Vasc. Pharmacol."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0079","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.breast.2016.04.017","article-title":"Clinical significance of fatty liver disease induced by tamoxifen and toremifene in breast cancer patients","volume":"28","author":"Yang","year":"2016","journal-title":"Breast"},{"key":"10.1016\/j.maturitas.2021.06.012_bib0080","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.molmet.2013.12.009","article-title":"Tissue-selective estrogen complexes with bazedoxifene prevent metabolic dysfunction in female mice","volume":"3","author":"Kim","year":"2014","journal-title":"Mol. Metab."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0081","doi-asserted-by":"crossref","first-page":"E345","DOI":"10.1152\/ajpendo.00653.2013","article-title":"Bazedoxifene and conjugated estrogen prevent diet-induced obesity, hepatic steatosis, and type 2 diabetes in mice without impacting the reproductive tract","volume":"307","author":"Barrera","year":"2014","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0082","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3748\/wjg.v18.i3.237","article-title":"Aging is a risk factor of nonalcoholic fatty liver disease in premenopausal women","volume":"18","author":"Hamaguchi","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0083","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1365-2265.2006.02543.x","article-title":"Effects of HRT on liver enzyme levels in women with type 2 diabetes: a randomized placebo-controlled trial","volume":"65","author":"McKenzie","year":"2006","journal-title":"Clin. Endocrinol. (Oxf)."},{"key":"10.1016\/j.maturitas.2021.06.012_bib0084","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/j.1365-2265.2008.03203.x","article-title":"Liver dysfunction in Turner's syndrome: prevalence, natural history and effect of exogenous oestrogen","volume":"69","author":"Koulouri","year":"2008","journal-title":"Clin. Endocrinol."}],"container-title":["Maturitas"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512221001171?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512221001171?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T09:18:10Z","timestamp":1759915090000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378512221001171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":84,"alternative-id":["S0378512221001171"],"URL":"https:\/\/doi.org\/10.1016\/j.maturitas.2021.06.012","relation":{},"ISSN":["0378-5122"],"issn-type":[{"value":"0378-5122","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The interplay between metabolic dysregulations and non-alcoholic fatty liver disease in women after menopause","name":"articletitle","label":"Article Title"},{"value":"Maturitas","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.maturitas.2021.06.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}