{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:53:50Z","timestamp":1792522430041,"version":"4.5.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["202340225"],"award-info":[{"award-number":["202340225"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","maturitas.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Maturitas"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.maturitas.2025.108710","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T06:59:39Z","timestamp":1756450779000},"page":"108710","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Diabetes is associated with impaired skeletal muscle quality, not quantity, in older adults, based on CT-derived chest muscle metrics"],"prefix":"10.1016","volume":"202","author":[{"given":"Li","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huazheng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bixia","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youyi","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1261-0960","authenticated-orcid":false,"given":"Xiaoyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.maturitas.2025.108710_bb0005","doi-asserted-by":"crossref","first-page":"107","DOI":"10.2991\/jegh.k.191028.001","article-title":"Epidemiology of type 2 diabetes - global burden of disease and forecasted trends","volume":"10","author":"Khan","year":"2020","journal-title":"J. Epidemiol. Glob. Health"},{"key":"10.1016\/j.maturitas.2025.108710_bb0010","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jamda.2019.12.012","article-title":"Asian Working Group for Sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment","volume":"21","author":"Chen","year":"2020","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"10.1016\/j.maturitas.2025.108710_bb0015","doi-asserted-by":"crossref","DOI":"10.4239\/wjd.v16.i7.105233","article-title":"Exploring the link: Hemogram-derived markers in type 2 diabetes mellitus and its complications","volume":"16","author":"Aktas","year":"2025","journal-title":"World J. Diabetes"},{"key":"10.1016\/j.maturitas.2025.108710_bb0020","doi-asserted-by":"crossref","first-page":"263","DOI":"10.4183\/aeb.2020.263","article-title":"The association between vitamin D levels and handgrip strength in elderly men","volume":"16","author":"Kocak","year":"2020","journal-title":"Acta Endocrinol. (Buchar.)"},{"key":"10.1016\/j.maturitas.2025.108710_bb0025","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/dom.13513","article-title":"Association of abdominal muscle composition with prediabetes and diabetes: the CARDIA study","volume":"21","author":"Granados","year":"2019","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.maturitas.2025.108710_bb0030","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00223-020-00742-y","article-title":"Type 2 diabetes mellitus is associated with increased risk of sarcopenia: a systematic review and meta-analysis","volume":"107","author":"Anagnostis","year":"2020","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.maturitas.2025.108710_bb0035","article-title":"A bi-directional Mendelian randomization study of sarcopenia-related traits and type 2 diabetes mellitus","volume":"14","author":"Chen","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.maturitas.2025.108710_bb0040","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12885-023-10522-0","article-title":"Comparison of CT derived body composition at the thoracic T4 and T12 with lumbar L3 vertebral levels and their utility in patients with rectal cancer","volume":"23","author":"Arayne","year":"2023","journal-title":"BMC Cancer"},{"key":"10.1016\/j.maturitas.2025.108710_bb0045","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-10266-0","article-title":"Prediction of abdominal CT body composition parameters by thoracic measurements as a new approach to detect sarcopenia in a COVID-19 cohort","volume":"12","author":"Molwitz","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.maturitas.2025.108710_bb0050","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1245\/s10434-021-11034-6","article-title":"Chest CT-derived muscle metrics for sarcopenia: choosing the right target","volume":"29","author":"Shah","year":"2022","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.maturitas.2025.108710_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.nut.2024.112558","article-title":"The chest CT perspective on sarcopenia: exploring reference values for muscle mass quantity\/quality and its application in old adults","volume":"128","author":"Tao","year":"2024","journal-title":"Nutrition"},{"key":"10.1016\/j.maturitas.2025.108710_bb0060","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.00963","article-title":"Myosteatosis in the context of skeletal muscle function deficit: an interdisciplinary workshop at the National Institute on Aging","volume":"11","author":"Correa-de-Araujo","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.maturitas.2025.108710_bb0065","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.2337\/db05-1183","article-title":"Decreased muscle strength and quality in older adults with type 2 diabetes: the health, aging, and body composition study","volume":"55","author":"Park","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.maturitas.2025.108710_bb0070","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1055\/s-0038-1641573","article-title":"Sarcopenia: beyond muscle atrophy and into the new frontiers of opportunistic imaging, precision medicine, and machine learning","volume":"22","author":"Lenchik","year":"2018","journal-title":"Semin. Musculoskelet. Radiol."},{"key":"10.1016\/j.maturitas.2025.108710_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105116","article-title":"Abdominal CT metrics in 17,646 patients reveal associations between myopenia, myosteatosis, and medical phenotypes: a phenome-wide association study","volume":"103","author":"Zambrano Chaves","year":"2024","journal-title":"EBioMedicine"},{"key":"10.1016\/j.maturitas.2025.108710_bb0080","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20190327","article-title":"Deep learning-based muscle segmentation and quantification at abdominal CT: application to a longitudinal adult screening cohort for sarcopenia assessment","volume":"92","author":"Graffy","year":"2019","journal-title":"Br. J. Radiol."},{"key":"10.1016\/j.maturitas.2025.108710_bb0085","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.2337\/dc22-S002","article-title":"2. Classification and diagnosis of diabetes: standards of medical care in diabetes-2022","volume":"45","year":"2022","journal-title":"Diabetes Care"},{"key":"10.1016\/j.maturitas.2025.108710_bb0090","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/jcsm.12946","article-title":"Reference values of skeletal muscle area for diagnosis of sarcopenia using chest computed tomography in Asian general population","volume":"13","author":"Moon","year":"2022","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.maturitas.2025.108710_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2022.109939","article-title":"Is imaging-based muscle quantity associated with risk of diabetes? A meta-analysis of cohort studies","volume":"189","author":"Qiu","year":"2022","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.maturitas.2025.108710_bb0100","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.3513","article-title":"Association between type 2 diabetes and skeletal muscle quality assessed by abdominal computed tomography scan","volume":"38","author":"Kim","year":"2022","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.maturitas.2025.108710_bb0105","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.2337\/dbi19-0006","article-title":"The metabolic significance of intermuscular adipose tissue: is IMAT a friend or a foe to metabolic health?","volume":"70","author":"Sparks","year":"2021","journal-title":"Diabetes"},{"key":"10.1016\/j.maturitas.2025.108710_bb0110","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/s41574-022-00784-2","article-title":"Intermuscular adipose tissue in metabolic disease","volume":"19","author":"Goodpaster","year":"2023","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.maturitas.2025.108710_bb0115","doi-asserted-by":"crossref","first-page":"140","DOI":"10.4093\/dmj.2016.40.2.140","article-title":"Hyperglycemia is associated with impaired muscle quality in older men with diabetes: the Korean Longitudinal Study on Health and Aging","volume":"40","author":"Yoon","year":"2016","journal-title":"Diabetes Metab. J."},{"key":"10.1016\/j.maturitas.2025.108710_bb0120","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.jamda.2013.02.006","article-title":"Patients with type 2 diabetes show a greater decline in muscle mass, muscle strength, and functional capacity with aging","volume":"14","author":"Leenders","year":"2013","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"10.1016\/j.maturitas.2025.108710_bb0125","doi-asserted-by":"crossref","first-page":"82","DOI":"10.2337\/dc14-1166","article-title":"Hyperglycemia predicts persistently lower muscle strength with aging","volume":"38","author":"Kalyani","year":"2015","journal-title":"Diabetes Care"},{"key":"10.1016\/j.maturitas.2025.108710_bb0130","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1111\/jdi.13070","article-title":"Hyperglycemia in non-obese patients with type 2 diabetes is associated with low muscle mass: the Multicenter Study for Clarifying Evidence for Sarcopenia in Patients with Diabetes Mellitus","volume":"10","author":"Sugimoto","year":"2019","journal-title":"J. Diabetes Investig."},{"key":"10.1016\/j.maturitas.2025.108710_bb0135","first-page":"102","article-title":"Sarcopenia in diabetic nephropathy: a cross-sectional study","volume":"56","author":"\u00c7eliker","year":"2018","journal-title":"Rom. J. Intern. Med."},{"key":"10.1016\/j.maturitas.2025.108710_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8030319","article-title":"Association of glucose fluctuations with sarcopenia in older adults with type 2 diabetes mellitus","volume":"8","author":"Ogama","year":"2019","journal-title":"J. Clin. Med."}],"container-title":["Maturitas"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512225005183?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512225005183?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T01:15:34Z","timestamp":1762305334000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378512225005183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":28,"alternative-id":["S0378512225005183"],"URL":"https:\/\/doi.org\/10.1016\/j.maturitas.2025.108710","relation":{},"ISSN":["0378-5122"],"issn-type":[{"value":"0378-5122","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diabetes is associated with impaired skeletal muscle quality, not quantity, in older adults, based on CT-derived chest muscle metrics","name":"articletitle","label":"Article Title"},{"value":"Maturitas","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.maturitas.2025.108710","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"108710"}}