{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T13:13:20Z","timestamp":1771506800682,"version":"3.50.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","maturitas.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Maturitas"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.maturitas.2026.108836","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T07:45:53Z","timestamp":1768981553000},"page":"108836","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Risk factors for acute kidney injury associated with intravenous acyclovir in older adults: ACICLOAGED study"],"prefix":"10.1016","volume":"206","author":[{"given":"Amandine","family":"Andr\u00e9","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Bri\u00e8re","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e9a","family":"Bourreau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sol\u00e8ne","family":"Tridon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathilde","family":"Petit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9dric","family":"Annweiler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Corvaisier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.maturitas.2026.108836_bb0005","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1056\/NEJMra052116","article-title":"Community-acquired bacterial meningitis in adults","volume":"354","author":"van de Beek","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.maturitas.2026.108836_bb0010","first-page":"550","article-title":"Drug-induced acute kidney injury: diverse mechanisms of tubular injury","volume":"25","author":"Perazella","year":"2019","journal-title":"Curr. Opin. Crit. Care"},{"key":"10.1016\/j.maturitas.2026.108836_bb0015","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S1474-4422(18)30033-4","article-title":"Technological advances and changing indications for lumbar puncture in neurological disorders","volume":"17","author":"Costerus","year":"2018","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.maturitas.2026.108836_bb0020","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00134-023-07032-9","article-title":"Clinical features, etiologies, and outcomes in adult patients with meningoencephalitis requiring intensive care (EURECA): an international prospective multicenter cohort study","volume":"49","author":"Sonneville","year":"2023","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.maturitas.2026.108836_bb0025","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1086\/589747","article-title":"Infectious Diseases Society of America, the management of encephalitis: clinical practice guidelines by the Infectious Diseases Society of America","volume":"47","author":"Tunkel","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.maturitas.2026.108836_bb0030","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.medmal.2017.01.005","article-title":"Reviewing group, guidelines on the management of infectious encephalitis in adults","volume":"47","author":"Stahl","year":"2017","journal-title":"Med. Mal. Infect."},{"key":"10.1016\/j.maturitas.2026.108836_bb0035","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s13730-012-0035-0","article-title":"Acute kidney injury due to acyclovir","volume":"2","author":"Yildiz","year":"2013","journal-title":"CEN Case Rep"},{"key":"10.1016\/j.maturitas.2026.108836_bb0040","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1080\/0886022X.2018.1487866","article-title":"The incidence, risk factors, and clinical outcomes of acute kidney injury (staged using the RIFLE classification) associated with intravenous acyclovir administration","volume":"40","author":"Lee","year":"2018","journal-title":"Ren. Fail."},{"key":"10.1016\/j.maturitas.2026.108836_bb0045","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s41999-021-00481-9","article-title":"Adverse drug reactions in older adults: a narrative review of the literature","volume":"12","author":"Zazzara","year":"2021","journal-title":"Eur Geriatr Med"},{"issue":"103","key":"10.1016\/j.maturitas.2026.108836_bb0050","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3917\/gs.103.0093","article-title":"Le risque iatrog\u00e8ne m\u00e9dicamenteux chez le sujet \u00e2g\u00e9","volume":"25 \/ n","author":"Ankri","year":"2002","journal-title":"G\u00e9rontol. Soc."},{"key":"10.1016\/j.maturitas.2026.108836_bb0055","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s15010-022-01927-3","article-title":"ENCEIF scientific committee, investigators group, infectious encephalitis in elderly patients: a prospective multicentre observational study in France 2016-2019","volume":"51","author":"Petitgas","year":"2023","journal-title":"Infection"},{"key":"10.1016\/j.maturitas.2026.108836_bb0060","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s40266-022-00940-3","article-title":"Scoping review of studies evaluating frailty and its association with medication harm","volume":"39","author":"Lam","year":"2022","journal-title":"Drugs Aging"},{"key":"10.1016\/j.maturitas.2026.108836_bb0065","doi-asserted-by":"crossref","first-page":"210","DOI":"10.5770\/cgj.23.463","article-title":"Using the clinical frailty scale in allocating scarce health care resources","volume":"23","author":"Rockwood","year":"2020","journal-title":"Can Geriatr J"},{"key":"10.1016\/j.maturitas.2026.108836_bb0070","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1007\/s41999-022-00686-6","article-title":"The clinical frailty scale can be used retrospectively to assess the frailty of patients with hip fracture: a validation study","volume":"13","author":"Kay","year":"2022","journal-title":"Eur Geriatr Med"},{"key":"10.1016\/j.maturitas.2026.108836_bb0075","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s13102-024-00937-y","article-title":"Evaluation of frailty in geriatric patients undergoing cardiac rehabilitation after cardiac procedure: results of a prospective, cross-sectional study","volume":"16","author":"Steinmetz","year":"2024","journal-title":"BMC Sports Sci. Med. Rehabil."},{"key":"10.1016\/j.maturitas.2026.108836_bb0080","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000521288","article-title":"Charlson comorbidity index: a critical review of Clinimetric properties","volume":"91","author":"Charlson","year":"2022","journal-title":"Psychother. Psychosom."},{"key":"10.1016\/j.maturitas.2026.108836_bb0085","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1471-2407-4-94","article-title":"An electronic application for rapidly calculating Charlson comorbidity score","volume":"4","author":"Hall","year":"2004","journal-title":"BMC Cancer"},{"key":"10.1016\/j.maturitas.2026.108836_bb0090","author":"Haute Autorit\u00e9 de Sant\u00e9 (HAS)"},{"key":"10.1016\/j.maturitas.2026.108836_bb0095","doi-asserted-by":"crossref","first-page":"e756","DOI":"10.1542\/peds.2013-0794","article-title":"Electronic health record identification of nephrotoxin exposure and associated acute kidney injury","volume":"132","author":"Goldstein","year":"2013","journal-title":"Pediatrics"},{"key":"10.1016\/j.maturitas.2026.108836_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.xkme.2024.100918","article-title":"Predicting nephrotoxic acute kidney injury in hospitalized adults: a machine learning algorithm","volume":"6","author":"Griffin","year":"2024","journal-title":"Kidney Med"},{"key":"10.1016\/j.maturitas.2026.108836_bb0105","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.jsps.2022.03.013","article-title":"Incidence, patterns, risk factors and clinical outcomes of intravenous acyclovir induced nephrotoxicity","volume":"30","author":"Al-Alawi","year":"2022","journal-title":"Saudi Pharm. J."},{"key":"10.1016\/j.maturitas.2026.108836_bb0110","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-18346-x","article-title":"Interaction effects of multimorbidity and frailty on adverse health outcomes in elderly hospitalised patients","volume":"12","author":"Lujic","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.maturitas.2026.108836_bb0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cger.2010.08.009","article-title":"The frailty syndrome: definition and natural history","volume":"27","author":"Xue","year":"2011","journal-title":"Clin. Geriatr. Med."},{"key":"10.1016\/j.maturitas.2026.108836_bb0120","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0140-6736(12)62167-9","article-title":"Frailty in elderly people","volume":"381","author":"Clegg","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.maturitas.2026.108836_bb0125","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13054-021-03510-y","article-title":"Frailty status among older critically ill patients with severe acute kidney injury","volume":"25","author":"Beaubien-Souligny","year":"2021","journal-title":"Crit. Care"},{"key":"10.1016\/j.maturitas.2026.108836_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0156444","article-title":"Frailty as a predictor of acute kidney injury in hospitalized elderly patients: a single center, retrospective cohort study","volume":"11","author":"Baek","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.maturitas.2026.108836_bb0135","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ijid.2018.07.002","article-title":"Acute kidney injury (AKI) associated with intravenous aciclovir in adults: incidence and risk factors in clinical practice","volume":"74","author":"Ryan","year":"2018","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.maturitas.2026.108836_bb0140","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s10522-010-9292-5","article-title":"Frailty, inflammation and the elderly","volume":"11","author":"Hubbard","year":"2010","journal-title":"Biogerontology"},{"key":"10.1016\/j.maturitas.2026.108836_bb0145","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1080\/0886022X.2019.1679644","article-title":"Association of acute kidney injury with frailty in elderly population: a systematic review and meta-analysis","volume":"41","author":"Jiesisibieke","year":"2019","journal-title":"Ren. Fail."},{"key":"10.1016\/j.maturitas.2026.108836_bb0150","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.archger.2016.10.007","article-title":"Frailty and chronic kidney disease: a systematic review","volume":"68","author":"Chowdhury","year":"2017","journal-title":"Arch. Gerontol. Geriatr."},{"key":"10.1016\/j.maturitas.2026.108836_bb0155","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1177\/00185787231188921","article-title":"Evaluation of dose adjustment in patients with renal impairment at Muhimbili National Hospital in Tanzania","volume":"59","author":"Maganda","year":"2024","journal-title":"Hosp. Pharm."}],"container-title":["Maturitas"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512226000137?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512226000137?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T12:26:20Z","timestamp":1771503980000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378512226000137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":31,"alternative-id":["S0378512226000137"],"URL":"https:\/\/doi.org\/10.1016\/j.maturitas.2026.108836","relation":{},"ISSN":["0378-5122"],"issn-type":[{"value":"0378-5122","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk factors for acute kidney injury associated with intravenous acyclovir in older adults: ACICLOAGED study","name":"articletitle","label":"Article Title"},{"value":"Maturitas","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.maturitas.2026.108836","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"108836"}}