{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:13:06Z","timestamp":1786993986698,"version":"build-2736575974"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T00:00:00Z","timestamp":1758326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017686","name":"Fujian Provincial Health Technology Project","doi-asserted-by":"publisher","award":["2022GGA021"],"award-info":[{"award-number":["2022GGA021"]}],"id":[{"id":"10.13039\/501100017686","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013795","name":"Fujian Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2022J01241"],"award-info":[{"award-number":["2022J01241"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203307"],"award-info":[{"award-number":["82203307"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","maturitas.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Maturitas"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.maturitas.2025.108735","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T05:33:46Z","timestamp":1758087226000},"page":"108735","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Prognostic nutritional index predicts survival in older patients with resectable invasive lung adenocarcinoma"],"prefix":"10.1016","volume":"202","author":[{"given":"Yuanpu","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.maturitas.2025.108735_bb0005","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.maturitas.2025.108735_bb0010","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0140-6736(21)00312-3","article-title":"Lung cancer","volume":"398","author":"Thai","year":"2021","journal-title":"Lancet (Lond. Engl.)"},{"key":"10.1016\/j.maturitas.2025.108735_bb0015","article-title":"Impact of low-dose computed tomography (LDCT) screening on lung cancer-related mortality","volume":"8","author":"Bonney","year":"2022","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.maturitas.2025.108735_bb0020","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/S1470-2045(23)00444-8","article-title":"Global variations in lung cancer incidence by histological subtype in 2020: a population-based study","volume":"24","author":"Zhang","year":"2023","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.maturitas.2025.108735_bb0025","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/1096-9098(200005)74:1<53::AID-JSO13>3.0.CO;2-D","article-title":"Biological prognostic factors for early stage completely resected non-small cell lung cancer","volume":"74","author":"Cagini","year":"2000","journal-title":"J. Surg. Oncol."},{"key":"10.1016\/j.maturitas.2025.108735_bb0030","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1016\/j.jtho.2019.05.031","article-title":"Body mass index (BMI), BMI change, and overall survival in patients with SCLC and NSCLC: a pooled analysis of the international lung cancer consortium","volume":"14","author":"Shepshelovich","year":"2019","journal-title":"J. Thorac. Oncol.: Off. Publ. Int. Assoc. Study Lung Cancer"},{"issue":"24","key":"10.1016\/j.maturitas.2025.108735_bb0035","article-title":"Prognostic significance of preoperative exercise tolerance in patients with early-stage lung cancer","volume":"S0022-5223","author":"Fukui","year":"2024","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.maturitas.2025.108735_bb0040","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/ejcts\/ezy301","article-title":"Guidelines for enhanced recovery after lung surgery: recommendations of the enhanced recovery after surgery (ERAS\u00ae) society and the European society of thoracic surgeons (ESTS)","volume":"55","author":"Batchelor","year":"2019","journal-title":"European Journal of Cardio-Thoracic Surgery"},{"key":"10.1016\/j.maturitas.2025.108735_bb0045","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3390\/ijerph8020514","article-title":"Hospital malnutrition: prevalence, identification and impact on patients and the healthcare system","volume":"8","author":"Barker","year":"2011","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.maturitas.2025.108735_bb0050","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1245\/s10434-018-7061-x","article-title":"Long-term prognostic impact of severe postoperative complications after lung cancer surgery","volume":"26","author":"Okada","year":"2019","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.maturitas.2025.108735_bb0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0106914","article-title":"Systemic inflammation, nutritional status and tumor immune microenvironment determine outcome of resected non-small cell lung cancer","volume":"9","author":"Alifano","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.maturitas.2025.108735_bb0060","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/bjc.2012.354","article-title":"Comparison of the prognostic value of inflammation-based prognostic scores in patients with hepatocellular carcinoma","volume":"107","author":"Kinoshita","year":"2012","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.maturitas.2025.108735_bb0065","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.athoracsur.2017.01.085","article-title":"Clinical significance of prognostic nutritional index after surgical treatment in lung cancer","volume":"104","author":"Okada","year":"2017","journal-title":"Ann. Thorac. Surg."},{"key":"10.1016\/j.maturitas.2025.108735_bb0070","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/4796598","article-title":"Geriatric nutritional risk index predicts adverse outcomes in human malignancy: a meta-analysis","volume":"2019","author":"Lv","year":"2019","journal-title":"Dis. Markers"},{"key":"10.1016\/j.maturitas.2025.108735_bb0075","doi-asserted-by":"crossref","first-page":"886","DOI":"10.21037\/tlcr.2019.11.16","article-title":"Prognostic biomarkers in stage IV non-small cell lung cancer (NSCLC): neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), platelet to lymphocyte ratio (PLR) and advanced lung cancer inflammation index (ALI)","volume":"8","author":"Mandaliya","year":"2019","journal-title":"Transl. Lung Cancer Res."},{"key":"10.1016\/j.maturitas.2025.108735_bb0080","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.22964","article-title":"Systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio can predict clinical outcomes in patients with metastatic non-small-cell lung cancer treated with nivolumab","volume":"33","author":"Liu","year":"2019","journal-title":"J. Clin. Lab. Anal."},{"key":"10.1016\/j.maturitas.2025.108735_bb0085","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.jtcvs.2020.06.030","article-title":"Comparison of three nutritional scoring systems for outcomes after complete resection of non-small cell lung cancer","volume":"162","author":"Takahashi","year":"2021","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.maturitas.2025.108735_bb0090","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1217967","article-title":"A novel immune-nutritional score predicts response to neoadjuvant immunochemotherapy after minimally invasive esophagectomy for esophageal squamous cell carcinoma","volume":"14","author":"Feng","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.maturitas.2025.108735_bb0095","doi-asserted-by":"crossref","first-page":"4484","DOI":"10.1111\/cas.15964","article-title":"Peripheral blood inflammatory biomarkers dynamics reflect treatment response and predict prognosis in non-small cell lung cancer patients with neoadjuvant immunotherapy","volume":"114","author":"Huai","year":"2023","journal-title":"Cancer Sci."},{"key":"10.1016\/j.maturitas.2025.108735_bb0100","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1038\/s41430-020-0629-0","article-title":"Relationship between markers of malnutrition and clinical outcomes in older adults with cancer: systematic review, narrative synthesis and meta-analysis","volume":"74","author":"Bullock","year":"2020","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.maturitas.2025.108735_bb0105","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.clnesp.2021.12.026","article-title":"Associations between pretreatment nutritional assessments and treatment complications in patients with stage I-III non-small cell lung cancer: a systematic review","volume":"47","author":"Voorn","year":"2022","journal-title":"Clin. Nutr. ESPEN"},{"key":"10.1016\/j.maturitas.2025.108735_bb0110","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1186\/s12885-023-11044-5","article-title":"Prognostic value of pre-therapeutic nutritional risk factors in elderly patients with locally advanced esophageal squamous cell carcinoma receiving definitive chemoradiotherapy or radiotherapy","volume":"23","author":"Qiu","year":"2023","journal-title":"BMC Cancer"},{"key":"10.1016\/j.maturitas.2025.108735_bb0115","doi-asserted-by":"crossref","first-page":"22078","DOI":"10.1038\/s41598-024-73123-2","article-title":"Comprehensive analysis of the prognostic value of pre-treatment nutritional indicators in elderly rectal cancer patients","volume":"14","author":"Qiu","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.maturitas.2025.108735_bb0120","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.jtho.2021.04.007","article-title":"Long-term prognosis of patients with resected adenocarcinoma in situ and minimally invasive adenocarcinoma of the lung","volume":"16","author":"Yotsukura","year":"2021","journal-title":"J. Thorac. Oncol.: Off. Publ. Int. Assoc. Study Lung Cancer"},{"key":"10.1016\/j.maturitas.2025.108735_bb0125","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jtho.2021.11.003","article-title":"The 2021 WHO classification of lung tumors: impact of advances since 2015","volume":"17","author":"Nicholson","year":"2022","journal-title":"J. Thorac. Oncol.: Off. Publ. Int. Assoc. Study Lung Cancer"},{"key":"10.1016\/j.maturitas.2025.108735_bb0130","doi-asserted-by":"crossref","first-page":"7252","DOI":"10.1158\/1078-0432.CCR-04-0713","article-title":"X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization","volume":"10","author":"Camp","year":"2004","journal-title":"Clin. Cancer Res.: Off. J. Am. Assoc. Cancer Res."},{"key":"10.1016\/j.maturitas.2025.108735_bb0135","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/0002-9610(80)90246-9","article-title":"Prognostic nutritional index in gastrointestinal surgery","volume":"139","author":"Buzby","year":"1980","journal-title":"Am. J. Surg."},{"key":"10.1016\/j.maturitas.2025.108735_bb0140","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/cpt.789","article-title":"Cancer-related systemic inflammation: the challenges and therapeutic opportunities for personalized medicine","volume":"102","author":"Shinko","year":"2017","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.maturitas.2025.108735_bb0145","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1038\/s43587-024-00746-5","article-title":"Age-related decline in CD8+ tissue resident memory T cells compromises antitumor immunity","volume":"4","author":"Pei","year":"2024","journal-title":"Nat. Aging"},{"key":"10.1016\/j.maturitas.2025.108735_bb0150","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.3390\/biomedicines12071554","article-title":"How general and inflammatory status impacts on the prognosis of patients affected by lung cancer: state of the art","volume":"12","author":"Mazzella","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.maturitas.2025.108735_bb0155","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3128933","article-title":"Tumor-associated inflammation: the tumor-promoting immunity in the early stages of tumorigenesis","volume":"2022","author":"Bi","year":"2022","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.maturitas.2025.108735_bb0160","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1093\/ageing\/afr182","article-title":"Frailty in the older surgical patient: a review","volume":"41","author":"Partridge","year":"2012","journal-title":"Age Ageing"},{"key":"10.1016\/j.maturitas.2025.108735_bb0165","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s40520-025-02948-2","article-title":"Comparison of surgical and radiotherapy outcomes in octogenarians with early-stage non-small cell lung cancer: a SEER database retrospective cohort study","volume":"37","author":"Hua","year":"2025","journal-title":"Aging Clin. Exp. Res."},{"key":"10.1016\/j.maturitas.2025.108735_bb0170","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/JTO.0b013e3181d6e052","article-title":"Stage I non-small cell lung cancer (NSCLC) in patients aged 75 years and older: does age determine survival after radical treatment?","volume":"5","author":"Palma","year":"2010","journal-title":"J. Thorac. Oncol.: Off. Publ. Int. Assoc. Study Lung Cancer"},{"key":"10.1016\/j.maturitas.2025.108735_bb0175","doi-asserted-by":"crossref","DOI":"10.1007\/s00595-024-02987-8","article-title":"Clinical significance of the preoperative prognostic nutritional index in patients with resectable non-small cell lung cancer: a multicenter study","author":"Takahashi","year":"2025","journal-title":"Surg. Today"}],"container-title":["Maturitas"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512225005432?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512225005432?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T15:29:46Z","timestamp":1761751786000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378512225005432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":35,"alternative-id":["S0378512225005432"],"URL":"https:\/\/doi.org\/10.1016\/j.maturitas.2025.108735","relation":{},"ISSN":["0378-5122"],"issn-type":[{"value":"0378-5122","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic nutritional index predicts survival in older patients with resectable invasive lung adenocarcinoma","name":"articletitle","label":"Article Title"},{"value":"Maturitas","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.maturitas.2025.108735","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"108735"}}