{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:36:02Z","timestamp":1792784162560,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Clinical Medicine Center of Digestive Diseases of Traditional Chinese Medicine in Jiangsu","award":["BL2014100-4"],"award-info":[{"award-number":["BL2014100-4"]}]},{"name":"Leading Talents of Traditional Chinese Medicine","award":["SLJ0206"],"award-info":[{"award-number":["SLJ0206"]}]},{"name":"Peak Academic Talents in Jiangsu Hospital of Traditional Chinese Medicine","award":["y2018rc05"],"award-info":[{"award-number":["y2018rc05"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","mayoclinicproceedings.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mayo Clinic Proceedings"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.mayocp.2020.01.042","type":"journal-article","created":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T07:33:09Z","timestamp":1590996789000},"page":"1671-1683","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":95,"title":["Effect of Acupuncture in Patients With Irritable Bowel Syndrome: A Randomized Controlled Trial"],"prefix":"10.1016","volume":"95","author":[{"given":"Lixia","family":"Pei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyu","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanye","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangdong","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoliang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjie","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3398-0346","authenticated-orcid":false,"given":"Jianhua","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mayocp.2020.01.042_bib1","doi-asserted-by":"crossref","first-page":"16014","DOI":"10.1038\/nrdp.2016.14","article-title":"Irritable bowel syndrome","volume":"2","author":"Enck","year":"2016","journal-title":"Nat Rev Dis Primers"},{"issue":"6","key":"10.1016\/j.mayocp.2020.01.042_bib2","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1136\/gutjnl-2015-311240","article-title":"The global prevalence of IBS in adults remains elusive due to the heterogeneity of studies: a Rome Foundation working team literature review","volume":"66","author":"Sperber","year":"2017","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.mayocp.2020.01.042_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/nmo.12897","article-title":"Prevalence and risk factors for functional bowel disorders in South China: a population based study using the Rome III criteria","volume":"29","author":"Long","year":"2017","journal-title":"Neurogastroenterol Motil"},{"issue":"5","key":"10.1016\/j.mayocp.2020.01.042_bib4","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1046\/j.1365-2036.2003.01456.x","article-title":"The prevalence, patterns and impact of irritable bowel syndrome: an international survey of 40,000 subjects","volume":"17","author":"Hungin","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"issue":"4","key":"10.1016\/j.mayocp.2020.01.042_bib5","first-page":"259","article-title":"Guidelines on the management of irritable bowel syndrome: in memory of Professor Witold Bartnik","volume":"13","author":"Pietrzak","year":"2018","journal-title":"Prz Gastroenterol"},{"issue":"1","key":"10.1016\/j.mayocp.2020.01.042_bib6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/jgh.13987","article-title":"Irritable bowel syndrome in Asia: pathogenesis, natural history, epidemiology, and management","volume":"33","author":"Gwee","year":"2018","journal-title":"J\u00a0Gastroenterol Hepatol"},{"key":"10.1016\/j.mayocp.2020.01.042_bib7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2147\/CEG.S46291","article-title":"Long-term efficacy and safety of otilonium bromide in the management of irritable bowel syndrome: a literature review","volume":"7","author":"Triantafillidis","year":"2014","journal-title":"Clin Exp Gastroenterol"},{"issue":"10","key":"10.1016\/j.mayocp.2020.01.042_bib8","first-page":"612","article-title":"Perceptions of the public healthcare system from private-care patients with irritable bowel syndrome with constipation in Spain","volume":"110","author":"Mira","year":"2018","journal-title":"Rev Esp Enferm Dig"},{"issue":"10","key":"10.1016\/j.mayocp.2020.01.042_bib9","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1007\/s12272-018-1068-5","article-title":"Recent advances in pharmacological research on the management of irritable bowel syndrome","volume":"41","author":"Nam","year":"2018","journal-title":"Arch Pharm Res"},{"issue":"5","key":"10.1016\/j.mayocp.2020.01.042_bib10","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1136\/gut.2005.078089","article-title":"Complementary and alternative medicine for functional gastrointestinal disorders","volume":"55","author":"Tillisch","year":"2006","journal-title":"Gut"},{"issue":"27","key":"10.1016\/j.mayocp.2020.01.042_bib11","doi-asserted-by":"crossref","first-page":"8304","DOI":"10.3748\/wjg.v21.i27.8304","article-title":"Acupuncture and regulation of gastrointestinal function","volume":"21","author":"Li","year":"2015","journal-title":"World J Gastroenterol"},{"issue":"6","key":"10.1016\/j.mayocp.2020.01.042_bib12","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/ajg.2012.66","article-title":"Acupuncture for irritable bowel syndrome: systematic review and meta-analysis","volume":"107","author":"Manheimer","year":"2012","journal-title":"Am J Gastroenterol"},{"issue":"8","key":"10.1016\/j.mayocp.2020.01.042_bib13","first-page":"679","article-title":"[Comparative observation on therapeutic effects between acupuncture and western medication for diarrhea-predominant irritable bowel syndrome][Chinese]","volume":"32","author":"Li","year":"2012","journal-title":"Zhongguo Zhen Jiu"},{"issue":"11","key":"10.1016\/j.mayocp.2020.01.042_bib14","first-page":"1095","article-title":"[Constipation predominant irritable bowel syndrome treated with acupuncture for regulating the mind and strengthening the spleen: a randomized controlled trial] [Chinese]","volume":"35","author":"Pei","year":"2015","journal-title":"Zhongguo Zhen Jiu"},{"issue":"1","key":"10.1016\/j.mayocp.2020.01.042_bib15","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1186\/s13063-018-2922-y","article-title":"Acupuncture for irritable bowel syndrome: study protocol for a multicenter randomized controlled trial","volume":"19","author":"Pei","year":"2018","journal-title":"Trials"},{"issue":"3","key":"10.1016\/j.mayocp.2020.01.042_bib16","first-page":"237","article-title":"Rome III: new standard for functional gastrointestinal disorders","volume":"15","author":"Drossman","year":"2006","journal-title":"J\u00a0Gastrointestin Liver Dis"},{"issue":"10","key":"10.1016\/j.mayocp.2020.01.042_bib17","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1007\/s11655-011-0875-z","article-title":"Clinical evaluation of Soothing Gan and invigorating Pi acupuncture treatment on diarrhea-predominant irritable bowel syndrome","volume":"17","author":"Sun","year":"2011","journal-title":"Chin J Integr Med"},{"issue":"5","key":"10.1016\/j.mayocp.2020.01.042_bib18","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1053\/j.gastro.2014.09.001","article-title":"American Gastroenterological Association Institute guideline on the pharmacological management of irritable bowel syndrome","volume":"147","author":"Weinberg","year":"2014","journal-title":"Gastroenterology"},{"issue":"9","key":"10.1016\/j.mayocp.2020.01.042_bib19","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1097\/MCG.0000000000000653","article-title":"Review Team. World Gastroenterology Organisation Global Guidelines Irritable Bowel Syndrome: a global perspective update September 2015","volume":"50","author":"Quigley","year":"2016","journal-title":"J\u00a0Clin Gastroenterol"},{"issue":"2","key":"10.1016\/j.mayocp.2020.01.042_bib20","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1046\/j.1365-2036.1997.142318000.x","article-title":"The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress","volume":"11","author":"Francis","year":"1997","journal-title":"Aliment Pharmacol Ther"},{"issue":"2","key":"10.1016\/j.mayocp.2020.01.042_bib21","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1023\/A:1018831127942","article-title":"Quality of life in persons with irritable bowel syndrome: development and validation of a new measure","volume":"43","author":"Patrick","year":"1998","journal-title":"Dig Dis Sci"},{"issue":"4","key":"10.1016\/j.mayocp.2020.01.042_bib22","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1111\/j.1572-0241.2000.01941.x","article-title":"Further validation of the IBS-QOL: a disease-specific quality-of-life questionnaire","volume":"95","author":"Drossman","year":"2000","journal-title":"Am J Gastroenterol"},{"issue":"7","key":"10.1016\/j.mayocp.2020.01.042_bib23","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1111\/j.1572-0241.2007.01283.x","article-title":"Characterization of health related quality of life (HRQOL) for patients with functional bowel disorder (FBD) and its response to treatment","volume":"102","author":"Drossman","year":"2007","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"10.1016\/j.mayocp.2020.01.042_bib24","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1136\/aim.26.1.8","article-title":"Acupuncture for irritable bowel syndrome an exploratory randomised controlled trial","volume":"26","author":"Reynolds","year":"2008","journal-title":"Acupunct Med"},{"key":"10.1016\/j.mayocp.2020.01.042_bib25","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/1471-230X-12-150","article-title":"Acupuncture for irritable bowel syndrome: primary care based pragmatic randomised controlled trial","volume":"12","author":"MacPherson","year":"2012","journal-title":"BMC Gastroenterol"},{"issue":"6","key":"10.1016\/j.mayocp.2020.01.042_bib26","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1038\/ajg.2009.156","article-title":"A\u00a0treatment trial of acupuncture in IBS patients","volume":"104","author":"Lembo","year":"2009","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"10.1016\/j.mayocp.2020.01.042_bib27","first-page":"111","article-title":"[The clinical research of relationship between radicals and irritable bowel syndrome and the effect of acupuncture][Chinese]","volume":"27","author":"Xue","year":"2009","journal-title":"Chinese Archives of Traditional Chinese Medicine"},{"issue":"5","key":"10.1016\/j.mayocp.2020.01.042_bib28","first-page":"72","article-title":"Clinical observation of electroacupuncture on diarrhea-predominant irritable bowel syndrome","volume":"42","author":"Shi","year":"2010","journal-title":"J\u00a0New Chinese Med"},{"issue":"11","key":"10.1016\/j.mayocp.2020.01.042_bib29","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s40261-014-0233-y","volume":"34","author":"Hou","year":"2014","journal-title":"Clin Drug Investig"},{"issue":"1","key":"10.1016\/j.mayocp.2020.01.042_bib30","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1136\/acupmed-2015-010854","article-title":"Acupuncture for irritable bowel syndrome: 2-year follow-up of a randomised controlled trial","volume":"35","author":"MacPherson","year":"2017","journal-title":"Acupunct Med"},{"issue":"3","key":"10.1016\/j.mayocp.2020.01.042_bib31","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s11302-015-9447-6","article-title":"Effect of electroacupuncture on P2X3 receptor regulation in the peripheral and central nervous systems of rats with visceral pain caused by irritable bowel syndrome","volume":"11","author":"Weng","year":"2015","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.mayocp.2020.01.042_bib32","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1186\/s12906-015-0863-5","article-title":"Electro-acupuncture decreases 5-HT, CGRP and increases NPY in the brain-gut axis in two rat models of diarrhea-predominant irritable bowel syndrome(D-IBS)","volume":"15","author":"Sun","year":"2015","journal-title":"BMC Complement Altern Med"},{"issue":"26","key":"10.1016\/j.mayocp.2020.01.042_bib33","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.3748\/wjg.v11.i26.4040","article-title":"Acupuncture for irritable bowel syndrome: a blinded placebo-controlled trial","volume":"11","author":"Forbes","year":"2005","journal-title":"World J Gastroenterol"},{"issue":"5A","key":"10.1016\/j.mayocp.2020.01.042_bib34","doi-asserted-by":"crossref","first-page":"91S","DOI":"10.1016\/S0002-9343(99)00086-8","article-title":"Problems and challenges in the design of irritable bowel syndrome clinical trials: experience from published trials","volume":"107","author":"Spiller","year":"1999","journal-title":"Am J Med"},{"key":"10.1016\/j.mayocp.2020.01.042_bib35","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.eujim.2016.12.006","article-title":"Patients\u2019 attitudes to the perioperative application of acupuncture: a Chinese survey","volume":"9","author":"Wang","year":"2017","journal-title":"Eur J Integr Med"},{"issue":"5","key":"10.1016\/j.mayocp.2020.01.042_bib36","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1136\/acupmed-2016-011191","article-title":"Knowledge of and willingness to try acupuncture for postoperative nausea and vomiting: an Australian survey of surgical patients","volume":"35","author":"Weeks","year":"2017","journal-title":"Acupunct Med"}],"container-title":["Mayo Clinic Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619620301518?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619620301518?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T01:34:10Z","timestamp":1758418450000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025619620301518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S0025619620301518"],"URL":"https:\/\/doi.org\/10.1016\/j.mayocp.2020.01.042","relation":{},"ISSN":["0025-6196"],"issn-type":[{"value":"0025-6196","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Acupuncture in Patients With Irritable Bowel Syndrome: A Randomized Controlled Trial","name":"articletitle","label":"Article Title"},{"value":"Mayo Clinic Proceedings","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mayocp.2020.01.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}