{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T21:18:53Z","timestamp":1788211133981,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG030153"],"award-info":[{"award-number":["R01 AG030153"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["1R03AG043052"],"award-info":[{"award-number":["1R03AG043052"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RC2 AG036619"],"award-info":[{"award-number":["RC2 AG036619"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["2RO1AG017644"],"award-info":[{"award-number":["2RO1AG017644"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["2RO1AG7644\\u201301A1"],"award-info":[{"award-number":["2RO1AG7644\\u201301A1"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["71904142"],"award-info":[{"award-number":["71904142"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["72004160"],"award-info":[{"award-number":["72004160"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["3-R01AG037031\\u201303S1"],"award-info":[{"award-number":["3-R01AG037031\\u201303S1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1-R21-AG031372\\u201301"],"award-info":[{"award-number":["1-R21-AG031372\\u201301"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","maturitas.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Maturitas"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.maturitas.2026.108936","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T06:13:19Z","timestamp":1775455999000},"page":"108936","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Associations of intrinsic capacity and social isolation with cardiometabolic diseases: A prospective multi-cohort study"],"prefix":"10.1016","volume":"209","author":[{"given":"Danni","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiqing","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaogang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.maturitas.2026.108936_bb0005","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1258\/000456307780480963","article-title":"Metabolic syndrome and cardiovascular disease","volume":"44","author":"Qiao","year":"2007","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.maturitas.2026.108936_bb0010","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.3502","article-title":"Metabolic syndrome and cardiovascular diseases: going beyond traditional risk factors","volume":"38","author":"Silveira Rossi","year":"2022","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.maturitas.2026.108936_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105447","article-title":"The evolving landscape of cardiometabolic diseases","volume":"109","author":"Eroglu","year":"2024","journal-title":"eBioMedicine"},{"key":"10.1016\/j.maturitas.2026.108936_bb0020","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1016\/S0140-6736(15)00516-4","article-title":"The world report on ageing and health: a policy framework for healthy ageing","volume":"387","author":"Beard","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.maturitas.2026.108936_bb0025","series-title":"World Report on Ageing and Health","author":"Organization WH","year":"2015"},{"key":"10.1016\/j.maturitas.2026.108936_bb0030","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3389\/fmed.2019.00133","article-title":"Frailty and intrinsic capacity: two distinct but related constructs","volume":"6","author":"Belloni","year":"2019","journal-title":"Front. Med."},{"key":"10.1016\/j.maturitas.2026.108936_bb0035","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2471\/BLT.22.288888","article-title":"Life-course inequalities in intrinsic capacity and healthy ageing, China","volume":"101","author":"Si","year":"2023","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.maturitas.2026.108936_bb0040","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/gerona\/glab279","article-title":"Intrinsic capacity predicts negative health outcomes in older adults","volume":"77","author":"Stolz","year":"2022","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.maturitas.2026.108936_bb0045","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1007\/s00125-020-05131-6","article-title":"Major depressive disorder and cardiometabolic diseases: a bidirectional Mendelian randomisation study","volume":"63","author":"Tang","year":"2020","journal-title":"Diabetologia"},{"key":"10.1016\/j.maturitas.2026.108936_bb0050","article-title":"Relationship between handgrip strength and incident diabetes in Korean adults according to gender: a population-based prospective cohort study","volume":"13","author":"Lee","year":"2024","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.maturitas.2026.108936_bb0055","article-title":"Association of visceral adiposity index and handgrip strength with cardiometabolic multimorbidity among middle-aged and older adults: findings from Charls 2011-2020","volume":"16","author":"Liu","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.maturitas.2026.108936_bb0060","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1186\/s12889-024-19521-7","article-title":"Association between muscle strength and cardiometabolic multimorbidity risk among middle-aged and older Chinese adults: a nationwide longitudinal cohort study","volume":"24","author":"Wang","year":"2024","journal-title":"BMC Public Health"},{"key":"10.1016\/j.maturitas.2026.108936_bb0065","doi-asserted-by":"crossref","DOI":"10.1093\/ageing\/afaf087","article-title":"Association between changes in physical functions and risk of stroke: a prospective cohort study","volume":"54","author":"Xie","year":"2025","journal-title":"Age Ageing"},{"key":"10.1016\/j.maturitas.2026.108936_bb0070","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1146\/annurev-soc-031021-012001","article-title":"Social isolation: an unequally distributed health hazard","volume":"49","author":"Umberson","year":"2023","journal-title":"Annu. Rev. Sociol."},{"key":"10.1016\/j.maturitas.2026.108936_bb0075","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1136\/heartjnl-2015-308790","article-title":"Loneliness and social isolation as risk factors for coronary heart disease and stroke: systematic review and meta-analysis of longitudinal observational studies","volume":"102","author":"Valtorta","year":"2016","journal-title":"Heart"},{"key":"10.1016\/j.maturitas.2026.108936_bb0080","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jchf.2022.11.028","article-title":"Association of social isolation and loneliness with incident heart failure in a population-based cohort study","volume":"11","author":"Liang","year":"2023","journal-title":"JACC Heart Fail."},{"key":"10.1016\/j.maturitas.2026.108936_bb0085","doi-asserted-by":"crossref","DOI":"10.2196\/45677","article-title":"Evaluation of social isolation trajectories and incident cardiovascular disease among middle-aged and older adults in China: National Cohort Study","volume":"9","author":"Guo","year":"2023","journal-title":"JMIR Public Health Surveill."},{"key":"10.1016\/j.maturitas.2026.108936_bb0090","doi-asserted-by":"crossref","first-page":"353","DOI":"10.14336\/AD.2021.0818","article-title":"Intrinsic capacity in older adults: recent advances","volume":"13","author":"Zhou","year":"2022","journal-title":"Aging Dis."},{"key":"10.1016\/j.maturitas.2026.108936_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2024.112656","article-title":"Association of handgrip strength asymmetry and weakness with intrinsic capacity impairment among older adults in China","volume":"199","author":"Li","year":"2025","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.maturitas.2026.108936_bb0100","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2318-8-24","article-title":"A standard procedure for creating a frailty index","volume":"8","author":"Searle","year":"2008","journal-title":"BMC Geriatr."},{"key":"10.1016\/j.maturitas.2026.108936_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.archger.2021.104533","article-title":"Multi-group frailty trajectories among older Koreans: results from the Korean Longitudinal Study of Aging","volume":"98","author":"Jung","year":"2022","journal-title":"Arch. Gerontol. Geriatr."},{"key":"10.1016\/j.maturitas.2026.108936_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.archger.2025.105772","article-title":"The relationship between trajectories of intrinsic capacity and differences in the risk of functional ability decline in community-dwelling older adults: a socio-ecological approach","volume":"131","author":"Shin","year":"2025","journal-title":"Arch. Gerontol. Geriatr."},{"key":"10.1016\/j.maturitas.2026.108936_bb0115","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.41714","article-title":"Association of adverse childhood experiences and social isolation with later-life cognitive function among adults in China","volume":"5","author":"Lin","year":"2022","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.maturitas.2026.108936_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2023.102236","article-title":"Social isolation, loneliness, and incident type 2 diabetes mellitus: results from two large prospective cohorts in Europe and East Asia and Mendelian randomization","volume":"64","author":"Song","year":"2023","journal-title":"eClinicalMedicine"},{"key":"10.1016\/j.maturitas.2026.108936_bb0125","doi-asserted-by":"crossref","first-page":"e480","DOI":"10.1016\/S2666-7568(24)00092-8","article-title":"Association of intrinsic capacity with functional decline and mortality in older adults: a systematic review and meta-analysis of longitudinal studies","volume":"5","author":"S\u00e1nchez-S\u00e1nchez","year":"2024","journal-title":"Lancet Healthy Longev."},{"key":"10.1016\/j.maturitas.2026.108936_bb0130","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1002\/jcsm.13283","article-title":"Association of intrinsic capacity with incidence and mortality of cardiovascular disease: prospective study in UK Biobank","volume":"14","author":"Ram\u00edrez-V\u00e9lez","year":"2023","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"key":"10.1016\/j.maturitas.2026.108936_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.archger.2024.105687","article-title":"Association of intrinsic capacity with incident type 2 diabetes mellitus in older Chinese: Guangzhou Biobank Cohort Study","volume":"129","author":"Gao","year":"2025","journal-title":"Arch. Gerontol. Geriatr."},{"key":"10.1016\/j.maturitas.2026.108936_bb0140","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41569-018-0064-2","article-title":"Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty","volume":"15","author":"Ferrucci","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.maturitas.2026.108936_bb0145","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1093\/gerona\/glac227","article-title":"Mitochondrial dysfunction and intrinsic capacity: insights from a narrative review","volume":"78","author":"Aragoni da Silva","year":"2023","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.maturitas.2026.108936_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.102175","article-title":"From biological aging to functional decline: insights into chronic inflammation and intrinsic capacity","volume":"93","author":"Li","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.maturitas.2026.108936_bb0155","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s12603-020-1533-y","article-title":"High serum tumor necrosis factor receptor 1 levels are related to risk of low intrinsic capacity in elderly adults","volume":"25","author":"Ma","year":"2021","journal-title":"J. Nutr. Health Aging"},{"key":"10.1016\/j.maturitas.2026.108936_bb0160","article-title":"MTHFR polymorphisms, homocysteine elevation, and ischemic stroke susceptibility in East Asian and European populations","volume":"104","author":"Wang","year":"2025","journal-title":"Neurology"},{"key":"10.1016\/j.maturitas.2026.108936_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2023.102236","article-title":"Social isolation, loneliness, and incident type 2 diabetes mellitus: results from two large prospective cohorts in Europe and East Asia and Mendelian randomization","volume":"64","author":"Song","year":"2023","journal-title":"eClinicalMedicine"},{"key":"10.1016\/j.maturitas.2026.108936_bb0170","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1037\/a0033413","article-title":"Suppression and interpersonal harmony: a cross-cultural comparison between Chinese and European Americans","volume":"60","author":"Wei","year":"2013","journal-title":"J. Couns. Psychol."},{"key":"10.1016\/j.maturitas.2026.108936_bb0175","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1177\/2047487318792696","article-title":"Loneliness, social isolation and risk of cardiovascular disease in the English Longitudinal Study of Ageing","volume":"25","author":"Valtorta","year":"2018","journal-title":"Eur. J. Prev. Cardiol."},{"key":"10.1016\/j.maturitas.2026.108936_bb0180","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1089\/ars.2017.7312","article-title":"Loneliness, social isolation, and cardiovascular health","volume":"28","author":"Xia","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.maturitas.2026.108936_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101585","article-title":"The role of oxidative stress in cardiovascular disease caused by social isolation and loneliness","volume":"37","author":"Li","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.maturitas.2026.108936_bb0190","doi-asserted-by":"crossref","DOI":"10.2174\/1573403X17666210129101845","article-title":"Loneliness and social isolation: determinants of cardiovascular outcomes","volume":"17","author":"Sharma","year":"2021","journal-title":"Curr. Cardiol. Rev."}],"container-title":["Maturitas"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512226001131?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512226001131?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T20:35:14Z","timestamp":1788208514000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378512226001131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":38,"alternative-id":["S0378512226001131"],"URL":"https:\/\/doi.org\/10.1016\/j.maturitas.2026.108936","relation":{},"ISSN":["0378-5122"],"issn-type":[{"value":"0378-5122","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Associations of intrinsic capacity and social isolation with cardiometabolic diseases: A prospective multi-cohort study","name":"articletitle","label":"Article Title"},{"value":"Maturitas","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.maturitas.2026.108936","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108936"}}