{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:49:09Z","timestamp":1789026549648,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RC-2022-2773270"],"award-info":[{"award-number":["RC-2022-2773270"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","mayoclinicproceedings.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mayo Clinic Proceedings"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.mayocp.2024.11.025","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T23:31:49Z","timestamp":1748043109000},"page":"1563-1574","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["The American College of Cardology\/American Heart Association Heart Failure Staging System Highlights Diagnostic Delay and Predicts Outcome in Transthyretin Cardiac Amyloidosis"],"prefix":"10.1016","volume":"100","author":[{"given":"Mattia","family":"Zampieri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Del Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Biagioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Tini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Musumeci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Barbato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Longhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Biagini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Saturi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldostefano","family":"Porcari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Merlo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Sinagra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camillo","family":"Autore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Canepa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Italo","family":"Porto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Argir\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta","family":"Mazzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Fumagalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Colio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tullio","family":"Catalucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iacopo","family":"Olivotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Perfetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cappelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"18","key":"10.1016\/j.mayocp.2024.11.025_bib1","first-page":"e895","article-title":"2022 AHA\/ACC\/HFSA guideline for the management of heart failure: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"145","author":"Heidenreich","year":"2022","journal-title":"Circulation"},{"issue":"36","key":"10.1016\/j.mayocp.2024.11.025_bib2","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur Heart J"},{"issue":"3","key":"10.1016\/j.mayocp.2024.11.025_bib3","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.jaccao.2020.06.007","article-title":"Diuretic dose and NYHA functional class are independent predictors of mortality in patients with transthyretin cardiac amyloidosis","volume":"2","author":"Cheng","year":"2020","journal-title":"JACC CardioOncol"},{"issue":"4","key":"10.1016\/j.mayocp.2024.11.025_bib4","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/hrt.2006.089656","article-title":"Limitations of the New York Heart Association functional classification system and self-reported walking distances in chronic heart failure","volume":"93","author":"Raphael","year":"2007","journal-title":"Heart"},{"issue":"21","key":"10.1016\/j.mayocp.2024.11.025_bib5","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1093\/eurheartj\/ehv510","article-title":"Beyond ejection fraction: an integrative approach for assessment of cardiac structure and function in heart failure","volume":"37","author":"Cikes","year":"2016","journal-title":"Eur Heart J"},{"issue":"24","key":"10.1016\/j.mayocp.2024.11.025_bib6","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1161\/CIRCULATIONAHA.116.021612","article-title":"Nonbiopsy diagnosis of cardiac transthyretin amyloidosis","volume":"133","author":"Gillmore","year":"2016","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.mayocp.2024.11.025_bib7","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/ajh.20381","article-title":"Definition of organ involvement and treatment response in immunoglobulin light chain amyloidosis (AL): a consensus opinion from the 10th International Symposium on Amyloid and Amyloidosis, Tours, France, 18-22 April 2004","volume":"79","author":"Gertz","year":"2005","journal-title":"Am J Hematol"},{"issue":"21","key":"10.1016\/j.mayocp.2024.11.025_bib8","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1016\/j.jacc.2015.09.075","article-title":"Diagnosis, prognosis, and therapy of transthyretin amyloidosis","volume":"66","author":"Gertz","year":"2015","journal-title":"J Am Coll Cardiol"},{"issue":"7","key":"10.1016\/j.mayocp.2024.11.025_bib9","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1002\/ajh.25819","article-title":"Immunoglobulin light chain amyloidosis: 2020 update on diagnosis, prognosis, and treatment","volume":"95","author":"Gertz","year":"2020","journal-title":"Am J Hematol"},{"issue":"13","key":"10.1016\/j.mayocp.2024.11.025_bib10","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1161\/CIRCULATIONAHA.108.843334","article-title":"Systemic cardiac amyloidoses: disease profiles and clinical courses of the 3 main types","volume":"120","author":"Rapezzi","year":"2009","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.mayocp.2024.11.025_bib11","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s12350-019-01761-5","article-title":"ASNC\/AHA\/ASE\/EANM\/HFSA\/ISA\/SCMR\/SNMMI expert consensus recommendations for multimodality imaging in cardiac amyloidosis: Part 2 of 2\u2013Diagnostic criteria and appropriate utilization","volume":"27","author":"Dorbala","year":"2020","journal-title":"J Nucl Cardiol"},{"issue":"3","key":"10.1016\/j.mayocp.2024.11.025_bib12","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/ejhf.2115","volume":"23","author":"Bozkurt","year":"2021","journal-title":"Eur J Heart Fail"},{"issue":"11","key":"10.1016\/j.mayocp.2024.11.025_bib13","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1056\/NEJMoa1805689","article-title":"Tafamidis treatment for patients with transthyretin amyloid cardiomyopathy","volume":"379","author":"Maurer","year":"2018","journal-title":"N Engl J Med"},{"issue":"16","key":"10.1016\/j.mayocp.2024.11.025_bib14","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1093\/eurheartj\/ehab072","article-title":"Diagnosis and treatment of cardiac amyloidosis: a position statement of the ESC Working Group on Myocardial and Pericardial Diseases","volume":"42","author":"Garcia-Pavia","year":"2021","journal-title":"Eur Heart J"},{"issue":"6","key":"10.1016\/j.mayocp.2024.11.025_bib15","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/ejhf.2823","article-title":"Diagnostic pathways to wild-type transthyretin amyloid cardiomyopathy: a multicentre network study","volume":"25","author":"Tini","year":"2023","journal-title":"Eur J Heart Fail"},{"issue":"8","key":"10.1016\/j.mayocp.2024.11.025_bib16","doi-asserted-by":"crossref","first-page":"493","DOI":"10.2459\/JCM.0000000000001337","article-title":"Red flags for the diagnosis of cardiac amyloidosis: simple suggestions to raise suspicion and achieve earlier diagnosis","volume":"23","author":"Argiro\u2019","year":"2022","journal-title":"J Cardiovasc Med (Hagerstown)"},{"issue":"1","key":"10.1016\/j.mayocp.2024.11.025_bib17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/13506129.2018.1556156","article-title":"Early diagnosis of ATTR amyloidosis through targeted follow-up of identified carriers of TTR gene mutations","volume":"26","author":"Concei\u00e7\u00e3o","year":"2019","journal-title":"Amyloid"},{"issue":"17","key":"10.1016\/j.mayocp.2024.11.025_bib18","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1056\/NEJMoa2300757","article-title":"Patisiran treatment in patients with transthyretin cardiac amyloidosis","volume":"389","author":"Maurer","year":"2023","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.mayocp.2024.11.025_bib19","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1056\/NEJMoa2305434","article-title":"Efficacy and safety of acoramidis in transthyretin amyloid cardiomyopathy","volume":"390","author":"Gillmore","year":"2024","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.mayocp.2024.11.025_bib20","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.jcmg.2019.10.011","article-title":"Multiparametric echocardiography scores for the diagnosis of cardiac amyloidosis","volume":"13","author":"Boldrini","year":"2020","journal-title":"JACC Cardiovasc Imaging"},{"issue":"4","key":"10.1016\/j.mayocp.2024.11.025_bib21","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1080\/13506129.2023.2229484","article-title":"Patients with transthyretin amyloidosis enrolled in THAOS between 2018 and 2021 continue to experience substantial diagnostic delay","volume":"30","author":"Coelho","year":"2023","journal-title":"Amyloid"},{"issue":"8","key":"10.1016\/j.mayocp.2024.11.025_bib22","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1016\/j.mayocp.2021.04.021","article-title":"Early diagnosis and outcome in patients with wild-type transthyretin cardiac amyloidosis","volume":"96","author":"Fumagalli","year":"2021","journal-title":"Mayo Clin Proc"},{"issue":"4","key":"10.1016\/j.mayocp.2024.11.025_bib23","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.jaccao.2022.07.007","article-title":"Prognosis of transthyretin cardiac amyloidosis without heart failure symptoms","volume":"4","author":"Gonzalez-Lopez","year":"2022","journal-title":"JACC CardioOncol"},{"issue":"5","key":"10.1016\/j.mayocp.2024.11.025_bib24","doi-asserted-by":"crossref","DOI":"10.1093\/ehjopen\/oead092","article-title":"Prognosis prediction in cardiac amyloidosis by cardiac magnetic resonance imaging: a systematic review with meta-analysis","volume":"3","author":"Boretto","year":"2023","journal-title":"Eur Heart J Open"},{"issue":"1","key":"10.1016\/j.mayocp.2024.11.025_bib25","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1161\/CIRCULATIONAHA.118.038169","article-title":"Natural history, quality of life, and outcome in cardiac transthyretin amyloidosis","volume":"140","author":"Lane","year":"2019","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.mayocp.2024.11.025_bib26","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.jacc.2016.06.033","article-title":"Natural history of wild-type transthyretin cardiac amyloidosis and risk stratification using a novel staging system","volume":"68","author":"Grogan","year":"2016","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"10.1016\/j.mayocp.2024.11.025_bib27","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.jcmg.2011.03.016","article-title":"Role of 99mTc-DPD scintigraphy in diagnosis and prognosis of hereditary transthyretin-related cardiac amyloidosis","volume":"4","author":"Rapezzi","year":"2011","journal-title":"JACC Cardiovasc Imaging"},{"issue":"21","key":"10.1016\/j.mayocp.2024.11.025_bib28","doi-asserted-by":"crossref","first-page":"4888","DOI":"10.3390\/jcm10214888","article-title":"Echocardiographic patterns of left ventricular diastolic function in cardiac amyloidosis: an updated evaluation","volume":"10","author":"Oghina","year":"2021","journal-title":"J Clin Med"},{"issue":"3","key":"10.1016\/j.mayocp.2024.11.025_bib29","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1080\/13506129.2016.1194264","article-title":"Prognostic value of right ventricular systolic function in cardiac amyloidosis","volume":"23","author":"Bodez","year":"2016","journal-title":"Amyloid"},{"issue":"3","key":"10.1016\/j.mayocp.2024.11.025_bib30","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1161\/01.CIR.83.3.808","article-title":"Prognostic significance of Doppler measures of diastolic function in cardiac amyloidosis: a Doppler echocardiography study","volume":"83","author":"Klein","year":"1991","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.mayocp.2024.11.025_bib31","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3109\/13506129.2013.844122","article-title":"Usefulness of plasma B-type natriuretic peptide as a prognostic marker of cardiac function in senile systemic amyloidosis and in familial amyloidotic polyneuropathy","volume":"20","author":"Usuku","year":"2013","journal-title":"Amyloid"},{"issue":"30","key":"10.1016\/j.mayocp.2024.11.025_bib32","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1093\/eurheartj\/ehx589","article-title":"A new staging system for cardiac transthyretin amyloidosis","volume":"39","author":"Gillmore","year":"2018","journal-title":"Eur Heart J"},{"issue":"6","key":"10.1016\/j.mayocp.2024.11.025_bib33","doi-asserted-by":"crossref","first-page":"e008105","DOI":"10.1161\/CIRCHEARTFAILURE.120.008105","article-title":"Prevalence and prognostic significance of frailty among patients with transthyretin amyloidosis cardiomyopathy","volume":"14","author":"Fine","year":"2021","journal-title":"Circ Heart Fail"},{"issue":"10","key":"10.1016\/j.mayocp.2024.11.025_bib34","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.nut.2015.04.011","article-title":"Nutritional counseling improves quality of life and preserves body weight in systemic immunoglobulin light-chain (AL) amyloidosis","volume":"31","author":"Caccialanza","year":"2015","journal-title":"Nutrition"},{"issue":"suppl 1","key":"10.1016\/j.mayocp.2024.11.025_bib35","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1016\/j.amjcard.2022.10.053","article-title":"Care of patients with transthyretin amyloidosis: the roles of nutrition, supplements, exercise, and mental health","volume":"185","author":"Dasgupta","year":"2022","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.mayocp.2024.11.025_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.amjcard.2023.01.007","article-title":"Anxious\/depressive symptoms alter the subjective perception of heart failure severity in transthyretin cardiac amyloidosis","volume":"192","author":"Ponti","year":"2023","journal-title":"Am J Cardiol"},{"issue":"1","key":"10.1016\/j.mayocp.2024.11.025_bib37","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13023-022-02601-5","article-title":"A survey exploring caregiver burden and health-related quality of life in hereditary transthyretin amyloidosis","volume":"18","author":"Acaster","year":"2023","journal-title":"Orphanet J Rare Dis"},{"issue":"6","key":"10.1016\/j.mayocp.2024.11.025_bib38","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1007\/s40520-023-02419-6","article-title":"Frailty and caregiver relationship quality in older patients diagnosed with transthyretin cardiac amyloidosis","volume":"35","author":"Fumagalli","year":"2023","journal-title":"Aging Clin Exp Res"},{"issue":"23","key":"10.1016\/j.mayocp.2024.11.025_bib39","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.jacc.2023.04.007","article-title":"Effect of 2022 ACC\/AHA\/HFSA criteria on stages of heart failure in a pooled community cohort","volume":"81","author":"Mohebi","year":"2023","journal-title":"J Am Coll Cardiol"}],"container-title":["Mayo Clinic Proceedings"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619624006529?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025619624006529?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T15:45:02Z","timestamp":1763307902000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025619624006529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":39,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S0025619624006529"],"URL":"https:\/\/doi.org\/10.1016\/j.mayocp.2024.11.025","relation":{},"ISSN":["0025-6196"],"issn-type":[{"value":"0025-6196","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The American College of Cardology\/American Heart Association Heart Failure Staging System Highlights Diagnostic Delay and Predicts Outcome in Transthyretin Cardiac Amyloidosis","name":"articletitle","label":"Article Title"},{"value":"Mayo Clinic Proceedings","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mayocp.2024.11.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}