{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:30:33Z","timestamp":1788561033660,"version":"build-2803163510"},"reference-count":92,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R00GM146111"],"award-info":[{"award-number":["R00GM146111"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Matrix Biology Plus"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.mbplus.2025.100172","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T19:04:23Z","timestamp":1742756663000},"page":"100172","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Crosstalk between T cells and fibroblasts in biomaterial-mediated fibrosis"],"prefix":"10.1016","volume":"26","author":[{"given":"Mathew","family":"Kibet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Abebayehu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mbplus.2025.100172_b0005","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.mser.2007.12.001","article-title":"Advanced biomaterials for skeletal tissue regeneration: Instructive and smart functions","volume":"59","author":"Barr\u00e8re","year":"2008","journal-title":"Materials Science & Engineering R: Reports"},{"key":"10.1016\/j.mbplus.2025.100172_b0010","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.surg.2008.03.015","article-title":"Intra-abdominal vagal blocking (VBLOC therapy): Clinical results with a new implantable medical device","volume":"143","author":"Camilleri","year":"2008","journal-title":"Surgery"},{"key":"10.1016\/j.mbplus.2025.100172_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mser.2014.10.001","article-title":"Metallic implant biomaterials","volume":"87","author":"Chen","year":"2015","journal-title":"Materials Science & Engineering R: Reports"},{"key":"10.1016\/j.mbplus.2025.100172_b0020","article-title":"Regenerative medicine and drug delivery: Progress via electrospun biomaterials","volume":"109","author":"Doostmohammadi","year":"2020","journal-title":"Materials Science and Engineering: C"},{"key":"10.1016\/j.mbplus.2025.100172_b0025","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.job.2015.08.001","article-title":"Biomaterial properties of titanium in dentistry","volume":"57","author":"Prasad","year":"2015","journal-title":"Journal of Oral Biosciences"},{"key":"10.1016\/j.mbplus.2025.100172_b0030","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3390\/bioengineering10020218","article-title":"Polymeric Materials, Advances and Applications in Tissue Engineering: A Review","volume":"10","author":"Socci","year":"2023","journal-title":"Bioengineering"},{"key":"10.1016\/j.mbplus.2025.100172_b0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/342304","article-title":"Innate Immunity and Biomaterials at the Nexus: Friends or Foes","volume":"2015","author":"Christo","year":"2015","journal-title":"Biomed Research International"},{"key":"10.1016\/j.mbplus.2025.100172_b0040","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.tibtech.2016.03.009","article-title":"Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response","volume":"34","author":"Vishwakarma","year":"2016","journal-title":"Trends in Biotechnology"},{"key":"10.1016\/j.mbplus.2025.100172_b0045","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/978-981-15-3262-7_8","article-title":"M. In Vivo Evaluation of the Biocompatibility of Biomaterial Device","volume":"1250","author":"Fraz\u00e3o","year":"2020","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"10.1016\/j.mbplus.2025.100172_b0050","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.addr.2017.07.006","article-title":"Key players in the immune response to biomaterial scaffolds for regenerative medicine","volume":"114","author":"Chung","year":"2017","journal-title":"Advanced Drug Delivery Reviews"},{"key":"10.1016\/j.mbplus.2025.100172_b0055","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.smim.2007.11.004","article-title":"Foreign body reaction to biomaterials","volume":"20","author":"Anderson","year":"2008","journal-title":"Seminars in Immunology"},{"key":"10.1016\/j.mbplus.2025.100172_b0060","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.actbio.2021.03.038","article-title":"Macrophage phenotypes in tissue repair and the foreign body response: Implications for biomaterial-based regenerative medicine strategies","volume":"133","author":"Martin","year":"2021","journal-title":"Acta Biomaterialia"},{"key":"10.1016\/j.mbplus.2025.100172_b0065","article-title":"Macrophage and Fibroblast Interactions in Biomaterial-Mediated Fibrosis","volume":"1801451","author":"Witherel","year":"2019","journal-title":"Advanced Healthcare Materials"},{"key":"10.1016\/j.mbplus.2025.100172_b0070","doi-asserted-by":"crossref","unstructured":"Yu, T., Tutwiler, V. J. & Spiller, K. The Role of Macrophages in the Foreign Body Response to Implanted Biomaterials. in Biomaterials in Regenerative Medicine and the Immune System (ed. Santambrogio, L.) 17\u201334 (Springer International Publishing, Cham, 2015). doi:10.1007\/978-3-319-18045-8_2.","DOI":"10.1007\/978-3-319-18045-8_2"},{"key":"10.1016\/j.mbplus.2025.100172_b0075","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/ac5574","article-title":"Foreign body response to synthetic polymer biomaterials and the role of adaptive immunity","volume":"17","author":"Kyriakides","year":"2022","journal-title":"Biomedical Materials"},{"key":"10.1016\/j.mbplus.2025.100172_b0080","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1089\/ten.tea.2016.0499","article-title":"Biomaterial Encapsulation Is Enhanced in the Early Stages of the Foreign Body Reaction During Conditional Macrophage Depletion in Transgenic Macrophage Fas-Induced Apoptosis Mice","volume":"23","author":"Bank","year":"2017","journal-title":"Tissue Engineering Part A"},{"key":"10.1016\/j.mbplus.2025.100172_b0085","doi-asserted-by":"crossref","unstructured":"Keselowsky, B. G., Acharya, A. & Lewis, J. S. Innate and Adaptive Immunity. in Biomaterials Science 747\u2013775 (Elsevier, 2020). doi:10.1016\/B978-0-12-816137-1.00049-0.","DOI":"10.1016\/B978-0-12-816137-1.00049-0"},{"key":"10.1016\/j.mbplus.2025.100172_b0090","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aax3799","article-title":"Interleukin 17 and senescent cells regulate the foreign body response to synthetic material implants in mice and humans","volume":"12","author":"Chung","year":"2020","journal-title":"Science Translational Medicine"},{"key":"10.1016\/j.mbplus.2025.100172_b0095","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abj5830","article-title":"Biomaterials direct functional B cell response in a material-specific manner","volume":"7","author":"Moore","year":"2021","journal-title":"Science Advances"},{"key":"10.1016\/j.mbplus.2025.100172_b0100","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1126\/science.aad9272","article-title":"Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells","volume":"352","author":"Sadtler","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.mbplus.2025.100172_b0105","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1089\/ten.teb.2021.0010","article-title":"Understanding Fibroblast Behavior in 3D Biomaterials","volume":"28","author":"Woodley","year":"2022","journal-title":"Tissue Engineering Part B, Reviews"},{"key":"10.1016\/j.mbplus.2025.100172_b0110","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.tcb.2005.09.002","article-title":"Inflammatory cells during wound repair: the good, the bad and the ugly","volume":"15","author":"Martin","year":"2005","journal-title":"Trends in Cell Biology"},{"key":"10.1016\/j.mbplus.2025.100172_b0115","doi-asserted-by":"crossref","first-page":"7730","DOI":"10.1039\/D3BM00629H","article-title":"The foreign body response: emerging cell types and considerations for targeted therapeutics","volume":"11","author":"Yang","year":"2023","journal-title":"Biomaterials Science"},{"key":"10.1016\/j.mbplus.2025.100172_b0120","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1002\/jor.22916","article-title":"Adverse local tissue reaction (ALTR) associated with corrosion products in metal\u2010on\u2010metal and dual modular neck total hip replacements is associated with upregulation of interferon gamma\u2010mediated chemokine signaling","volume":"33","author":"Kolatat","year":"2015","journal-title":"Journal of Orthopaedic Research"},{"key":"10.1016\/j.mbplus.2025.100172_b0125","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.actbio.2023.07.052","article-title":"Contribution of \u03b1\u03b2 T cells to macrophage polarization and MSC recruitment and proliferation on titanium implants","volume":"169","author":"Avery","year":"2023","journal-title":"Acta Biomaterialia"},{"key":"10.1016\/j.mbplus.2025.100172_b0130","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1002\/jbm.a.36416","article-title":"Lack of interferon\u2010gamma attenuates foreign body reaction to subcutaneous implants in mice","volume":"106","author":"Cassini-Vieira","year":"2018","journal-title":"Journal of Biomedical Materials Research Part A"},{"key":"10.1016\/j.mbplus.2025.100172_b0135","doi-asserted-by":"crossref","unstructured":"Wolfram, D. et al. T Regulatory Cells and TH17 Cells in Peri\u2013Silicone Implant Capsular Fibrosis: Plastic Reconstructive Surgery 129, 327e\u2013337e (2012).","DOI":"10.1097\/PRS.0b013e31823aeacf"},{"key":"10.1016\/j.mbplus.2025.100172_b0140","doi-asserted-by":"crossref","first-page":"636","DOI":"10.3390\/ijms20030636","article-title":"Biomaterials: Foreign Bodies or Tuners for the Immune Response?","volume":"20","author":"Mariani","year":"2019","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.mbplus.2025.100172_b0145","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.biomaterials.2016.10.019","article-title":"Shifts in macrophage phenotype at the biomaterial interface via IL-4 eluting coatings are associated with improved implant integration","volume":"112","author":"Hachim","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.mbplus.2025.100172_b0150","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.biomaterials.2018.08.029","article-title":"Macrophage response to hydrophilic biomaterials regulates MSC recruitment and T-helper cell populations","volume":"182","author":"Hotchkiss","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.mbplus.2025.100172_b0155","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/jbm.a.10425","article-title":"In vivo leukocyte cytokine mRNA responses to biomaterials are dependent on surface chemistry","volume":"64A","author":"Brodbeck","year":"2003","journal-title":"Journal of Biomedical Materials Research Part A"},{"key":"10.1016\/j.mbplus.2025.100172_b0160","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1097\/00007890-200106150-00024","article-title":"Xenogeneic extracellular matrix grafts elicit a th2-restricted immune response1","volume":"71","author":"Allman","year":"2001","journal-title":"Transplantation"},{"key":"10.1016\/j.mbplus.2025.100172_b0165","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.1159\/000093676","article-title":"Influence of TH1\/TH2 Switched Immune Response on Renal Ischemia-Reperfusion Injury","volume":"104","author":"Marques","year":"2006","journal-title":"Nephron Experimental Nephrology"},{"key":"10.1016\/j.mbplus.2025.100172_b0170","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aar8356","article-title":"PD-1 up-regulation on CD4 + T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-\u03b21 production","volume":"10","author":"Celada","year":"2018","journal-title":"Science Translational Medicine"},{"key":"10.1016\/j.mbplus.2025.100172_b0175","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.cell.2008.05.009","article-title":"Regulatory T Cells and Immune Tolerance","volume":"133","author":"Sakaguchi","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.mbplus.2025.100172_b0180","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/j.ajpath.2020.02.010","article-title":"Apoptotic Cell\u2013Directed Resolution of Lung Inflammation Requires Myeloid \u03b1v Integrin\u2013Mediated Induction of Regulatory T Lymphocytes","volume":"190","author":"Zhang","year":"2020","journal-title":"The American Journal of Pathology"},{"key":"10.1016\/j.mbplus.2025.100172_b0185","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1161\/CIRCULATIONAHA.116.023106","article-title":"Infarcted Myocardium-Primed Dendritic Cells Improve Remodeling and Cardiac Function After Myocardial Infarction by Modulating the Regulatory T Cell and Macrophage Polarization","volume":"135","author":"Choo","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.mbplus.2025.100172_b0190","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/imm.12791","article-title":"Regulatory T cells in skin","volume":"152","author":"Ali","year":"2017","journal-title":"Immunology"},{"key":"10.1016\/j.mbplus.2025.100172_b0195","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s10029-021-02396-7","article-title":"Characterization of innate and adaptive immune cells involved in the foreign body reaction to polypropylene meshes in the human abdomen","volume":"26","author":"Dievernich","year":"2022","journal-title":"Hernia"},{"key":"10.1016\/j.mbplus.2025.100172_b0200","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.actbio.2019.07.031","article-title":"Mesh induced fibrosis: The protective role of T regulatory cells","volume":"96","author":"Artsen","year":"2019","journal-title":"Acta Biomaterialia"},{"key":"10.1016\/j.mbplus.2025.100172_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122534","article-title":"ROS-responsive drug-releasing injectable microgels for ameliorating myocardial infarction","volume":"307","author":"Wang","year":"2024","journal-title":"Biomaterials"},{"key":"10.1016\/j.mbplus.2025.100172_b0210","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.immuni.2009.04.010","article-title":"Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression","volume":"30","author":"Shevach","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.mbplus.2025.100172_b0215","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.immuni.2005.01.016","article-title":"Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3","volume":"22","author":"Fontenot","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.mbplus.2025.100172_b0220","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1161\/CIRCRESAHA.115.303895","article-title":"Foxp3+ CD4+ T Cells Improve Healing After Myocardial Infarction by Modulating Monocyte\/Macrophage Differentiation","volume":"115","author":"Weirather","year":"2014","journal-title":"Circulation Research"},{"key":"10.1016\/j.mbplus.2025.100172_b0225","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.biomaterials.2014.10.017","article-title":"Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds","volume":"37","author":"Spiller","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.mbplus.2025.100172_b0230","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1089\/ten.tea.2016.0304","article-title":"The Scaffold Immune Microenvironment: Biomaterial-Mediated Immune Polarization in Traumatic and Nontraumatic Applications <sup\/>","volume":"23","author":"Sadtler","year":"2017","journal-title":"Tissue Engineering Part A"},{"key":"10.1016\/j.mbplus.2025.100172_b0235","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1097\/HJH.0b013e328349c62d","article-title":"CD4+CD25+Foxp3+ regulatory T cells suppress cardiac fibrosis in the hypertensive heart","volume":"29","author":"Kanellakis","year":"2011","journal-title":"Journal of Hypertension"},{"key":"10.1016\/j.mbplus.2025.100172_b0240","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/nm.3179","article-title":"Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells","volume":"19","author":"Gagliani","year":"2013","journal-title":"Nature Medicine"},{"key":"10.1016\/j.mbplus.2025.100172_b0245","doi-asserted-by":"crossref","first-page":"5986","DOI":"10.4049\/jimmunol.172.10.5986","article-title":"IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells","volume":"172","author":"Vieira","year":"2004","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.mbplus.2025.100172_b0250","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2012.00030","article-title":"The Cellular and Molecular Mechanisms of Immuno-Suppression by Human Type 1 Regulatory T Cells","volume":"3","author":"Gregori","year":"2012","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.mbplus.2025.100172_b0255","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/39614","article-title":"A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis","volume":"389","author":"Groux","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.mbplus.2025.100172_b0260","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1097\/SLA.0000000000004984","article-title":"Interleukin-10 Producing T Lymphocytes Attenuate Dermal Scarring","volume":"274","author":"Short","year":"2021","journal-title":"Annals of Surgery"},{"key":"10.1016\/j.mbplus.2025.100172_b0265","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.4049\/jimmunol.1102757","article-title":"Substrate Rigidity Regulates Human T Cell Activation and Proliferation","volume":"189","author":"O\u2019Connor","year":"2012","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.mbplus.2025.100172_b0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121928","article-title":"Substrate stiffness enhances human regulatory T cell induction and metabolism","volume":"292","author":"Shi","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.mbplus.2025.100172_b0275","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20200053","article-title":"Mechanosensing through YAP controls T cell activation and metabolism","volume":"217","author":"Meng","year":"2020","journal-title":"The Journal of Experimental Medicine"},{"key":"10.1016\/j.mbplus.2025.100172_b0280","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1083\/jcb.200506179","article-title":"Focal adhesion size controls tension-dependent recruitment of \u03b1-smooth muscle actin to stress fibers","volume":"172","author":"Goffin","year":"2006","journal-title":"The Journal of Cell Biology"},{"key":"10.1016\/j.mbplus.2025.100172_b0285","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1038\/s41551-021-00722-z","article-title":"Suppression of the fibrotic encapsulation of silicone implants by inhibiting the mechanical activation of pro-fibrotic TGF-\u03b2","volume":"5","author":"Noskovicova","year":"2021","journal-title":"Nature Biomedical Engineering"},{"key":"10.1016\/j.mbplus.2025.100172_b0290","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10137","article-title":"Role of YAP\/TAZ in mechanotransduction","volume":"474","author":"Dupont","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.mbplus.2025.100172_b0295","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2213837120","article-title":"Macrophages modulate stiffness-related foreign body responses through plasma membrane deformation","volume":"120","author":"Ni","year":"2023","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.mbplus.2025.100172_b0300","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/s41586-020-2612-2","article-title":"Effects of extracellular matrix viscoelasticity on cellular behaviour","volume":"584","author":"Chaudhuri","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.mbplus.2025.100172_b0305","doi-asserted-by":"crossref","unstructured":"Cameron, Andrew. R., Frith, Jessica. E. & Cooper-White, Justin. J. The influence of substrate creep on mesenchymal stem cell behaviour and phenotype. Biomaterials 32, 5979\u20135993 (2011).","DOI":"10.1016\/j.biomaterials.2011.04.003"},{"key":"10.1016\/j.mbplus.2025.100172_b0310","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1038\/s41551-023-01052-y","article-title":"Generation of functionally distinct T-cell populations by altering the viscoelasticity of their extracellular matrix","volume":"7","author":"Adu-Berchie","year":"2023","journal-title":"Nature Biomedical Engineering"},{"key":"10.1016\/j.mbplus.2025.100172_b0315","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmat4866","article-title":"Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates","volume":"16","author":"Doloff","year":"2017","journal-title":"Nature Materials"},{"key":"10.1016\/j.mbplus.2025.100172_b0320","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jbiomech.2009.09.020","article-title":"The myofibroblast: Paradigm for a mechanically active cell","volume":"43","author":"Hinz","year":"2010","journal-title":"Journal of Biomechanics"},{"key":"10.1016\/j.mbplus.2025.100172_b0325","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201804950","article-title":"Hierarchical Hydrogel Composite Interfaces with Robust Mechanical Properties for Biomedical Applications","volume":"31","author":"Zhu","year":"2019","journal-title":"Advanced Materials"},{"key":"10.1016\/j.mbplus.2025.100172_b0330","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nri2448","article-title":"Exploring the full spectrum of macrophage activation","volume":"8","author":"Mosser","year":"2008","journal-title":"Nature Reviews Immunology"},{"key":"10.1016\/j.mbplus.2025.100172_b0335","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/s44161-022-00116-7","article-title":"Antigen presentation by cardiac fibroblasts promotes cardiac dysfunction","volume":"1","author":"Ngwenyama","year":"2022","journal-title":"Nature Cardiovascular Research"},{"key":"10.1016\/j.mbplus.2025.100172_b0340","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nri.2017.90","article-title":"Type 2 immunity in tissue repair and fibrosis","volume":"18","author":"Gieseck","year":"2018","journal-title":"Nature Reviews Immunology"},{"key":"10.1016\/j.mbplus.2025.100172_b0345","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.immuni.2019.04.011","article-title":"T Follicular Helper Cell Biology: A Decade of Discovery and Diseases","volume":"50","author":"Crotty","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.mbplus.2025.100172_b0350","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s12943-021-01428-1","article-title":"Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives","volume":"20","author":"Mao","year":"2021","journal-title":"Molecular Cancer"},{"key":"10.1016\/j.mbplus.2025.100172_b0355","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adf2675","article-title":"A Thy-1\u2013negative immunofibroblast population emerges as a key determinant of fibrotic outcomes to biomaterials","volume":"10","author":"Abebayehu","year":"2024","journal-title":"Science Advances"},{"key":"10.1016\/j.mbplus.2025.100172_b0360","doi-asserted-by":"crossref","first-page":"H1233","DOI":"10.1152\/ajpheart.00328.2014","article-title":"Regulatory T cells are recruited in the infarcted mouse myocardium and may modulate fibroblast phenotype and function","volume":"307","author":"Saxena","year":"2014","journal-title":"he American Journal of Physiology-Heart and Circulatory Physiology"},{"key":"10.1016\/j.mbplus.2025.100172_b0365","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1093\/cvr\/cvu062","article-title":"Crosstalk between fibroblasts and inflammatory cells","volume":"102","author":"Van Linthout","year":"2014","journal-title":"Cardiovascular Research"},{"key":"10.1016\/j.mbplus.2025.100172_b0370","article-title":"Adoptive Transfer of Regulatory T Cells Protects against Coxsackievirus B3-Induced Cardiac Fibrosis","volume":"8","author":"Cao","year":"2013","journal-title":"PLoS One1"},{"key":"10.1016\/j.mbplus.2025.100172_b0375","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/617145","article-title":"IL-10 Treatment Is Associated with Prohibitin Expression in the Crohn\u2019s Disease Intestinal Fibrosis Mouse Model","volume":"2013","author":"Yuan","year":"2013","journal-title":"Mediators of Inflammation"},{"key":"10.1016\/j.mbplus.2025.100172_b0380","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.add7399","article-title":"Amphiregulin couples IL1RL1 + regulatory T cells and cancer-associated fibroblasts to impede antitumor immunity","volume":"9","author":"Sun","year":"2023","journal-title":"Science Advances"},{"key":"10.1016\/j.mbplus.2025.100172_b0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2019.154799","article-title":"Interleukin-4 and interleukin-13 as possible therapeutic targets in systemic sclerosis","volume":"125","author":"Gasparini","year":"2020","journal-title":"Cytokine"},{"key":"10.1016\/j.mbplus.2025.100172_b0390","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/eji.201546043","article-title":"TGF\u2010\u03b2 induces the differentiation of human CXCL13\u2010producing CD4 + T cells","volume":"46","author":"Kobayashi","year":"2016","journal-title":"European Journal of Immunology"},{"key":"10.1016\/j.mbplus.2025.100172_b0395","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1186\/ar113","article-title":"No title found","volume":"2","author":"Pap","year":"2000","journal-title":"Arthritis Research"},{"key":"10.1016\/j.mbplus.2025.100172_b0400","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.3389\/fimmu.2019.01395","article-title":"Regulation of Immune Responses and Chronic Inflammation by Fibroblast-Like Synoviocytes","volume":"10","author":"Yoshitomi","year":"2019","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.mbplus.2025.100172_b0405","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/art.30093","article-title":"Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin\u201017A production","volume":"63","author":"Van Hamburg","year":"2011","journal-title":"Arthritis and Rheumatism"},{"key":"10.1016\/j.mbplus.2025.100172_b0410","doi-asserted-by":"crossref","first-page":"L1049","DOI":"10.1152\/ajplung.00321.2001","article-title":"Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells","volume":"282","author":"Liu","year":"2002","journal-title":"American Journal of Physiology Lung Cellular and Molecular Physiology"},{"key":"10.1016\/j.mbplus.2025.100172_b0415","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nri1412","article-title":"Fibrotic disease and the TH1\/TH2 paradigm","volume":"4","author":"Wynn","year":"2004","journal-title":"Nature Reviews Immunology"},{"key":"10.1016\/j.mbplus.2025.100172_b0420","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1038\/labinvest.2010.128","article-title":"Fibroblasts stimulated via HLA-II molecules produce prostaglandin E2 and regulate cytokine production from helper T cells","volume":"90","author":"Kato-Kogoe","year":"2010","journal-title":"Laboratory Investigation"},{"key":"10.1016\/j.mbplus.2025.100172_b0425","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3389\/fimmu.2020.00220","article-title":"T-Cell Proapoptotic and Antifibrotic Activity Against Autologous Skin Fibroblasts in vitro Is Associated With IL-17A Axis Upregulation in Systemic Sclerosis","volume":"11","author":"Vettori","year":"2020","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.mbplus.2025.100172_b0430","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/btm2.10063","article-title":"Designing biomaterials with immunomodulatory properties for tissue engineering and regenerative medicine","volume":"2","author":"Andorko","year":"2017","journal-title":"Bioengineering & Translational Medicine"},{"key":"10.1016\/j.mbplus.2025.100172_b0435","doi-asserted-by":"crossref","first-page":"6060","DOI":"10.1039\/D3BM00835E","article-title":"Matrisomal components involved in regenerative wound healing in axolotl and Acomys\u00a0: implications for biomaterial development","volume":"11","author":"Avila-Martinez","year":"2023","journal-title":"Biomaterials Science"},{"key":"10.1016\/j.mbplus.2025.100172_b0440","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s10974-022-09631-3","article-title":"Mammalian organ regeneration in spiny mice","volume":"44","author":"Okamura","year":"2023","journal-title":"Journal of Muscle Research and Cell Motility"},{"key":"10.1016\/j.mbplus.2025.100172_b0445","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nature11499","article-title":"Skin shedding and tissue regeneration in African spiny mice (Acomys)","volume":"489","author":"Seifert","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.mbplus.2025.100172_b0450","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142931","article-title":"A Comparative Analysis of Gene Expression Profiles during Skin Regeneration in Mus and Acomys","volume":"10","author":"Brant","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.mbplus.2025.100172_b0455","doi-asserted-by":"crossref","first-page":"9415","DOI":"10.1073\/pnas.1300290110","article-title":"Macrophages are required for adult salamander limb regeneration","volume":"110","author":"Godwin","year":"2013","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.mbplus.2025.100172_b0460","doi-asserted-by":"crossref","first-page":"4717","DOI":"10.1016\/j.cell.2022.11.004","article-title":"Fibroblast inflammatory priming determines regenerative versus fibrotic skin repair in reindeer","volume":"185","author":"Sinha","year":"2022","journal-title":"Cell"}],"container-title":["Matrix Biology Plus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590028525000055?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590028525000055?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:39:02Z","timestamp":1778906342000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590028525000055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":92,"alternative-id":["S2590028525000055"],"URL":"https:\/\/doi.org\/10.1016\/j.mbplus.2025.100172","relation":{},"ISSN":["2590-0285"],"issn-type":[{"value":"2590-0285","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Crosstalk between T cells and fibroblasts in biomaterial-mediated fibrosis","name":"articletitle","label":"Article Title"},{"value":"Matrix Biology Plus","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mbplus.2025.100172","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100172"}}