{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:24:43Z","timestamp":1792027483171,"version":"4.4.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T00:00:00Z","timestamp":1649376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","maturitas.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Maturitas"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.maturitas.2022.04.003","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T20:13:58Z","timestamp":1650917638000},"page":"23-30","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Are serum estrogen concentrations associated with menopausal symptom bother among postmenopausal women? Baseline results from two MsFLASH clinical trials"],"prefix":"10.1016","volume":"162","author":[{"given":"Carolyn J.","family":"Crandall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph C.","family":"Larson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine E.","family":"Ensrud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Z.","family":"LaCroix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A.","family":"Guthrie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan D.","family":"Reed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalender","family":"Bhasin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Diem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.maturitas.2022.04.003_bb0005","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.2105\/AJPH.2005.066936","article-title":"Longitudinal analysis of the association between vasomotor symptoms and race\/ethnicity across the menopausal transition: study of women's health across the nation","volume":"96","author":"Gold","year":"2006","journal-title":"Am. J. Public Health"},{"issue":"5","key":"10.1016\/j.maturitas.2022.04.003_bb0010","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1093\/aje\/152.5.463","article-title":"Relation of demographic and lifestyle factors to symptoms in a multi-racial\/ethnic population of women 40\u201355 years of age","volume":"152","author":"Gold","year":"2000","journal-title":"Am. J. Epidemiol."},{"issue":"3","key":"10.1016\/j.maturitas.2022.04.003_bb0015","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1097\/gme.0b013e3181948dd0","article-title":"Longitudinal changes in sexual functioning as women transition through menopause: results from the study of Women's health across the nation","volume":"16","author":"Avis","year":"2009","journal-title":"Menopause"},{"issue":"11","key":"10.1016\/j.maturitas.2022.04.003_bb0020","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1097\/GME.0000000000001226","article-title":"Correlates of sexual function among multi-ethnic middle-aged women: results from the study of Women's health across the nation (SWAN)","volume":"25","author":"Avis","year":"2018","journal-title":"Menopause"},{"issue":"1","key":"10.1016\/j.maturitas.2022.04.003_bb0025","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3109\/13697137.2011.647840","article-title":"Vaginal Health: Insights, Views & Attitudes (VIVA) - results from an international survey","volume":"15","author":"Nappi","year":"2012","journal-title":"Climacteric"},{"key":"10.1016\/j.maturitas.2022.04.003_bb0030","author":"Medicine"},{"key":"10.1016\/j.maturitas.2022.04.003_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.maturitas.2018.10.007","article-title":"Hormone variability and hot flash experience: Results from the midlife women's health study","volume":"119","author":"Chiang","year":"2019","journal-title":"Maturitas"},{"issue":"10","key":"10.1016\/j.maturitas.2022.04.003_bb0040","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1097\/GME.0000000000000434","article-title":"Risk factors for hot flashes among women undergoing the menopausal transition: baseline results from the Midlife Women's Health Study","volume":"22","author":"Gallicchio","year":"2015","journal-title":"Menopause"},{"issue":"2","key":"10.1016\/j.maturitas.2022.04.003_bb0045","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.maturitas.2006.11.009","article-title":"Genetic polymorphisms, hormone levels, and hot flashes in midlife women","volume":"57","author":"Schilling","year":"2007","journal-title":"Maturitas"},{"issue":"6","key":"10.1016\/j.maturitas.2022.04.003_bb0050","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1097\/01.AOG.0000187308.67021.98","article-title":"Cytochrome gene polymorphisms, serum estrogens, and hot flushes in midlife women","volume":"106","author":"Visvanathan","year":"2005","journal-title":"Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.maturitas.2022.04.003_bb0055","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1210\/jc.2014-1725","article-title":"Masturbation frequency and sexual function domains are associated with serum reproductive hormone levels across the menopausal transition","volume":"100","author":"Randolph","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"11","key":"10.1016\/j.maturitas.2022.04.003_bb0060","doi-asserted-by":"crossref","first-page":"6106","DOI":"10.1210\/jc.2005-1374","article-title":"The relationship of longitudinal change in reproductive hormones and vasomotor symptoms during the menopausal transition","volume":"90","author":"Randolph","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"10","key":"10.1016\/j.maturitas.2022.04.003_bb0065","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1097\/GME.0000000000001597","article-title":"Effects of pharmacologic and nonpharmacologic interventions on menopause-related quality of life: a pooled analysis of individual participant data from four MsFLASH trials","volume":"27","author":"Diem","year":"2020","journal-title":"Menopause"},{"issue":"4","key":"10.1016\/j.maturitas.2022.04.003_bb0070","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/GME.0000000000001461","article-title":"Lights on MsFLASH: a review of contributions","volume":"27","author":"Reed","year":"2020","journal-title":"Menopause"},{"issue":"5","key":"10.1016\/j.maturitas.2022.04.003_bb0075","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1001\/jamainternmed.2018.0116","article-title":"Efficacy of vaginal estradiol or vaginal moisturizer vs placebo for treating postmenopausal vulvovaginal symptoms: a randomized clinical trial","volume":"178","author":"Mitchell","year":"2018","journal-title":"JAMA Intern. Med."},{"issue":"7","key":"10.1016\/j.maturitas.2022.04.003_bb0080","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1001\/jamainternmed.2014.1891","article-title":"Low-dose estradiol and the serotonin-norepinephrine reuptake inhibitor venlafaxine for vasomotor symptoms: a randomized clinical trial","volume":"174","author":"Joffe","year":"2014","journal-title":"JAMA Intern. Med."},{"issue":"3","key":"10.1016\/j.maturitas.2022.04.003_bb0085","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0378-5122(96)82006-8","article-title":"A menopause-specific quality of life questionnaire: development and psychometric properties","volume":"24","author":"Hilditch","year":"1996","journal-title":"Maturitas"},{"issue":"7","key":"10.1016\/j.maturitas.2022.04.003_bb0090","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1056\/NEJMoa1506119","article-title":"I. Testosterone trials, effects of testosterone treatment in older men","volume":"374","author":"Snyder","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"9","key":"10.1016\/j.maturitas.2022.04.003_bb0095","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1002\/sim.5727","article-title":"Testing for improvement in prediction model performance","volume":"32","author":"Pepe","year":"2013","journal-title":"Stat. Med."},{"key":"10.1016\/j.maturitas.2022.04.003_bb0100","series-title":"Applied Logistic Regression","author":"Hosmer","year":"2000"},{"issue":"1","key":"10.1016\/j.maturitas.2022.04.003_bb0105","first-page":"43","article-title":"Sociodemographic characteristics, biological factors, and symptom reporting in midlife women","volume":"5","author":"Wilbur","year":"1998","journal-title":"Menopause"},{"issue":"2","key":"10.1016\/j.maturitas.2022.04.003_bb0110","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0028-2243(94)90051-5","article-title":"The menopausal transition: a dynamic approach to the pathogenesis of neurovegetative complaints","volume":"57","author":"Pansini","year":"1994","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.maturitas.2022.04.003_bb0115","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.maturitas.2016.03.017","article-title":"Hot flushes and reproductive hormone levels during the menopausal transition","volume":"89","author":"Dhanoya","year":"2016","journal-title":"Maturitas"},{"issue":"3","key":"10.1016\/j.maturitas.2022.04.003_bb0120","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0029-7844(96)00196-2","article-title":"Hot flushes, menstrual status, and hormone levels in a population-based sample of midlife women","volume":"88","author":"Guthrie","year":"1996","journal-title":"Obstet. Gynecol."},{"issue":"2","key":"10.1016\/j.maturitas.2022.04.003_bb0125","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.maturitas.2003.12.007","article-title":"Endogenous estrogen levels affect sexual function in elderly post-menopausal women","volume":"49","author":"Modelska","year":"2004","journal-title":"Maturitas"},{"issue":"3","key":"10.1016\/j.maturitas.2022.04.003_bb0130","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.ogc.2011.05.004","article-title":"Reproductive hormones and the menopause transition","volume":"38","author":"Santoro","year":"2011","journal-title":"Obstet. Gynecol. Clin. N. Am."}],"container-title":["Maturitas"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512222000780?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512222000780?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T09:20:00Z","timestamp":1759915200000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378512222000780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":26,"alternative-id":["S0378512222000780"],"URL":"https:\/\/doi.org\/10.1016\/j.maturitas.2022.04.003","relation":{},"ISSN":["0378-5122"],"issn-type":[{"value":"0378-5122","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Are serum estrogen concentrations associated with menopausal symptom bother among postmenopausal women? Baseline results from two MsFLASH clinical trials","name":"articletitle","label":"Article Title"},{"value":"Maturitas","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.maturitas.2022.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}