{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:56Z","timestamp":1790726456450,"version":"4.1.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["#205321_219486 \/ 1"],"award-info":[{"award-number":["#205321_219486 \/ 1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mechanobiology in Medicine"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.mbm.2026.100213","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:08:05Z","timestamp":1789495685000},"page":"100213","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Restoring the lost heat of the joint: Thermomechanical stimulation as a candidate treatment for early-stage osteoarthritis"],"prefix":"10.1016","volume":"4","author":[{"given":"Antoine","family":"Reitzel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz Cemre","family":"Turgut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line Samira","family":"Wyss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Stadelmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5535-5296","authenticated-orcid":false,"given":"Dominique P.","family":"Pioletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mbm.2026.100213_bib1","doi-asserted-by":"crossref","first-page":"e508","DOI":"10.1016\/S2665-9913(23)00163-7","article-title":"Global, regional, and national burden of osteoarthritis, 1990\u20132020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021","volume":"5","year":"2023","journal-title":"Lancet Rheumatol"},{"key":"10.1016\/j.mbm.2026.100213_bib2","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.joca.2019.06.011","article-title":"OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis","volume":"27","author":"Bannuru","year":"2019","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.mbm.2026.100213_bib3","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/s41584-021-00673-4","article-title":"Early-stage symptomatic osteoarthritis of the knee \u2014 time for action","volume":"17","author":"Mahmoudian","year":"2021","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.mbm.2026.100213_bib4","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s00776-011-0093-8","article-title":"The effects of radiofrequency hyperthermia on pain and function in patients with knee osteoarthritis: a preliminary report","volume":"16","author":"Takahashi","year":"2011","journal-title":"J Orthop Sci"},{"key":"10.1016\/j.mbm.2026.100213_bib5","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1471-2474-9-46","article-title":"Intra-articular temperatures of the knee in sports \u2013 an in-vivo study of jogging and alpine skiing","volume":"9","author":"Becher","year":"2008","journal-title":"BMC Muscoskelet Disord"},{"key":"10.1016\/j.mbm.2026.100213_bib6","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/jor.20421","article-title":"Effects of heat stimulation via microwave applicator on cartilage matrix gene and HSP70 expression in the rabbit knee joint","volume":"26","author":"Tonomura","year":"2008","journal-title":"J Orthop Res"},{"key":"10.1016\/j.mbm.2026.100213_bib7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1177\/1947603516678974","article-title":"Effectiveness of radiofrequency hyperthermia for treating cartilage in Guinea pigs with primary osteoarthritis","volume":"9","author":"Takahashi","year":"2018","journal-title":"Cartilage"},{"key":"10.1016\/j.mbm.2026.100213_bib8","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3109\/02656730903107519","article-title":"Hyperthermia for the treatment of articular cartilage with osteoarthritis","volume":"25","author":"Hiraoka","year":"2009","journal-title":"Int J Hyperther"},{"key":"10.1016\/j.mbm.2026.100213_bib9","article-title":"Exercise for osteoarthritis of the knee","volume":"12","author":"Lawford","year":"2024","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.mbm.2026.100213_bib10","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1136\/bjsports-2017-098661","article-title":"Impact of exercise on articular cartilage in people at risk of, or with established, knee osteoarthritis: a systematic review of randomised controlled trials","volume":"53","author":"Bricca","year":"2019","journal-title":"Br J Sports Med"},{"key":"10.1016\/j.mbm.2026.100213_bib11","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/j.joca.2013.08.021","article-title":"Moderate dynamic compression inhibits pro-catabolic response of cartilage to mechanical injury, tumor necrosis factor-\u03b1 and interleukin-6, but accentuates degradation above a strain threshold","volume":"21","author":"Li","year":"2013","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.mbm.2026.100213_bib12","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jmbbm.2013.10.025","article-title":"Intrinsic viscoelasticity increases temperature in knee cartilage under physiological loading","volume":"30","author":"Abdel-Sayed","year":"2014","journal-title":"J Mech Behav Biomed Mater"},{"key":"10.1016\/j.mbm.2026.100213_bib13","doi-asserted-by":"crossref","first-page":"171","DOI":"10.22203\/eCM.v026a12","article-title":"Cartilage self-heating contributes to chondrogenic expression","volume":"26","author":"Abdel-Sayed","year":"2013","journal-title":"Eur Cell Mater"},{"key":"10.1016\/j.mbm.2026.100213_bib14","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.joca.2018.12.025","article-title":"The evolving large-strain shear responses of progressively osteoarthritic human cartilage","volume":"27","author":"Maier","year":"2019","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.mbm.2026.100213_bib15","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/j.biomaterials.2013.11.048","article-title":"The role of energy dissipation of polymeric scaffolds in the mechanobiological modulation of chondrogenic expression","volume":"35","author":"Abdel-Sayed","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.mbm.2026.100213_bib16","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.72068","article-title":"Temperature evolution following joint loading promotes chondrogenesis by synergistic cues via calcium signaling","volume":"11","author":"Nasrollahzadeh","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.mbm.2026.100213_bib17","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1021\/acsbiomaterials.2c00723","article-title":"Mimicking loading-induced cartilage self-heating in vitro promotes matrix formation in chondrocyte-laden constructs with different mechanical properties","volume":"9","author":"Stampoultzis","year":"2023","journal-title":"ACS Biomater Sci Eng"},{"key":"10.1016\/j.mbm.2026.100213_bib18","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.joca.2024.04.008","article-title":"HSP70 \u2014 a key regulator in chondrocyte homeostasis under naturally coupled hydrostatic pressure-thermal stimuli","volume":"32","author":"Guo","year":"2024","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.mbm.2026.100213_bib19","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1589\/jpts.32.823","article-title":"Deep heat therapy system with resonant cavity applicator for articular cartilage in knee osteoarthritis","volume":"32","author":"Shindo","year":"2020","journal-title":"J Phys Ther Sci"},{"key":"10.1016\/j.mbm.2026.100213_bib20","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1007\/s00167-010-1350-7","article-title":"Localized hyperthermia induced by microwave diathermy in osteoarthritis of the knee: a randomized placebo-controlled double-blind clinical trial","volume":"19","author":"Giombini","year":"2011","journal-title":"Knee Surg Sports Traumatol Arthrosc"}],"container-title":["Mechanobiology in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2949907026000409?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2949907026000409?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:14:34Z","timestamp":1790723674000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2949907026000409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S2949907026000409"],"URL":"https:\/\/doi.org\/10.1016\/j.mbm.2026.100213","relation":{},"ISSN":["2949-9070"],"issn-type":[{"value":"2949-9070","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Restoring the lost heat of the joint: Thermomechanical stimulation as a candidate treatment for early-stage osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Mechanobiology in Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mbm.2026.100213","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine.","name":"copyright","label":"Copyright"}],"article-number":"100213"}}