{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T13:51:14Z","timestamp":1793022674592,"version":"4.5.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","maturitas.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Maturitas"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.maturitas.2026.109147","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:14:09Z","timestamp":1791778449000},"page":"109147","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Determinants of bone mineral density in women with functional hypothalamic amenorrhea, with a focus on the ultrasonographic morphology of polycystic ovaries"],"prefix":"10.1016","volume":"214","author":[{"given":"Magdalena","family":"Boegl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Pedoth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schwameis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Dewailly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klara","family":"Hofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2761-5262","authenticated-orcid":false,"given":"Johannes","family":"Ott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.maturitas.2026.109147_bb0005","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.923791","article-title":"Bone perspectives in functional hypothalamic amenorrhoea: an update and future avenues","volume":"13","author":"Behary","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.maturitas.2026.109147_bb0010","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.946695","article-title":"Bone health in functional hypothalamic amenorrhea: what the endocrinologist needs to know","volume":"13","author":"Indirli","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"3","key":"10.1016\/j.maturitas.2026.109147_bb0015","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0889-8529(05)70346-7","article-title":"Growth hormones and sex steroid interactions at puberty","volume":"25","author":"Clark","year":"1996","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"issue":"5","key":"10.1016\/j.maturitas.2026.109147_bb0020","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1210\/jcem-71-5-1083","article-title":"Effects of hormonal status on bone density in adolescent girls","volume":"71","author":"Dhuper","year":"1990","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.maturitas.2026.109147_bb0025","article-title":"Association of Sex Hormones and Sex Hormone-Binding Globulin Levels With Bone Mineral Density in Adolescents Aged 12-19 Years","volume":"13","author":"Xu","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"6","key":"10.1016\/j.maturitas.2026.109147_bb0030","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1542\/peds.2004-0540","article-title":"Effects of anorexia nervosa on clinical, hematologic, biochemical, and bone density parameters in community-dwelling adolescent girls","volume":"114","author":"Misra","year":"2004","journal-title":"Pediatrics"},{"issue":"12","key":"10.1016\/j.maturitas.2026.109147_bb0035","doi-asserted-by":"crossref","first-page":"4710","DOI":"10.1210\/jc.2009-1046","article-title":"Hypercortisolemia is associated with severity of bone loss and depression in hypothalamic amenorrhea and anorexia nervosa","volume":"94","author":"Lawson","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.maturitas.2026.109147_bb0040","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3109\/09513590.2011.613972","article-title":"Skeletal status and body composition in young women with functional hypothalamic amenorrhea","volume":"28","author":"Podfigurna-Stopa","year":"2012","journal-title":"Gynecol. Endocrinol."},{"issue":"2","key":"10.1016\/j.maturitas.2026.109147_bb0045","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1210\/jcem-70-2-311","article-title":"Abnormal cortisol secretion and responses to corticotropin-releasing hormone in women with hypothalamic amenorrhea","volume":"70","author":"Biller","year":"1990","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.maturitas.2026.109147_bb0050","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1093\/humupd\/dmae030","article-title":"Functional hypothalamic amenorrhoea and polycystic ovarian morphology: a narrative review about an intriguing association","volume":"31","author":"Ott","year":"2025","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.maturitas.2026.109147_bb0055","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.904706","article-title":"Polycystic ovary syndrome phenotype D versus functional hypothalamic amenorrhea with polycystic ovarian morphology: a retrospective study about a frequent differential diagnosis","volume":"13","author":"Beitl","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"11","key":"10.1016\/j.maturitas.2026.109147_bb0060","doi-asserted-by":"crossref","first-page":"4236","DOI":"10.1210\/jc.2012-1836","article-title":"Polycystic Ovary-Like Abnormalities (PCO-L) in women with functional hypothalamic amenorrhea","volume":"97","author":"Robin","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.maturitas.2026.109147_bb0065","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1016\/j.fertnstert.2009.05.063","article-title":"Hypothalamic amenorrhea in young women with underlying polycystic ovary syndrome","volume":"92","author":"Sum","year":"2009","journal-title":"Fertil. Steril."},{"issue":"5","key":"10.1016\/j.maturitas.2026.109147_bb0070","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1210\/jc.2017-00131","article-title":"Functional hypothalamic amenorrhea: an endocrine society clinical practice guideline","volume":"102","author":"Gordon","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.maturitas.2026.109147_bb0075","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s00198-007-0518-6","article-title":"Strategies to reverse bone loss in women with functional hypothalamic amenorrhea: a systematic review of the literature","volume":"19","author":"Vescovi","year":"2008","journal-title":"Osteoporos. Int."},{"issue":"9","key":"10.1016\/j.maturitas.2026.109147_bb0080","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1093\/humrep\/dead156","article-title":"Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndromedagger","volume":"38","author":"Teede","year":"2023","journal-title":"Hum. Reprod."},{"issue":"4","key":"10.1016\/j.maturitas.2026.109147_bb0085","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.rbmo.2017.06.020","article-title":"Implications of the 2014 Androgen Excess and Polycystic Ovary Syndrome Society guidelines on polycystic ovarian morphology for polycystic ovary syndrome diagnosis","volume":"35","author":"Christ","year":"2017","journal-title":"Reprod. Biomed. Online"},{"issue":"3","key":"10.1016\/j.maturitas.2026.109147_bb0090","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1093\/humupd\/dmt061","article-title":"Definition and significance of polycystic ovarian morphology: a task force report from the Androgen Excess and Polycystic Ovary Syndrome Society","volume":"20","author":"Dewailly","year":"2014","journal-title":"Hum. Reprod. Update"},{"issue":"1","key":"10.1016\/j.maturitas.2026.109147_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.jocd.2023.101435","article-title":"Executive summary of the 2023 adult position development conference of the international society for clinical densitometry: DXA reporting, follow-up BMD testing and trabecular bone score application and reporting","volume":"27","author":"Shuhart","year":"2024","journal-title":"J. Clin. Densitom."},{"issue":"9","key":"10.1016\/j.maturitas.2026.109147_bb0100","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.mayocp.2023.05.027","article-title":"Functional hypothalamic amenorrhea: recognition and management of a challenging diagnosis","volume":"98","author":"Saadedine","year":"2023","journal-title":"Mayo Clin. Proc."},{"issue":"6","key":"10.1016\/j.maturitas.2026.109147_bb0105","first-page":"2049","article-title":"Severity of osteopenia in estrogen-deficient women with anorexia nervosa and hypothalamic amenorrhea","volume":"84","author":"Grinspoon","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"10","key":"10.1016\/j.maturitas.2026.109147_bb0110","doi-asserted-by":"crossref","first-page":"790","DOI":"10.7326\/0003-4819-133-10-200011210-00011","article-title":"Prevalence and predictive factors for regional osteopenia in women with anorexia nervosa","volume":"133","author":"Grinspoon","year":"2000","journal-title":"Ann. Intern. Med."},{"issue":"12","key":"10.1016\/j.maturitas.2026.109147_bb0115","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1359\/JBMR.050803","article-title":"Estrogen and testosterone use different cellular pathways to inhibit osteoclastogenesis and bone resorption","volume":"20","author":"Michael","year":"2005","journal-title":"J. Bone Miner. Res."},{"issue":"5","key":"10.1016\/j.maturitas.2026.109147_bb0120","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1210\/jc.2005-2596","article-title":"Effects of testosterone replacement in androgen-deficient women with hypopituitarism: a randomized, double-blind, placebo-controlled study","volume":"91","author":"Miller","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.maturitas.2026.109147_bb0125","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s12958-025-01482-0","article-title":"Changes in anti-mullerian hormone levels after recovery from functional hypothalamic amenorrhea: a retrospective cohort study about women with and without polycystic ovarian morphology","volume":"23","author":"Ott","year":"2025","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"1","key":"10.1016\/j.maturitas.2026.109147_bb0130","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11914-008-0007-7","article-title":"Treatment of premenopausal women with low bone mineral density","volume":"6","author":"Cohen","year":"2008","journal-title":"Curr. Osteoporos. Rep."}],"container-title":["Maturitas"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512226003245?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0378512226003245?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T13:20:50Z","timestamp":1793020850000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0378512226003245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":26,"alternative-id":["S0378512226003245"],"URL":"https:\/\/doi.org\/10.1016\/j.maturitas.2026.109147","relation":{},"ISSN":["0378-5122"],"issn-type":[{"value":"0378-5122","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Determinants of bone mineral density in women with functional hypothalamic amenorrhea, with a focus on the ultrasonographic morphology of polycystic ovaries","name":"articletitle","label":"Article Title"},{"value":"Maturitas","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.maturitas.2026.109147","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"109147"}}