{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T07:49:12Z","timestamp":1758440952127,"version":"3.44.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","mayoclinicproceedings.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mayo Clinic Proceedings"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.mayocp.2020.12.018","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T09:55:10Z","timestamp":1620035710000},"page":"1356-1362","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Management of the Patient With Patent Foramen Ovale in 2021: A Spectrum of Cases"],"prefix":"10.1016","volume":"96","author":[{"given":"Guy S.","family":"Reeder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathaniel W.","family":"Taggart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naser M.","family":"Ammash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.mayocp.2020.12.018_bib1","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.jacc.2005.10.044","article-title":"Patent foramen ovale: Innocent or guilty? Evidence from a prospective population-based study","volume":"47","author":"Meissner","year":"2006","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"5","key":"10.1016\/j.mayocp.2020.12.018_bib2","doi-asserted-by":"crossref","first-page":"602","DOI":"10.4065\/81.5.602","article-title":"Population-based study of the relationship between patent foramen ovale and cerebrovascular ischemic events","volume":"81","author":"Petty","year":"2006","journal-title":"Mayo Clin Proc"},{"issue":"7","key":"10.1016\/j.mayocp.2020.12.018_bib3","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1001\/jamaneurol.2020.0458","article-title":"Proposal for updated nomenclature and classification of potential causative mechanism in patent foramen ovale\u2013associated stroke","volume":"77","author":"Elgendy","year":"2020","journal-title":"JAMA Neurol"},{"issue":"20","key":"10.1016\/j.mayocp.2020.12.018_bib4","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1016\/j.jacc.2018.02.046","article-title":"Cryptogenic stroke and high-risk patent foramen ovale: The DEFENSE-PFO Trial","volume":"71","author":"Lee","year":"2018","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"11","key":"10.1016\/j.mayocp.2020.12.018_bib5","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1056\/NEJMoa1705915","article-title":"Patent foramen ovale closure or anticoagulation vs. antiplatelets after stroke","volume":"377","author":"Mas","year":"2017","journal-title":"N\u00a0Engl J Med"},{"issue":"11","key":"10.1016\/j.mayocp.2020.12.018_bib6","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1056\/NEJMoa1610057","article-title":"Long-term outcomes of patent foramen ovale closure or medical therapy after stroke","volume":"377","author":"Saver","year":"2017","journal-title":"N\u00a0Engl J Med"},{"issue":"11","key":"10.1016\/j.mayocp.2020.12.018_bib7","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1056\/NEJMoa1707404","article-title":"Patent foramen ovale closure or antiplatelet therapy for cryptogenic stroke","volume":"377","author":"S\u00f8ndergaard","year":"2017","journal-title":"N\u00a0Engl J Med"},{"issue":"7","key":"10.1016\/j.mayocp.2020.12.018_bib8","doi-asserted-by":"crossref","first-page":"e023761","DOI":"10.1136\/bmjopen-2018-023761","article-title":"Patent foramen ovale closure, antiplatelet therapy or anticoagulation in patients with patent foramen ovale and cryptogenic stroke: A systematic review and network meta-analysis incorporating complementary external evidence","volume":"8","author":"Mir","year":"2018","journal-title":"BMJ Open"},{"issue":"20","key":"10.1016\/j.mayocp.2020.12.018_bib9","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1212\/WNL.0000000000009443","article-title":"Practice advisory update summary: Patent foramen ovale and secondary stroke prevention","volume":"94","author":"Mess\u00e9","year":"2020","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.mayocp.2020.12.018_bib10","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.amjcard.2005.05.061","article-title":"Comparison of transthoracic versus transesophageal echocardiography for detection of right-to-left atrial shunting using agitated saline contrast","volume":"96","author":"Thanigaraj","year":"2005","journal-title":"Am J Cardiol"},{"issue":"18","key":"10.1016\/j.mayocp.2020.12.018_bib11","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1016\/j.jcin.2016.08.002","article-title":"Platypnea-orthodeoxia syndrome: An overlooked cause of hypoxemia","volume":"9","author":"Tobis","year":"2016","journal-title":"JACC Cardiovasc Interv"},{"issue":"8","key":"10.1016\/j.mayocp.2020.12.018_bib12","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.amjcard.2013.06.022","article-title":"Effectiveness of percutaneous closure of patent foramen ovale for hypoxemia","volume":"112","author":"Fenster","year":"2013","journal-title":"Am J Cardiol"},{"issue":"1","key":"10.1016\/j.mayocp.2020.12.018_bib13","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/CRD.0000000000000205","article-title":"Patent foramen ovale and hypoxemia","volume":"27","author":"Mojadidi","year":"2019","journal-title":"Cardiol Rev"},{"issue":"13","key":"10.1016\/j.mayocp.2020.12.018_bib14","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1161\/CIRCULATIONAHA.113.003540","article-title":"Stroke or transient ischemic attack in patients with transvenous pacemaker or defibrillator and echocardiographically detected patent foramen ovale","volume":"128","author":"DeSimone Christopher","year":"2013","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.mayocp.2020.12.018_bib15","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.jcin.2014.04.025","article-title":"Risk of Cerebrovascular events in patients with patent foramen ovale and intracardiac devices","volume":"7","author":"Poddar","year":"2014","journal-title":"JACC Cardiovasc Interv"},{"issue":"1","key":"10.1016\/j.mayocp.2020.12.018_bib16","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/2046-7648-2-10","article-title":"Patent foramen ovale and scuba diving: A practical guide for physicians on when to refer for screening","volume":"2","author":"Sykes","year":"2013","journal-title":"Extrem Physiol Med"},{"issue":"9","key":"10.1016\/j.mayocp.2020.12.018_bib17","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.jacc.2020.06.072","article-title":"Patent foramen ovale closure is effective in divers: Long-term results from the DIVE-PFO Registry","volume":"76","author":"Hon\u011bk","year":"2020","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"11","key":"10.1016\/j.mayocp.2020.12.018_bib18","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1161\/CIRCULATIONAHA.107.727271","article-title":"Migraine intervention with STARFlex Technology (MIST) Trial","volume":"117","author":"Dowson","year":"2008","journal-title":"Circulation"},{"issue":"26","key":"10.1016\/j.mayocp.2020.12.018_bib19","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1093\/eurheartj\/ehw027","article-title":"Percutaneous closure of patent foramen ovale in migraine with aura, a randomized controlled trial","volume":"37","author":"Mattle","year":"2016","journal-title":"Eur Heart J"},{"issue":"22","key":"10.1016\/j.mayocp.2020.12.018_bib20","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1016\/j.jacc.2017.09.1105","article-title":"Percutaneous closure of patent foramen ovale in patients with migraine: The PREMIUM Trial","volume":"70","author":"Tobis","year":"2017","journal-title":"J\u00a0Am Coll Cardiol"}],"container-title":["Mayo Clinic Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619620314816?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619620314816?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T01:35:36Z","timestamp":1758418536000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025619620314816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S0025619620314816"],"URL":"https:\/\/doi.org\/10.1016\/j.mayocp.2020.12.018","relation":{},"ISSN":["0025-6196"],"issn-type":[{"type":"print","value":"0025-6196"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Management of the Patient With Patent Foramen Ovale in 2021: A Spectrum of Cases","name":"articletitle","label":"Article Title"},{"value":"Mayo Clinic Proceedings","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mayocp.2020.12.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Mayo Foundation for Medical Education and Research","name":"copyright","label":"Copyright"}]}}