{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:40:31Z","timestamp":1789674031650,"version":"4.0.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","mayoclinicproceedings.org","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mayo Clinic Proceedings"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.mayocp.2021.05.020","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T12:09:23Z","timestamp":1628165363000},"page":"2464-2473","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Rational Fluid Resuscitation in Sepsis for the Hospitalist"],"prefix":"10.1016","volume":"96","author":[{"given":"Adam Timothy","family":"Ladzinski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guramrinder Singh","family":"Thind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4321-4944","authenticated-orcid":false,"given":"Matthew T.","family":"Siuba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10219","key":"10.1016\/j.mayocp.2021.05.020_bib1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990\u20132017: analysis for the Global Burden of Disease Study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.mayocp.2021.05.020_bib2","doi-asserted-by":"crossref","first-page":"a016345","DOI":"10.1101\/cshperspect.a016345","article-title":"Inflammation and the blood microvascular system","volume":"7","author":"Pober","year":"2015","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"19","key":"10.1016\/j.mayocp.2021.05.020_bib3","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1056\/NEJMoa010307","article-title":"Early goal-directed therapy in the treatment of severe sepsis and septic shock","volume":"345","author":"Rivers","year":"2001","journal-title":"N\u00a0Engl J Med"},{"issue":"3","key":"10.1016\/j.mayocp.2021.05.020_bib4","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1097\/01.CCM.0000117317.18092.E4","article-title":"Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock","volume":"32","author":"Dellinger","year":"2004","journal-title":"Crit Care Med"},{"issue":"18","key":"10.1016\/j.mayocp.2021.05.020_bib5","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1056\/NEJMoa1401602","article-title":"A\u00a0randomized trial of protocol-based care for early septic shock","volume":"370","author":"Yearly","year":"2014","journal-title":"N\u00a0Engl J Med"},{"issue":"14","key":"10.1016\/j.mayocp.2021.05.020_bib6","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1056\/NEJMoa1500896","article-title":"Trial of early, goal-directed resuscitation for septic shock","volume":"372","author":"Mouncey","year":"2015","journal-title":"N\u00a0Engl J Med"},{"issue":"16","key":"10.1016\/j.mayocp.2021.05.020_bib7","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1056\/NEJMoa1404380","article-title":"Goal-directed resuscitation for patients with early septic shock","volume":"371","author":"Peake","year":"2014","journal-title":"N\u00a0Engl J Med"},{"issue":"3","key":"10.1016\/j.mayocp.2021.05.020_bib8","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1097\/CCM.0000000000002255","article-title":"Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016","volume":"45","author":"Rhodes","year":"2017","journal-title":"Crit Care Med"},{"issue":"13","key":"10.1016\/j.mayocp.2021.05.020_bib9","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1001\/jama.2017.10913","article-title":"Effect of an early resuscitation protocol on in-hospital mortality among adults with sepsis and hypotension: a randomized clinical trial","volume":"318","author":"Andrews","year":"2017","journal-title":"JAMA"},{"issue":"9","key":"10.1016\/j.mayocp.2021.05.020_bib10","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1056\/NEJMoa1711584","article-title":"Balanced crystalloids versus saline in critically ill adults","volume":"378","author":"Semler","year":"2018","journal-title":"N\u00a0Engl J Med"},{"issue":"12","key":"10.1016\/j.mayocp.2021.05.020_bib11","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1164\/rccm.201903-0557OC","article-title":"Balanced crystalloids versus saline in sepsis: a secondary analysis of the SMART clinical trial","volume":"200","author":"Brown","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"issue":"9","key":"10.1016\/j.mayocp.2021.05.020_bib12","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1164\/rccm.201806-1034OC","article-title":"Early Use of Norepinephrine in Septic Shock Resuscitation (CENSER): a randomized trial","volume":"199","author":"Permpikul","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"issue":"7","key":"10.1016\/j.mayocp.2021.05.020_bib13","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1001\/jama.2019.0071","article-title":"Effect of a resuscitation strategy targeting peripheral perfusion status vs serum lactate levels on 28-day mortality among patients with septic shock: the ANDROMEDA-SHOCK randomized clinical trial","volume":"321","author":"Hern\u00e1ndez","year":"2019","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.mayocp.2021.05.020_bib14","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1164\/rccm.201905-0968OC","article-title":"Effects of a resuscitation strategy targeting peripheral perfusion status vs serum lactate levels among patients with septic shock: a Bayesian reanalysis of the ANDROMEDA-SHOCK trial","volume":"201","author":"Zampieri","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"10.1016\/j.mayocp.2021.05.020_bib15","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/j.chest.2020.04.025","article-title":"Fluid response evaluation in sepsis hypotension and shock: a randomized clinical trial","volume":"158","author":"Douglas","year":"2020","journal-title":"Chest"},{"issue":"2","key":"10.1016\/j.mayocp.2021.05.020_bib16","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/CCM.0b013e3181feeb15","article-title":"Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality","volume":"39","author":"Boyd","year":"2011","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1016\/j.mayocp.2021.05.020_bib17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13613-018-0439-x","article-title":"Renal failure in critically ill patients, beware of applying (central venous) pressure on the kidney","volume":"8","author":"Chen","year":"2018","journal-title":"Ann Intensive Care"},{"issue":"1","key":"10.1016\/j.mayocp.2021.05.020_bib18","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13613-018-0402-x","article-title":"Principles of fluid management and stewardship in septic shock: it is time to consider the four D\u2019s and the four phases of fluid therapy","volume":"8","author":"Malbrain","year":"2018","journal-title":"Ann Intensive Care"},{"issue":"6","key":"10.1016\/j.mayocp.2021.05.020_bib19","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1097\/SLA.0000000000000346","article-title":"A\u00a0randomized, controlled, double-blind crossover study on the effects of 2-L infusions of 0.9% saline and plasma-lyte(R) 148 on renal blood flow velocity and renal cortical tissue perfusion in healthy volunteers","volume":"258","author":"Chowdhury","year":"2013","journal-title":"Ann Surg"},{"issue":"1","key":"10.1016\/j.mayocp.2021.05.020_bib20","doi-asserted-by":"crossref","first-page":"R15","DOI":"10.1186\/cc9420","article-title":"Dynamic arterial elastance to predict arterial pressure response to volume loading in preload-dependent patients","volume":"15","author":"Monge Garc\u00eda","year":"2011","journal-title":"Crit Care"},{"issue":"4","key":"10.1016\/j.mayocp.2021.05.020_bib21","doi-asserted-by":"crossref","first-page":"R142","DOI":"10.1186\/cc9207","article-title":"Early administration of norepinephrine increases cardiac preload and cardiac output in septic patients with life-threatening hypotension","volume":"14","author":"Hamzaoui","year":"2010","journal-title":"Crit Care"},{"issue":"5","key":"10.1016\/j.mayocp.2021.05.020_bib22","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1186\/s13054-014-0503-3","article-title":"Sepsis-associated hyperlactatemia","volume":"18","author":"Garcia-Alvarez","year":"2014","journal-title":"Crit Care"},{"issue":"1","key":"10.1016\/j.mayocp.2021.05.020_bib23","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s13613-020-00732-1","article-title":"A\u00a0lactate-targeted resuscitation strategy may be associated with higher mortality in patients with septic shock and normal capillary refill time: a post hoc analysis of the ANDROMEDA-SHOCK study","volume":"10","author":"Kattan","year":"2020","journal-title":"Ann Intensive Care"},{"issue":"4","key":"10.1016\/j.mayocp.2021.05.020_bib24","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1378\/chest.13-2702","article-title":"Increased fluid administration in the first three hours of sepsis resuscitation is associated with reduced mortality: a retrospective cohort study","volume":"146","author":"Lee","year":"2014","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.mayocp.2021.05.020_bib25","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1186\/s13054-017-1872-1","article-title":"Iatrogenic hemodilution: a possible cause for avoidable blood transfusions?","volume":"21","author":"Perel","year":"2017","journal-title":"Crit Care"},{"issue":"7","key":"10.1016\/j.mayocp.2021.05.020_bib26","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1097\/CCM.0b013e31828a25fd","article-title":"Does the central venous pressure predict fluid responsiveness? An updated meta-analysis and a plea for some common sense","volume":"41","author":"Marik","year":"2013","journal-title":"Crit Care Med"},{"issue":"3","key":"10.1016\/j.mayocp.2021.05.020_bib27","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1097\/ALN.0000000000001753","article-title":"Mini-fluid challenge of 100\u2009ml of crystalloid predicts fluid responsiveness in the operating room","volume":"127","author":"Biais","year":"2017","journal-title":"Anesthesiology"},{"issue":"1","key":"10.1016\/j.mayocp.2021.05.020_bib28","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00134-008-1293-3","article-title":"Passive leg raising for predicting fluid responsiveness: importance of the postural change","volume":"35","author":"Jabot","year":"2008","journal-title":"Intensive Care Med"},{"issue":"1","key":"10.1016\/j.mayocp.2021.05.020_bib29","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13054-014-0708-5","article-title":"Passive leg raising: five rules, not a drop of fluid!","volume":"19","author":"Monnet","year":"2015","journal-title":"Crit Care"},{"issue":"1","key":"10.1016\/j.mayocp.2021.05.020_bib30","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s13613-019-0612-x","article-title":"How to detect a positive response to a fluid bolus when cardiac output is not measured?","volume":"9","author":"Ait-Hamou","year":"2019","journal-title":"Ann Intensive Care"},{"issue":"2","key":"10.1016\/j.mayocp.2021.05.020_bib31","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1530\/ERP-16-0008","article-title":"Predicting and measuring fluid responsiveness with echocardiography","volume":"3","author":"Miller","year":"2016","journal-title":"Echo Res Pract"},{"issue":"2","key":"10.1016\/j.mayocp.2021.05.020_bib32","first-page":"127","article-title":"Feasibility of common carotid artery point of care ultrasound in cardiac output measurements compared to invasive methods","volume":"18","author":"Gassner","year":"2015","journal-title":"J\u00a0Ultrasound"},{"key":"10.1016\/j.mayocp.2021.05.020_bib33","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.resuscitation.2015.07.024","article-title":"Carotid Doppler blood flow measurement during cardiopulmonary resuscitation is feasible: a first in man study","volume":"96","author":"Adedipe","year":"2015","journal-title":"Resuscitation"},{"issue":"8","key":"10.1016\/j.mayocp.2021.05.020_bib34","doi-asserted-by":"crossref","first-page":"569","DOI":"10.14740\/jocmr2617w","article-title":"Estimating right atrial pressure using ultrasounds: an old issue revisited with new methods","volume":"8","author":"Vecchis","year":"2016","journal-title":"J\u00a0Clin Med Res"},{"issue":"3","key":"10.1016\/j.mayocp.2021.05.020_bib35","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.chest.2016.11.017","article-title":"COUNTERPOINT: Should acute fluid resuscitation be guided primarily by inferior vena cava ultrasound for patients in shock? No","volume":"151","author":"Kory","year":"2017","journal-title":"Chest"}],"container-title":["Mayo Clinic Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619621004286?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619621004286?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T02:58:48Z","timestamp":1631156328000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025619621004286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S0025619621004286"],"URL":"https:\/\/doi.org\/10.1016\/j.mayocp.2021.05.020","relation":{},"ISSN":["0025-6196"],"issn-type":[{"value":"0025-6196","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rational Fluid Resuscitation in Sepsis for the Hospitalist","name":"articletitle","label":"Article Title"},{"value":"Mayo Clinic Proceedings","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mayocp.2021.05.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Mayo Foundation for Medical Education and Research","name":"copyright","label":"Copyright"}]}}