{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:06:04Z","timestamp":1789733164069,"version":"4.0.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007601","name":"European Union\u2019s Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MRI-GENIE","award":["NIH-NINDS R01NS086905"],"award-info":[{"award-number":["NIH-NINDS R01NS086905"]}]},{"name":"Cerovenus"},{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004326","name":"Bayer AG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bristol-Myers Squibb Company"},{"name":"BrainsGate"},{"DOI":"10.13039\/100004326","name":"Bayer AG","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Pfizer Inc"},{"DOI":"10.13039\/100010891","name":"Portola Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010891","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Boehringer Ingelheim International GmbH"},{"name":"Genentech, Inc"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","mayoclinicproceedings.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mayo Clinic Proceedings"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.mayocp.2020.01.027","type":"journal-article","created":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:36:23Z","timestamp":1588293383000},"page":"955-965","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Brain Volume: An Important Determinant of Functional Outcome After Acute Ischemic Stroke"],"prefix":"10.1016","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9561-0239","authenticated-orcid":false,"given":"Markus D.","family":"Schirmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen L.","family":"Donahue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco J.","family":"Nardin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian V.","family":"Dalca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Katrin","family":"Giese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Etherton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.T.","family":"Mocking","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elissa C.","family":"McIntosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Cole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Holmegaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Jood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Jimenez-Conde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Kittner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Lemmens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4475-8142","authenticated-orcid":false,"given":"James F.","family":"Meschia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Rosand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Roquer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Rundek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph L.","family":"Sacco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhold","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Slowik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara M.","family":"Stanne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achala","family":"Vagal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Wasselius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Bevan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Heitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Ling","family":"Phuah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Strbian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Turgut","family":"Tatlisumak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R.","family":"Levi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Attia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick F.","family":"McArdle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradford B.","family":"Worrall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ona","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Jern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Lindgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Maguire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Thijs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia S.","family":"Rost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9913","key":"10.1016\/j.mayocp.2020.01.027_bib1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0140-6736(13)61953-4","article-title":"Global and regional burden of stroke during 1990-2010: findings from the Global Burden of Disease Study 2010 [published correction appears in Lancet. 2014;383(9913):218]","volume":"383","author":"Feigin","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.mayocp.2020.01.027_bib2","series-title":"Neurological Disorders: Public Health Challenges","year":"2006"},{"issue":"12","key":"10.1016\/j.mayocp.2020.01.027_bib3","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1161\/01.STR.0000035261.28528.C8","article-title":"Addressing the heterogeneity of the ischemic stroke phenotype in human genetics research","volume":"33","author":"Meschia","year":"2002","journal-title":"Stroke"},{"issue":"8","key":"10.1016\/j.mayocp.2020.01.027_bib4","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nrn896","article-title":"Neuroscience of attention-deficit\/hyperactivity disorder: the search for endophenotypes","volume":"3","author":"Castellanos","year":"2002","journal-title":"Nat Rev Neurosci"},{"issue":"7","key":"10.1016\/j.mayocp.2020.01.027_bib5","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1001\/archneur.60.7.989","article-title":"A\u00a0longitudinal study of brain volume changes in normal aging using serial registered magnetic resonance imaging","volume":"60","author":"Scahill","year":"2003","journal-title":"Arch Neurol"},{"key":"10.1016\/j.mayocp.2020.01.027_bib6","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1192\/bjp.188.6.510","article-title":"Brain volume in first-episode schizophrenia: systematic review and meta-analysis of magnetic resonance imaging studies","volume":"188","author":"Steen","year":"2006","journal-title":"Br J Psychiatry"},{"issue":"1","key":"10.1016\/j.mayocp.2020.01.027_bib7","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1001\/archneurol.2007.27","article-title":"Brain volume decline in aging: evidence for a relation between socioeconomic status, preclinical Alzheimer disease, and reserve","volume":"65","author":"Fotenos","year":"2008","journal-title":"Arch Neurol"},{"issue":"10","key":"10.1016\/j.mayocp.2020.01.027_bib8","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1002\/gps.1205","article-title":"Intracranial volume in mild cognitive impairment, Alzheimer\u2019s disease and vascular dementia: evidence for brain reserve?","volume":"19","author":"Wolf","year":"2004","journal-title":"Int J Geriatr Psychiatry"},{"issue":"1","key":"10.1016\/j.mayocp.2020.01.027_bib9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.09.003","article-title":"Effective reserve: a latent variable to improve outcome prediction in stroke","volume":"28","author":"Schirmer","year":"2019","journal-title":"J\u00a0Stroke Cerebrovasc Dis"},{"issue":"3","key":"10.1016\/j.mayocp.2020.01.027_bib10","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0896-6273(02)00569-X","article-title":"Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain","volume":"33","author":"Fischl","year":"2002","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.mayocp.2020.01.027_bib11","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/hbm.10062","article-title":"Fast robust automated brain extraction","volume":"17","author":"Smith","year":"2002","journal-title":"Hum Brain Mapp"},{"issue":"9","key":"10.1016\/j.mayocp.2020.01.027_bib12","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1109\/TMI.2011.2138152","article-title":"Robust brain extraction across datasets and comparison with publicly available methods","volume":"30","author":"Iglesias","year":"2011","journal-title":"IEEE Trans Med Imaging"},{"key":"10.1016\/j.mayocp.2020.01.027_bib13","doi-asserted-by":"crossref","first-page":"101884","DOI":"10.1016\/j.nicl.2019.101884","article-title":"White matter hyperintensity quantification in large-scale clinical acute ischemic stroke cohorts \u2013 the MRI-GENIE study","volume":"23","author":"Schirmer","year":"2019","journal-title":"Neuroimage Clin"},{"issue":"5","key":"10.1016\/j.mayocp.2020.01.027_bib14","doi-asserted-by":"crossref","first-page":"e180","DOI":"10.1212\/NXG.0000000000000180","article-title":"Design and rationale for examining neuroimaging genetics in ischemic stroke: the MRI-GENIE study","volume":"3","author":"Giese","year":"2017","journal-title":"Neurol Genet"},{"issue":"16, suppl","key":"10.1016\/j.mayocp.2020.01.027_bib15","first-page":"S19","article-title":"Fully automated pipeline for white matter hyperintensity segmentation using clinical scans in patients with acute ischemic stroke [abstract]","volume":"88","author":"Schirmer","year":"2017","journal-title":"Neurology"},{"issue":"14","key":"10.1016\/j.mayocp.2020.01.027_bib16","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1212\/WNL.0b013e3181f612ce","article-title":"The Causative Classification of Stroke system: an international reliability and optimization study","volume":"75","author":"Arsava","year":"2010","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.mayocp.2020.01.027_bib17","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1177\/2396987317704547","article-title":"GISCOME \u2013 Genetics of Ischaemic Stroke Functional Outcome network: a protocol for an international multicentre genetic association study","volume":"2","author":"Maguire","year":"2017","journal-title":"Eur Stroke J"},{"key":"10.1016\/j.mayocp.2020.01.027_bib18","first-page":"9290","article-title":"Anatomical priors in convolutional networks for unsupervised biomedical segmentation","author":"Dalca","year":"2018","journal-title":"Proc IEEE Comput Soc Conf Comput Vis Pattern Recognit"},{"key":"10.1016\/j.mayocp.2020.01.027_bib19","unstructured":"Zeiler MD. ADADELTA: an adaptive learning rate method. arXiv:12125701."},{"key":"10.1016\/j.mayocp.2020.01.027_bib20","doi-asserted-by":"crossref","first-page":"e453","DOI":"10.7717\/peerj.453","article-title":"scikit-image: image processing in Python","volume":"2","author":"van der Walt","year":"2014","journal-title":"PeerJ"},{"key":"10.1016\/j.mayocp.2020.01.027_bib21","series-title":"R: A language and environment for statistical computing","year":"2018"},{"issue":"9","key":"10.1016\/j.mayocp.2020.01.027_bib22","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1016\/j.neurobiolaging.2009.10.013","article-title":"White matter hyperintensities and cognition: testing the reserve hypothesis","volume":"32","author":"Brickman","year":"2011","journal-title":"Neurobiol Aging"},{"issue":"6","key":"10.1016\/j.mayocp.2020.01.027_bib23","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1093\/cercor\/11.6.490","article-title":"Normal sexual dimorphism of the adult human brain assessed by in\u00a0vivo magnetic resonance imaging","volume":"11","author":"Goldstein","year":"2001","journal-title":"Cereb Cortex"},{"issue":"8","key":"10.1016\/j.mayocp.2020.01.027_bib24","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1097\/HJH.0b013e32836184b5","article-title":"Blood pressure levels and brain volume reduction: a systematic review and meta-analysis [published correction appears in J Hypertens. 2013;31(10):2106]","volume":"31","author":"Beauchet","year":"2013","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.mayocp.2020.01.027_bib25","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.neuroimage.2015.05.077","article-title":"Alzheimer's Disease Neuroimaging Initiative. Diurnal fluctuations in brain volume: statistical analyses of MRI from large populations","volume":"118","author":"Nakamura","year":"2015","journal-title":"Neuroimage"}],"container-title":["Mayo Clinic Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619620300859?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619620300859?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T01:32:07Z","timestamp":1758418327000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025619620300859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S0025619620300859"],"URL":"https:\/\/doi.org\/10.1016\/j.mayocp.2020.01.027","relation":{},"ISSN":["0025-6196"],"issn-type":[{"value":"0025-6196","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brain Volume: An Important Determinant of Functional Outcome After Acute Ischemic Stroke","name":"articletitle","label":"Article Title"},{"value":"Mayo Clinic Proceedings","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mayocp.2020.01.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Mayo Foundation for Medical Education and Research","name":"copyright","label":"Copyright"}]}}