{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:28:18Z","timestamp":1788449298993,"version":"build-2803163510"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100016350","name":"Sichuan Provincial Administration of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["2024MS406"],"award-info":[{"award-number":["2024MS406"]}],"id":[{"id":"10.13039\/501100016350","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","maturitas.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Maturitas"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.maturitas.2025.108790","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T16:21:27Z","timestamp":1764001287000},"page":"108790","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Cross-national evidence on frailty\u2013depression multi-trajectories and osteoporosis risk: Findings from the ELSA and HRS cohorts"],"prefix":"10.1016","volume":"204","author":[{"given":"Shufang","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2021","key":"10.1016\/j.maturitas.2025.108790_bb0005","first-page":"e580","article-title":"Fracture collaborators, global, regional, and national burden of bone fractures in 204 countries and territories, 1990-2019: a systematic analysis from the global burden of disease study 2019","volume":"2","author":"GBD","year":"2019","journal-title":"Lancet Healthy Longev."},{"key":"10.1016\/j.maturitas.2025.108790_bb0010","article-title":"The global, regional, and national burden attributable to low bone mineral density, 1990-2020: an analysis of a modifiable risk factor from the global burden of disease study 2021, the lancet","year":"2025","journal-title":"Rheumatology"},{"key":"10.1016\/j.maturitas.2025.108790_bb0015","first-page":"96","article-title":"Prevalence of frailty in 62 countries across the world: a systematic review and meta-analysis of population-level studies","volume":"50","author":"O. R, S. D, O. Mr, M. Dw, C. A, R. K, L. A","year":"2020","journal-title":"Age Ageing"},{"key":"10.1016\/j.maturitas.2025.108790_bb0020","article-title":"Global prevalence of depression in older adults: a systematic review and meta-analysis of epidemiological surveys","volume":"80","author":"C. H, J. Y, L. R, Z. Q, S. Z, U. Gs, T. Yl, N. Ch, L. Xh, X. Yt","year":"2023","journal-title":"Asian J. Psychiatr."},{"key":"10.1016\/j.maturitas.2025.108790_bb0025","article-title":"Frailty in older adults, N","volume":"391","author":"Dh","year":"2024","journal-title":"Engl. J. Med."},{"key":"10.1016\/j.maturitas.2025.108790_bb0030","article-title":"Multidimensional frailty as a predictor of mortality among older adults: a systematic review and meta-analysis","volume":"24","author":"L. W, Q. R, Q. Y, L. T, Q. B, Y. K, C. Z, M. B, L. Y","year":"2024","journal-title":"BMC Geriatr."},{"key":"10.1016\/j.maturitas.2025.108790_bb0035","doi-asserted-by":"crossref","first-page":"e214","DOI":"10.1016\/S2666-7568(23)00263-5","article-title":"The relationship between frailty and social vulnerability: a systematic review","volume":"5","author":"H. P, W. H, P. M, K. S, J. C, A. Mk, V. Dl, D. E, H. Eo","year":"2024","journal-title":"Lancet Healthy Longev."},{"key":"10.1016\/j.maturitas.2025.108790_bb0040","article-title":"The role of the hypothalamic-pituitary-adrenal axis in depression across the female reproductive lifecycle: current knowledge and future directions","volume":"14","author":"H. L, J. Km, N. Am, B. R, di S. Tl, O. A, M. Ec, S. Di, D. S, K. Sl, N. M, W. Sj","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.maturitas.2025.108790_bb0045","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7150\/ijms.50680","article-title":"Potential mechanisms linking psychological stress to bone health","volume":"18","author":"Js","year":"2021","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.maturitas.2025.108790_bb0050","first-page":"550","article-title":"Association between physical activity and risk of depression: a systematic review and meta-analysis, JAMA","volume":"79","author":"P. M, G. L, A. A, S. T, S. Fb, G. R, K. P, K. S, U. M, L. Y, M. A, S. A, T. M, B. S, W. J","year":"2022","journal-title":"Psychiatry"},{"key":"10.1016\/j.maturitas.2025.108790_bb0055","article-title":"Malnutrition in older adults-recent advances and remaining challenges","volume":"13","author":"N. K, H. U, P. M","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.maturitas.2025.108790_bb0060","article-title":"The risk of fracture among women starting selective serotonin reuptake inhibitors","author":"Dh","year":"2025","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.maturitas.2025.108790_bb0065","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1093\/jbmr\/zjad019","article-title":"Frailty increases the long-term risk for fall and fracture-related hospitalizations and all-cause mortality in community-dwelling older women","volume":"39","author":"D. E, D.V. J, B. T, H. Eo, G. Ak, S. C, Z. K, P. Rl, L. Jr, S. M","year":"2024","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.maturitas.2025.108790_bb0070","doi-asserted-by":"crossref","first-page":"e861","DOI":"10.3399\/BJGP.2024.0055","article-title":"Severe mental illness as a risk factor for recorded diagnosis of osteoporosis and fragility fractures in people aged \u226550 years: retrospective cohort study using UK primary care data","volume":"74","author":"A. C, W. K, B.-A. Jc, O. D, W. Rm, C. A, P. I","year":"2024","journal-title":"Br. J. Gen. Pract."},{"key":"10.1016\/j.maturitas.2025.108790_bb0075","article-title":"Association of coexistence of frailty and depressive symptoms with mortality in community-dwelling older adults: Kashiwa cohort study","volume":"119","author":"H. S, S. Y, S. Bk, T. T, L. W, T.-I. R, K. S, D. A, H. M, I. M, I. K","year":"2024","journal-title":"Arch. Gerontol. Geriatr."},{"key":"10.1016\/j.maturitas.2025.108790_bb0080","article-title":"Association of blood biomarkers with frailty-a mapping review","volume":"109","author":"F. L, B. F, R. D, D. M, D. D","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.maturitas.2025.108790_bb0085","article-title":"Inflammatory biomarkers in depression: scoping review","volume":"10","author":"P. W, S. S","year":"2024","journal-title":"BJPsych Open"},{"key":"10.1016\/j.maturitas.2025.108790_bb0090","article-title":"New insights into inflammatory osteoclast precursors as therapeutic targets for rheumatoid arthritis and periodontitis","volume":"11","author":"H. E, B. F, B.-W. C, G. J, L. P, C. A","year":"2023","journal-title":"Bone Res."},{"key":"10.1016\/j.maturitas.2025.108790_bb0095","article-title":"The cortisol axis and psychiatric disorders: an updated review","author":"My","year":"2025","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.maturitas.2025.108790_bb0100","article-title":"Sedentary lifestyle and physical inactivity: a mutual interplay with early and overt frailty","volume":"35","author":"B. F, D. F, V. M, E. A, N. D","year":"2025","journal-title":"Nutr. Metab. Cardiovas."},{"key":"10.1016\/j.maturitas.2025.108790_bb0105","article-title":"Four-year trajectories of depressive symptoms and subsequent risk of hip fracture: evidence from China health and retirement longitudinal study","author":"L. M, L. Y","year":"2025","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.maturitas.2025.108790_bb0110","article-title":"A systematic review of frailty trajectories: their shape and influencing factors","volume":"61","author":"W. M, J. Nd, R. Tc, L. M, M.-T. G","year":"2021","journal-title":"Gerontologist"},{"key":"10.1016\/j.maturitas.2025.108790_bb0115","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1093\/ije\/dys168","article-title":"Cohort profile: the English longitudinal study of ageing","volume":"42","author":"Steptoe","year":"2012","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.maturitas.2025.108790_bb0120","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1093\/ije\/dyu067","article-title":"Cohort profile: the health and retirement study (HRS)","volume":"43","author":"Sonnega","year":"2014","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.maturitas.2025.108790_bb0125","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1146\/annurev-clinpsy-081122-012416","article-title":"Recent advances in group-based trajectory modeling for clinical research","volume":"20","author":"Ds","year":"2024","journal-title":"Annu. Rev. Clin. Psychol."},{"key":"10.1016\/j.maturitas.2025.108790_bb0130","article-title":"A standard procedure for creating a frailty index","volume":"8","author":"Sd","year":"2008","journal-title":"BMC Geriatr."},{"key":"10.1016\/j.maturitas.2025.108790_bb0135","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0749-3797(18)30622-6","article-title":"Screening for depression in well older adults: evaluation of a short form of the CES-D (center for epidemiologic studies depression scale)","volume":"10","author":"Andresen","year":"1994","journal-title":"Am. J. Prev. Med."},{"key":"10.1016\/j.maturitas.2025.108790_bb0140","article-title":"The association between osteoporosis and frailty: a cross-sectional observational study and mendelian randomization analysis","volume":"19","author":"Q. Z, L. Y, C. D, X. K, X. W, S. N, Y. Q, R. G","year":"2024","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.maturitas.2025.108790_bb0145","article-title":"Prevalence of frailty in senile osteoporosis: a systematic review and meta-analysis","volume":"130","author":"H. Y, X. H, J. W, Y. J, L. H, L. K, Z. L, H. C, G. J","year":"2025","journal-title":"Arch. Gerontol. Geriatr."},{"key":"10.1016\/j.maturitas.2025.108790_bb0150","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.puhe.2023.10.022","article-title":"Osteoporosis is associated with depression among older adults: A nationwide population-based study in the USA from 2005 to 2020","volume":"226","author":"Chen","year":"2024","journal-title":"Public Health"},{"key":"10.1016\/j.maturitas.2025.108790_bb0155","article-title":"Depressive symptoms and osteoporosis in middle-aged and older adults: a cross-sectional analysis of NHANES and HRS data","volume":"16","author":"Z. W, T. Y, C. L, Z. Z, H. X, C. K, Z. J, T. P","year":"2025","journal-title":"Geriatric Orthopaedic Surgery & Rehabilitation"},{"key":"10.1016\/j.maturitas.2025.108790_bb0160","article-title":"Coexisting depression and frailty as an accelerated aging phenotype of late-life depression","volume":"35","author":"Wd","year":"2023","journal-title":"Int. Psychogeriatr."},{"key":"10.1016\/j.maturitas.2025.108790_bb0165","article-title":"Joint trajectories of pain, depression and frailty and associations with adverse outcomes among community-dwelling older adults: a longitudinal study","volume":"59","author":"L. Q, H. Y, W. B, L. Y, Z. W, Y. J, C. H, W. C","year":"2024","journal-title":"Geriatr. Nur. (Lond.)"},{"key":"10.1016\/j.maturitas.2025.108790_bb0170","article-title":"RANKL biology: bone metabolism, the immune system, and beyond","volume":"40","author":"O. T, H. M, S. F, N. T","year":"2020","journal-title":"Inflammation and Regeneration"},{"key":"10.1016\/j.maturitas.2025.108790_bb0175","article-title":"Ageing-related bone and immunity changes: insights into the complex interplay between the skeleton and the immune system","volume":"12","author":"M. B, X. Y, K. S, A. M, P. Ac, W. H, L. S, L. G, L. G","year":"2024","journal-title":"Bone Res."},{"key":"10.1016\/j.maturitas.2025.108790_bb0180","article-title":"Inflammatory mediators in major depression and bipolar disorder","volume":"14","author":"P. S, M. Mg, B. F","year":"2024","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.maturitas.2025.108790_bb0185","article-title":"NLRP3 inflammasome: a new target for prevention and control of osteoporosis?","volume":"12","author":"J. N, A. J, Y. K, L. J, G. C, M. C, T. X","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.maturitas.2025.108790_bb0190","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.2147\/JIR.S457927","article-title":"The impact of NLRP3 inflammasome on osteoblasts and osteogenic differentiation: a literature review","volume":"Volume 17","author":"Y. Z, X. J, K. T, C. X, Z. C","year":"2024","journal-title":"J. Inflammation Res."},{"key":"10.1016\/j.maturitas.2025.108790_bb0195","article-title":"A novel inhibitor INF 39 promotes osteogenesis via blocking the NLRP3\/IL-1 \u03b2 axis, biomed res","volume":"2022","author":"C. W, T. P, F. S, J. X","year":"2022","journal-title":"Int"},{"key":"10.1016\/j.maturitas.2025.108790_bb0200","article-title":"Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation","volume":"7","author":"A. Y, W. C, R. B, X. J, Q. C, Z. W, N. Dv, A.-A. Y, C. R, M. G","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.maturitas.2025.108790_bb0205","article-title":"Wnt\/\u03b2-catenin signaling components and mechanisms in bone formation, homeostasis, and disease","volume":"12","author":"H. L, C. W, Q. A, L. Yp","year":"2024","journal-title":"Bone Res."},{"key":"10.1016\/j.maturitas.2025.108790_bb0210","article-title":"Mapping RANKL- and OPG-expressing cells in bone tissue: the bone surface cells as activators of osteoclastogenesis and promoters of the denosumab rebound effect","volume":"12","author":"Bm","year":"2024","journal-title":"Bone Res."},{"key":"10.1016\/j.maturitas.2025.108790_bb0215","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41392-024-01738-y","article-title":"Major depressive disorder: hypothesis, mechanism, prevention and treatment","volume":"9","author":"Cui","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.maturitas.2025.108790_bb0220","article-title":"Risk of osteoporotic fractures in menopausal women with common mental health diagnoses prescribed SSRIs\/SNRIs: cohort and self-controlled case series analyses","volume":"19","author":"A. D, A. M, A. C, T. V, W. L, B. R","year":"2024","journal-title":"Arch. Osteoporos."},{"key":"10.1016\/j.maturitas.2025.108790_bb0225","first-page":"803","volume":"10","author":"de F. R, M. M, S. G, D.F. P, S.-G. C, F. F, G. G, G. O","year":"2022","journal-title":"Antidepressants and vertebral and hip risk fracture: An updated systematic review and meta-analysis"},{"key":"10.1016\/j.maturitas.2025.108790_bb0230","article-title":"Aging, osteo-sarcopenia, and musculoskeletal mechano-transduction","volume":"2","author":"Jm","year":"2021","journal-title":"Front. Rehabil. Sci."},{"key":"10.1016\/j.maturitas.2025.108790_bb0235","article-title":"Irisin in degenerative musculoskeletal diseases: functions in system and potential in therapy","volume":"210","author":"Yt","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.maturitas.2025.108790_bb0240","article-title":"Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo","volume":"9","author":"Eg","year":"2020","journal-title":"eLife"},{"key":"10.1016\/j.maturitas.2025.108790_bb0245","doi-asserted-by":"crossref","first-page":"5813","DOI":"10.1096\/fj.201700983RR","article-title":"Irisin promotes proliferation but inhibits differentiation in osteoclast precursor cells","volume":"32","author":"M. Y, Q. X, Z. R, C. R, Z. J, L. Y, N. Y, H. Y, Y. Z, Z. J, L. L, X. W, X. Cc, X. L","year":"2018","journal-title":"FASEB J."},{"key":"10.1016\/j.maturitas.2025.108790_bb0250","article-title":"Gut-bone axis research: unveiling the impact of gut microbiota on postmenopausal osteoporosis and osteoclasts through mendelian randomization","volume":"15","author":"X. H, W. Y, C. Y, C. R, Y. C, G. B, X. Y","year":"2024","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.maturitas.2025.108790_bb0255","first-page":"373","article-title":"Gut-bone axis perturbation: mechanisms and interventions via gut microbiota as a primary driver of osteoporosis, journal of Orthopaedic","volume":"50","author":"W. J, L. Q, Y. Hy, L. Ac, J. Y, Y. Y, L. Y, Z. X, X. L","year":"2025","journal-title":"Translation"},{"key":"10.1016\/j.maturitas.2025.108790_bb0260","first-page":"1360","article-title":"Gut feelings: linking Dysbiosis to depression-a narrative literature review","volume":"61","author":"Ac","year":"2025","journal-title":"Med. Lith."},{"key":"10.1016\/j.maturitas.2025.108790_bb0265","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3390\/geriatrics9050110","article-title":"Impact of gut microbiota on aging and frailty: a narrative review of the literature","volume":"9","author":"E.-B. S, O.-C. A, N.-C. At, L.-P. L, P.-P. M, C.-M. A","year":"2024","journal-title":"Geriatrics"},{"key":"10.1016\/j.maturitas.2025.108790_bb0270","first-page":"275","article-title":"Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review","volume":"19","author":"D.V. F, D.G. A, P. V, L. Lr, S. F","year":"2023","journal-title":"Intern. Emerg. Med."}],"container-title":["Maturitas"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512225005985?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512225005985?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T09:24:11Z","timestamp":1766136251000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378512225005985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":54,"alternative-id":["S0378512225005985"],"URL":"https:\/\/doi.org\/10.1016\/j.maturitas.2025.108790","relation":{},"ISSN":["0378-5122"],"issn-type":[{"value":"0378-5122","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cross-national evidence on frailty\u2013depression multi-trajectories and osteoporosis risk: Findings from the ELSA and HRS cohorts","name":"articletitle","label":"Article Title"},{"value":"Maturitas","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.maturitas.2025.108790","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108790"}}