{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:42:37Z","timestamp":1785465757153,"version":"3.56.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Prothena Inc."},{"DOI":"10.13039\/100006436","name":"Celgene","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006436","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Takeda"},{"name":"Janssen"},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Alnylam"},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","mayoclinicproceedings.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mayo Clinic Proceedings"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.mayocp.2018.07.025","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T23:15:27Z","timestamp":1549062927000},"page":"447-454","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Utility of the Serum Free Light Chain Assay in the Diagnosis of Light Chain Amyloidosis in Patients With Heart Failure"],"prefix":"10.1016","volume":"94","author":[{"given":"Ian C.","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Dispenzieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan S.","family":"Jaffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle W.","family":"Klarich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Grogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.mayocp.2018.07.025_bib1","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1182\/blood.V79.7.1817.1817","article-title":"Incidence and natural history of primary systemic amyloidosis in Olmsted County,\u00a0Minnesota, 1950 through 1989","volume":"79","author":"Kyle","year":"1992","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.mayocp.2018.07.025_bib2","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/joim.12383","article-title":"Cardiac amyloidosis: where are we today?","volume":"278","author":"Patel","year":"2015","journal-title":"J\u00a0Intern Med"},{"issue":"2","key":"10.1016\/j.mayocp.2018.07.025_bib3","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/leu.2008.307","article-title":"International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders","volume":"23","author":"Dispenzieri","year":"2009","journal-title":"Leukemia"},{"issue":"12","key":"10.1016\/j.mayocp.2018.07.025_bib4","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1002\/ajh.23828","article-title":"Immunoglobulin light chain amyloidosis: 2014 update on diagnosis, prognosis, and treatment","volume":"89","author":"Gertz","year":"2014","journal-title":"Am J Hematol"},{"issue":"9","key":"10.1016\/j.mayocp.2018.07.025_bib5","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1200\/JCO.2011.38.5724","article-title":"Revised prognostic staging system for light chain amyloidosis incorporating cardiac biomarkers and serum free light chain measurements","volume":"30","author":"Kumar","year":"2012","journal-title":"J\u00a0Clin Oncol"},{"issue":"14","key":"10.1016\/j.mayocp.2018.07.025_bib6","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1136\/heartjnl-2016-310704","article-title":"Light-chain cardiac amyloidosis: strategies to promote early diagnosis and cardiac response","volume":"103","author":"Grogan","year":"2017","journal-title":"Heart"},{"issue":"11, suppl","key":"10.1016\/j.mayocp.2018.07.025_bib7","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/S0735-1097(17)34217-1","article-title":"Utility of routine serum free light chain assay for amyloidosis in patients with heart failure","volume":"69","author":"Chang","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.mayocp.2018.07.025_bib8","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/bjh.13156","article-title":"Guidelines on the diagnosis and investigation of AL amyloidosis","volume":"168","author":"Gillmore","year":"2015","journal-title":"Br J Haematol"},{"issue":"7","key":"10.1016\/j.mayocp.2018.07.025_bib9","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/j.1445-5994.2007.01368.x","article-title":"Diagnostic and prognostic utility of the serum free light chain assay in patients with AL amyloidosis","volume":"37","author":"Morris","year":"2007","journal-title":"Intern Med J"},{"issue":"8","key":"10.1016\/j.mayocp.2018.07.025_bib10","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1373\/clinchem.2009.126664","article-title":"Screening panels for detection of monoclonal gammopathies","volume":"55","author":"Katzmann","year":"2009","journal-title":"Clin Chem"},{"issue":"4","key":"10.1016\/j.mayocp.2018.07.025_bib11","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/clinchem\/47.4.673","article-title":"Highly sensitive, automated immunoassay for immunoglobulin free light chains in serum and urine","volume":"47","author":"Bradwell","year":"2001","journal-title":"Clin Chem"},{"issue":"2","key":"10.1016\/j.mayocp.2018.07.025_bib12","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1309\/LYWM47K2L8XYFFB3","article-title":"Quantitative analysis of serum free light chains: a new marker for the diagnostic evaluation of primary systemic amyloidosis","volume":"119","author":"Abraham","year":"2003","journal-title":"Am J Clin Pathol"},{"issue":"6","key":"10.1016\/j.mayocp.2018.07.025_bib13","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1515\/cclm-2015-0938","article-title":"Free light chain testing for the diagnosis, monitoring and prognostication of AL amyloidosis","volume":"54","author":"Mollee","year":"2016","journal-title":"Clin Chem Lab Med"},{"issue":"1","key":"10.1016\/j.mayocp.2018.07.025_bib14","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1177\/2040620712466863","article-title":"Serum free light-chain assay for the detection and monitoring of multiple myeloma and related conditions","volume":"4","author":"Tosi","year":"2013","journal-title":"Ther Adv Hematol"},{"issue":"3","key":"10.1016\/j.mayocp.2018.07.025_bib15","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1373\/clinchem.2008.117143","article-title":"Identification of amyloidogenic light chains requires the combination of serum-free light chain assay with immunofixation of serum and urine","volume":"55","author":"Palladini","year":"2009","journal-title":"Clin Chem"},{"issue":"1","key":"10.1016\/j.mayocp.2018.07.025_bib16","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1046\/j.1365-2141.2003.04433.x","article-title":"Outcome in systemic AL amyloidosis in relation to changes in concentration of circulating free immunoglobulin light chains following chemotherapy","volume":"122","author":"Lachmann","year":"2003","journal-title":"Br J Haematol"},{"issue":"8","key":"10.1016\/j.mayocp.2018.07.025_bib17","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1182\/blood-2005-07-2922","article-title":"Absolute values of immunoglobulin free light chains are prognostic in patients with primary systemic amyloidosis undergoing peripheral blood stem cell transplantation","volume":"107","author":"Dispenzieri","year":"2006","journal-title":"Blood"},{"issue":"25","key":"10.1016\/j.mayocp.2018.07.025_bib18","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1200\/JCO.2013.50.0892","article-title":"Increased serum free light chains precede the presentation of immunoglobulin light chain amyloidosis","volume":"32","author":"Weiss","year":"2014","journal-title":"J\u00a0Clin Oncol"},{"issue":"8","key":"10.1016\/j.mayocp.2018.07.025_bib19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11886-016-0752-7","article-title":"Recent advances in cardiovascular imaging relevant to the management of patients with suspected cardiac amyloidosis","volume":"18","author":"White","year":"2016","journal-title":"Curr Cardiol Rep"},{"issue":"3","key":"10.1016\/j.mayocp.2018.07.025_bib20","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1161\/CIRCIMAGING.113.001396","article-title":"How to image cardiac amyloidosis","volume":"7","author":"Falk","year":"2014","journal-title":"Circ Cardiovasc Imaging"},{"issue":"pt 5","key":"10.1016\/j.mayocp.2018.07.025_bib21","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1177\/0004563213518758","article-title":"Serum-free light-chain assay: clinical utility and limitations","volume":"51","author":"Bhole","year":"2014","journal-title":"Ann Clin Biochem"},{"issue":"11","key":"10.1016\/j.mayocp.2018.07.025_bib22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1471-2369-9-11","article-title":"Serum free light chain measurement aids the diagnosis of myeloma in patients with severe renal failure","volume":"9","author":"Hutchison","year":"2008","journal-title":"BMC Nephrol"}],"container-title":["Mayo Clinic Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619618306827?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619618306827?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T01:30:21Z","timestamp":1758418221000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025619618306827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S0025619618306827"],"URL":"https:\/\/doi.org\/10.1016\/j.mayocp.2018.07.025","relation":{},"ISSN":["0025-6196"],"issn-type":[{"value":"0025-6196","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Utility of the Serum Free Light Chain Assay in the Diagnosis of Light Chain Amyloidosis in Patients With Heart Failure","name":"articletitle","label":"Article Title"},{"value":"Mayo Clinic Proceedings","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mayocp.2018.07.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Mayo Foundation for Medical Education and Research","name":"copyright","label":"Copyright"}]}}