{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T01:06:11Z","timestamp":1780707971726,"version":"3.54.1"},"reference-count":16,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","mcpiqojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mayo Clinic Proceedings: Innovations, Quality & Outcomes"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.mayocpiqo.2026.100711","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T17:25:53Z","timestamp":1775755553000},"page":"100711","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Mobilization Outcomes With Tenecteplase Treatment in Acute Ischemic Stroke (EMOTE-TNK) Study: Safety and Tolerability"],"prefix":"10.1016","volume":"10","author":[{"given":"Isabelle Delos","family":"Reyes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saptarshi","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Boykin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Perez","family":"Vega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher Joseph","family":"Yelvington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg M.","family":"Worsowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David O.","family":"Hodge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo Moreno","family":"Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesia H.","family":"Mooney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2326-0633","authenticated-orcid":false,"given":"William D.","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.mayocpiqo.2026.100711_bib1","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1161\/CIR.0000000000001303","article-title":"2025 heart disease and stroke statistics: a report of US and Global Data from the American Heart Association","volume":"151","author":"Martin","year":"2025","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.mayocpiqo.2026.100711_bib2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.7861\/clinmedicine.17-2-161","article-title":"Thrombolysis and thrombectomy for acute ischaemic stroke","volume":"17","author":"Tawil","year":"2017","journal-title":"Clin Med (Lond)"},{"issue":"3","key":"10.1016\/j.mayocpiqo.2026.100711_bib3","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.4506","article-title":"Off-label use of tenecteplase for the treatment of acute ischemic stroke: a systematic review and meta-analysis","volume":"5","author":"Katsanos","year":"2022","journal-title":"JAMA Netw Open"},{"issue":"10377","key":"10.1016\/j.mayocpiqo.2026.100711_bib4","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0140-6736(22)02600-9","article-title":"Tenecteplase versus alteplase in acute ischaemic cerebrovascular events (TRACE-2): a phase 3, multicentre, open-label, randomised controlled, non-inferiority trial","volume":"401","author":"Wang","year":"2023","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.mayocpiqo.2026.100711_bib5","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000209903","article-title":"Tenecteplase vs alteplase in acute ischemic stroke within 4.5 hours: a systematic review and meta-analysis of randomized trials","volume":"103","author":"Palaiodimou","year":"2024","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.mayocpiqo.2026.100711_bib6","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.annemergmed.2023.03.022","article-title":"Tenecteplase versus alteplase for acute stroke: mortality and bleeding complications","volume":"82","author":"Murphy","year":"2023","journal-title":"Ann Emerg Med"},{"issue":"5","key":"10.1016\/j.mayocpiqo.2026.100711_bib7","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1161\/STROKEAHA.122.042335","article-title":"Complications of intravenous tenecteplase versus alteplase for the treatment of acute ischemic stroke: a systematic review and meta-analysis","volume":"54","author":"Rose","year":"2023","journal-title":"Stroke"},{"issue":"3","key":"10.1016\/j.mayocpiqo.2026.100711_bib8","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1177\/1747493020938306","article-title":"Tenecteplase versus alteplase after acute ischemic stroke at high age","volume":"16","author":"Thommessen","year":"2021","journal-title":"Int J Stroke"},{"issue":"6","key":"10.1016\/j.mayocpiqo.2026.100711_bib9","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.01.007","article-title":"Very early mobilization in stroke patients treated with intravenous recombinant tissue plasminogen activator","volume":"24","author":"Arnold","year":"2015","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"2","key":"10.1016\/j.mayocpiqo.2026.100711_bib10","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1007\/s12028-018-0632-7","article-title":"Early progressive mobilization of patients with external ventricular drains: safety and feasibility","volume":"30","author":"Yataco","year":"2019","journal-title":"Neurocrit Care"},{"issue":"2","key":"10.1016\/j.mayocpiqo.2026.100711_bib11","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/10749357.2021.2008595","article-title":"Early mobilization in acute stroke phase: a systematic review","volume":"30","author":"Mariana de Aquino Miranda","year":"2023","journal-title":"Top Stroke Rehabil"},{"issue":"4","key":"10.1016\/j.mayocpiqo.2026.100711_bib12","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jclinepi.2007.11.008","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"61","author":"von Elm","year":"2008","journal-title":"J Clin Epidemiol"},{"issue":"10","key":"10.1016\/j.mayocpiqo.2026.100711_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001885","article-title":"The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) statement","volume":"12","author":"Benchimol","year":"2015","journal-title":"PLoS Med"},{"key":"10.1016\/j.mayocpiqo.2026.100711_bib14","doi-asserted-by":"crossref","DOI":"10.1161\/STR.0000000000000513","article-title":"2026 guideline for the early management of patients with acute ischemic stroke: a guideline from the American Heart Association\/American Stroke Association","author":"Prabhakaran","year":"2026","journal-title":"Stroke"},{"issue":"54","key":"10.1016\/j.mayocpiqo.2026.100711_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta21540","article-title":"A Very Early Rehabilitation Trial after stroke (AVERT): a phase III, multicentre, randomised controlled trial","volume":"21","author":"Langhorne","year":"2017","journal-title":"Health Technol Assess"},{"issue":"7","key":"10.1016\/j.mayocpiqo.2026.100711_bib16","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1200\/OP.22.00761","article-title":"Benefits of an early mobility program for hospitalized patients with cancer","volume":"19","author":"Aronson","year":"2023","journal-title":"JCO Oncol Pract"}],"container-title":["Mayo Clinic Proceedings: Innovations, Quality & Outcomes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2542454826000184?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2542454826000184?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T00:43:23Z","timestamp":1780706603000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2542454826000184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2542454826000184"],"URL":"https:\/\/doi.org\/10.1016\/j.mayocpiqo.2026.100711","relation":{},"ISSN":["2542-4548"],"issn-type":[{"value":"2542-4548","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early Mobilization Outcomes With Tenecteplase Treatment in Acute Ischemic Stroke (EMOTE-TNK) Study: Safety and Tolerability","name":"articletitle","label":"Article Title"},{"value":"Mayo Clinic Proceedings: Innovations, Quality & Outcomes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mayocpiqo.2026.100711","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc on behalf of Mayo Foundation for Medical Education and Research.","name":"copyright","label":"Copyright"}],"article-number":"100711"}}