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Guig\u00f3, The GENCODE v7 Catalog of Human Long Noncoding RNAs: Analysis of Their Gene Structure, Evolution, and Expression, (n.d.). doi:https:\/\/doi.org\/10.1101\/gr.132159.111.","DOI":"10.1101\/gr.132159.111"},{"key":"10.1016\/j.mbplus.2021.100060_bb0280","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-319-42059-2_1","article-title":"Non-coding RNAs: classification, biology and functioning","volume":"937","author":"Hombach","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.mbplus.2021.100060_bb0285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2014.06.043","article-title":"The ways of action of long non-coding RNAs in cytoplasm and nucleus","volume":"547","author":"Zhang","year":"2014","journal-title":"Gene."},{"key":"10.1016\/j.mbplus.2021.100060_bb0290","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.tig.2009.11.002","article-title":"A global view of genomic information - moving beyond the gene and the master regulator","volume":"26","author":"Mattick","year":"2010","journal-title":"Trends Genet."},{"key":"10.1016\/j.mbplus.2021.100060_bb0295","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.gde.2015.07.001","article-title":"The long noncoding RNA regulation at the MYC locus","volume":"33","author":"Xiang","year":"2015","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.mbplus.2021.100060_bb0300","doi-asserted-by":"crossref","first-page":"20693","DOI":"10.1073\/pnas.1310201110","article-title":"H19 lncRNA controls gene expression of the imprinted gene network by recruiting MBD1","volume":"110","author":"Monnier","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mbplus.2021.100060_bb0305","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.cell.2014.10.019","article-title":"ATRX directs binding of PRC2 to Xist RNA and Polycomb targets","volume":"159","author":"Sarma","year":"2014","journal-title":"Cell."},{"key":"10.1016\/j.mbplus.2021.100060_bb0310","doi-asserted-by":"crossref","unstructured":"V. Tripathi, J.D. Ellis, Z. Shen, D.Y. Song, Q. Pan, A.T. Watt, S.M. Freier, C.F. Bennett, A. Sharma, P.A. Bubulya, B.J. Blencowe, S.G. Prasanth, K. V. Prasanth, The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation, Molecular Cell. 39 (2010) 925\u2013938. doi:https:\/\/doi.org\/10.1016\/j.molcel.2010.08.011.","DOI":"10.1016\/j.molcel.2010.08.011"},{"key":"10.1016\/j.mbplus.2021.100060_bb0315","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.devcel.2013.03.002","article-title":"Endogenous miRNA sponge lincRNA-RoR regulates Oct4, Nanog, and Sox2 in human embryonic stem cell self-renewal","volume":"25","author":"Wang","year":"2013","journal-title":"Dev. 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A."},{"key":"10.1016\/j.mbplus.2021.100060_bb0330","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature07672","article-title":"Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals","volume":"458","author":"Guttman","year":"2009","journal-title":"Nature."},{"key":"10.1016\/j.mbplus.2021.100060_bb0335","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1101\/gad.17446611","article-title":"Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses","volume":"25","author":"Cabili","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.mbplus.2021.100060_bb0340","doi-asserted-by":"crossref","first-page":"R72","DOI":"10.1186\/gb-2010-11-7-r72","article-title":"Long noncoding RNA genes: conservation of sequence and brain expression among diverse amniotes","volume":"11","author":"Chodroff","year":"2010","journal-title":"Genome Biol."},{"key":"10.1016\/j.mbplus.2021.100060_bb0345","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/nrg3802","article-title":"Evolutionary dynamics of coding and non-coding transcriptomes","volume":"15","author":"Necsulea","year":"2014","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.mbplus.2021.100060_bb0350","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1101\/gr.6036807","article-title":"Functionality or transcriptional noise? Evidence for selection within long noncoding RNAs","volume":"17","author":"Ponjavic","year":"2007","journal-title":"Genome Res."},{"key":"10.1016\/j.mbplus.2021.100060_bb0355","doi-asserted-by":"crossref","first-page":"R124","DOI":"10.1186\/gb-2009-10-11-r124","article-title":"Catalogues of mammalian long noncoding RNAs: modest conservation and incompleteness","volume":"10","author":"Marques","year":"2009","journal-title":"Genome Biol."},{"key":"10.1016\/j.mbplus.2021.100060_bb0360","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.cell.2009.02.006","article-title":"Evolution and functions of long noncoding RNAs","volume":"136","author":"Ponting","year":"2009","journal-title":"Cell."},{"key":"10.1016\/j.mbplus.2021.100060_bb0365","doi-asserted-by":"crossref","first-page":"924","DOI":"10.4161\/rna.24604","article-title":"On the classification of long non-coding RNAs","volume":"10","author":"Ma","year":"2013","journal-title":"RNA Biol."},{"key":"10.1016\/j.mbplus.2021.100060_bb0370","doi-asserted-by":"crossref","unstructured":"X. Zhang, W. Wang, W. Zhu, J. Dong, Y. Cheng, Z. Yin, F. Shen, Mechanisms and functions of long non-coding RNAs at multiple regulatory levels, International Journal of Molecular Sciences. 20 (2019). doi:https:\/\/doi.org\/10.3390\/ijms20225573.","DOI":"10.3390\/ijms20225573"},{"key":"10.1016\/j.mbplus.2021.100060_bb0375","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev-biochem-051410-092902","article-title":"Genome regulation by long noncoding RNAs","volume":"81","author":"Rinn","year":"2012","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.mbplus.2021.100060_bb0380","doi-asserted-by":"crossref","unstructured":"M. Morlando, M. Ballarino, A. Fatica, Long non-coding RNAs: New players in hematopoiesis and leukemia, Frontiers in Medicine. 2 (2015). doi:https:\/\/doi.org\/10.3389\/fmed.2015.00023.","DOI":"10.3389\/fmed.2015.00023"},{"key":"10.1016\/j.mbplus.2021.100060_bb0385","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.ccell.2016.03.010","article-title":"Long noncoding RNAs in cancer pathways","volume":"29","author":"Schmitt","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.mbplus.2021.100060_bb0390","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.yjmcc.2015.01.011","article-title":"Noncoding RNA in age-related cardiovascular diseases","volume":"83","author":"Greco","year":"2015","journal-title":"J. Mol. Cell. 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Chakrabarti, Increased extracellular matrix protein production in chronic diabetic complications: implications of non-coding RNAs, Non-Coding RNA. 5 (2019). doi:https:\/\/doi.org\/10.3390\/ncrna5010030.","DOI":"10.3390\/ncrna5010030"},{"key":"10.1016\/j.mbplus.2021.100060_bb0445","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ncrna.2018.08.002","article-title":"Long non-coding RNA and extracellular matrix: the hidden players in cancer-stroma cross-talk","volume":"3","author":"D\u2019Angelo","year":"2018","journal-title":"Non-Coding RNA Research."},{"key":"10.1016\/j.mbplus.2021.100060_bb0450","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1002\/art.38309","article-title":"Long noncoding RNA related to cartilage injury promotes chondrocyte extracellular matrix degradation in osteoarthritis","volume":"66","author":"Liu","year":"2014","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.mbplus.2021.100060_bb0455","first-page":"630","article-title":"Long non-coding RNA XIST promotes extracellular matrix degradation by functioning as a competing endogenous RNA of miR-1277-5p in osteoarthritis","volume":"44","author":"Wang","year":"2019","journal-title":"Int. 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Sinclair, R. de Cabo, SRT1720 improves survival and healthspan of obese mice, Scientific Reports. 1 (2011). doi:https:\/\/doi.org\/10.1038\/srep00070.","DOI":"10.1038\/srep00070"},{"key":"10.1016\/j.mbplus.2021.100060_bb0575","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1101\/gad.13.19.2570","article-title":"The SIR2\/3\/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms","volume":"13","author":"Kaeberlein","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.mbplus.2021.100060_bb0580","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/35065638","article-title":"Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans","volume":"410","author":"Tissenbaum","year":"2001","journal-title":"Nature."},{"key":"10.1016\/j.mbplus.2021.100060_bb0585","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1007\/s00109-007-0281-3","article-title":"Hypoxia and cancer","volume":"85","author":"Brahimi-Horn","year":"2007","journal-title":"J. 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Res. 12 (2020) 950\u2013958. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32269726 (accessed December 2, 2020)."},{"key":"10.1016\/j.mbplus.2021.100060_bb0620","first-page":"73","article-title":"Long non-coding RNAs in the cytoplasm, genomics","volume":"14","author":"Rashid","year":"2016","journal-title":"Proteomics and Bioinformatics."},{"key":"10.1016\/j.mbplus.2021.100060_bb0625","doi-asserted-by":"crossref","unstructured":"J.H. Yoon, K. Abdelmohsen, J. Kim, X. Yang, J.L. Martindale, K. Tominaga-Yamanaka, E.J. White, A. V. Orjalo, J.L. Rinn, S.G. Kreft, G.M. Wilson, M. Gorospe, Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination, Nature Communications. 4 (2013) 1\u201314. doi:https:\/\/doi.org\/10.1038\/ncomms3939.","DOI":"10.1038\/ncomms3939"},{"key":"10.1016\/j.mbplus.2021.100060_bb0630","doi-asserted-by":"crossref","unstructured":"J.H. Noh, K.M. Kim, W.G. McClusky, K. Abdelmohsen, M. 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