{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T03:32:21Z","timestamp":1768879941503,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mayo Clinic Proceedings"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.mayocp.2015.06.002","type":"journal-article","created":{"date-parts":[[2015,7,20]],"date-time":"2015-07-20T10:53:05Z","timestamp":1437389585000},"page":"1104-1115","source":"Crossref","is-referenced-by-count":56,"title":["Critical Update of the 2010 Endocrine Society Clinical Practice Guidelines for Male Hypogonadism"],"prefix":"10.1016","volume":"90","author":[{"given":"Allen D.","family":"Seftel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Kathrins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig","family":"Niederberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.mayocp.2015.06.002_bib1","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1210\/jcem.86.2.7219","article-title":"Longitudinal effects of aging on serum total and free testosterone levels in healthy men","volume":"86","author":"Harman","year":"2001","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"15","key":"10.1016\/j.mayocp.2015.06.002_bib2","first-page":"2013","article-title":"Trends in androgen prescribing in the United States, 2001 to 2011","volume":"173","author":"Baillargeon","year":"2014","journal-title":"JAMA Intern Med"},{"issue":"6","key":"10.1016\/j.mayocp.2015.06.002_bib3","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1210\/jc.2009-2354","article-title":"Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline","volume":"95","author":"Bhasin","year":"2010","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.mayocp.2015.06.002_bib4","unstructured":"Bone, Reproductive, and Urologic Drugs Advisory Committee, Food and Drug Administration. Update: FDA cautions about using testosterone products for low testosterone due to aging; requires labeling change to inform of possible increased risk of heart attack and stroke with use. http:\/\/www.fda.gov\/downloads\/Drugs\/DrugSafety\/UCM436270.pdf. Published March 3, 2015. Accessed March 15,\u00a02015."},{"issue":"5","key":"10.1016\/j.mayocp.2015.06.002_bib5","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ijsu.2010.02.007","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"8","author":"Moher","year":"2010","journal-title":"Int J Surg"},{"issue":"3","key":"10.1016\/j.mayocp.2015.06.002_bib6","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00345-011-0667-2","article-title":"Rating the quality of evidence and the strength of recommendations using GRADE","volume":"29","author":"Canfield","year":"2011","journal-title":"World J Urol"},{"issue":"5","key":"10.1016\/j.mayocp.2015.06.002_bib7","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/j.1464-410X.2009.09181.x","article-title":"Levels of evidence ratings in the urological literature: an assessment of interobserver agreement","volume":"105","author":"Turpen","year":"2010","journal-title":"BJU Int"},{"key":"10.1016\/j.mayocp.2015.06.002_bib8","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration's tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"issue":"4","key":"10.1016\/j.mayocp.2015.06.002_bib9","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/j.1365-2265.2012.04413.x","article-title":"Effects of testosterone therapy on sleep and breathing in obese men with severe obstructive sleep apnoea: a randomized placebo-controlled trial","volume":"77","author":"Hoyos","year":"2012","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"3","key":"10.1016\/j.mayocp.2015.06.002_bib10","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/jsr.12027","article-title":"Obstructive sleep apnea: the effects of testosterone on ventilatory responses in men with obstructive sleep apnea : a randomised, placebo-controlled trial","volume":"22","author":"Killick","year":"2013","journal-title":"J\u00a0Sleep Res"},{"issue":"5","key":"10.1016\/j.mayocp.2015.06.002_bib11","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1210\/jc.2012-3695","article-title":"Effects of testosterone and progressive resistance exercise in healthy, highly functioning older men with low-normal testosterone levels","volume":"98","author":"Hildreth","year":"2013","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"9","key":"10.1016\/j.mayocp.2015.06.002_bib12","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1007\/s00520-013-1832-5","article-title":"Testosterone replacement for fatigue in hypogonadal ambulatory males with advanced cancer: a preliminary double-blind placebo-controlled trial","volume":"21","author":"Del Fabbro","year":"2013","journal-title":"Support. Care Cancer"},{"issue":"5","key":"10.1016\/j.mayocp.2015.06.002_bib13","first-page":"1134","article-title":"Effects of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels, low bone mass, and physical frailty","volume":"56","author":"Kenny","year":"2010","journal-title":"J\u00a0Gerontol A Biol Sci Med Sci"},{"issue":"5","key":"10.1016\/j.mayocp.2015.06.002_bib14","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/j.1365-2265.2010.03845.x","article-title":"Effects of testosterone supplementation on markers of the metabolic syndrome and inflammation in hypogonadal men with the metabolic syndrome: the double-blinded placebo controlled Moscow study","volume":"73","author":"Kalinchenko","year":"2010","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"2","key":"10.1016\/j.mayocp.2015.06.002_bib15","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1210\/jc.2009-1251","article-title":"Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study","volume":"95","author":"Srinivas-Shankar","year":"2010","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"7","key":"10.1016\/j.mayocp.2015.06.002_bib16","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1111\/bju.12037","article-title":"Efficacy and safety of long-acting intramuscular testosterone undecanoate in aging men: a randomised controlled study","volume":"111","author":"Tan","year":"2013","journal-title":"BJU Int"},{"issue":"6","key":"10.1016\/j.mayocp.2015.06.002_bib17","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.ahj.2012.09.016","article-title":"Testosterone therapy during exercise rehabilitation in male patients with chronic heart failure who have low testosterone status: a double-blind randomized controlled feasibility study","volume":"164","author":"Stout","year":"2012","journal-title":"Am Heart J"},{"issue":"6","key":"10.1016\/j.mayocp.2015.06.002_bib18","first-page":"1612","article-title":"Testosterone replacement therapy with long-acting testosterone undecanoate improves sexual function and quality-of-life parameters vs. placebo in a population of men with type 2 diabetes","volume":"10","author":"Hackett","year":"2013","journal-title":"J\u00a0Sex Med"},{"issue":"3","key":"10.1016\/j.mayocp.2015.06.002_bib19","first-page":"840","article-title":"Testosterone replacement therapy improves metabolic parameters in hypogonadal men with type 2 diabetes but not in men with coexisting depression: the BLAST study","volume":"11","author":"Hackett","year":"2014","journal-title":"J\u00a0Sex Med"},{"issue":"4","key":"10.1016\/j.mayocp.2015.06.002_bib20","doi-asserted-by":"crossref","first-page":"828","DOI":"10.2337\/dc10-1233","article-title":"Testosterone replacement in hypogonadal men with type 2 diabetes and\/or metabolic syndrome (the TIMES2 study)","volume":"34","author":"Jones","year":"2011","journal-title":"Diabetes Care"},{"issue":"10","key":"10.1016\/j.mayocp.2015.06.002_bib21","first-page":"3495","article-title":"Effects of testosterone undecanoate on cardiovascular risk factors and atherosclerosis in middle-aged men with late-onset hypogonadism and metabolic syndrome: results from a 24-month, randomized, double-blind, placebo-controlled study","volume":"7","author":"Aversa","year":"2010","journal-title":"J\u00a0Sex Med"},{"issue":"8","key":"10.1016\/j.mayocp.2015.06.002_bib22","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.2337\/dc13-2845","article-title":"Effect of testosterone treatment on glucose metabolism in men with type 2 diabetes: a randomized controlled trial","volume":"37","author":"Gianatti","year":"2014","journal-title":"Diabetes Care"},{"issue":"10","key":"10.1016\/j.mayocp.2015.06.002_bib23","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.1210\/jc.2014-1872","article-title":"Effect of testosterone treatment on constitutional and sexual symptoms in men with type 2 diabetes in a randomized, placebo-controlled clinical trial","volume":"99","author":"Gianatti","year":"2014","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.mayocp.2015.06.002_bib24","doi-asserted-by":"crossref","first-page":"570","DOI":"10.4158\/EP09355.OR","article-title":"Treatment of hypogonadism with testosterone in patients with type 2 diabetes mellitus","volume":"16","author":"Gopal","year":"2010","journal-title":"Endocr Pract"},{"issue":"4","key":"10.1016\/j.mayocp.2015.06.002_bib25","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/aja.2011.178","article-title":"Effect of long-acting testosterone undecanoate treatment on quality of life in men with testosterone deficiency syndrome: a double blind randomized controlled trial","volume":"14","author":"Tong","year":"2012","journal-title":"Asian J Androl"},{"issue":"2","key":"10.1016\/j.mayocp.2015.06.002_bib26","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/JCP.0b013e3181d207ca","article-title":"Parallel-group placebo-controlled trial of testosterone gel in men with major depressive disorder displaying an incomplete response to standard antidepressant treatment","volume":"30","author":"Pope","year":"2010","journal-title":"J\u00a0Clin Psychopharmacol"},{"issue":"4","key":"10.1016\/j.mayocp.2015.06.002_bib27","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/0092623X.2011.582425","article-title":"Testosterone gel replacement improves sexual function in depressed men taking serotonergic antidepressants: a randomized, placebo-controlled clinical trial","volume":"37","author":"Amiaz","year":"2011","journal-title":"J\u00a0Sex Marital Ther"},{"issue":"1","key":"10.1016\/j.mayocp.2015.06.002_bib28","first-page":"284","article-title":"Hypogonadal men nonresponders to the PDE5 inhibitor tadalafil benefit from normalization of testosterone levels with a 1% hydroalcoholic testosterone gel in the treatment of erectile dysfunction (TADTEST study)","volume":"8","author":"Buvat","year":"2011","journal-title":"J\u00a0Sex Med"},{"issue":"3","key":"10.1016\/j.mayocp.2015.06.002_bib29","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.2047-2927.2013.00075.x","article-title":"The effect of testosterone on mood and well-being in men with erectile dysfunction in a randomized, placebo-controlled trial","volume":"1","author":"Spitzer","year":"2013","journal-title":"Andrology"},{"issue":"10","key":"10.1016\/j.mayocp.2015.06.002_bib30","doi-asserted-by":"crossref","first-page":"681","DOI":"10.7326\/0003-4819-157-10-201211200-00004","article-title":"Effect of testosterone replacement on response to sildenafil citrate in men with erectile dysfunction","volume":"157","author":"Spitzer","year":"2012","journal-title":"Ann Intern Med"},{"issue":"11","key":"10.1016\/j.mayocp.2015.06.002_bib31","first-page":"1451","article-title":"Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials","volume":"60","author":"Calof","year":"2005","journal-title":"J\u00a0Gerontol"},{"issue":"2","key":"10.1016\/j.mayocp.2015.06.002_bib32","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1056\/NEJMoa1000485","article-title":"Adverse events associated with testosterone administration","volume":"363","author":"Basaria","year":"2010","journal-title":"N\u00a0Engl J Med"},{"issue":"2","key":"10.1016\/j.mayocp.2015.06.002_bib33","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/gerona\/gls138","article-title":"Risk factors associated with cardiovascular events during testosterone administration in older men with mobility limitation","volume":"68","author":"Basaria","year":"2013","journal-title":"J\u00a0Gerontol A Biol Sci Med Sci"},{"issue":"11","key":"10.1016\/j.mayocp.2015.06.002_bib34","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/gerona\/glq118","article-title":"Effects of testosterone on skeletal muscle architecture in intermediate-frail and frail elderly men","volume":"65","author":"Atkinson","year":"2010","journal-title":"J\u00a0Gerontol A Biol Sci Med Sci"},{"issue":"4","key":"10.1016\/j.mayocp.2015.06.002_bib35","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1530\/EJE-12-0525","article-title":"Body compositional and cardiometabolic effects of testosterone therapy in obese men with severe obstructive sleep apnoea: a randomised placebo-controlled trial","volume":"167","author":"Hoyos","year":"2012","journal-title":"Eur J Endocrinol"},{"issue":"17","key":"10.1016\/j.mayocp.2015.06.002_bib36","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1001\/jama.2013.280386","article-title":"Association of testosterone therapy with mortality, myocardial Infarction, and stroke in men with low testosterone levels","volume":"310","author":"Vigen","year":"2013","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.mayocp.2015.06.002_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0085805","article-title":"Increased risk of non-fatal myocardial infarction following testosterone therapy prescription in men","volume":"9","author":"Finkle","year":"2014","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.mayocp.2015.06.002_bib38","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1177\/1060028014539918","article-title":"Risk of myocardial infarction in older men receiving testosterone therapy","volume":"48","author":"Baillargeon","year":"2014","journal-title":"Ann Pharmacother"}],"container-title":["Mayo Clinic Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002561961500467X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002561961500467X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T20:25:58Z","timestamp":1537475158000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002561961500467X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["S002561961500467X"],"URL":"https:\/\/doi.org\/10.1016\/j.mayocp.2015.06.002","relation":{},"ISSN":["0025-6196"],"issn-type":[{"value":"0025-6196","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]}}}