{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T01:25:13Z","timestamp":1785806713121,"version":"3.56.0"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T00:00:00Z","timestamp":1585008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AR048311"],"award-info":[{"award-number":["P30 AR048311"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 DK079337"],"award-info":[{"award-number":["P30 DK079337"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA013148"],"award-info":[{"award-number":["P30 CA013148"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008333","name":"University of Alabama at Birmingham","doi-asserted-by":"publisher","award":["W81XWH-14-1-0203"],"award-info":[{"award-number":["W81XWH-14-1-0203"]}],"id":[{"id":"10.13039\/100008333","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Matrix Biology Plus"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.mbplus.2020.100034","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T20:49:20Z","timestamp":1585946960000},"page":"100034","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Calreticulin is important for the development of renal fibrosis and dysfunction in diabetic nephropathy"],"prefix":"10.1016","volume":"8","author":[{"given":"Ailing","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel A.","family":"Pallero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin Y.","family":"Owusu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton V.","family":"Borovjagin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqi","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne E.","family":"Murphy-Ullrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.mbplus.2020.100034_bb0005","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1681\/ASN.2007121313","article-title":"Proteinuria and hyperglycemia induce endoplasmic reticulum stress","volume":"19","author":"Lindenmeyer","year":"2008","journal-title":"Journal of the American Society of Nephrology"},{"issue":"1","key":"10.1016\/j.mbplus.2020.100034_bb0010","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1159\/000210573","article-title":"Endoplasmic reticulum stress in the kidney as a novel mediator of kidney injury","volume":"112","author":"Inagi","year":"2009","journal-title":"Nephron. Experimental Nephrology"},{"issue":"5","key":"10.1016\/j.mbplus.2020.100034_bb0015","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s10157-008-0060-7","article-title":"Endoplasmic reticulum stress in the kidney","volume":"12","author":"Kitamura","year":"2008","journal-title":"Clinical and Experimental Nephrology"},{"issue":"3","key":"10.1016\/j.mbplus.2020.100034_bb0020","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/ki.2009.389","article-title":"Endoplasmic reticulum stress in proteinuric kidney disease","volume":"77","author":"Cybulsky","year":"2010","journal-title":"Kidney International"},{"issue":"3","key":"10.1016\/j.mbplus.2020.100034_bb0025","doi-asserted-by":"crossref","first-page":"608","DOI":"10.2337\/diabetes.55.03.06.db05-1284","article-title":"Mechanisms of [Ca2+]i transient decrease in cardiomyopathy of db\/db type 2 diabetic mice","volume":"55","author":"Pereira","year":"2006","journal-title":"Diabetes"},{"issue":"5","key":"10.1016\/j.mbplus.2020.100034_bb0030","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.metabol.2010.07.021","article-title":"Attenuation of diabetic nephropathy in diabetes rats induced by streptozotocin by regulating the endoplasmic reticulum stress inflammatory response","volume":"60","author":"Qi","year":"2011","journal-title":"Metabolism"},{"issue":"2","key":"10.1016\/j.mbplus.2020.100034_bb0035","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1538\/expanim.58.113","article-title":"Aortic ER stress in streptozotocin-induced diabetes mellitus in APA hamsters","volume":"58","author":"Kurokawa","year":"2009","journal-title":"Experimental Animals"},{"issue":"4","key":"10.1016\/j.mbplus.2020.100034_bb0040","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.bbrc.2008.04.031","article-title":"Apoptosis induced by endoplasmic reticulum stress involved in diabetic kidney disease","volume":"370","author":"Liu","year":"2008","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"35","key":"10.1016\/j.mbplus.2020.100034_bb0045","doi-asserted-by":"crossref","first-page":"21751","DOI":"10.1074\/jbc.272.35.21751","article-title":"Endoplasmic reticulum chaperones GRP78 and calreticulin prevent oxidative stress, Ca2+ disturbances, and cell death in renal epithelial cells","volume":"272","author":"Liu","year":"1997","journal-title":"The Journal of Biological Chemistry"},{"issue":"7","key":"10.1016\/j.mbplus.2020.100034_bb0050","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1161\/CIRCRESAHA.110.224766","article-title":"The role of endoplasmic reticulum stress in the progression of atherosclerosis","volume":"107","author":"Tabas","year":"2010","journal-title":"Circulation Research"},{"issue":"8","key":"10.1016\/j.mbplus.2020.100034_bb0055","doi-asserted-by":"crossref","first-page":"L721","DOI":"10.1152\/ajplung.00410.2011","article-title":"Emerging evidence for endoplasmic reticulum stress in the pathogenesis of idiopathic pulmonary fibrosis","volume":"302","author":"Tanjore","year":"2012","journal-title":"American Journal of Physiology. Lung Cellular and Molecular Physiology"},{"issue":"35","key":"10.1016\/j.mbplus.2020.100034_bb0060","doi-asserted-by":"crossref","first-page":"30972","DOI":"10.1074\/jbc.M110.181164","article-title":"Alveolar epithelial cells undergo epithelial-to-mesenchymal transition in response to endoplasmic reticulum stress","volume":"286","author":"Tanjore","year":"2011","journal-title":"The Journal of Biological Chemistry"},{"issue":"6","key":"10.1016\/j.mbplus.2020.100034_bb0065","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1097\/BOR.0b013e3283588dbb","article-title":"The role of endoplasmic reticulum stress and the unfolded protein response in fibrosis","volume":"24","author":"Lenna","year":"2012","journal-title":"Current Opinion in Rheumatology"},{"issue":"7","key":"10.1016\/j.mbplus.2020.100034_bb0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0159682","article-title":"Inhibition of the unfolded protein response mechanism prevents cardiac fibrosis","volume":"11","author":"Groenendyk","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.mbplus.2020.100034_bb0075","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.matbio.2018.03.015","article-title":"Endoplasmic reticulum stress in pulmonary fibrosis","volume":"68-69","author":"Burman","year":"2018","journal-title":"Matrix Biology"},{"issue":"16","key":"10.1016\/j.mbplus.2020.100034_bb0080","doi-asserted-by":"crossref","first-page":"22116","DOI":"10.18632\/oncotarget.7904","article-title":"Chemical chaperon 4-phenylbutyrate protects against the endoplasmic reticulum stress-mediated renal fibrosis in vivo and in vitro","volume":"7","author":"Liu","year":"2016","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.mbplus.2020.100034_bb0085","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18020305","article-title":"Anti-fibrotic effect of losartan, an angiotensin II receptor blocker, is mediated through inhibition of ER stress via up-regulation of SIRT1, followed by induction of HO-1 and Thioredoxin","volume":"18","author":"Kim","year":"2017","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.mbplus.2020.100034_bb0090","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ejphar.2017.03.061","article-title":"Matrine attenuates cardiac fibrosis by affecting ATF6 signaling pathway in diabetic cardiomyopathy","volume":"804","author":"Liu","year":"2017","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.mbplus.2020.100034_bb0095","doi-asserted-by":"crossref","unstructured":"K.Y. Tsang, D. Chan, J.F. Bateman, K.S. Cheah, In vivo cellular adaptation to ER stress: survival strategies with double-edged consequences, Journal of Cell Science 123(Pt 13) 2145\u201354.","DOI":"10.1242\/jcs.068833"},{"issue":"20","key":"10.1016\/j.mbplus.2020.100034_bb0100","doi-asserted-by":"crossref","first-page":"14584","DOI":"10.1074\/jbc.M112.447243","article-title":"Calreticulin regulates transforming growth factor-beta-stimulated extracellular matrix production","volume":"288","author":"Zimmerman","year":"2013","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.mbplus.2020.100034_bb0105","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.matbio.2018.02.006","article-title":"Renal fibrosis: primacy of the proximal tubule","volume":"68\u201369","author":"Gewin","year":"2018","journal-title":"Matrix Biology"},{"issue":"3","key":"10.1016\/j.mbplus.2020.100034_bb0110","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1042\/BJ20081847","article-title":"Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum","volume":"417","author":"Michalak","year":"2009","journal-title":"The Biochemical Journal"},{"issue":"3","key":"10.1016\/j.mbplus.2020.100034_bb0115","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S1016-8478(23)13056-1","article-title":"Calreticulin, Ca2+, and calcineurin - signaling from the endoplasmic reticulum","volume":"17","author":"Groenendyk","year":"2004","journal-title":"Molecules and Cells"},{"issue":"Pt 14","key":"10.1016\/j.mbplus.2020.100034_bb0120","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1242\/jcs.00600","article-title":"Thrombospondin signaling through the calreticulin\/LDL receptor-related protein co-complex stimulates random and directed cell migration","volume":"116","author":"Orr","year":"2003","journal-title":"Journal of Cell Science"},{"issue":"21","key":"10.1016\/j.mbplus.2020.100034_bb0125","doi-asserted-by":"crossref","first-page":"15085","DOI":"10.1074\/jbc.274.21.15085","article-title":"Calreticulin affects focal contact-dependent but not close contact-dependent cell-substratum adhesion","volume":"274","author":"Fadel","year":"1999","journal-title":"The Journal of Biological Chemistry"},{"issue":"46","key":"10.1016\/j.mbplus.2020.100034_bb0130","doi-asserted-by":"crossref","first-page":"36358","DOI":"10.1074\/jbc.M005951200","article-title":"Thrombospondin mediates focal adhesion disassembly through interactions with cell surface calreticulin","volume":"275","author":"Goicoechea","year":"2000","journal-title":"The Journal of Biological Chemistry"},{"issue":"2","key":"10.1016\/j.mbplus.2020.100034_bb0135","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.cell.2005.08.032","article-title":"Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte","volume":"123","author":"Gardai","year":"2005","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.mbplus.2020.100034_bb0140","doi-asserted-by":"crossref","first-page":"3968","DOI":"10.1096\/fj.07-104802","article-title":"Thrombospondin 1 binding to calreticulin-LRP1 signals resistance to anoikis","volume":"22","author":"Pallero","year":"2008","journal-title":"The FASEB Journal"},{"issue":"3","key":"10.1016\/j.mbplus.2020.100034_bb0145","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.matbio.2012.01.006","article-title":"Thrombospondin1 in tissue repair and fibrosis: TGF-beta-dependent and independent mechanisms","volume":"31","author":"Sweetwyne","year":"2012","journal-title":"Matrix Biology"},{"issue":"3","key":"10.1016\/j.mbplus.2020.100034_bb0150","doi-asserted-by":"crossref","first-page":"610","DOI":"10.2353\/ajpath.2008.071027","article-title":"Calreticulin enhances porcine wound repair by diverse biological effects","volume":"173","author":"Nanney","year":"2008","journal-title":"The American Journal of Pathology"},{"issue":"5","key":"10.1016\/j.mbplus.2020.100034_bb0155","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/j.1524-475X.2012.00822.x","article-title":"Exogenous calreticulin improves diabetic wound healing","volume":"20","author":"Greives","year":"2012","journal-title":"Wound Repair and Regeneration"},{"issue":"3","key":"10.1016\/j.mbplus.2020.100034_bb0160","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1096\/fj.09-145482","article-title":"Calreticulin: non-endoplasmic reticulum functions in physiology and disease","volume":"24","author":"Gold","year":"2010","journal-title":"The FASEB Journal"},{"issue":"1","key":"10.1016\/j.mbplus.2020.100034_bb0165","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s12079-017-0426-2","article-title":"The role of the endoplasmic reticulum protein calreticulin in mediating TGF-beta-stimulated extracellular matrix production in fibrotic disease","volume":"12","author":"Owusu","year":"2018","journal-title":"Journal of Cell Communication and Signaling"},{"issue":"22","key":"10.1016\/j.mbplus.2020.100034_bb0170","doi-asserted-by":"crossref","first-page":"16585","DOI":"10.1074\/jbc.M701011200","article-title":"Calreticulin affects fibronectin-based cell-substratum adhesion via the regulation of c-Src activity","volume":"282","author":"Papp","year":"2007","journal-title":"The Journal of Biological Chemistry"},{"issue":"6","key":"10.1016\/j.mbplus.2020.100034_bb0175","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.yexcr.2008.01.008","article-title":"Kinase-dependent adhesion to fibronectin: regulation by calreticulin","volume":"314","author":"Papp","year":"2008","journal-title":"Experimental Cell Research"},{"issue":"10","key":"10.1016\/j.mbplus.2020.100034_bb0180","doi-asserted-by":"crossref","first-page":"7067","DOI":"10.1074\/jbc.M109.006841","article-title":"Intracellular calreticulin regulates multiple steps in fibrillar collagen expression, trafficking, and processing into the extracellular matrix","volume":"285","author":"Van Duyn Graham","year":"2010","journal-title":"The Journal of Biological Chemistry"},{"issue":"1","key":"10.1016\/j.mbplus.2020.100034_bb0185","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/jcp.21122","article-title":"Differential calreticulin expression affects focal contacts via the calmodulin\/CaMK II pathway","volume":"213","author":"Szabo","year":"2007","journal-title":"Journal of Cellular Physiology"},{"issue":"7","key":"10.1016\/j.mbplus.2020.100034_bb0190","doi-asserted-by":"crossref","first-page":"887","DOI":"10.17219\/acem\/74430","article-title":"Calreticulin promotes proliferation and extracellular matrix expression through notch pathway in cardiac fibroblasts","volume":"27","author":"Fan","year":"2018","journal-title":"Advances in Clinical and Experimental Medicine"},{"issue":"5","key":"10.1016\/j.mbplus.2020.100034_bb0195","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.stemcr.2017.03.018","article-title":"Calreticulin is required for TGF-beta-induced epithelial-to-mesenchymal transition during Cardiogenesis in mouse embryonic stem cells","volume":"8","author":"Karimzadeh","year":"2017","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.mbplus.2020.100034_bb0200","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.biocel.2017.07.023","article-title":"Calreticulin regulates TGF-beta1-induced epithelial mesenchymal transition through modulating Smad signaling and calcium signaling","volume":"90","author":"Wu","year":"2017","journal-title":"The International Journal of Biochemistry & Cell Biology"},{"issue":"5","key":"10.1016\/j.mbplus.2020.100034_bb0205","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1016\/j.ajpath.2013.07.014","article-title":"Epithelial calreticulin up-regulation promotes profibrotic responses and tubulointerstitial fibrosis development","volume":"183","author":"Prakoura","year":"2013","journal-title":"The American Journal of Pathology"},{"issue":"5","key":"10.1016\/j.mbplus.2020.100034_bb0210","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1159\/000443884","article-title":"Calreticulin regulates neointima formation and collagen deposition following carotid artery ligation","volume":"52","author":"Zimmerman","year":"2015","journal-title":"Journal of Vascular Research"},{"issue":"2","key":"10.1016\/j.mbplus.2020.100034_bb0215","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.bbapap.2008.10.001","article-title":"Proteomic analysis of homocysteine induced proliferation of cultured neonatal rat vascular smooth muscle cells","volume":"1794","author":"Liu","year":"2009","journal-title":"Biochimica et Biophysica Acta"},{"issue":"4","key":"10.1016\/j.mbplus.2020.100034_bb0220","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/jcb.1194","article-title":"Iron-induced oxidative stress up-regulates calreticulin levels in intestinal epithelial (Caco-2) cells","volume":"82","author":"N\u00fa\u00f1ez","year":"2001","journal-title":"Journal of Cellular Biochemistry"},{"issue":"1","key":"10.1016\/j.mbplus.2020.100034_bb0225","doi-asserted-by":"crossref","first-page":"C47","DOI":"10.1152\/ajpcell.00019.2007","article-title":"Novel anti-oxidative role of calreticulin in protecting A549 human type II alveolar epithelial cells against hypoxic injury","volume":"294","author":"Jia","year":"2008","journal-title":"American Journal of Physiology. Cell Physiology"},{"issue":"3","key":"10.1016\/j.mbplus.2020.100034_bb0230","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1083\/jcb.138.3.547","article-title":"Regulation of calreticulin gene expression by calcium","volume":"138","author":"Waser","year":"1997","journal-title":"The Journal of Cell Biology"},{"issue":"Pt 2","key":"10.1016\/j.mbplus.2020.100034_bb0235","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1042\/bj3290389","article-title":"Induction of calreticulin expression in response to amino acid deprivation in Chinese hamster ovary cells","volume":"329","author":"Heal","year":"1998","journal-title":"The Biochemical Journal"},{"issue":"12","key":"10.1016\/j.mbplus.2020.100034_bb0240","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1002\/pmic.200700831","article-title":"Altered expression of calreticulin during the development of fibrosis","volume":"8","author":"Kypreou","year":"2008","journal-title":"Proteomics"},{"issue":"5","key":"10.1016\/j.mbplus.2020.100034_bb0245","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1096\/fj.11-194381","article-title":"The KUPKB: a novel web application to access multiomics data on kidney disease","volume":"26","author":"Klein","year":"2012","journal-title":"The FASEB Journal"},{"issue":"3","key":"10.1016\/j.mbplus.2020.100034_bb0250","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.jprot.2010.11.007","article-title":"Proteomics characterization of cell model with renal fibrosis phenotype: osmotic stress as fibrosis triggering factor","volume":"74","author":"Dihazi","year":"2011","journal-title":"Journal of Proteomics"},{"issue":"9","key":"10.1016\/j.mbplus.2020.100034_bb0255","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s00592-017-1013-y","article-title":"Poly(ADP-ribosylated) proteins in mononuclear cells from patients with type 2 diabetes identified by proteomic studies","volume":"54","author":"Giorgi","year":"2017","journal-title":"Acta Diabetologica"},{"issue":"9","key":"10.1016\/j.mbplus.2020.100034_bb0260","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.2337\/db08-0604","article-title":"Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals","volume":"57","author":"Boden","year":"2008","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.mbplus.2020.100034_bb0265","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/oby.2011.144","article-title":"Metabolic syndrome and acute hyperglycemia are associated with endoplasmic reticulum stress in human mononuclear cells","volume":"20","author":"Sage","year":"2012","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.mbplus.2020.100034_bb0270","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.arr.2018.07.004","article-title":"Towards frailty biomarkers: candidates from genes and pathways regulated in aging and age-related diseases","volume":"47","author":"Cardoso","year":"2018","journal-title":"Ageing Research Reviews"},{"issue":"10","key":"10.1016\/j.mbplus.2020.100034_bb0275","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1161\/01.RES.0000189260.46084.e5","article-title":"Calreticulin destabilizes glucose transporter-1 mRNA in vascular endothelial and smooth muscle cells under high-glucose conditions","volume":"97","author":"Totary-Jain","year":"2005","journal-title":"Circulation Research"},{"issue":"4","key":"10.1016\/j.mbplus.2020.100034_bb0280","doi-asserted-by":"crossref","first-page":"808","DOI":"10.2337\/db09-1207","article-title":"The natural protective mechanism against hyperglycemia in vascular endothelial cells: roles of the lipid peroxidation product 4-hydroxydodecadienal and peroxisome proliferator-activated receptor delta","volume":"59","author":"Riahi","year":"2010","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.mbplus.2020.100034_bb0285","doi-asserted-by":"crossref","first-page":"E499","DOI":"10.1152\/ajpendo.00507.2009","article-title":"Hexosamine biosynthesis pathway flux promotes endoplasmic reticulum stress, lipid accumulation, and inflammatory gene expression in hepatic cells","volume":"298","author":"Sage","year":"2010","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"issue":"1\u20132","key":"10.1016\/j.mbplus.2020.100034_bb0290","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s11010-009-0092-7","article-title":"Molecular convergence of hexosamine biosynthetic pathway and ER stress leading to insulin resistance in L6 skeletal muscle cells","volume":"328","author":"Srinivasan","year":"2009","journal-title":"Molecular and Cellular Biochemistry"},{"issue":"10","key":"10.1016\/j.mbplus.2020.100034_bb0295","first-page":"1217","article-title":"Activation of the Nkx2.5-Calr-p53 signaling pathway by hyperglycemia induces cardiac remodeling and dysfunction in adult zebrafish","volume":"10","author":"Sun","year":"2017","journal-title":"Disease models & mechanisms"},{"issue":"1","key":"10.1016\/j.mbplus.2020.100034_bb0300","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1038\/s41598-017-02213-1","article-title":"Comparative proteomic analysis of the mitochondria-associated ER membrane (MAM) in a long-term type 2 diabetic rodent model","volume":"7","author":"Ma","year":"2017","journal-title":"Scientific Reports"},{"issue":"2","key":"10.1016\/j.mbplus.2020.100034_bb0305","first-page":"18","article-title":"Calreticulin is involved in diabetic nephropathy through inducing epithelial mesenchymal transition","volume":"3","author":"Yan","year":"2018","journal-title":"Advances in Biology and Medicine"},{"key":"10.1016\/j.mbplus.2020.100034_bb0310","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.matbio.2017.12.009","article-title":"Thrombospondin-1 regulation of latent TGF-beta activation: a therapeutic target for fibrotic disease","volume":"68\u201369","author":"Murphy-Ullrich","year":"2018","journal-title":"Matrix Biology"},{"issue":"1","key":"10.1016\/j.mbplus.2020.100034_bb0315","doi-asserted-by":"crossref","first-page":"5542","DOI":"10.1038\/s41598-018-23839-9","article-title":"Combining streptozotocin and unilateral nephrectomy is an effective method for inducing experimental diabetic nephropathy in the 'resistant' C57Bl\/6J mouse strain","volume":"8","author":"Uil","year":"2018","journal-title":"Scientific Reports"},{"issue":"1","key":"10.1016\/j.mbplus.2020.100034_bb0320","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.matbio.2007.07.003","article-title":"Unilateral nephrectomy leads to up-regulation of syndecan-2- and TGF-beta-mediated glomerulosclerosis in syndecan-4 deficient male mice","volume":"27","author":"Cevikbas","year":"2008","journal-title":"Matrix Biology"},{"key":"10.1016\/j.mbplus.2020.100034_bb0325","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ebiom.2018.10.006","article-title":"Endoplasmic reticulum stress is activated in post-ischemic kidneys to promote chronic kidney disease","volume":"37","author":"Shu","year":"2018","journal-title":"EBioMedicine"},{"issue":"2","key":"10.1016\/j.mbplus.2020.100034_bb0330","doi-asserted-by":"crossref","first-page":"F517","DOI":"10.1152\/ajprenal.00291.2005","article-title":"Urinary kidney injury molecule-1: a sensitive quantitative biomarker for early detection of kidney tubular injury","volume":"290","author":"Vaidya","year":"2006","journal-title":"American Journal of Physiology. Renal Physiology"},{"issue":"3","key":"10.1016\/j.mbplus.2020.100034_bb0335","doi-asserted-by":"crossref","first-page":"F552","DOI":"10.1152\/ajprenal.00285.2002","article-title":"Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury","volume":"286","author":"Ichimura","year":"2004","journal-title":"American Journal of Physiology. Renal Physiology"},{"issue":"2","key":"10.1016\/j.mbplus.2020.100034_bb0340","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.semnephrol.2007.01.012","article-title":"Histopathology of diabetic nephropathy","volume":"27","author":"Fioretto","year":"2007","journal-title":"Seminars in Nephrology"},{"key":"10.1016\/j.mbplus.2020.100034_bb0345","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.matbio.2016.12.009","article-title":"The nature and biology of basement membranes","volume":"57-58","author":"Pozzi","year":"2017","journal-title":"Matrix Biology"},{"issue":"5","key":"10.1016\/j.mbplus.2020.100034_bb0350","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1083\/jcb.144.5.857","article-title":"Calreticulin is essential for cardiac development","volume":"144","author":"Mesaeli","year":"1999","journal-title":"The Journal of Cell Biology"},{"issue":"15","key":"10.1016\/j.mbplus.2020.100034_bb0355","doi-asserted-by":"crossref","first-page":"15561","DOI":"10.1074\/jbc.M308759200","article-title":"Involvement of calcineurin in transforming growth factor-beta-mediated regulation of extracellular matrix accumulation","volume":"279","author":"Gooch","year":"2004","journal-title":"The Journal of Biological Chemistry"},{"issue":"1","key":"10.1016\/j.mbplus.2020.100034_bb0360","doi-asserted-by":"crossref","first-page":"F144","DOI":"10.1152\/ajprenal.00158.2002","article-title":"Calcineurin is activated in diabetes and is required for glomerular hypertrophy and ECM accumulation","volume":"284","author":"Gooch","year":"2003","journal-title":"American Journal of Physiology. Renal Physiology"},{"issue":"2","key":"10.1016\/j.mbplus.2020.100034_bb0365","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/bph.12292","article-title":"NFAT2 inhibitor ameliorates diabetic nephropathy and podocyte injury in db\/db mice","volume":"170","author":"Zhang","year":"2013","journal-title":"British Journal of Pharmacology"},{"issue":"10","key":"10.1016\/j.mbplus.2020.100034_bb0370","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1681\/ASN.2009121253","article-title":"Activation of NFAT signaling in podocytes causes glomerulosclerosis","volume":"21","author":"Wang","year":"2010","journal-title":"Journal of the American Society of Nephrology"},{"issue":"2","key":"10.1016\/j.mbplus.2020.100034_bb0375","doi-asserted-by":"crossref","first-page":"481","DOI":"10.2215\/CJN.04800908","article-title":"Calcineurin inhibitor nephrotoxicity","volume":"4","author":"Naesens","year":"2009","journal-title":"Clinical Journal of the American Society of Nephrology"},{"issue":"20","key":"10.1016\/j.mbplus.2020.100034_bb0380","doi-asserted-by":"crossref","first-page":"7554","DOI":"10.1073\/pnas.0401835101","article-title":"Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules","volume":"101","author":"Roehrl","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"10","key":"10.1016\/j.mbplus.2020.100034_bb0385","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1080\/0886022X.2016.1193816","article-title":"Kidney injury molecule-1 in kidney disease","volume":"38","author":"Yin","year":"2016","journal-title":"Renal Failure"},{"issue":"2","key":"10.1016\/j.mbplus.2020.100034_bb0390","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.bbrc.2007.07.186","article-title":"NFATc is required for TGFbeta-mediated transcriptional regulation of fibronectin","volume":"362","author":"Cobbs","year":"2007","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"7","key":"10.1016\/j.mbplus.2020.100034_bb0400","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.yexcr.2013.01.007","article-title":"NFAT2 mediates high glucose-induced glomerular podocyte apoptosis through increased Bax expression","volume":"319","author":"Li","year":"2013","journal-title":"Experimental Cell Research"},{"issue":"7","key":"10.1016\/j.mbplus.2020.100034_bb0405","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1111\/j.1476-5381.2010.00989.x","article-title":"Activation of a nuclear factor of activated T-lymphocyte-3 (NFAT3) by oxidative stress in carboplatin-mediated renal apoptosis","volume":"161","author":"Lin","year":"2010","journal-title":"British Journal of Pharmacology"},{"issue":"12","key":"10.1016\/j.mbplus.2020.100034_bb0410","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1016\/j.bbamcr.2008.08.014","article-title":"Calreticulin regulates insulin receptor expression and its downstream PI3 kinase\/Akt signalling pathway","volume":"1783","author":"Jalali","year":"2008","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.mbplus.2020.100034_bb0415","doi-asserted-by":"crossref","first-page":"7755","DOI":"10.1074\/jbc.RA118.006939","article-title":"Cell surface expression of 78 kDa glucose regulated protein (GRP78) mediates diabetic nephropathy","volume":"294","author":"Van Krieken","year":"2019","journal-title":"The Journal of Biological Chemistry"},{"issue":"1","key":"10.1016\/j.mbplus.2020.100034_bb0420","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/hep.24368","article-title":"Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice","volume":"54","author":"Ji","year":"2011","journal-title":"Hepatology"},{"issue":"11\u221212","key":"10.1016\/j.mbplus.2020.100034_bb0425","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.2119\/molmed.2011.00131","article-title":"Endoplasmic reticulum stress implicated in the development of renal fibrosis","volume":"17","author":"Chiang","year":"2011","journal-title":"Molecular Medicine"},{"issue":"5","key":"10.1016\/j.mbplus.2020.100034_bb0430","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s004280050191","article-title":"Bleomycin-induced pulmonary fibrosis in rat is associated with increased expression of collagen-binding heat shock protein (HSP) 47","volume":"432","author":"Razzaque","year":"1998","journal-title":"Virchows Archiv"},{"issue":"6","key":"10.1016\/j.mbplus.2020.100034_bb0435","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1074\/jbc.TM118.002812","article-title":"Roles of the endoplasmic reticulum-resident, collagen-specific molecular chaperone Hsp47 in vertebrate cells and human disease","volume":"294","author":"Ito","year":"2019","journal-title":"The Journal of Biological Chemistry"},{"issue":"12","key":"10.1016\/j.mbplus.2020.100034_bb0440","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1111\/jcmm.13413","article-title":"Endoplasmic reticulum in health and disease: the 12th International Calreticulin Workshop, Delphi, Greece","volume":"21","author":"Charonis","year":"2017","journal-title":"Journal of Cellular and Molecular Medicine"},{"issue":"9","key":"10.1016\/j.mbplus.2020.100034_bb0445","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1517\/14728222.2016.1164695","article-title":"Calreticulin, a therapeutic target?","volume":"20","author":"Eggleton","year":"2016","journal-title":"Expert Opinion on Therapeutic Targets"},{"key":"10.1016\/j.mbplus.2020.100034_bb0450","doi-asserted-by":"crossref","first-page":"14254","DOI":"10.1038\/srep14254","article-title":"Calreticulin is required for development of the cumulus oocyte complex and female fertility","volume":"5","author":"Tokuhiro","year":"2015","journal-title":"Scientific Reports"}],"container-title":["Matrix Biology Plus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590028520300156?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590028520300156?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:38:41Z","timestamp":1778906321000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590028520300156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":89,"alternative-id":["S2590028520300156"],"URL":"https:\/\/doi.org\/10.1016\/j.mbplus.2020.100034","relation":{},"ISSN":["2590-0285"],"issn-type":[{"value":"2590-0285","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Calreticulin is important for the development of renal fibrosis and dysfunction in diabetic nephropathy","name":"articletitle","label":"Article Title"},{"value":"Matrix Biology Plus","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mbplus.2020.100034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100034"}}