{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T17:06:32Z","timestamp":1793207192329,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","mayoclinicproceedings.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mayo Clinic Proceedings"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.mayocp.2020.05.030","type":"journal-article","created":{"date-parts":[[2020,6,6]],"date-time":"2020-06-06T05:04:40Z","timestamp":1591419880000},"page":"1621-1631","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":384,"title":["Smell and Taste Dysfunction in Patients With COVID-19: A Systematic Review and Meta-analysis"],"prefix":"10.1016","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8866-3524","authenticated-orcid":false,"given":"Akosua Adom","family":"Agyeman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken L.","family":"Chin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia B.","family":"Landersdorfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Liew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6643-3269","authenticated-orcid":false,"given":"Richard","family":"Ofori-Asenso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"18","key":"10.1016\/j.mayocp.2020.05.030_bib2","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical characteristics of coronavirus disease 2019 in China","volume":"382","author":"Guan","year":"2020","journal-title":"N\u00a0Engl J Med"},{"issue":"10223","key":"10.1016\/j.mayocp.2020.05.030_bib3","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0140-6736(20)30211-7","article-title":"Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study","volume":"395","author":"Chen","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.mayocp.2020.05.030_bib4","author":"Lechien"},{"issue":"3","key":"10.1016\/j.mayocp.2020.05.030_bib5","doi-asserted-by":"crossref","first-page":"295","DOI":"10.4193\/Rhin20.116","article-title":"Presentation of new onset anosmia during the COVID-19 pandemic","volume":"58","author":"Hopkins","year":"2020","journal-title":"Rhinology"},{"key":"10.1016\/j.mayocp.2020.05.030_bib6","author":"Bagheri"},{"key":"10.1016\/j.mayocp.2020.05.030_bib7","author":"Walker"},{"key":"10.1016\/j.mayocp.2020.05.030_bib10","doi-asserted-by":"crossref","first-page":"b2535","DOI":"10.1136\/bmj.b2535","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"339","author":"Moher","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.mayocp.2020.05.030_bib11","author":"Higgins"},{"issue":"2","key":"10.1016\/j.mayocp.2020.05.030_bib12","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1136\/bmjebm-2017-110853","article-title":"Methodological quality and synthesis of case series and case reports","volume":"23","author":"Murad","year":"2018","journal-title":"BMJ Evid Based Med"},{"issue":"1","key":"10.1016\/j.mayocp.2020.05.030_bib13","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/2049-3258-72-39","article-title":"Metaprop: a Stata command to perform meta-analysis of binomial data","volume":"72","author":"Nyaga","year":"2014","journal-title":"Arch Public Health"},{"issue":"4","key":"10.1016\/j.mayocp.2020.05.030_bib14","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1177\/1536867X0800800403","article-title":"Meta-regression in Stata","volume":"8","author":"Harbord","year":"2008","journal-title":"Stata J"},{"issue":"16","key":"10.1016\/j.mayocp.2020.05.030_bib15","doi-asserted-by":"crossref","first-page":"2000508","DOI":"10.2807\/1560-7917.ES.2020.25.16.2000508","article-title":"Strong associations and moderate predictive value of early symptoms for SARS-CoV-2 test positivity among healthcare workers, the Netherlands, March 2020","volume":"25","author":"Tostmann","year":"2020","journal-title":"Euro Surveill"},{"key":"10.1016\/j.mayocp.2020.05.030_bib16","author":"Giacomelli"},{"key":"10.1016\/j.mayocp.2020.05.030_bib17","author":"B\u00e9n\u00e9zit"},{"key":"10.1016\/j.mayocp.2020.05.030_bib18","author":"Klopfenstein"},{"key":"10.1016\/j.mayocp.2020.05.030_bib19","author":"Tomlins"},{"key":"10.1016\/j.mayocp.2020.05.030_bib20","author":"Luers"},{"key":"10.1016\/j.mayocp.2020.05.030_bib21","author":"Yan"},{"key":"10.1016\/j.mayocp.2020.05.030_bib22","author":"Chico-Garc\u00eda"},{"key":"10.1016\/j.mayocp.2020.05.030_bib23","author":"Moein"},{"key":"10.1016\/j.mayocp.2020.05.030_bib24","author":"Mao"},{"key":"10.1016\/j.mayocp.2020.05.030_bib25","author":"Levinson"},{"key":"10.1016\/j.mayocp.2020.05.030_bib26","author":"Fontanet"},{"issue":"6","key":"10.1016\/j.mayocp.2020.05.030_bib27","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1002\/hed.26204","article-title":"Objective evaluation of anosmia and ageusia in COVID-19 patients: single-center experience on 72 cases","volume":"42","author":"Vaira","year":"2020","journal-title":"Head Neck"},{"key":"10.1016\/j.mayocp.2020.05.030_bib28","author":"Lechien"},{"issue":"2","key":"10.1016\/j.mayocp.2020.05.030_bib29","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1515\/dx-2020-0046","article-title":"Clinical features, laboratory characteristics, and outcomes of patients hospitalized with coronavirus disease 2019 (COVID-19): early report from the United States","volume":"7","author":"Aggarwal","year":"2020","journal-title":"Diagnosis (Berl)"},{"issue":"18","key":"10.1016\/j.mayocp.2020.05.030_bib30","doi-asserted-by":"crossref","first-page":"e174","DOI":"10.3346\/jkms.2020.35.e174","article-title":"Prevalence and duration of acute loss of smell or taste in COVID-19 patients","volume":"35","author":"Lee","year":"2020","journal-title":"J\u00a0Korean Med Sci"},{"key":"10.1016\/j.mayocp.2020.05.030_bib31","author":"Hornuss"},{"key":"10.1016\/j.mayocp.2020.05.030_bib32","author":"Just"},{"key":"10.1016\/j.mayocp.2020.05.030_bib33","author":"Lechien"},{"key":"10.1016\/j.mayocp.2020.05.030_bib34","author":"Borobia"},{"key":"10.1016\/j.mayocp.2020.05.030_bib35","author":"Cavagna"},{"key":"10.1016\/j.mayocp.2020.05.030_bib36","author":"H\u00e4rter"},{"key":"10.1016\/j.mayocp.2020.05.030_bib37","author":"Allenbach"},{"key":"10.1016\/j.mayocp.2020.05.030_bib38","author":"Vaira"},{"key":"10.1016\/j.mayocp.2020.05.030_bib39","first-page":"125","article-title":"Olfactory disorders following upper respiratory tract infections","volume":"63","author":"Welge-L\u00fcssen","year":"2006","journal-title":"Adv Otorhinolaryngol"},{"issue":"7","key":"10.1016\/j.mayocp.2020.05.030_bib40","first-page":"3440","article-title":"Defining the burden of olfactory dysfunction in COVID-19 patients","volume":"24","author":"Ralli","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"5","key":"10.1016\/j.mayocp.2020.05.030_bib41","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1093\/infdis\/jiv499","article-title":"Middle East respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human dipeptidyl peptidase 4","volume":"213","author":"Li","year":"2016","journal-title":"J\u00a0Infect Dis"},{"issue":"2","key":"10.1016\/j.mayocp.2020.05.030_bib42","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1177\/10454411000110020501","article-title":"Role of saliva in the maintenance of taste sensitivity","volume":"11","author":"Matsuo","year":"2000","journal-title":"Crit Rev Oral Biol Med"},{"issue":"8","key":"10.1016\/j.mayocp.2020.05.030_bib43","doi-asserted-by":"crossref","first-page":"4025","DOI":"10.1128\/JVI.02292-10","article-title":"Epithelial cells lining salivary gland ducts are early target cells of severe acute respiratory syndrome coronavirus infection in the upper respiratory tracts of rhesus Macaques","volume":"85","author":"Liu","year":"2011","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.mayocp.2020.05.030_bib44","author":"Wee"},{"key":"10.1016\/j.mayocp.2020.05.030_bib45","author":"Kaye"},{"issue":"6","key":"10.1016\/j.mayocp.2020.05.030_bib46","first-page":"e14","article-title":"Clinical features of COVID-19 in elderly patients: a comparison with young and middle-aged patients","volume":"80","author":"Liu","year":"2020","journal-title":"J\u00a0Infect"},{"key":"10.1016\/j.mayocp.2020.05.030_bib47","author":"Lao"},{"key":"10.1016\/j.mayocp.2020.05.030_bib48","author":"Tong"},{"issue":"6","key":"10.1016\/j.mayocp.2020.05.030_bib49","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/chemse\/24.6.627","article-title":"Confusing tastes and smells: how odours can influence the perception of sweet and sour tastes","volume":"24","author":"Stevenson","year":"1999","journal-title":"Chem Senses"},{"issue":"3","key":"10.1016\/j.mayocp.2020.05.030_bib50","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1027\/2151-2604\/a000251","article-title":"Avoiding methodological biases in meta-analysis: use of online versus offline individual participant data (IPD) in educational psychology","volume":"224","author":"Kaufmann","year":"2016","journal-title":"Zeitschrift f\u00fcr Psychologie"}],"container-title":["Mayo Clinic Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619620305462?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619620305462?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T01:33:17Z","timestamp":1758418397000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025619620305462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":47,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S0025619620305462"],"URL":"https:\/\/doi.org\/10.1016\/j.mayocp.2020.05.030","relation":{},"ISSN":["0025-6196"],"issn-type":[{"value":"0025-6196","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Smell and Taste Dysfunction in Patients With COVID-19: A Systematic Review and Meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Mayo Clinic Proceedings","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mayocp.2020.05.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Mayo Foundation for Medical Education and Research","name":"copyright","label":"Copyright"}]}}