{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:47:10Z","timestamp":1785844030256,"version":"3.56.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006785","name":"Google","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400445"],"award-info":[{"award-number":["82400445"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270404"],"award-info":[{"award-number":["82270404"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","mcpiqojournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mayo Clinic Proceedings: Innovations, Quality & Outcomes"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.mayocpiqo.2026.100726","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T20:46:29Z","timestamp":1781124389000},"page":"100726","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Supranormal Ejection Fraction as a Clinical Red Flag: Differentiating Hemodynamic Stress From Intrinsic Cardiomyopathy in Heart Failure"],"prefix":"10.1016","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9116-3520","authenticated-orcid":false,"given":"Yanjia","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuxiu","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeping","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.mayocpiqo.2026.100726_bib1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1056\/NEJMcp2305181","article-title":"Heart failure with preserved ejection fraction","volume":"392","author":"Cannata","year":"2025","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.mayocpiqo.2026.100726_bib2","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/ehf2.12418","article-title":"Clinical characteristics of hospitalized heart failure patients with preserved, mid-range, and reduced ejection fractions in Japan","volume":"6","author":"Shiga","year":"2019","journal-title":"ESC Heart Fail"},{"issue":"5_Suppl","key":"10.1016\/j.mayocpiqo.2026.100726_bib3","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.7326\/ANNALS-25-00991","article-title":"Cardiology: what you may have missed in 2024","volume":"178","author":"Khattak","year":"2025","journal-title":"Ann Intern Med"},{"issue":"5","key":"10.1016\/j.mayocpiqo.2026.100726_bib4","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s00392-025-02620-9","article-title":"Heart failure with supranormal ejection fraction: clinical characteristics and outcomes compared to mildly reduced and preserved ejection fraction","volume":"114","author":"Segev","year":"2025","journal-title":"Clin Res Cardiol"},{"issue":"8","key":"10.1016\/j.mayocpiqo.2026.100726_bib5","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1002\/ejhf.3654","article-title":"Clinical and plasma proteomic characterization of heart failure with supranormal left ventricular ejection fraction: an emerging entity of heart failure","volume":"27","author":"Sakata","year":"2025","journal-title":"Eur J Heart Fail"},{"issue":"12","key":"10.1016\/j.mayocpiqo.2026.100726_bib6","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1002\/ejhf.70061","article-title":"A U-shaped relationship between left ventricular ejection fraction and risk of worsening heart failure","volume":"27","author":"Chang","year":"2025","journal-title":"Eur J Heart Fail"},{"issue":"11","key":"10.1016\/j.mayocpiqo.2026.100726_bib7","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1002\/ejhf.2657","article-title":"Heart failure with supra-normal left ventricular ejection fraction: distinct polygenic bases of an unrecognized phenotype","volume":"24","author":"Sinagra","year":"2022","journal-title":"Eur J Heart Fail"},{"issue":"6","key":"10.1016\/j.mayocpiqo.2026.100726_bib8","doi-asserted-by":"crossref","first-page":"196","DOI":"10.31083\/j.rcm2306196","article-title":"The heart in Fabry disease: mechanisms beyond storage and forthcoming therapies","volume":"23","author":"Pieroni","year":"2022","journal-title":"Rev Cardiovasc Med"},{"issue":"5","key":"10.1016\/j.mayocpiqo.2026.100726_bib9","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41569-022-00806-6","article-title":"Regression of cardiac hypertrophy in health and disease: mechanisms and therapeutic potential","volume":"20","author":"Martin","year":"2023","journal-title":"Nat Rev Cardiol"},{"issue":"13","key":"10.1016\/j.mayocpiqo.2026.100726_bib10","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.jacc.2024.06.002","article-title":"2024 ACC Expert Consensus decision pathway on clinical assessment, management, and trajectory of patients hospitalized with heart failure focused update: a report of the American College of Cardiology Solution Set Oversight Committee","volume":"84","author":"Hollenberg","year":"2024","journal-title":"J Am Coll Cardiol"},{"issue":"18","key":"10.1016\/j.mayocpiqo.2026.100726_bib11","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/j.jacc.2023.03.393","article-title":"2023 ACC Expert Consensus Decision Pathway on Management of Heart Failure With Preserved Ejection Fraction: A Report of the American College of Cardiology Solution Set Oversight Committee","volume":"81","author":"Kittleson","year":"2023","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.mayocpiqo.2026.100726_bib12","doi-asserted-by":"crossref","DOI":"10.1111\/echo.70079","article-title":"Left atrial mechanics and atrioventricular coupling in hypertension with supra-normal left ventricular ejection fraction","volume":"42","author":"Liu","year":"2025","journal-title":"Echocardiography"},{"issue":"4","key":"10.1016\/j.mayocpiqo.2026.100726_bib13","doi-asserted-by":"crossref","first-page":"426","DOI":"10.3390\/jcm14020426","article-title":"Supra-normal ejection fraction at hospital admission stratifies mortality risk in HFpEF patients aged \u2265 70 years","volume":"14","author":"Sonaglioni","year":"2025","journal-title":"J Clin Med"},{"issue":"11","key":"10.1016\/j.mayocpiqo.2026.100726_bib14","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1002\/ejhf.2482","article-title":"Genetic and phenotypic profiling of supranormal ejection fraction reveals decreased survival and underdiagnosed heart failure","volume":"24","author":"Forrest","year":"2022","journal-title":"Eur J Heart Fail"},{"issue":"37","key":"10.1016\/j.mayocpiqo.2026.100726_bib15","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1093\/eurheartj\/ehad195","article-title":"2023 Focused Update of the 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"44","author":"McDonagh","year":"2023","journal-title":"Eur Heart J"},{"issue":"23","key":"10.1016\/j.mayocpiqo.2026.100726_bib16","doi-asserted-by":"crossref","first-page":"e1239","DOI":"10.1161\/CIR.0000000000001250","article-title":"2024 AHA\/ACC\/AMSSM\/HRS\/PACES\/SCMR guideline for the management of hypertrophic cardiomyopathy: a report of the American Heart Association\/American College of Cardiology Joint Committee on Clinical Practice Guidelines","volume":"149","author":"Ommen","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.mayocpiqo.2026.100726_bib17","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.pcad.2025.08.003","article-title":"Fabry disease cardiomyopathy: A state-of-the-art review","volume":"92","author":"Pande","year":"2025","journal-title":"Prog Cardiovasc Dis"},{"issue":"16","key":"10.1016\/j.mayocpiqo.2026.100726_bib18","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1093\/eurheartj\/ehae148","article-title":"Anderson-Fabry disease management: role of the cardiologist","volume":"45","author":"Pieroni","year":"2024","journal-title":"Eur Heart J"},{"issue":"9","key":"10.1016\/j.mayocpiqo.2026.100726_bib19","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1002\/ejhf.3339","article-title":"Evaluation of the 2021 ESC recommendations for family screening in hereditary transthyretin cardiac amyloidosis","volume":"26","author":"Muller","year":"2024","journal-title":"Eur J Heart Fail"},{"issue":"3","key":"10.1016\/j.mayocpiqo.2026.100726_bib20","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/ehjci\/jev014","article-title":"Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"16","author":"Lang","year":"2015","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"11","key":"10.1016\/j.mayocpiqo.2026.100726_bib21","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1002\/ejhf.2654","article-title":"Clinical characteristics and 1-year outcomes in hospitalized patients with heart failure with preserved ejection fraction: results from the China Cardiovascular Association Database-Heart Failure Center Registry","volume":"24","author":"Cai","year":"2022","journal-title":"Eur J Heart Fail"},{"issue":"23","key":"10.1016\/j.mayocpiqo.2026.100726_bib22","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.1161\/CIRCULATIONAHA.107.698985","article-title":"Evaluation of left ventricular filling pressures by Doppler echocardiography in patients with hypertrophic cardiomyopathy: correlation with direct left atrial pressure measurement at cardiac catheterization","volume":"116","author":"Geske","year":"2007","journal-title":"Circulation"}],"container-title":["Mayo Clinic Proceedings: Innovations, Quality & Outcomes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2542454826000330?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2542454826000330?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:29:56Z","timestamp":1785842996000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2542454826000330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S2542454826000330"],"URL":"https:\/\/doi.org\/10.1016\/j.mayocpiqo.2026.100726","relation":{},"ISSN":["2542-4548"],"issn-type":[{"value":"2542-4548","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Supranormal Ejection Fraction as a Clinical Red Flag: Differentiating Hemodynamic Stress From Intrinsic Cardiomyopathy in Heart Failure","name":"articletitle","label":"Article Title"},{"value":"Mayo Clinic Proceedings: Innovations, Quality & Outcomes","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mayocpiqo.2026.100726","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc on behalf of Mayo Foundation for Medical Education and Research.","name":"copyright","label":"Copyright"}],"article-number":"100726"}}