{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:48:33Z","timestamp":1792075713158,"version":"4.4.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","maturitas.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Maturitas"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.maturitas.2026.109138","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:40:55Z","timestamp":1790350855000},"page":"109138","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Longitudinal trajectories of the C-reactive protein-triglyceride-glucose index and frailty progression in two nationwide prospective cohorts"],"prefix":"10.1016","volume":"214","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0565-0781","authenticated-orcid":false,"given":"Zhen-Yu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Ling","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10206","key":"10.1016\/j.maturitas.2026.109138_bb0005","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/S0140-6736(19)31785-4","article-title":"Management of frailty: opportunities, challenges, and future directions","volume":"394","author":"Dent","year":"2019","journal-title":"Lancet"},{"issue":"9868","key":"10.1016\/j.maturitas.2026.109138_bb0010","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0140-6736(12)62167-9","article-title":"Frailty in elderly people","volume":"381","author":"Clegg","year":"2013","journal-title":"Lancet"},{"issue":"10206","key":"10.1016\/j.maturitas.2026.109138_bb0015","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S0140-6736(19)31786-6","article-title":"Frailty: implications for clinical practice and public health","volume":"394","author":"Hoogendijk","year":"2019","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.maturitas.2026.109138_bb0020","article-title":"Prevalence of frailty in 62 countries across the world: a systematic review and meta-analysis of population-level studies","volume":"50","author":"O'Caoimh","year":"2021","journal-title":"Age Ageing"},{"key":"10.1016\/j.maturitas.2026.109138_bb0025","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2318-8-24","article-title":"A standard procedure for creating a frailty index","volume":"8","author":"Searle","year":"2008","journal-title":"BMC Geriatr."},{"issue":"1","key":"10.1016\/j.maturitas.2026.109138_bb0030","doi-asserted-by":"crossref","DOI":"10.1093\/geroni\/igad131","article-title":"Frailty trajectories in Chinese older adults: evidence from the China health and retirement longitudinal study","volume":"8","author":"Guo","year":"2023","journal-title":"Innov. Aging"},{"issue":"3","key":"10.1016\/j.maturitas.2026.109138_bb0035","doi-asserted-by":"crossref","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","article-title":"Frailty in older adults: evidence for a phenotype","volume":"56","author":"Fried","year":"2001","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"issue":"7","key":"10.1016\/j.maturitas.2026.109138_bb0040","doi-asserted-by":"crossref","first-page":"e323","DOI":"10.1016\/S2468-2667(18)30091-4","article-title":"Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493737 UK biobank participants","volume":"3","author":"Hanlon","year":"2018","journal-title":"Lancet Public Health"},{"issue":"9","key":"10.1016\/j.maturitas.2026.109138_bb0045","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41569-018-0064-2","article-title":"Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty","volume":"15","author":"Ferrucci","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"issue":"10","key":"10.1016\/j.maturitas.2026.109138_bb0050","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/s41574-018-0059-4","article-title":"Inflammaging: a new immune-metabolic viewpoint for age-related diseases","volume":"14","author":"Franceschi","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"issue":"1","key":"10.1016\/j.maturitas.2026.109138_bb0055","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s40001-026-03895-y","article-title":"Prospective association between the triglyceride-glucose index and frailty in middle-aged and older adults: insights from a nationwide cohort study","volume":"31","author":"Hou","year":"2026","journal-title":"Eur. J. Med. Res."},{"issue":"1","key":"10.1016\/j.maturitas.2026.109138_bb0060","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/s12933-023-02002-3","article-title":"Association of triglyceride-glucose index trajectory and frailty in urban older residents: evidence from the 10-year follow-up in a cohort study","volume":"22","author":"Yuan","year":"2023","journal-title":"Cardiovasc. Diabetol."},{"issue":"3","key":"10.1016\/j.maturitas.2026.109138_bb0065","doi-asserted-by":"crossref","DOI":"10.1093\/gerona\/glaf273","article-title":"Associations between the triglyceride glucose-body roundness index and frailty trajectory in populations with cardiovascular-kidney-metabolic syndrome: a nationwide prospective cohort study","volume":"81","author":"Fu","year":"2026","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"issue":"6","key":"10.1016\/j.maturitas.2026.109138_bb0070","doi-asserted-by":"crossref","first-page":"461","DOI":"10.14740\/jocmr2959w","article-title":"C-reactive protein and frailty in the elderly: a literature review","volume":"9","author":"Velissaris","year":"2017","journal-title":"J. Clin. Med. Res."},{"issue":"1","key":"10.1016\/j.maturitas.2026.109138_bb0075","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/s12877-024-04836-2","article-title":"Unraveling the relationship between high-sensitivity C-reactive protein and frailty: evidence from longitudinal cohort study and genetic analysis","volume":"24","author":"Luo","year":"2024","journal-title":"BMC Geriatr."},{"issue":"1","key":"10.1016\/j.maturitas.2026.109138_bb0080","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12944-026-02859-9","article-title":"Association between different dimensions of C-reactive protein-triglyceride-glucose index and the incidence of frailty in middle-aged and elderly adults in China: a nationwide prospective cohort study","volume":"25","author":"Chen","year":"2026","journal-title":"Lipids Health Dis."},{"issue":"1","key":"10.1016\/j.maturitas.2026.109138_bb0085","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1186\/s12933-025-02876-5","article-title":"Association between the C-reactive protein-triglyceride glucose index and new-onset coronary heart disease among metabolically heterogeneous individuals","volume":"24","author":"Chen","year":"2025","journal-title":"Cardiovasc. Diabetol."},{"issue":"1","key":"10.1016\/j.maturitas.2026.109138_bb0090","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1186\/s12933-025-02848-9","article-title":"C-reactive protein-triglyceride glucose index in evaluating cardiovascular disease and all-cause mortality incidence among individuals across stages 0-3 of cardiovascular-kidney-metabolic syndrome: a nationwide prospective cohort study","volume":"24","author":"Ou","year":"2025","journal-title":"Cardiovasc. Diabetol."},{"issue":"1","key":"10.1016\/j.maturitas.2026.109138_bb0095","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1097\/JS9.0000000000003560","article-title":"The C-reactive protein-triglyceride glucose index (CTI) predicts mortality in cardiovascular-kidney-metabolic syndrome: a dual-cohort study with machine learning validation","volume":"112","author":"Song","year":"2025","journal-title":"Int. J. Surg."},{"issue":"1","key":"10.1016\/j.maturitas.2026.109138_bb0100","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s12916-018-1148-x","article-title":"Frailty trajectories to identify end of life: a longitudinal population-based study","volume":"16","author":"Stow","year":"2018","journal-title":"BMC Med."},{"issue":"5","key":"10.1016\/j.maturitas.2026.109138_bb0105","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1007\/s41999-024-00998-9","article-title":"Longitudinal analysis on inflammatory markers and frailty progression: based on the English longitudinal study of aging","volume":"15","author":"He","year":"2024","journal-title":"Eur Geriatr Med"},{"issue":"4","key":"10.1016\/j.maturitas.2026.109138_bb0110","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1093\/ageing\/aft059","article-title":"New horizons in frailty: ageing and the deficit-scaling problem","volume":"42","author":"Howlett","year":"2013","journal-title":"Age Ageing"},{"issue":"1","key":"10.1016\/j.maturitas.2026.109138_bb0115","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/ije\/dys203","article-title":"Cohort profile: the China health and retirement longitudinal study (CHARLS)","volume":"43","author":"Zhao","year":"2012","journal-title":"Int. J. Epidemiol."},{"issue":"6","key":"10.1016\/j.maturitas.2026.109138_bb0120","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1093\/ije\/dys168","article-title":"Cohort profile: the English longitudinal study of ageing","volume":"42","author":"Steptoe","year":"2012","journal-title":"Int. J. Epidemiol."},{"issue":"8","key":"10.1016\/j.maturitas.2026.109138_bb0125","doi-asserted-by":"crossref","first-page":"573","DOI":"10.7326\/0003-4819-147-8-200710160-00010","article-title":"The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"147","author":"von Elm","year":"2007","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.maturitas.2026.109138_bb0130","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehag451","article-title":"Statins and survival free of incident frailty among older US veterans","author":"Qazi","year":"2026","journal-title":"Eur. Heart J."},{"issue":"4","key":"10.1016\/j.maturitas.2026.109138_bb0135","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1111\/j.1532-5415.2010.02764.x","article-title":"Prevalence and 10-year outcomes of frailty in older adults in relation to deficit accumulation","volume":"58","author":"Song","year":"2010","journal-title":"J. Am. Geriatr. Soc."},{"issue":"30","key":"10.1016\/j.maturitas.2026.109138_bb0140","doi-asserted-by":"crossref","first-page":"E4104","DOI":"10.1073\/pnas.1506264112","article-title":"Quantification of biological aging in young adults","volume":"112","author":"Belsky","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.maturitas.2026.109138_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2009.10.002","article-title":"Allostatic load biomarkers of chronic stress and impact on health and cognition","volume":"35","author":"Juster","year":"2009","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"5 Suppl 1","key":"10.1016\/j.maturitas.2026.109138_bb0150","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.amjmed.2006.01.009","article-title":"Etiology of insulin resistance","volume":"119","author":"Petersen","year":"2006","journal-title":"Am. J. Med."},{"key":"10.1016\/j.maturitas.2026.109138_bb0155","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13098-020-0523-x","article-title":"Mechanism of increased risk of insulin resistance in aging skeletal muscle","volume":"12","author":"Shou","year":"2020","journal-title":"Diabetol. Metab. Syndr."},{"issue":"6","key":"10.1016\/j.maturitas.2026.109138_bb0160","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.2337\/db11-1300","article-title":"The critical role of metabolic pathways in aging","volume":"61","author":"Barzilai","year":"2012","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.maturitas.2026.109138_bb0165","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: revised European consensus on definition and diagnosis","volume":"48","author":"Cruz-Jentoft","year":"2019","journal-title":"Age Ageing"},{"issue":"6","key":"10.1016\/j.maturitas.2026.109138_bb0170","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.maturitas.2026.109138_bb0175","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/nrm2233","article-title":"Cellular senescence: when bad things happen to good cells","volume":"8","author":"Campisi","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.maturitas.2026.109138_bb0180","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1172\/JCI64098","article-title":"Cellular senescence and the senescent secretory phenotype: therapeutic opportunities","volume":"123","author":"Tchkonia","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.maturitas.2026.109138_bb0185","doi-asserted-by":"crossref","DOI":"10.1007\/BF03324754","article-title":"Men: good health and high mortality. Sex differences in health and aging","volume":"20","author":"Oksuzyan","year":"2008","journal-title":"Aging Clin. Exp. Res."},{"issue":"3","key":"10.1016\/j.maturitas.2026.109138_bb0190","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.maturitas.2011.04.006","article-title":"Frailty in older women","volume":"69","author":"Hubbard","year":"2011","journal-title":"Maturitas"},{"issue":"1","key":"10.1016\/j.maturitas.2026.109138_bb0195","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41581-023-00781-2","article-title":"Sex differences in energy metabolism: natural selection, mechanisms and consequences","volume":"20","author":"Mauvais-Jarvis","year":"2023","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.maturitas.2026.109138_bb0200","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13293-015-0033-y","article-title":"Sex differences in metabolic homeostasis, diabetes, and obesity","volume":"6","author":"Mauvais-Jarvis","year":"2015","journal-title":"Biol. Sex Differ."},{"issue":"1","key":"10.1016\/j.maturitas.2026.109138_bb0205","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1001\/jama.2012.113905","article-title":"Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis","volume":"309","author":"Flegal","year":"2013","journal-title":"JAMA"},{"issue":"Suppl 2(Suppl 2)","key":"10.1016\/j.maturitas.2026.109138_bb0210","doi-asserted-by":"crossref","first-page":"S276","DOI":"10.2337\/dcS13-2023","article-title":"Obesity paradox does exist","volume":"36","author":"Hainer","year":"2013","journal-title":"Diabetes Care"},{"issue":"11","key":"10.1016\/j.maturitas.2026.109138_bb0215","doi-asserted-by":"crossref","first-page":"758","DOI":"10.7326\/0003-4819-159-11-201312030-00008","article-title":"Are metabolically healthy overweight and obesity benign conditions?: a systematic review and meta-analysis","volume":"159","author":"Kramer","year":"2013","journal-title":"Ann. Intern. Med."},{"issue":"2","key":"10.1016\/j.maturitas.2026.109138_bb0220","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S2213-8587(13)70062-7","article-title":"Metabolically healthy obesity: epidemiology, mechanisms, and clinical implications","volume":"1","author":"Stefan","year":"2013","journal-title":"Lancet Diabetes Endocrinol."}],"container-title":["Maturitas"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512226003154?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512226003154?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:41:56Z","timestamp":1792075316000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378512226003154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":44,"alternative-id":["S0378512226003154"],"URL":"https:\/\/doi.org\/10.1016\/j.maturitas.2026.109138","relation":{},"ISSN":["0378-5122"],"issn-type":[{"value":"0378-5122","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Longitudinal trajectories of the C-reactive protein-triglyceride-glucose index and frailty progression in two nationwide prospective cohorts","name":"articletitle","label":"Article Title"},{"value":"Maturitas","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.maturitas.2026.109138","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109138"}}