{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T22:46:30Z","timestamp":1794264390195,"version":"4.9.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","mayoclinicproceedings.org","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mayo Clinic Proceedings"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.mayocp.2021.04.023","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T04:08:05Z","timestamp":1625198885000},"page":"2768-2778","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":172,"title":["Artificial Intelligence\u2013Enhanced Electrocardiogram for the Early Detection of Cardiac Amyloidosis"],"prefix":"10.1016","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2541-4440","authenticated-orcid":false,"given":"Martha","family":"Grogan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5788-9734","authenticated-orcid":false,"given":"Francisco","family":"Lopez-Jimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Cohen-Shelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Dispenzieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachi I.","family":"Attia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar F.","family":"Abou Ezzedine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2283-4340","authenticated-orcid":false,"given":"Suraj","family":"Kapa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel D.","family":"Borgeson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5052-2948","authenticated-orcid":false,"given":"Paul A.","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7800-455X","authenticated-orcid":false,"suffix":"Jr.","given":"Dennis H.","family":"Murphree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"15","key":"10.1016\/j.mayocp.2021.04.023_bib1","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1182\/blood-2016-11-751628","article-title":"Improved outcomes for newly diagnosed AL amyloidosis between 2000 and 2014: cracking the glass ceiling of early death","volume":"129","author":"Muchtar","year":"2017","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.mayocp.2021.04.023_bib2","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1007\/s12325-015-0250-0","article-title":"Light chain amyloidosis: patient experience survey from the Amyloidosis Research Consortium","volume":"32","author":"Lousada","year":"2015","journal-title":"Adv Ther"},{"issue":"22","key":"10.1016\/j.mayocp.2021.04.023_bib3","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1016\/j.jacc.2019.04.003","article-title":"Transthyretin amyloid cardiomyopathy: JACC state-of-the-art review","volume":"73","author":"Ruberg","year":"2019","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"10.1016\/j.mayocp.2021.04.023_bib4","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ccl.2019.07.013","article-title":"Diagnosis and treatment of cardiac amyloidosis related to plasma cell dyscrasias","volume":"37","author":"Alexander","year":"2019","journal-title":"Cardiol Clin"},{"issue":"11","key":"10.1016\/j.mayocp.2021.04.023_bib5","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1056\/NEJMoa1805689","article-title":"Tafamidis treatment for patients with transthyretin amyloid cardiomyopathy","volume":"379","author":"Maurer","year":"2018","journal-title":"N Engl J Med"},{"issue":"12","key":"10.1016\/j.mayocp.2021.04.023_bib6","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.jacc.2016.06.053","article-title":"AL (light-chain) cardiac amyloidosis: a review of diagnosis and therapy","volume":"68","author":"Falk","year":"2016","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.mayocp.2021.04.023_bib7","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nrcardio.2014.165","article-title":"Pathophysiology and treatment of cardiac amyloidosis","volume":"12","author":"Gertz","year":"2015","journal-title":"Nat Rev Cardiol"},{"issue":"10","key":"10.1016\/j.mayocp.2021.04.023_bib8","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.jacc.2016.06.033","article-title":"Natural history of wild-type transthyretin cardiac amyloidosis and risk stratification using a novel staging system [erratum appears in J Am Coll Cardiol. 2017;69(23):2882]","volume":"68","author":"Grogan","year":"2016","journal-title":"J Am Coll Cardiol"},{"issue":"24","key":"10.1016\/j.mayocp.2021.04.023_bib9","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1161\/CIRCULATIONAHA.116.021612","article-title":"Nonbiopsy diagnosis of cardiac transthyretin amyloidosis","volume":"133","author":"Gillmore","year":"2016","journal-title":"Circulation"},{"issue":"25","key":"10.1016\/j.mayocp.2021.04.023_bib10","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1016\/j.jacc.2016.03.593","article-title":"Efficacy of chemotherapy for light-chain amyloidosis in patients presenting with symptomatic heart failure","volume":"67","author":"Sperry","year":"2016","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"10.1016\/j.mayocp.2021.04.023_bib11","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.amjcard.2004.10.028","article-title":"Electrocardiographic findings in primary systemic amyloidosis and biopsy-proven cardiac involvement","volume":"95","author":"Murtagh","year":"2005","journal-title":"Am J Cardiol"},{"issue":"7","key":"10.1016\/j.mayocp.2021.04.023_bib12","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.jacc.2019.12.030","article-title":"Detection of hypertrophic cardiomyopathy using a convolutional neural network\u2013enabled electrocardiogram","volume":"75","author":"Ko","year":"2020","journal-title":"J Am Coll Cardiol"},{"issue":"24","key":"10.1016\/j.mayocp.2021.04.023_bib13","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.1182\/blood-2009-07-230722","article-title":"Classification of amyloidosis by laser microdissection and mass spectrometry\u2013based proteomic analysis in clinical biopsy specimens","volume":"114","author":"Vrana","year":"2009","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.mayocp.2021.04.023_bib14","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.cardfail.2019.08.002","article-title":"ASNC\/AHA\/ASE\/EANM\/HFSA\/ISA\/SCMR\/SNMMI expert consensus recommendations for multimodality imaging in cardiac amyloidosis: part 2 of 2\u2014diagnostic criteria and appropriate utilization","volume":"25","author":"Dorbala","year":"2019","journal-title":"J Card Fail"},{"issue":"9","key":"10.1016\/j.mayocp.2021.04.023_bib15","doi-asserted-by":"crossref","first-page":"e007284","DOI":"10.1161\/CIRCEP.119.007284","article-title":"Age and sex estimation using artificial intelligence from standard 12-lead ECGs","volume":"12","author":"Attia","year":"2019","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"10.1016\/j.mayocp.2021.04.023_bib16","series-title":"Deep Learning","author":"Goodfellow","year":"2016"},{"issue":"1","key":"10.1016\/j.mayocp.2021.04.023_bib17","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3","article-title":"Index for rating diagnostic tests","volume":"3","author":"Youden","year":"1950","journal-title":"Cancer"},{"key":"10.1016\/j.mayocp.2021.04.023_bib18","series-title":"R: a language and environment for statistical computing, version 3.5. 3","year":"2019"},{"issue":"3","key":"10.1016\/j.mayocp.2021.04.023_bib19","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1001\/jamacardio.2019.5233","article-title":"Tafamidis\u2014a pricey therapy for a not-so-rare condition","volume":"5","author":"Gurwitz","year":"2020","journal-title":"JAMA Cardiol"},{"issue":"38","key":"10.1016\/j.mayocp.2021.04.023_bib20","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1093\/eurheartj\/ehx350","article-title":"Unveiling transthyretin cardiac amyloidosis and its predictors among elderly patients with severe aortic stenosis undergoing transcatheter aortic valve replacement","volume":"38","author":"Castano","year":"2017","journal-title":"Eur Heart J"},{"issue":"38","key":"10.1016\/j.mayocp.2021.04.023_bib21","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1093\/eurheartj\/ehv338","article-title":"Wild-type transthyretin amyloidosis as a cause of heart failure with preserved ejection fraction","volume":"36","author":"Gonzalez-Lopez","year":"2015","journal-title":"Eur Heart J"},{"issue":"7","key":"10.1016\/j.mayocp.2021.04.023_bib22","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/gim.2016.200","article-title":"Transthyretin V122I (pV142I)\u2217 cardiac amyloidosis: an age-dependent autosomal dominant cardiomyopathy too common to be overlooked as a cause of significant heart disease in elderly African Americans","volume":"19","author":"Buxbaum","year":"2017","journal-title":"Genet Med"},{"issue":"13","key":"10.1016\/j.mayocp.2021.04.023_bib23","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1161\/CIRCULATIONAHA.108.843334","article-title":"Systemic cardiac amyloidoses: disease profiles and clinical courses of the 3 main types","volume":"120","author":"Rapezzi","year":"2009","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.mayocp.2021.04.023_bib24","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.carpath.2015.07.008","article-title":"Cardiac amyloidosis: pathology, nomenclature, and typing","volume":"24","author":"Maleszewski","year":"2015","journal-title":"Cardiovasc Pathol"},{"issue":"1","key":"10.1016\/j.mayocp.2021.04.023_bib25","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.jjcc.2008.11.002","article-title":"Echocardiographic features of cardiac amyloidosis presenting as endomyocardial disease in a 54-year-old male","volume":"54","author":"Fealey","year":"2009","journal-title":"J Cardiol"},{"issue":"4","key":"10.1016\/j.mayocp.2021.04.023_bib26","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.echo.2013.12.010","article-title":"Advanced cardiac amyloidosis associated with normal interventricular septal thickness: an uncommon presentation of infiltrative cardiomyopathy","volume":"27","author":"Suresh","year":"2014","journal-title":"J Am Soc Echocardiogr"},{"issue":"9","key":"10.1016\/j.mayocp.2021.04.023_bib27","doi-asserted-by":"crossref","first-page":"e005289","DOI":"10.1161\/CIRCOUTCOMES.118.005289","article-title":"Automated and interpretable patient ECG profiles for disease detection, tracking, and discovery","volume":"12","author":"Tison","year":"2019","journal-title":"Circ Cardiovasc Qual Outcomes"}],"updated-by":[{"DOI":"10.1016\/j.mayocp.2022.10.002","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000}}],"container-title":["Mayo Clinic Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619621003530?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619621003530?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T14:09:43Z","timestamp":1672582183000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025619621003530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":27,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S0025619621003530"],"URL":"https:\/\/doi.org\/10.1016\/j.mayocp.2021.04.023","relation":{},"ISSN":["0025-6196"],"issn-type":[{"value":"0025-6196","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Artificial Intelligence\u2013Enhanced Electrocardiogram for the Early Detection of Cardiac Amyloidosis","name":"articletitle","label":"Article Title"},{"value":"Mayo Clinic Proceedings","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mayocp.2021.04.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Mayo Foundation for Medical Education and Research","name":"copyright","label":"Copyright"}]}}