{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T07:49:34Z","timestamp":1758440974220,"version":"3.44.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","mayoclinicproceedings.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mayo Clinic Proceedings"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.mayocp.2021.05.030","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T02:00:54Z","timestamp":1632708054000},"page":"3071-3085","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Investigating the Relations Between Caffeine-Derived Metabolites and Plasma Lipids in 2 Population-Based Studies"],"prefix":"10.1016","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3684-4582","authenticated-orcid":false,"given":"Dusan","family":"Petrovic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menno","family":"Pruijm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4730-6050","authenticated-orcid":false,"given":"Bel\u00e9n","family":"Ponte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasser A.","family":"Dhayat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Ackermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Ehret","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Ansermot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Vogt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre-Yves","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Stringhini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Estoppey-Youn\u00e8s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutgarde","family":"Thijs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesus D.","family":"Melgarejo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin B.","family":"Eap","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan A.","family":"Staessen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murielle","family":"Bochud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idris","family":"Guessous","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.mayocp.2021.05.030_bib1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.pop.2012.11.003","article-title":"Hyperlipidemia as a risk factor for cardiovascular disease","volume":"40","author":"Nelson","year":"2013","journal-title":"Prim Care"},{"issue":"4","key":"10.1016\/j.mayocp.2021.05.030_bib2","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/aje\/153.4.353","article-title":"Coffee consumption and serum lipids: a meta-analysis of randomized controlled clinical trials","volume":"153","author":"Jee","year":"2001","journal-title":"Am J Epidemiol"},{"issue":"8","key":"10.1016\/j.mayocp.2021.05.030_bib3","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/ejcn.2012.68","article-title":"The effect of coffee consumption on serum lipids: a meta-analysis of randomized controlled trials","volume":"66","author":"Cai","year":"2012","journal-title":"Eur J Clin Nutr"},{"issue":"1","key":"10.1016\/j.mayocp.2021.05.030_bib4","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jada.2004.10.027","article-title":"Food sources and intakes of caffeine in the diets of persons in the United States","volume":"105","author":"Frary","year":"2005","journal-title":"J\u00a0Am Diet Assoc"},{"key":"10.1016\/j.mayocp.2021.05.030_bib5","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12986-016-0144-4","article-title":"Relation of 24-hour urinary caffeine and caffeine metabolite excretions with self-reported consumption of coffee and other caffeinated beverages in the general population","volume":"13","author":"Petrovic","year":"2016","journal-title":"Nutr Metab (Lond)"},{"key":"10.1016\/j.mayocp.2021.05.030_bib6","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/978-3-642-13443-2_16","article-title":"The cardiovascular effects of methylxanthines","volume":"200","author":"Riksen","year":"2011","journal-title":"Handb Exp Pharmacol"},{"issue":"3","key":"10.1016\/j.mayocp.2021.05.030_bib7","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/mnfr.200400109","article-title":"Coffee consumption and human health\u2014beneficial or detrimental?\u2014Mechanisms for effects of coffee consumption on different risk factors for cardiovascular disease and type 2 diabetes mellitus","volume":"49","author":"Ranheim","year":"2005","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.mayocp.2021.05.030_bib8","series-title":"Hormone action & signal transduction. In: Harper's Biochemistry","first-page":"456","author":"Granner","year":"2003"},{"issue":"4","key":"10.1016\/j.mayocp.2021.05.030_bib9","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s10654-009-9323-1","article-title":"Relationship between long-term coffee consumption and components of the metabolic syndrome: the Amsterdam Growth and Health Longitudinal Study","volume":"24","author":"Balk","year":"2009","journal-title":"Eur J Epidemiol"},{"issue":"4","key":"10.1016\/j.mayocp.2021.05.030_bib10","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s10654-004-7536-x","article-title":"Association of serum caffeine concentrations with blood lipids in caffeine-drug users and nonusers\u2014results of German National Health Surveys from 1984 to 1999","volume":"20","author":"Du","year":"2005","journal-title":"Eur J Epidemiol"},{"issue":"9","key":"10.1016\/j.mayocp.2021.05.030_bib11","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1007\/s11906-014-0468-2","article-title":"Blood pressure in relation to coffee and caffeine consumption","volume":"16","author":"Guessous","year":"2014","journal-title":"Curr Hypertens Rep"},{"key":"10.1016\/j.mayocp.2021.05.030_bib12","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3389\/fpsyt.2018.00573","article-title":"Association between plasma caffeine and other methylxanthines and metabolic parameters in a psychiatric population treated with psychotropic drugs inducing metabolic disturbances","volume":"9","author":"Delacr\u00e9taz","year":"2018","journal-title":"Front Psychiatry"},{"issue":"4","key":"10.1016\/j.mayocp.2021.05.030_bib13","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1139\/h11-052","article-title":"Prevalence of caffeine use in elite athletes following its removal from the World Anti-Doping Agency list of banned substances","volume":"36","author":"Del Coso","year":"2011","journal-title":"Appl Physiol Nutr Metab"},{"issue":"9","key":"10.1016\/j.mayocp.2021.05.030_bib14","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1055\/s-2005-872921","article-title":"Distribution of caffeine levels in urine in different sports in relation to doping control before and after the removal of caffeine from the WADA doping list","volume":"27","author":"Van Thuyne","year":"2006","journal-title":"Int J Sports Med"},{"issue":"4","key":"10.1016\/j.mayocp.2021.05.030_bib15","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1097\/00004872-200304000-00016","article-title":"An epidemiological study of blood pressure and metabolic phenotypes in relation to the G\u03b23 C825T polymorphism","volume":"21","author":"Brand","year":"2003","journal-title":"J\u00a0Hypertens"},{"issue":"7","key":"10.1016\/j.mayocp.2021.05.030_bib16","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1093\/ndt\/gfx258","article-title":"Desphospho-uncarboxylated matrix Gla protein is a novel circulating biomarker predicting deterioration of renal function in the general population","volume":"33","author":"Wei","year":"2018","journal-title":"Nephrol Dial Transplant"},{"issue":"2","key":"10.1016\/j.mayocp.2021.05.030_bib17","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1161\/HYPERTENSIONAHA.114.04494","article-title":"Inactive matrix Gla protein is causally related to adverse health outcomes: a Mendelian randomization study in a Flemish population","volume":"65","author":"Liu","year":"2015","journal-title":"Hypertension"},{"issue":"9","key":"10.1016\/j.mayocp.2021.05.030_bib18","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A\u00a0new equation to estimate glomerular filtration rate [erratum appears in Ann Intern Med. 2011;155(6):408]","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"issue":"6998","key":"10.1016\/j.mayocp.2021.05.030_bib19","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1136\/bmj.311.6998.158","article-title":"Waist circumference as a measure for indicating need for weight management","volume":"311","author":"Lean","year":"1995","journal-title":"BMJ"},{"key":"10.1016\/j.mayocp.2021.05.030_bib20","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.psyneuen.2016.02.003","article-title":"Sociodemographic, behavioral and genetic determinants of allostatic load in a Swiss population-based study","volume":"67","author":"Petrovic","year":"2016","journal-title":"Psychoneuroendocrinology"},{"issue":"4","key":"10.1016\/j.mayocp.2021.05.030_bib21","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/00126097-200208000-00003","article-title":"Quality control of the blood pressure phenotype in the European Project on Genes in Hypertension","volume":"7","author":"Kuznetsova","year":"2002","journal-title":"Blood Press Monit"},{"issue":"1","key":"10.1016\/j.mayocp.2021.05.030_bib22","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1161\/HYPERTENSIONAHA.113.02321","article-title":"Reference values and factors associated with renal resistive index in a family-based population study","volume":"63","author":"Ponte","year":"2014","journal-title":"Hypertension"},{"issue":"6","key":"10.1016\/j.mayocp.2021.05.030_bib23","doi-asserted-by":"crossref","first-page":"e39877","DOI":"10.1371\/journal.pone.0039877","article-title":"1999\u20132009 Trends in prevalence, unawareness, treatment and control of hypertension in Geneva, Switzerland","volume":"7","author":"Guessous","year":"2012","journal-title":"PloS One"},{"issue":"5","key":"10.1016\/j.mayocp.2021.05.030_bib24","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1093\/ndt\/14.5.1247","article-title":"Glomerular filtration rate estimation from plasma creatinine after inhibition of tubular secretion: relevance of the creatinine assay","volume":"14","author":"Kemperman","year":"1999","journal-title":"Nephrol Dial Transplant"},{"issue":"suppl 4","key":"10.1016\/j.mayocp.2021.05.030_bib25","doi-asserted-by":"crossref","first-page":"S64","DOI":"10.1097\/EDE.0b013e3181ce9f08","article-title":"Estimating population distributions when some data are below a limit of detection by using a reverse Kaplan-Meier estimator","volume":"21","author":"Gillespie","year":"2010","journal-title":"Epidemiology"},{"issue":"3","key":"10.1016\/j.mayocp.2021.05.030_bib26","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1080\/08940630.1989.10466534","article-title":"Observations less than the analytical limit of detection: a new approach","volume":"39","author":"Cohen","year":"1989","journal-title":"JAPCA"},{"issue":"12","key":"10.1016\/j.mayocp.2021.05.030_bib27","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.jacc.2013.06.035","article-title":"Effects of habitual coffee consumption on cardiometabolic disease, cardiovascular health, and all-cause mortality","volume":"62","author":"O'Keefe","year":"2013","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"4","key":"10.1016\/j.mayocp.2021.05.030_bib28","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1038\/nutd.2012.6","article-title":"Association of coffee consumption with serum adiponectin, leptin, inflammation and metabolic markers in Japanese workers: a cross-sectional study","volume":"2","author":"Yamashita","year":"2012","journal-title":"Nutr Diabetes"},{"issue":"1","key":"10.1016\/j.mayocp.2021.05.030_bib29","first-page":"BC01","article-title":"Relationship of caffeine with adiponectin and blood sugar levels in subjects with and without diabetes","volume":"9","author":"Bhaktha","year":"2015","journal-title":"J\u00a0Clin Diagn Res"},{"issue":"6","key":"10.1016\/j.mayocp.2021.05.030_bib30","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/0009-9236(95)90025-X","article-title":"Sympathomimetic effects of paraxanthine and caffeine in humans","volume":"58","author":"Benowitz","year":"1995","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.mayocp.2021.05.030_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0074-7742(08)00001-9","article-title":"Gender differences in pharmacological response","volume":"83","author":"Anderson","year":"2008","journal-title":"Int Rev Neurobiol"},{"key":"10.1016\/j.mayocp.2021.05.030_bib32","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1743-7075-7-12","article-title":"Coffee consumption and CYP1A2 genotype in relation to bone mineral density of the proximal femur in elderly men and women: a cohort study","volume":"7","author":"Hallstr\u00f6m","year":"2010","journal-title":"Nutr Metab (Lond)"},{"issue":"3","key":"10.1016\/j.mayocp.2021.05.030_bib33","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1161\/HYPERTENSIONAHA.114.04512","article-title":"Associations of ambulatory blood pressure with urinary caffeine and caffeine metabolite excretions [erratum appears in Hypertension. 2016;67(2):e2]","volume":"65","author":"Guessous","year":"2015","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.mayocp.2021.05.030_bib34","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/0026-0495(83)90002-1","article-title":"Relationship of plasma HDL-cholesterol to testosterone, estradiol, and sex-hormone-binding globulin levels in men and women","volume":"32","author":"Semmens","year":"1983","journal-title":"Metabolism"},{"issue":"9","key":"10.1016\/j.mayocp.2021.05.030_bib35","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1177\/00912709922008560","article-title":"Inhibition of caffeine metabolism by estrogen replacement therapy in postmenopausal women","volume":"39","author":"Pollock","year":"1999","journal-title":"J\u00a0Clin Pharmacol"},{"issue":"8","key":"10.1016\/j.mayocp.2021.05.030_bib36","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1289\/ehp.02110771","article-title":"Sexual maturation in relation to polychlorinated aromatic hydrocarbons: Sharpe and Skakkebaek's hypothesis revisited","volume":"110","author":"Den Hond","year":"2002","journal-title":"Environ Health Perspect"},{"issue":"7","key":"10.1016\/j.mayocp.2021.05.030_bib37","first-page":"748","article-title":"Gender differences in coffee consumption and its effects in young people","volume":"4","author":"Demura","year":"2013","journal-title":"Food Nutr Sci"},{"issue":"6","key":"10.1016\/j.mayocp.2021.05.030_bib39","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.jada.2004.03.019","article-title":"Dietary sources of nutrients among US adults, 1994 to 1996","volume":"104","author":"Cotton","year":"2004","journal-title":"J\u00a0Am Diet Assoc"},{"key":"10.1016\/j.mayocp.2021.05.030_bib40","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/978-3-642-13443-2_7","article-title":"Theobromine and the pharmacology of cocoa","volume":"200","author":"Smit","year":"2011","journal-title":"Handb Exp Pharmacol"},{"issue":"10","key":"10.1016\/j.mayocp.2021.05.030_bib41","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/S0271-5317(00)80032-9","article-title":"Comparative effects of theobromine and cocoa extract on lipid profile in rats","volume":"20","author":"Eteng","year":"2000","journal-title":"Nutr Res"},{"issue":"6","key":"10.1016\/j.mayocp.2021.05.030_bib42","doi-asserted-by":"crossref","first-page":"425","DOI":"10.2165\/00003088-199936060-00004","article-title":"Drug interactions with tobacco smoking","volume":"36","author":"Zevin","year":"1999","journal-title":"Clin Pharmacokinet"},{"issue":"1","key":"10.1016\/j.mayocp.2021.05.030_bib43","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.lungcan.2006.06.016","article-title":"Effects of type of smoking (pipe, cigars or cigarettes) on biological indices of tobacco exposure and toxicity","volume":"54","author":"Funck-Brentano","year":"2006","journal-title":"Lung Cancer"},{"issue":"2","key":"10.1016\/j.mayocp.2021.05.030_bib44","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.amjcard.2011.08.042","article-title":"Effects of physical activity on cardiovascular disease","volume":"109","author":"Ahmed","year":"2012","journal-title":"Am J Cardiol"},{"issue":"5","key":"10.1016\/j.mayocp.2021.05.030_bib45","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2165\/00007256-199928050-00002","article-title":"Physical activity and high density lipoprotein cholesterol levels","volume":"28","author":"Kokkinos","year":"1999","journal-title":"Sports Med"},{"issue":"14","key":"10.1016\/j.mayocp.2021.05.030_bib46","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.1093\/hmg\/dds137","article-title":"Caffeine intake and CYP1A2 variants associated with high caffeine intake protect non-smokers from hypertension","volume":"21","author":"Guessous","year":"2012","journal-title":"Hum Mol Genet"},{"issue":"8","key":"10.1016\/j.mayocp.2021.05.030_bib47","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1097\/HJH.0b013e32832ba850","article-title":"CYP1A2 genotype modifies the association between coffee intake and the risk of hypertension","volume":"27","author":"Palatini","year":"2009","journal-title":"J\u00a0Hypertens"},{"issue":"6","key":"10.1016\/j.mayocp.2021.05.030_bib48","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1001\/jama.1992.03480060057030","article-title":"The effect of filtered-coffee consumption on plasma lipid levels: results of a randomized clinical trial","volume":"267","author":"Fried","year":"1992","journal-title":"JAMA"},{"issue":"18","key":"10.1016\/j.mayocp.2021.05.030_bib49","first-page":"2545","article-title":"Lipid Research Clinics Program","volume":"252","year":"1984","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.mayocp.2021.05.030_bib50","doi-asserted-by":"crossref","first-page":"e000519","DOI":"10.1161\/JAHA.113.000519","article-title":"Coronary heart disease risks associated with high levels of HDL cholesterol","volume":"3","author":"Wilkins","year":"2014","journal-title":"J\u00a0Am Heart Assoc"},{"issue":"3","key":"10.1016\/j.mayocp.2021.05.030_bib51","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1161\/CIRCOUTCOMES.115.002436","article-title":"Is isolated low high-density lipoprotein cholesterol a cardiovascular disease risk factor? New insights from the Framingham Offspring Study","volume":"9","author":"Bartlett","year":"2016","journal-title":"Circ Cardiovasc Qual Outcomes"},{"issue":"6","key":"10.1016\/j.mayocp.2021.05.030_bib52","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1093\/ajcn\/61.6.1277","article-title":"A\u00a0placebo-controlled parallel study of the effect of two types of coffee oil on serum lipids and transaminases: identification of chemical substances involved in the cholesterol-raising effect of coffee","volume":"61","author":"van Rooij","year":"1995","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"10.1016\/j.mayocp.2021.05.030_bib53","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1056\/NEJMra1816604","article-title":"Coffee, caffeine, and health","volume":"383","author":"van Dam","year":"2020","journal-title":"N\u00a0Engl J Med"},{"issue":"12","key":"10.1016\/j.mayocp.2021.05.030_bib54","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1097\/HJH.0b013e3283588d73","article-title":"The effect of coffee consumption on blood pressure and the development of hypertension: a systematic review and meta-analysis","volume":"30","author":"Steffen","year":"2012","journal-title":"J\u00a0Hypertens"},{"issue":"1","key":"10.1016\/j.mayocp.2021.05.030_bib55","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s12263-007-0043-4","article-title":"Coffee, CYP1A2 genotype and risk of myocardial infarction","volume":"2","author":"El-Sohemy","year":"2007","journal-title":"Genes Nutr"}],"container-title":["Mayo Clinic Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619621005516?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619621005516?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T01:37:14Z","timestamp":1758418634000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025619621005516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":54,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S0025619621005516"],"URL":"https:\/\/doi.org\/10.1016\/j.mayocp.2021.05.030","relation":{},"ISSN":["0025-6196"],"issn-type":[{"type":"print","value":"0025-6196"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigating the Relations Between Caffeine-Derived Metabolites and Plasma Lipids in 2 Population-Based Studies","name":"articletitle","label":"Article Title"},{"value":"Mayo Clinic Proceedings","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mayocp.2021.05.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}