{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:43:53Z","timestamp":1792079033993,"version":"4.4.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003653","name":"Korea National Institute of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003653","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","maturitas.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Maturitas"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.maturitas.2026.109117","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:09:40Z","timestamp":1789186180000},"page":"109117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Progressive increase in ascending aortic diameter across the menopausal transition: A longitudinal study using AI-based automated measurement from chest radiographs"],"prefix":"10.1016","volume":"214","author":[{"given":"Yoonyoung","family":"Jang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoosoo","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeonggyu","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungho","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"25","key":"10.1016\/j.maturitas.2026.109117_bb0005","doi-asserted-by":"crossref","first-page":"e506","DOI":"10.1161\/CIR.0000000000000912","article-title":"Menopause transition and cardiovascular disease risk: implications for timing of early prevention: a scientific statement from the American Heart Association","volume":"142","author":"El Khoudary","year":"2020","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.maturitas.2026.109117_bb0010","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/gme.0b013e3182611787","article-title":"Progression rates of carotid intima-media thickness and adventitial diameter during the menopausal transition","volume":"20","author":"El Khoudary","year":"2013","journal-title":"Menopause"},{"issue":"7","key":"10.1016\/j.maturitas.2026.109117_bb0015","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.amjcard.2018.06.039","article-title":"Serial studies in subclinical atherosclerosis during menopausal transition (from the study of women\u2019s health across the nation)","volume":"122","author":"Khan","year":"2018","journal-title":"Am. J. Cardiol."},{"issue":"2","key":"10.1016\/j.maturitas.2026.109117_bb0020","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1161\/ATVBAHA.120.315355","article-title":"HDL (high-density lipoprotein) subclasses, lipid content, and function trajectories across the menopause transition: SWAN-HDL study","volume":"41","author":"El Khoudary","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.maturitas.2026.109117_bb0025","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/jmri.24183","article-title":"Determinants and normal values of ascending aortic diameter by age, gender, and race\/ethnicity in the Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"39","author":"Turkbey","year":"2014","journal-title":"J. Magn. Reson. Imaging"},{"issue":"9","key":"10.1016\/j.maturitas.2026.109117_bb0030","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.jacc.2023.05.067","article-title":"Sex differences in thoracic aortic disease and dissection: JACC review topic of the week","volume":"82","author":"Crousillat","year":"2023","journal-title":"J. Am. Coll. Cardiol."},{"issue":"22","key":"10.1016\/j.maturitas.2026.109117_bb0035","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1136\/heartjnl-2021-320574","article-title":"Longitudinal changes of thoracic aortic diameters in the general population aged 55 years or older","volume":"108","author":"Thijssen","year":"2022","journal-title":"Heart"},{"issue":"2","key":"10.1016\/j.maturitas.2026.109117_bb0040","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1136\/heartjnl-2019-315320","article-title":"Sex-specific distributions and determinants of thoracic aortic diameters in the elderly","volume":"106","author":"Bons","year":"2020","journal-title":"Heart"},{"issue":"1","key":"10.1016\/j.maturitas.2026.109117_bb0045","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1148\/radiol.210861","article-title":"Thoracic aortic diameter and cardiovascular events and mortality among women and men","volume":"304","author":"Rueda-Ochoa","year":"2022","journal-title":"Radiology"},{"issue":"1","key":"10.1016\/j.maturitas.2026.109117_bb0050","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00330-024-10965-4","article-title":"Association of aortic diameters and mortality in the general population-an MRI-based study","volume":"35","author":"Mensel","year":"2025","journal-title":"Eur. Radiol."},{"issue":"7","key":"10.1016\/j.maturitas.2026.109117_bb0055","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.038821","article-title":"Thoracic aortic aneurysm growth rates and predicting factors: a systematic review and meta-analysis","volume":"14","author":"Henry","year":"2025","journal-title":"J. Am. Heart Assoc."},{"issue":"1","key":"10.1016\/j.maturitas.2026.109117_bb0060","doi-asserted-by":"crossref","DOI":"10.1186\/s40560-018-0287-7","article-title":"Management of acute aortic dissection and thoracic aortic rupture","volume":"6","author":"Fukui","year":"2018","journal-title":"J. Intensive Care"},{"issue":"1","key":"10.1016\/j.maturitas.2026.109117_bb0065","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0003-4975(01)03236-2","article-title":"Yearly rupture or dissection rates for thoracic aortic aneurysms: simple prediction based on size","volume":"73","author":"Davies","year":"2002","journal-title":"Ann. Thorac. Surg."},{"issue":"2","key":"10.1016\/j.maturitas.2026.109117_bb0070","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jcmg.2007.11.005","article-title":"Aortic size assessment by noncontrast cardiac computed tomography: normal limits by age, gender, and body surface area","volume":"1","author":"Wolak","year":"2008","journal-title":"JACC Cardiovasc. Imaging"},{"issue":"2","key":"10.1016\/j.maturitas.2026.109117_bb0075","doi-asserted-by":"crossref","DOI":"10.1148\/ryai.210076","article-title":"Quantification of the thoracic aorta and detection of aneurysm at CT: development and validation of a fully automatic methodology","volume":"4","author":"Macruz","year":"2022","journal-title":"Radiol. Artif. Intell."},{"key":"10.1016\/j.maturitas.2026.109117_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejrad.2025.112380","article-title":"Deep learning-based detection of ascending aortic dilatation on chest radiographs: a diagnostic study","volume":"192","author":"Lee","year":"2025","journal-title":"Eur. J. Radiol."},{"issue":"2","key":"10.1016\/j.maturitas.2026.109117_bb0085","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3109\/13697137.2011.650656","article-title":"Executive summary of the Stages of Reproductive Aging Workshop+ 10: addressing the unfinished agenda of staging reproductive aging","volume":"15","author":"Harlow","year":"2012","journal-title":"Climacteric"},{"key":"10.1016\/j.maturitas.2026.109117_bb0090","doi-asserted-by":"crossref","DOI":"10.1017\/S2045796025100334","article-title":"Longitudinal patterns and group heterogeneity of depressive symptoms during menopausal transition in middle-aged Korean women","volume":"34","author":"Jang","year":"2025","journal-title":"Epidemiol. Psychiatr. Sci."},{"issue":"11","key":"10.1016\/j.maturitas.2026.109117_bb0095","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1111\/1471-0528.17224","article-title":"Metabolically healthy and unhealthy obesity and risk of vasomotor symptoms in premenopausal women: cross-sectional and cohort studies","volume":"129","author":"Namgoung","year":"2022","journal-title":"Bjog"},{"issue":"45","key":"10.1016\/j.maturitas.2026.109117_bb0100","doi-asserted-by":"crossref","DOI":"10.3346\/jkms.2024.39.e286","article-title":"Impact of mass screening using chest X-ray on mortality reduction and treatment adherence among pulmonary tuberculosis patients","volume":"39","author":"Baek","year":"2024","journal-title":"J. Korean Med. Sci."},{"issue":"6","key":"10.1016\/j.maturitas.2026.109117_bb0105","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1161\/CIRCULATIONAHA.123.067626","article-title":"Development and validation of the American Heart Association\u2019s PREVENT equations","volume":"149","author":"Khan","year":"2024","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.maturitas.2026.109117_bb0110","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.amepre.2020.11.003","article-title":"Association of smoking and smoking cessation with overall and cause-specific mortality","volume":"60","author":"Zhu","year":"2021","journal-title":"Am. J. Prev. Med."},{"key":"10.1016\/j.maturitas.2026.109117_bb0115","series-title":"The Asia-Pacific Perspective: Redefining Obesity and its Treatment","author":"W.H. Organization","year":"2000"},{"issue":"18","key":"10.1016\/j.maturitas.2026.109117_bb0120","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1161\/CIRCULATIONAHA.111.088633","article-title":"Moderate aortic enlargement and bicuspid aortic valve are associated with aortic dissection in turner syndrome: report of the international turner syndrome aortic dissection registry","volume":"126","author":"Carlson","year":"2012","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.maturitas.2026.109117_bb0125","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1161\/ATVBAHA.119.313622","article-title":"Arterial stiffness accelerates within 1 year of the final menstrual period: the SWAN heart study","volume":"40","author":"Samargandy","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.maturitas.2026.109117_bb0130","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1210\/rp.57.1.257","article-title":"Hormonal changes in the menopause transition","volume":"57","author":"Burger","year":"2002","journal-title":"Recent Prog. Horm. Res."},{"key":"10.1016\/j.maturitas.2026.109117_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.maturitas.2024.107974","article-title":"Menopause transition and cardiovascular disease risk","volume":"185","author":"Uddenberg","year":"2024","journal-title":"Maturitas"},{"key":"10.1016\/j.maturitas.2026.109117_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.maturitas.2025.108608","article-title":"Menopause and arterial stiffness index: insights from the women's UK Biobank cohort","volume":"198","author":"Vall\u00e9e","year":"2025","journal-title":"Maturitas"},{"issue":"5","key":"10.1016\/j.maturitas.2026.109117_bb0145","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1093\/ejcts\/ezt597","article-title":"Gender-related changes in aortic geometry throughout life","volume":"45","author":"Rylski","year":"2014","journal-title":"Eur. J. Cardiothorac. Surg."},{"issue":"6","key":"10.1016\/j.maturitas.2026.109117_bb0150","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/S0735-1097(96)00361-0","article-title":"Effects of menopause on aortic root function in hypertensive women","volume":"28","author":"Karpanou","year":"1996","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.maturitas.2026.109117_bb0155","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.crphys.2021.03.003","article-title":"Signalling mechanisms in the cardiovascular protective effects of estrogen: with a focus on rapid\/membrane signalling","volume":"4","author":"Ni\u021b\u0103","year":"2021","journal-title":"Curr. Res. Physiol."},{"issue":"6","key":"10.1016\/j.maturitas.2026.109117_bb0160","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqad079","article-title":"Estrogen and the vascular endothelium: the unanswered questions","volume":"164","author":"SenthilKumar","year":"2023","journal-title":"Endocrinology"},{"key":"10.1016\/j.maturitas.2026.109117_bb0165","article-title":"Regulatory actions of estrogen receptor signaling in the cardiovascular system","volume":"10 - 2019","author":"Ueda","year":"2020","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.maturitas.2026.109117_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/204390","article-title":"Vascular aging across the menopause transition in healthy women","volume":"2014","author":"Moreau","year":"2014","journal-title":"Adv. Vasc. Med."},{"issue":"1","key":"10.1016\/j.maturitas.2026.109117_bb0175","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jss.2008.03.003","article-title":"Effect of hormones on matrix metalloproteinases gene regulation in human aortic smooth muscle cells","volume":"148","author":"Grandas","year":"2008","journal-title":"J. Surg. Res."},{"issue":"83","key":"10.1016\/j.maturitas.2026.109117_bb0180","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2012.1004","article-title":"Elastin and collagen fibre microstructure of the human aorta in ageing and disease: a review","volume":"10","author":"Tsamis","year":"2013","journal-title":"J. R. Soc. Interface"},{"issue":"3","key":"10.1016\/j.maturitas.2026.109117_bb0185","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1161\/res.90.3.251","article-title":"Matrix metalloproteinases in vascular remodeling and atherogenesis","volume":"90","author":"Galis","year":"2002","journal-title":"Circ. Res."},{"issue":"9","key":"10.1016\/j.maturitas.2026.109117_bb0190","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1161\/CIRCULATIONAHA.110.937839","article-title":"Aortic root remodeling over the adult life course: longitudinal data from the Framingham Heart Study","volume":"122","author":"Lam","year":"2010","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.maturitas.2026.109117_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacadv.2025.101682","article-title":"Pathobiology of aortic aneurysms and dissections: synthesis of recent investigations and evolving insights","volume":"4","author":"Buja","year":"2025","journal-title":"JACC Adv."},{"key":"10.1016\/j.maturitas.2026.109117_bb0200","series-title":"Transitioning the Menopause: A Stiff Challenge","first-page":"850","author":"McEniery","year":"2020"},{"issue":"1, Supplement","key":"10.1016\/j.maturitas.2026.109117_bb0205","doi-asserted-by":"crossref","first-page":"3A","DOI":"10.1016\/j.amjcard.2009.10.007","article-title":"Cardiovascular disease risk factors: epidemiology and risk assessment","volume":"105","author":"Dahl\u00f6f","year":"2010","journal-title":"Am. J. Cardiol."},{"issue":"3","key":"10.1016\/j.maturitas.2026.109117_bb0210","doi-asserted-by":"crossref","first-page":"168","DOI":"10.4082\/kjfm.22.0052","article-title":"Current status of the national health screening programs in South Korea","volume":"43","author":"Kang","year":"2022","journal-title":"Korean J. Fam. Med."},{"issue":"2","key":"10.1016\/j.maturitas.2026.109117_bb0215","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1148\/radiol.2015151169","article-title":"Radiomics: images are more than pictures, they are data","volume":"278","author":"Gillies","year":"2016","journal-title":"Radiology"},{"key":"10.1016\/j.maturitas.2026.109117_bb0220","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1053\/j.sult.2022.02.003","article-title":"Radiomics: a primer on processing workflow and analysis","author":"Avery","year":"2022","journal-title":"Semin. Ultrasound CT MRI"}],"container-title":["Maturitas"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037851222600294X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S037851222600294X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:44:11Z","timestamp":1792075451000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S037851222600294X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":44,"alternative-id":["S037851222600294X"],"URL":"https:\/\/doi.org\/10.1016\/j.maturitas.2026.109117","relation":{},"ISSN":["0378-5122"],"issn-type":[{"value":"0378-5122","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Progressive increase in ascending aortic diameter across the menopausal transition: A longitudinal study using AI-based automated measurement from chest radiographs","name":"articletitle","label":"Article Title"},{"value":"Maturitas","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.maturitas.2026.109117","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109117"}}