{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:42:55Z","timestamp":1788799375093,"version":"build-2803163510"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","mayoclinicproceedings.org","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mayo Clinic Proceedings"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.mayocp.2016.10.008","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T15:03:43Z","timestamp":1488380623000},"page":"360-369","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["CHA2DS2-VASc Score: A Predictor of Thromboembolic Events and Mortality in Patients With an Implantable Monitoring Device Without Atrial Fibrillation"],"prefix":"10.1016","volume":"92","author":[{"given":"Christine","family":"Parsons","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma I.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Cha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Win-Kuang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alanna M.","family":"Chamberlain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushil Allen","family":"Luis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria I.","family":"Aguilar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart M.","family":"Demaerschalk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farouk","family":"Mookadam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi","family":"Shamoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.mayocp.2016.10.008_bib1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1378\/chest.09-1584","article-title":"Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the Euro Heart Survey on Atrial Fibrillation","volume":"137","author":"Lip","year":"2010","journal-title":"Chest"},{"issue":"12","key":"10.1016\/j.mayocp.2016.10.008_bib2","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1093\/eurheartj\/ehr488","article-title":"Evaluation of risk stratification schemes for ischaemic stroke and bleeding in 182 678 patients with atrial fibrillation: the Swedish Atrial Fibrillation cohort study","volume":"33","author":"Friberg","year":"2012","journal-title":"Eur Heart J"},{"issue":"6","key":"10.1016\/j.mayocp.2016.10.008_bib3","doi-asserted-by":"crossref","first-page":"603.e1","DOI":"10.1016\/j.amjmed.2011.09.030","article-title":"Impact of the CHA2DS2-VASc score on anticoagulation recommendations for atrial fibrillation","volume":"125","author":"Mason","year":"2012","journal-title":"Am J Med"},{"issue":"6","key":"10.1016\/j.mayocp.2016.10.008_bib4","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1160\/TH12-03-0175","article-title":"The value of the CHA2DS2-VASc score for refining stroke risk stratification in patients with atrial fibrillation with a CHADS2 score 0-1: a nationwide cohort study","volume":"107","author":"Olesen","year":"2012","journal-title":"Thromb Haemost"},{"issue":"21","key":"10.1016\/j.mayocp.2016.10.008_bib5","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jacc.2014.03.022","article-title":"2014 AHA\/ACC\/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society","volume":"64","author":"January","year":"2014","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"13","key":"10.1016\/j.mayocp.2016.10.008_bib6","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1001\/archinte.1994.00420130036007","article-title":"Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation: analysis of pooled data from five randomized controlled trials","volume":"154","year":"1994","journal-title":"Arch Intern Med"},{"issue":"16","key":"10.1016\/j.mayocp.2016.10.008_bib7","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1001\/jama.279.16.1273","article-title":"Patients with nonvalvular atrial fibrillation at low risk of stroke during treatment with aspirin: Stroke Prevention in Atrial Fibrillation III Study","volume":"279","author":"SPAF III Writing Committee for the Stroke Prevention in Atrial Fibrillation Investigators","year":"1998","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.mayocp.2016.10.008_bib8","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1212\/01.wnl.0000267275.68538.8d","article-title":"Independent predictors of stroke in patients with atrial fibrillation: a systematic review","volume":"69","author":"Stroke Risk in Atrial Fibrillation Working Group","year":"2007","journal-title":"Neurology"},{"issue":"8","key":"10.1016\/j.mayocp.2016.10.008_bib9","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1001\/jama.290.8.1049","article-title":"A\u00a0risk score for predicting stroke or death in individuals with new-onset atrial fibrillation in the community: the Framingham Heart Study","volume":"290","author":"Wang","year":"2003","journal-title":"JAMA"},{"issue":"1-2","key":"10.1016\/j.mayocp.2016.10.008_bib10","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jns.2011.03.046","article-title":"CHADS2 score is associated with 3-month clinical outcomes after intravenous rt-PA therapy in stroke patients with atrial fibrillation: SAMURAI rt-PA Registry","volume":"306","author":"Koga","year":"2011","journal-title":"J\u00a0Neurol Sci"},{"issue":"1","key":"10.1016\/j.mayocp.2016.10.008_bib11","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ijcard.2008.11.122","article-title":"Survival after stroke\u2014the impact of CHADS2 score and atrial fibrillation","volume":"141","author":"Henriksson","year":"2010","journal-title":"Int J Cardiol"},{"issue":"2","key":"10.1016\/j.mayocp.2016.10.008_bib12","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/eurjhf\/hfr172","article-title":"Stroke aetiology and predictors of outcome in patients with heart failure and acute stroke: a 10-year follow-up study","volume":"14","author":"Vemmos","year":"2012","journal-title":"Eur J Heart Fail"},{"issue":"12","key":"10.1016\/j.mayocp.2016.10.008_bib13","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1136\/jnnp.2008.146092","article-title":"Predictive value of the Essen Stroke Risk Score and Ankle Brachial Index in acute ischaemic stroke patients from 85 German stroke units","volume":"79","author":"Weimar","year":"2008","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"issue":"11","key":"10.1016\/j.mayocp.2016.10.008_bib14","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1212\/WNL.0b013e318287281b","article-title":"CHADS2, CHA2S2DS2-VASc, and long-term stroke outcome in patients without atrial fibrillation","volume":"80","author":"Ntaios","year":"2013","journal-title":"Neurology"},{"issue":"11","key":"10.1016\/j.mayocp.2016.10.008_bib15","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.amjcard.2015.08.049","article-title":"Stroke risk factors beyond the CHA2DS2-VASc score: can we improve our identification of \u201chigh stroke risk\u201d patients with atrial fibrillation?","volume":"116","author":"Szymanski","year":"2015","journal-title":"Am J Cardiol"},{"issue":"5","key":"10.1016\/j.mayocp.2016.10.008_bib16","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1160\/TH13-01-0054","article-title":"Does chronic kidney disease improve the predictive value of the CHADS2 and CHA2DS2-VASc stroke stratification risk scores for atrial fibrillation?","volume":"109","author":"Rold\u00e1n","year":"2013","journal-title":"Thromb Haemost"},{"issue":"2","key":"10.1016\/j.mayocp.2016.10.008_bib17","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1161\/CIRCULATIONAHA.112.107128","volume":"127","author":"Piccini","year":"2013","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.mayocp.2016.10.008_bib18","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.mayocp.2012.08.012","article-title":"History of the Rochester Epidemiology Project: half a century of medical records linkage in a US population","volume":"87","author":"Rocca","year":"2012","journal-title":"Mayo Clin Proc"},{"issue":"2","key":"10.1016\/j.mayocp.2016.10.008_bib19","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.amjcard.2012.03.021","article-title":"Usefulness of continuous electrocardiographic monitoring for atrial fibrillation","volume":"110","author":"Camm","year":"2012","journal-title":"Am J Cardiol"},{"issue":"7","key":"10.1016\/j.mayocp.2016.10.008_bib20","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.mayocp.2013.04.021","article-title":"Age and sex patterns of drug prescribing in a defined American population","volume":"88","author":"Zhong","year":"2013","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.mayocp.2016.10.008_bib21","series-title":"The Statistical Analysis of Failure Time Data","author":"Kalbfleisch","year":"1980"},{"issue":"4","key":"10.1016\/j.mayocp.2016.10.008_bib22","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1159\/000353670","article-title":"Pre-stroke CHADS2 and CHA2DS2-VASc scores are useful in stratifying three-month outcomes in patients with and without atrial fibrillation","volume":"36","author":"Tu","year":"2013","journal-title":"Cerebrovasc Dis"},{"issue":"2","key":"10.1016\/j.mayocp.2016.10.008_bib23","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1056\/NEJMoa1105575","article-title":"Subclinical atrial fibrillation and the risk of stroke","volume":"366","author":"Healey","year":"2012","journal-title":"N\u00a0Engl J Med"},{"issue":"12","key":"10.1016\/j.mayocp.2016.10.008_bib24","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1161\/01.CIR.0000057981.70380.45","article-title":"Atrial high rate episodes detected by pacemaker diagnostics predict death and stroke: report of the Atrial Diagnostics Ancillary Study of the MOde Selection Trial (MOST)","volume":"107","author":"Glotzer","year":"2003","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.mayocp.2016.10.008_bib25","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1161\/CIRCEP.109.849638","article-title":"The relationship between daily atrial tachyarrhythmia burden from implantable device diagnostics and stroke risk: the TRENDS study","volume":"2","author":"Glotzer","year":"2009","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"21","key":"10.1016\/j.mayocp.2016.10.008_bib26","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1161\/CIRCULATIONAHA.113.007825","article-title":"Temporal relationship between subclinical atrial fibrillation and embolic events","volume":"129","author":"Brambatti","year":"2014","journal-title":"Circulation"},{"issue":"20","key":"10.1016\/j.mayocp.2016.10.008_bib27","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1016\/j.jacc.2015.03.557","article-title":"Fibrotic atrial cardiomyopathy, atrial fibrillation, and thromboembolism: mechanistic links and clinical inferences","volume":"65","author":"Hirsh","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"8","key":"10.1016\/j.mayocp.2016.10.008_bib28","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1093\/eurheartj\/eht491","article-title":"Device-detected atrial fibrillation and risk for stroke: an analysis of >10,000 patients from the SOS AF project (Stroke preventiOn Strategies based on Atrial Fibrillation information from implanted devices)","volume":"35","author":"Boriani","year":"2014","journal-title":"Eur Heart J"},{"issue":"22","key":"10.1016\/j.mayocp.2016.10.008_bib29","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1016\/j.jacc.2012.04.063","article-title":"Inflammation in atrial fibrillation","volume":"60","author":"Guo","year":"2012","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.mayocp.2016.10.008_bib30","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1253\/circj.CJ-14-0630","article-title":"Predictors of left atrial coagulation activity among paroxysmal atrial fibrillation patients","volume":"79","author":"Yashiro","year":"2015","journal-title":"Circ J"},{"issue":"1","key":"10.1016\/j.mayocp.2016.10.008_bib31","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.amjcard.2009.02.053","article-title":"Relation of multiple inflammatory biomarkers to incident atrial fibrillation","volume":"104","author":"Schnabel","year":"2009","journal-title":"Am J Cardiol"},{"issue":"14","key":"10.1016\/j.mayocp.2016.10.008_bib32","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1093\/eurheartj\/ehq146","article-title":"A\u00a0multimarker approach to assess the influence of inflammation on the incidence of atrial fibrillation in women","volume":"31","author":"Conen","year":"2010","journal-title":"Eur Heart J"},{"issue":"4","key":"10.1016\/j.mayocp.2016.10.008_bib33","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.hrthm.2011.11.013","article-title":"Long-term effects of catheter ablation for lone atrial fibrillation: progressive atrial electroanatomic substrate remodeling despite successful ablation","volume":"9","author":"Teh","year":"2012","journal-title":"Heart Rhythm"},{"issue":"7","key":"10.1016\/j.mayocp.2016.10.008_bib34","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.jacc.2010.09.049","article-title":"Association of left atrial fibrosis detected by delayed-enhancement magnetic resonance imaging and the risk of stroke in patients with atrial fibrillation","volume":"57","author":"Daccarett","year":"2011","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.mayocp.2016.10.008_bib35","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.2147\/TCRM.S94955","article-title":"Association of epicardial adipose tissue thickness and inflammation parameters with CHA2DS2-VASASc score in patients with nonvalvular atrial fibrillation","volume":"11","author":"Akdag","year":"2015","journal-title":"Ther Clin Risk Manag"},{"issue":"10","key":"10.1016\/j.mayocp.2016.10.008_bib36","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1001\/jama.2015.10725","article-title":"Assessment of the CHA2DS2-VASc score in predicting ischemic stroke, thromboembolism, and death in patients with heart failure with and without atrial fibrillation","volume":"314","author":"Melgaard","year":"2015","journal-title":"JAMA"},{"issue":"8","key":"10.1016\/j.mayocp.2016.10.008_bib37","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.amjmed.2016.02.029","article-title":"Usefulness of CHADS2 and CHA2DS2-VASc scores in the prediction of new-onset atrial fibrillation: a population-based study","volume":"129","author":"Saliba","year":"2016","journal-title":"Am J Med"}],"container-title":["Mayo Clinic Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619616306292?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619616306292?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T23:23:48Z","timestamp":1536017028000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025619616306292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S0025619616306292"],"URL":"https:\/\/doi.org\/10.1016\/j.mayocp.2016.10.008","relation":{},"ISSN":["0025-6196"],"issn-type":[{"value":"0025-6196","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CHA2DS2-VASc Score: A Predictor of Thromboembolic Events and Mortality in Patients With an Implantable Monitoring Device Without Atrial Fibrillation","name":"articletitle","label":"Article Title"},{"value":"Mayo Clinic Proceedings","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mayocp.2016.10.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Mayo Foundation for Medical Education and Research","name":"copyright","label":"Copyright"}]}}