{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:43:14Z","timestamp":1773297794131,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T00:00:00Z","timestamp":1494806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["mcpiqojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mayo Clinic Proceedings: Innovations, Quality &amp; Outcomes"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.mayocpiqo.2017.05.003","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T03:23:45Z","timestamp":1498188225000},"page":"57-66","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Normalization of Testosterone Levels After Testosterone Replacement Therapy Is Not Associated With Reduced Myocardial Infarction in Smokers"],"prefix":"10.1016","volume":"1","author":[{"given":"Olurinde A.","family":"Oni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rishi","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mukut","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Buddhadeb","family":"Dawn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepak","family":"Parashara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia J.","family":"Savin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Cherian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Ambrose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajat S.","family":"Barua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mayocpiqo.2017.05.003_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/bmb\/ldp028","article-title":"Global and regional causes of death","volume":"92","author":"Mathers","year":"2009","journal-title":"Br Med Bull"},{"issue":"9","key":"10.1016\/j.mayocpiqo.2017.05.003_bib2","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.2105\/AJPH.88.9.1348","article-title":"The development of sex differences in cardiovascular disease mortality: a historical perspective","volume":"88","author":"Nikiforov","year":"1998","journal-title":"Am J Public Health"},{"issue":"2","key":"10.1016\/j.mayocpiqo.2017.05.003_bib3","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/oxfordjournals.aje.a113527","article-title":"The sex differential in mortality from all causes and ischemic heart disease","volume":"117","author":"Wingard","year":"1983","journal-title":"Am J Epidemiol"},{"issue":"3","key":"10.1016\/j.mayocpiqo.2017.05.003_bib4","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1161\/01.CIR.93.3.450","article-title":"Smoking, serum lipids, blood pressure, and sex differences in myocardial infarction: a 12-year follow-up of the Finnmark Study","volume":"93","author":"Njolstad","year":"1996","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.mayocpiqo.2017.05.003_bib5","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1161\/01.CIR.91.11.2742","article-title":"Testosterone increases human platelet thromboxane A2 receptor density and aggregation responses","volume":"91","author":"Ajayi","year":"1995","journal-title":"Circulation"},{"issue":"40","key":"10.1016\/j.mayocpiqo.2017.05.003_bib6","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.1093\/eurheartj\/ehv346","article-title":"Normalization of testosterone level is associated with reduced incidence of myocardial\u00a0infarction and mortality in men","volume":"36","author":"Sharma","year":"2015","journal-title":"Eur Heart J"},{"issue":"5","key":"10.1016\/j.mayocpiqo.2017.05.003_bib7","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.jacc.2015.12.005","article-title":"Testosterone and cardiovascular disease","volume":"67","author":"Kloner","year":"2016","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"9","key":"10.1016\/j.mayocpiqo.2017.05.003_bib8","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1177\/1060028014539918","article-title":"Risk of myocardial infarction in older men receiving testosterone therapy","volume":"48","author":"Baillargeon","year":"2014","journal-title":"Ann Pharmacother"},{"issue":"10","key":"10.1016\/j.mayocpiqo.2017.05.003_bib9","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1517\/14740338.2014.950653","article-title":"Cardiovascular risk associated with testosterone-boosting medications: a systematic review and meta-analysis","volume":"13","author":"Corona","year":"2014","journal-title":"Expert Opin Drug Saf"},{"issue":"17","key":"10.1016\/j.mayocpiqo.2017.05.003_bib10","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1001\/jama.2013.280386","article-title":"Association of testosterone therapy with mortality, myocardial infarction, and stroke\u00a0in men with low testosterone levels","volume":"310","author":"Vigen","year":"2013","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.mayocpiqo.2017.05.003_bib11","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1056\/NEJMoa1000485","article-title":"Adverse events associated with testosterone administration","volume":"363","author":"Basaria","year":"2010","journal-title":"N\u00a0Engl J Med"},{"issue":"10002","key":"10.1016\/j.mayocpiqo.2017.05.003_bib12","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/S0140-6736(15)00340-2","article-title":"Contrasting male and female trends in tobacco-attributed mortality in China: evidence from successive nationwide prospective cohort studies","volume":"386","author":"Chen","year":"2015","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.mayocpiqo.2017.05.003_bib13","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/j.jacc.2003.12.047","article-title":"The pathophysiology of cigarette smoking and cardiovascular disease: an update","volume":"43","author":"Ambrose","year":"2004","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.mayocpiqo.2017.05.003_bib14","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1001\/jama.290.1.86","article-title":"Mortality risk reduction associated with smoking cessation in patients with coronary heart disease: a systematic review","volume":"290","author":"Critchley","year":"2003","journal-title":"JAMA"},{"issue":"12","key":"10.1016\/j.mayocpiqo.2017.05.003_bib15","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.jacc.2015.07.037","article-title":"Cardiovascular effects of exposure to cigarette smoke and electronic cigarettes: clinical perspectives from the Prevention of Cardiovascular Disease Section Leadership Council and Early Career Councils of the American College of Cardiology","volume":"66","author":"Morris","year":"2015","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"7","key":"10.1016\/j.mayocpiqo.2017.05.003_bib16","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1001\/jama.1988.03720070025028","article-title":"Cigarette smoking as a risk factor for stroke. The Framingham Study","volume":"259","author":"Wolf","year":"1988","journal-title":"JAMA"},{"issue":"7","key":"10.1016\/j.mayocpiqo.2017.05.003_bib17","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1161\/ATVBAHA.112.300154","article-title":"Mechanisms of coronary thrombosis in cigarette smoke exposure","volume":"33","author":"Barua","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.mayocpiqo.2017.05.003_bib18","doi-asserted-by":"crossref","first-page":"572","DOI":"10.3389\/fimmu.2015.00572","article-title":"Cigarette smoke amplifies inflammatory response and atherosclerosis progression through activation of the H1R-TLR2\/4-COX2 axis","volume":"6","author":"Barua","year":"2015","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.mayocpiqo.2017.05.003_bib19","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/S0735-1097(96)00570-0","article-title":"Testosterone worsens endothelial dysfunction associated with hypercholesterolemia and environmental tobacco smoke exposure in male rabbit aorta","volume":"29","author":"Hutchison","year":"1997","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"3","key":"10.1016\/j.mayocpiqo.2017.05.003_bib21","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.ahj.2012.12.009","article-title":"Data quality of an electronic health record tool to support VA cardiac catheterization laboratory quality improvement: the VA Clinical Assessment, Reporting, and Tracking System for Cath Labs (CART) program","volume":"165","author":"Byrd","year":"2013","journal-title":"Am Heart J"},{"issue":"6","key":"10.1016\/j.mayocpiqo.2017.05.003_bib22","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1210\/jc.2009-2354","article-title":"Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline","volume":"95","author":"Bhasin","year":"2010","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.mayocpiqo.2017.05.003_bib23","first-page":"1085","article-title":"Wide variability in laboratory reference values for serum testosterone","volume":"3","author":"Lazarou","year":"2006","journal-title":"J\u00a0Sex Med"},{"issue":"2","key":"10.1016\/j.mayocpiqo.2017.05.003_bib24","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1210\/jc.2006-1864","article-title":"Position statement: utility, limitations, and pitfalls in measuring testosterone: an Endocrine Society position statement","volume":"92","author":"Rosner","year":"2007","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.mayocpiqo.2017.05.003_bib25","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1210\/jc.2003-031287","article-title":"Measurement of total serum testosterone in adult men: comparison of current laboratory methods versus liquid chromatography-tandem mass spectrometry","volume":"89","author":"Wang","year":"2004","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"3-5","key":"10.1016\/j.mayocpiqo.2017.05.003_bib26","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.jsbmb.2010.03.032","article-title":"Standardization of testosterone measurements in humans","volume":"121","author":"Vesper","year":"2010","journal-title":"J\u00a0Steroid Biochem Mol Biol"},{"issue":"3","key":"10.1016\/j.mayocpiqo.2017.05.003_bib27","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1080\/00273171.2011.568786","article-title":"An introduction to propensity score methods for reducing the effects of confounding in observational studies","volume":"46","author":"Austin","year":"2011","journal-title":"Multivariate Behav Res"},{"issue":"3","key":"10.1016\/j.mayocpiqo.2017.05.003_bib28","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1037\/a0019623","article-title":"Propensity score techniques and the assessment of measured covariate balance to test causal associations in psychological research","volume":"15","author":"Harder","year":"2010","journal-title":"Psychol Methods"},{"issue":"11","key":"10.1016\/j.mayocpiqo.2017.05.003_bib29","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1056\/NEJM199603143341107","article-title":"Androgens in men\u2013uses and abuses","volume":"334","author":"Bagatell","year":"1996","journal-title":"N\u00a0Engl J Med"},{"issue":"10","key":"10.1016\/j.mayocpiqo.2017.05.003_bib30","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1210\/jc.2009-0417","article-title":"Sex hormones and frailty in older men: the osteoporotic fractures in men (MrOS) study","volume":"94","author":"Cawthon","year":"2009","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.mayocpiqo.2017.05.003_bib31","doi-asserted-by":"crossref","first-page":"e85805","DOI":"10.1371\/journal.pone.0085805","article-title":"Increased risk of non-fatal myocardial infarction following testosterone therapy prescription in men","volume":"9","author":"Finkle","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.mayocpiqo.2017.05.003_bib32","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/1741-7015-11-108","article-title":"Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials","volume":"11","author":"Xu","year":"2013","journal-title":"BMC Med"},{"issue":"22","key":"10.1016\/j.mayocpiqo.2017.05.003_bib33","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1136\/hrt.2010.195412","article-title":"Low serum testosterone and increased mortality in men with coronary heart disease","volume":"96","author":"Malkin","year":"2010","journal-title":"Heart"},{"issue":"11","key":"10.1016\/j.mayocpiqo.2017.05.003_bib34","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.jacc.2007.04.088","article-title":"Low serum testosterone and high serum estradiol associate with lower extremity peripheral arterial disease in elderly men. The MrOS Study in Sweden","volume":"50","author":"Tivesten","year":"2007","journal-title":"J\u00a0Am Coll Cardiol"},{"issue":"6","key":"10.1016\/j.mayocpiqo.2017.05.003_bib35","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1530\/eje.1.02166","article-title":"Testosterone replacement therapy improves insulin resistance, glycaemic control, visceral adiposity and hypercholesterolaemia in hypogonadal men with type 2 diabetes","volume":"154","author":"Kapoor","year":"2006","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"10.1016\/j.mayocpiqo.2017.05.003_bib36","first-page":"726","article-title":"Fifty-two-week treatment with diet and exercise plus transdermal testosterone reverses the metabolic syndrome and improves glycemic control in men with newly diagnosed type 2 diabetes and subnormal plasma testosterone","volume":"30","author":"Heufelder","year":"2009","journal-title":"J\u00a0Androl"},{"issue":"6","key":"10.1016\/j.mayocpiqo.2017.05.003_bib37","first-page":"1763","article-title":"Evaluation of the effects of cigarette smoking on testosterone levels in adult men","volume":"6","author":"Halmenschlager","year":"2009","journal-title":"J\u00a0Sex Med"},{"issue":"6","key":"10.1016\/j.mayocpiqo.2017.05.003_bib38","first-page":"811","article-title":"Lifestyle factors and serum androgens among 636 middle aged men from seven countries in the European Prospective Investigation into Cancer and Nutrition (EPIC)","volume":"20","author":"Suzuki","year":"2009","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.mayocpiqo.2017.05.003_bib39","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.chest.2016.05.007","article-title":"Association between testosterone replacement therapy and the incidence of DVT and pulmonary embolism: a retrospective cohort study of the Veterans Administration Database","volume":"150","author":"Sharma","year":"2016","journal-title":"Chest"}],"container-title":["Mayo Clinic Proceedings: Innovations, Quality &amp; Outcomes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2542454817300139?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2542454817300139?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T14:08:01Z","timestamp":1762870081000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2542454817300139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S2542454817300139"],"URL":"https:\/\/doi.org\/10.1016\/j.mayocpiqo.2017.05.003","relation":{},"ISSN":["2542-4548"],"issn-type":[{"value":"2542-4548","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Normalization of Testosterone Levels After Testosterone Replacement Therapy Is Not Associated With Reduced Myocardial Infarction in Smokers","name":"articletitle","label":"Article Title"},{"value":"Mayo Clinic Proceedings: Innovations, Quality & Outcomes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mayocpiqo.2017.05.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}