{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:10:27Z","timestamp":1789661427601,"version":"4.0.1"},"reference-count":96,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","mayoclinicproceedings.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mayo Clinic Proceedings"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.mayocp.2012.08.013","type":"journal-article","created":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T16:01:09Z","timestamp":1351785669000},"page":"1214-1225","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":331,"title":["Postural Tachycardia Syndrome: A Heterogeneous and Multifactorial Disorder"],"prefix":"10.1016","volume":"87","author":[{"given":"Eduardo E.","family":"Benarroch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4, suppl 5","key":"10.1016\/j.mayocp.2012.08.013_bib1","first-page":"S19","article-title":"Postural tachycardia syndrome (POTS)","volume":"45","author":"Low","year":"1995","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.mayocp.2012.08.013_bib2","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/j.1540-8167.2008.01407.x","article-title":"Postural tachycardia syndrome (POTS)","volume":"20","author":"Low","year":"2009","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"2","key":"10.1016\/j.mayocp.2012.08.013_bib3","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10286-011-0119-5","article-title":"Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome","volume":"21","author":"Freeman","year":"2011","journal-title":"Clin Auton Res"},{"key":"10.1016\/j.mayocp.2012.08.013_bib4","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0b013e31826d5f95","article-title":"Deconditioning in patients with orthostatic intolerance [published online ahead of print September 19, 2012]","author":"Parsaik","year":"2012","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.mayocp.2012.08.013_bib5","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jpeds.2011.08.054","article-title":"Postural tachycardia in children and adolescents: what is abnormal?","volume":"160","author":"Singer","year":"2012","journal-title":"J Pediatr"},{"issue":"11","key":"10.1016\/j.mayocp.2012.08.013_bib6","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.4065\/74.11.1106","article-title":"Postural tachycardia syndrome: clinical features and follow-up study","volume":"74","author":"Sandroni","year":"1999","journal-title":"Mayo Clin Proc"},{"issue":"3","key":"10.1016\/j.mayocp.2012.08.013_bib7","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S0025-6196(11)61027-6","article-title":"Postural orthostatic tachycardia syndrome: the Mayo Clinic experience","volume":"82","author":"Thieben","year":"2007","journal-title":"Mayo Clin Proc"},{"issue":"2","key":"10.1016\/j.mayocp.2012.08.013_bib8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/01.crd.0000233768.68421.40","article-title":"The postural tachycardia syndrome","volume":"15","author":"Medow","year":"2007","journal-title":"Cardiol Rev"},{"issue":"1","key":"10.1016\/j.mayocp.2012.08.013_bib9","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/europace\/eun324","article-title":"A review of postural orthostatic tachycardia syndrome","volume":"11","author":"Carew","year":"2009","journal-title":"Europace"},{"issue":"pt 10","key":"10.1016\/j.mayocp.2012.08.013_bib10","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1093\/brain\/awp179","article-title":"Symptoms and signs of syncope: a review of the link between physiology and clinical clues","volume":"132","author":"Wieling","year":"2009","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.mayocp.2012.08.013_bib11","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s10286-007-0445-9","article-title":"Postural tachycardia syndrome with asystole on head-up tilt","volume":"18","author":"Alshekhlee","year":"2008","journal-title":"Clin Auton Res"},{"issue":"1","key":"10.1016\/j.mayocp.2012.08.013_bib12","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nrneurol.2011.187","article-title":"Postural tachycardia syndrome\u2014current experience and concepts","volume":"8","author":"Mathias","year":"2011","journal-title":"Nat Rev Neurol"},{"issue":"8","key":"10.1016\/j.mayocp.2012.08.013_bib13","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1212\/01.wnl.0000267663.05398.40","article-title":"The hemodynamic and neurohumoral phenotype of postural tachycardia syndrome","volume":"69","author":"Garland","year":"2007","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.mayocp.2012.08.013_bib14","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1161\/01.HYP.0000205120.46149.34","article-title":"Beta2-adrenoceptor genotype and function affect hemodynamic profile heterogeneity in postural tachycardia syndrome","volume":"47","author":"Jacob","year":"2006","journal-title":"Hypertension"},{"issue":"1-2","key":"10.1016\/j.mayocp.2012.08.013_bib15","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.autneu.2005.05.001","article-title":"A screen of candidate genes and influence of beta2-adrenergic receptor genotypes in postural tachycardia syndrome","volume":"120","author":"Nickander","year":"2005","journal-title":"Auton Neurosci"},{"issue":"3","key":"10.1016\/j.mayocp.2012.08.013_bib16","doi-asserted-by":"crossref","first-page":"H1319","DOI":"10.1152\/ajpheart.00086.2004","article-title":"Regional blood volume and peripheral blood flow in postural tachycardia syndrome","volume":"287","author":"Stewart","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"14","key":"10.1016\/j.mayocp.2012.08.013_bib17","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1056\/NEJM200010053431404","article-title":"The neuropathic postural tachycardia syndrome","volume":"343","author":"Jacob","year":"2000","journal-title":"N Engl J Med"},{"issue":"19","key":"10.1016\/j.mayocp.2012.08.013_bib18","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1161\/01.CIR.0000016348.55378.C4","article-title":"Pooling in chronic orthostatic intolerance: arterial vasoconstrictive but not venous compliance defects","volume":"105","author":"Stewart","year":"2002","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.mayocp.2012.08.013_bib19","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/jnnp.2008.168484","article-title":"Cardiac neurotransmission imaging with 123I-meta-iodobenzylguanidine in postural tachycardia syndrome","volume":"81","author":"Haensch","year":"2010","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"5","key":"10.1016\/j.mayocp.2012.08.013_bib20","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1172\/JCI114878","article-title":"Pathogenesis of hyperadrenergic orthostatic hypotension: evidence of disordered venous innervation exclusively in the lower limbs","volume":"86","author":"Streeten","year":"1990","journal-title":"J Clin Invest"},{"issue":"2","key":"10.1016\/j.mayocp.2012.08.013_bib21","first-page":"84","article-title":"The postural tachycardia syndrome (POTS): pathophysiology, diagnosis & management","volume":"6","author":"Raj","year":"2006","journal-title":"Indian Pacing Electrophysiol J"},{"issue":"8","key":"10.1016\/j.mayocp.2012.08.013_bib22","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1056\/NEJM200002243420803","article-title":"Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency","volume":"342","author":"Shannon","year":"2000","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.mayocp.2012.08.013_bib23","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1161\/01.HYP.0000158259.68614.40","article-title":"Hyperadrenergic postural tachycardia syndrome in mast cell activation disorders","volume":"45","author":"Shibao","year":"2005","journal-title":"Hypertension"},{"issue":"9","key":"10.1016\/j.mayocp.2012.08.013_bib24","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1055\/s-0028-1128139","article-title":"The protean manifestations of pheochromocytoma","volume":"41","author":"Manger","year":"2009","journal-title":"Horm Metab Res"},{"issue":"4","key":"10.1016\/j.mayocp.2012.08.013_bib25","first-page":"339","article-title":"Anti-VGKC antibody-associated limbic encephalitis\/Morvan syndrome [in Japanese]","volume":"62","author":"Misawa","year":"2010","journal-title":"Brain Nerve"},{"issue":"1","key":"10.1016\/j.mayocp.2012.08.013_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0002-9629(15)40790-6","article-title":"The roles of orthostatic hypotension, orthostatic tachycardia, and subnormal erythrocyte volume in the pathogenesis of the chronic fatigue syndrome","volume":"320","author":"Streeten","year":"2000","journal-title":"Am J Med Sci"},{"issue":"1","key":"10.1016\/j.mayocp.2012.08.013_bib27","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/MAJ.0b013e318063c6c0","article-title":"Blood volume perturbations in the postural tachycardia syndrome","volume":"334","author":"Raj","year":"2007","journal-title":"Am J Med Sci"},{"issue":"5","key":"10.1016\/j.mayocp.2012.08.013_bib28","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1161\/HYPERTENSIONAHA.108.127357","article-title":"Defects in cutaneous angiotensin-converting enzyme 2 and angiotensin-(1-7) production in postural tachycardia syndrome","volume":"53","author":"Stewart","year":"2009","journal-title":"Hypertension"},{"issue":"25","key":"10.1016\/j.mayocp.2012.08.013_bib29","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1016\/j.jacc.2010.02.043","article-title":"Cardiac origins of the postural orthostatic tachycardia syndrome","volume":"55","author":"Fu","year":"2010","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"10.1016\/j.mayocp.2012.08.013_bib30","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1152\/japplphysiol.00175.2007","article-title":"Reduced stroke volume during exercise in postural tachycardia syndrome","volume":"103","author":"Masuki","year":"2007","journal-title":"J Appl Physiol"},{"issue":"6","key":"10.1016\/j.mayocp.2012.08.013_bib31","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/s10286-008-0487-7","article-title":"POTS versus deconditioning: the same or different?","volume":"18","author":"Joyner","year":"2008","journal-title":"Clin Auton Res"},{"key":"10.1016\/j.mayocp.2012.08.013_bib32","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1749-6632.2001.tb03698.x","article-title":"Regulation of sympathetic nervous system function after cardiovascular deconditioning","volume":"940","author":"Hasser","year":"2001","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.mayocp.2012.08.013_bib33","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1109\/CIC.2002.1166705","article-title":"Effects of prolonged bed rest on the total peripheral resistance baroreflex","volume":"29","author":"Xiao","year":"2002","journal-title":"Comput Cardiol"},{"issue":"1","key":"10.1016\/j.mayocp.2012.08.013_bib34","doi-asserted-by":"crossref","first-page":"H368","DOI":"10.1152\/ajpheart.00193.2011","article-title":"Effects of short-term and prolonged bed rest on the vestibulosympathetic reflex","volume":"302","author":"Dyckman","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"5","key":"10.1016\/j.mayocp.2012.08.013_bib35","doi-asserted-by":"crossref","first-page":"H2230","DOI":"10.1152\/ajpheart.2001.280.5.H2230","article-title":"Regulation of muscle sympathetic nerve activity after bed rest deconditioning","volume":"280","author":"Pawelczyk","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"5","key":"10.1016\/j.mayocp.2012.08.013_bib36","doi-asserted-by":"crossref","first-page":"R1256","DOI":"10.1152\/ajpregu.00613.2002","article-title":"Reduced baroreflex control of heart period after bed rest is normalized by acute plasma volume restoration","volume":"287","author":"Iwasaki","year":"2004","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"1","key":"10.1016\/j.mayocp.2012.08.013_bib37","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jpeds.2010.07.005","article-title":"Comorbidities in pediatric patients with postural orthostatic tachycardia syndrome","volume":"158","author":"Ojha","year":"2011","journal-title":"J Pediatr"},{"issue":"2","key":"10.1016\/j.mayocp.2012.08.013_bib38","doi-asserted-by":"crossref","first-page":"89","DOI":"10.5455\/medarh.2012.66.89-91","article-title":"Upper functional gastrointestinal disorders in young adults","volume":"66","author":"Adibi","year":"2012","journal-title":"Med Arh"},{"issue":"2","key":"10.1016\/j.mayocp.2012.08.013_bib39","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1159\/000334652","article-title":"Management and pathophysiology of functional gastrointestinal disorders","volume":"85","author":"Fukudo","year":"2012","journal-title":"Digestion"},{"issue":"5","key":"10.1016\/j.mayocp.2012.08.013_bib40","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s11894-010-0125-0","article-title":"Functional abdominal pain","volume":"12","author":"Grover","year":"2010","journal-title":"Curr Gastroenterol Rep"},{"issue":"9","key":"10.1016\/j.mayocp.2012.08.013_bib41","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1136\/gutjnl-2011-300474","article-title":"The brain-gut pathway in functional gastrointestinal disorders is bidirectional: a 12-year prospective population-based study","volume":"61","author":"Koloski","year":"2012","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.mayocp.2012.08.013_bib42","doi-asserted-by":"crossref","first-page":"13","DOI":"10.5056\/jnm.2012.18.1.13","article-title":"Psychological co-morbidity in functional gastrointestinal disorders: epidemiology, mechanisms and management","volume":"18","author":"Wu","year":"2012","journal-title":"J Neurogastroenterol Motil"},{"issue":"5","key":"10.1016\/j.mayocp.2012.08.013_bib43","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1042\/CS20110241","article-title":"Increasing orthostatic stress impairs neurocognitive functioning in chronic fatigue syndrome with postural tachycardia syndrome","volume":"122","author":"Ocon","year":"2012","journal-title":"Clin Sci (Lond)"},{"issue":"2","key":"10.1016\/j.mayocp.2012.08.013_bib44","doi-asserted-by":"crossref","first-page":"204","DOI":"10.5664\/jcsm.28110","article-title":"Sleep disturbances and diminished quality of life in postural tachycardia syndrome","volume":"7","author":"Bagai","year":"2011","journal-title":"J Clin Sleep Med"},{"issue":"4","key":"10.1016\/j.mayocp.2012.08.013_bib45","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1042\/CS20110200","article-title":"Neurohumoral and haemodynamic profile in postural tachycardia and chronic fatigue syndromes","volume":"122","author":"Okamoto","year":"2012","journal-title":"Clin Sci (Lond)"},{"issue":"6","key":"10.1016\/j.mayocp.2012.08.013_bib46","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s11926-008-0076-8","article-title":"Autonomic dysfunction in fibromyalgia syndrome: postural orthostatic tachycardia","volume":"10","author":"Staud","year":"2008","journal-title":"Curr Rheumatol Rep"},{"issue":"1","key":"10.1016\/j.mayocp.2012.08.013_bib47","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0002-9343(03)00235-3","article-title":"Dysautonomia in the joint hypermobility syndrome","volume":"115","author":"Gazit","year":"2003","journal-title":"Am J Med"},{"issue":"4","key":"10.1016\/j.mayocp.2012.08.013_bib48","first-page":"173","article-title":"Comparative clinical profile of postural orthostatic tachycardia patients with and without joint hypermobility syndrome","volume":"10","author":"Kanjwal","year":"2010","journal-title":"Indian Pacing Electrophysiol J"},{"issue":"3","key":"10.1016\/j.mayocp.2012.08.013_bib49","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/01.hco.0000221577.41125.c8","article-title":"Familial orthostatic tachycardia","volume":"21","author":"Keller","year":"2006","journal-title":"Curr Opin Cardiol"},{"issue":"6","key":"10.1016\/j.mayocp.2012.08.013_bib50","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1111\/j.1365-2133.2010.09949.x","article-title":"Tenascin-X deficiency and Ehlers-Danlos syndrome: a case report and review of the literature","volume":"163","author":"O'Connell","year":"2010","journal-title":"Br J Dermatol"},{"issue":"2","key":"10.1016\/j.mayocp.2012.08.013_bib51","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0885-3924(97)00007-9","article-title":"Chronic pain is a manifestation of the Ehlers-Danlos syndrome","volume":"14","author":"Sacheti","year":"1997","journal-title":"J Pain Symptom Manage"},{"issue":"2","key":"10.1016\/j.mayocp.2012.08.013_bib52","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2190\/PM.41.2.g","article-title":"Association between psychopathological factors and joint hypermobility syndrome in a group of undergraduates from a French university","volume":"41","author":"Baeza-Velasco","year":"2011","journal-title":"Int J Psychiatry Med"},{"issue":"2","key":"10.1016\/j.mayocp.2012.08.013_bib53","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.spen.2010.04.006","article-title":"Orthostatic intolerance and the headache patient","volume":"17","author":"Mack","year":"2010","journal-title":"Semin Pediatr Neurol"},{"issue":"10","key":"10.1016\/j.mayocp.2012.08.013_bib54","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1024\/1661-8157\/a00534","article-title":"Orthostatic headache with tachycardia [in German]","volume":"100","author":"Mathys","year":"2011","journal-title":"Praxis (Bern 1994)"},{"issue":"7","key":"10.1016\/j.mayocp.2012.08.013_bib55","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1212\/01.WNL.0000085868.37963.7D","article-title":"Orthostatic headaches without CSF leak in postural tachycardia syndrome","volume":"61","author":"Mokri","year":"2003","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.mayocp.2012.08.013_bib56","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1136\/jnnp.2004.048330","article-title":"Orthostatic intolerance and syncope associated with Chiari type I malformation","volume":"76","author":"Prilipko","year":"2005","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"10.1016\/j.mayocp.2012.08.013_bib57","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000081854","article-title":"Postural orthostatic tachycardia warrants investigation of Chiari I malformation as a possible cause","volume":"103","author":"Pasupuleti","year":"2005","journal-title":"Cardiology"},{"issue":"4","key":"10.1016\/j.mayocp.2012.08.013_bib58","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/BF02298959","article-title":"Postural tachycardia syndrome in syringomyelia: response to fludrocortisone and beta-blockers","volume":"11","author":"Nogu\u00e9s","year":"2001","journal-title":"Clin Auton Res"},{"issue":"7","key":"10.1016\/j.mayocp.2012.08.013_bib59","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/S0002-9343(01)00922-6","article-title":"Chiari I malformation as a cause of orthostatic intolerance symptoms: a media myth?","volume":"111","author":"Garland","year":"2001","journal-title":"Am J Med"},{"issue":"5","key":"10.1016\/j.mayocp.2012.08.013_bib60","first-page":"482","article-title":"Autonomic dysfunction presenting as postural tachycardia syndrome following traumatic brain injury","volume":"17","author":"Kanjwal","year":"2010","journal-title":"Cardiol J"},{"issue":"1","key":"10.1016\/j.mayocp.2012.08.013_bib61","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.otc.2008.09.011","article-title":"Chronic subjective dizziness","volume":"42","author":"Ruckenstein","year":"2009","journal-title":"Otolaryngol Clin North Am"},{"key":"10.1016\/j.mayocp.2012.08.013_bib62","first-page":"225","article-title":"Somatoform phobic postural vertigo and psychogenic disorders of stance and gait","volume":"87","author":"Dieterich","year":"2001","journal-title":"Adv Neurol"},{"issue":"3","key":"10.1016\/j.mayocp.2012.08.013_bib63","doi-asserted-by":"crossref","first-page":"R681","DOI":"10.1152\/ajpregu.00896.2007","article-title":"Sympathetic responses to vestibular activation in humans","volume":"294","author":"Carter","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"6","key":"10.1016\/j.mayocp.2012.08.013_bib64","doi-asserted-by":"crossref","first-page":"531","DOI":"10.4065\/77.6.531","article-title":"Quality of life in patients with postural tachycardia syndrome","volume":"77","author":"Benrud-Larson","year":"2002","journal-title":"Mayo Clin Proc"},{"issue":"6, suppl 69","key":"10.1016\/j.mayocp.2012.08.013_bib65","first-page":"S109","article-title":"Brain imaging in fibromyalgia syndrome","volume":"29","author":"Staud","year":"2011","journal-title":"Clin Exp Rheumatol"},{"issue":"9","key":"10.1016\/j.mayocp.2012.08.013_bib66","doi-asserted-by":"crossref","first-page":"907","DOI":"10.4065\/mcp.2011.0206","article-title":"The science of fibromyalgia","volume":"86","author":"Clauw","year":"2011","journal-title":"Mayo Clin Proc"},{"issue":"6","key":"10.1016\/j.mayocp.2012.08.013_bib67","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.clinph.2009.03.019","article-title":"The impact of chronic primary insomnia on the heart rate\u2014EEG variability link","volume":"120","author":"Jurysta","year":"2009","journal-title":"Clin Neurophysiol"},{"issue":"3","key":"10.1016\/j.mayocp.2012.08.013_bib68","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1142\/S0219635208001903","article-title":"The effects of a poor night sleep on mood, cognitive, autonomic and electrophysiological measures","volume":"7","author":"Barnett","year":"2008","journal-title":"J Integr Neurosci"},{"key":"10.1016\/j.mayocp.2012.08.013_bib69","doi-asserted-by":"crossref","DOI":"10.1113\/expphysiol.2012.065557","article-title":"Altered cortical activation patterns associated with baroreflex unloading following 24 hours of physical deconditioning [published online ahead of print May 21, 2012]","author":"Shoemaker","year":"2012","journal-title":"Exp Physiol"},{"key":"10.1016\/j.mayocp.2012.08.013_bib70","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1146\/annurev.neuro.25.032502.111311","article-title":"The central autonomic nervous system: conscious visceral perception and autonomic pattern generation","volume":"25","author":"Saper","year":"2002","journal-title":"Annu Rev Neurosci"},{"issue":"4","key":"10.1016\/j.mayocp.2012.08.013_bib71","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S0959-4388(03)00090-4","article-title":"Interoception: the sense of the physiological condition of the body","volume":"13","author":"Craig","year":"2003","journal-title":"Curr Opin Neurobiol"},{"issue":"1","key":"10.1016\/j.mayocp.2012.08.013_bib72","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/cne.20749","article-title":"Neural mechanisms of autonomic, affective, and cognitive integration","volume":"493","author":"Critchley","year":"2005","journal-title":"J Comp Neurol"},{"issue":"1-2","key":"10.1016\/j.mayocp.2012.08.013_bib73","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.autneu.2010.09.005","article-title":"Dissecting axes of autonomic control in humans: insights from neuroimaging","volume":"161","author":"Critchley","year":"2011","journal-title":"Auton Neurosci"},{"key":"10.1016\/j.mayocp.2012.08.013_bib74","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0079-6123(08)61855-5","article-title":"The emotional motor system","volume":"107","author":"Holstege","year":"1996","journal-title":"Prog Brain Res"},{"issue":"2","key":"10.1016\/j.mayocp.2012.08.013_bib75","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.neuroscience.2004.05.059","article-title":"Evidence for macular gravity receptor modulation of hypothalamic, limbic and autonomic nuclei","volume":"129","author":"Fuller","year":"2004","journal-title":"Neuroscience"},{"issue":"21","key":"10.1016\/j.mayocp.2012.08.013_bib76","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1212\/01.wnl.0000335246.93495.92","article-title":"The arterial baroreflex: functional organization and involvement in neurologic disease","volume":"71","author":"Benarroch","year":"2008","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.mayocp.2012.08.013_bib77","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nrn1902","article-title":"The sympathetic control of blood pressure","volume":"7","author":"Guyenet","year":"2006","journal-title":"Nat Rev Neurosci"},{"issue":"4","key":"10.1016\/j.mayocp.2012.08.013_bib78","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.neuron.2012.02.004","article-title":"Rethinking the emotional brain [published correction appears in Neuron. 2012;73(5):1052]","volume":"73","author":"LeDoux","year":"2012","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.mayocp.2012.08.013_bib79","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ijpsycho.2009.01.012","article-title":"Psychophysiology of neural, cognitive and affective integration: fMRI and autonomic indicants","volume":"73","author":"Critchley","year":"2009","journal-title":"Int J Psychophysiol"},{"issue":"pt 1","key":"10.1016\/j.mayocp.2012.08.013_bib80","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1113\/jphysiol.2005.091637","article-title":"Cortical regions associated with autonomic cardiovascular regulation during lower body negative pressure in humans","volume":"569","author":"Kimmerly","year":"2005","journal-title":"J Physiol"},{"issue":"6","key":"10.1016\/j.mayocp.2012.08.013_bib81","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.neuron.2012.06.002","article-title":"Psychopathology and the human connectome: toward a transdiagnostic model of risk for mental illness","volume":"74","author":"Buckholtz","year":"2012","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.mayocp.2012.08.013_bib82","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.pneurobio.2010.10.005","article-title":"The pain matrix reloaded: a salience detection system for the body","volume":"93","author":"Legrain","year":"2011","journal-title":"Prog Neurobiol"},{"issue":"12","key":"10.1016\/j.mayocp.2012.08.013_bib83","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/j.pmrj.2011.05.018","article-title":"Central nervous system reorganization in a variety of chronic pain states: a review","volume":"3","author":"Henry","year":"2011","journal-title":"PM R"},{"issue":"8","key":"10.1016\/j.mayocp.2012.08.013_bib84","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1111\/j.1540-8159.1988.tb03973.x","article-title":"The usefulness of head-up tilt testing and hemodynamic investigations in the workup of syncope of unknown origin","volume":"11","author":"Abi-Samra","year":"1988","journal-title":"Pacing Clin Electrophysiol"},{"issue":"1","key":"10.1016\/j.mayocp.2012.08.013_bib85","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/BF01819146","article-title":"Physical manoeuvres that reduce postural hypotension in autonomic failure","volume":"3","author":"Wieling","year":"1993","journal-title":"Clin Auton Res"},{"issue":"5","key":"10.1016\/j.mayocp.2012.08.013_bib86","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1152\/japplphysiol.01250.2004","article-title":"Leg crossing, muscle tensing, squatting, and the crash position are effective against vasovagal reactions solely through increases in cardiac output","volume":"99","author":"Krediet","year":"2005","journal-title":"J Appl Physiol"},{"issue":"1","key":"10.1016\/j.mayocp.2012.08.013_bib87","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/BF02291387","article-title":"Hemodynamic and symptomatic effects of acute interventions on tilt in patients with postural tachycardia syndrome","volume":"10","author":"Gordon","year":"2000","journal-title":"Clin Auton Res"},{"issue":"3","key":"10.1016\/j.mayocp.2012.08.013_bib88","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s10286-004-0187-x","article-title":"Use of lower abdominal compression to combat orthostatic hypotension in patients with autonomic dysfunction","volume":"14","author":"Smit","year":"2004","journal-title":"Clin Auton Res"},{"issue":"pt 15","key":"10.1016\/j.mayocp.2012.08.013_bib89","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.1113\/jphysiol.2012.233858","article-title":"Short-term exercise training improves the cardiovascular response to exercise in the postural orthostatic tachycardia syndrome","volume":"590","author":"Shibata","year":"2012","journal-title":"J Physiol"},{"issue":"5","key":"10.1016\/j.mayocp.2012.08.013_bib90","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/BF02281112","article-title":"Clinical improvement in patients with orthostatic intolerance after treatment with bisoprolol and fludrocortisone","volume":"10","author":"Freitas","year":"2000","journal-title":"Clin Auton Res"},{"issue":"4","key":"10.1016\/j.mayocp.2012.08.013_bib91","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1253\/circj.CJ-10-0514","article-title":"Midodrine hydrochloride is effective in the treatment of children with postural orthostatic tachycardia syndrome","volume":"75","author":"Chen","year":"2011","journal-title":"Circ J"},{"issue":"9","key":"10.1016\/j.mayocp.2012.08.013_bib92","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1161\/CIRCULATIONAHA.108.846501","article-title":"Propranolol decreases tachycardia and improves symptoms in the postural tachycardia syndrome: less is more","volume":"120","author":"Raj","year":"2009","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.mayocp.2012.08.013_bib93","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/ncpcardio0068","article-title":"The sinus tachycardias","volume":"2","author":"Yusuf","year":"2005","journal-title":"Nat Clin Pract Cardiovasc Med"},{"issue":"5","key":"10.1016\/j.mayocp.2012.08.013_bib94","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1097\/01.wnp.0000229946.01494.4c","article-title":"Acetylcholinesterase inhibition in patients with orthostatic intolerance","volume":"23","author":"Singer","year":"2006","journal-title":"J Clin Neurophysiol"},{"issue":"21","key":"10.1016\/j.mayocp.2012.08.013_bib95","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1161\/CIRCULATIONAHA.104.497594","article-title":"Acetylcholinesterase inhibition improves tachycardia in postural tachycardia syndrome","volume":"111","author":"Raj","year":"2005","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.mayocp.2012.08.013_bib96","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/j.1540-8159.2011.03047.x","article-title":"Pyridostigmine in the treatment of postural orthostatic tachycardia: a single-center experience","volume":"34","author":"Kanjwal","year":"2011","journal-title":"Pacing Clin Electrophysiol"}],"container-title":["Mayo Clinic Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619612008968?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619612008968?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T01:27:52Z","timestamp":1758418072000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025619612008968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":96,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0025619612008968"],"URL":"https:\/\/doi.org\/10.1016\/j.mayocp.2012.08.013","relation":{},"ISSN":["0025-6196"],"issn-type":[{"value":"0025-6196","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Postural Tachycardia Syndrome: A Heterogeneous and Multifactorial Disorder","name":"articletitle","label":"Article Title"},{"value":"Mayo Clinic Proceedings","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mayocp.2012.08.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}