{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:13:13Z","timestamp":1786993993050,"version":"build-2736575974"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017023","name":"The Paul G Allen Frontiers Group","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"National Heart Lung and Blood Institute Division of Intramural Research","doi-asserted-by":"publisher","award":["RO1HL15698701"],"award-info":[{"award-number":["RO1HL15698701"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Matrix Biology Plus"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.mbplus.2025.100186","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T14:29:37Z","timestamp":1763648977000},"page":"100186","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Generation of a conditional Adamts6 mouse allele reveals roles in lung maturation in addition to cardiac and musculoskeletal development"],"prefix":"10.1016","volume":"28","author":[{"given":"Jessica M.","family":"Sirek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth H.","family":"Rush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Darodkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suneel S.","family":"Apte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1891-3652","authenticated-orcid":false,"given":"Timothy J.","family":"Mead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mbplus.2025.100186_b0005","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.matbio.2018.06.002","article-title":"ADAMTS proteins in human disorders","volume":"71\u201372","author":"Mead","year":"2018","journal-title":"Matrix Biology"},{"key":"10.1016\/j.mbplus.2025.100186_b0010","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.71142","article-title":"Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development","volume":"11","author":"Mead","year":"2022","journal-title":"eLife"},{"key":"10.1016\/j.mbplus.2025.100186_b0015","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.matbio.2015.03.001","article-title":"Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics","volume":"44\u201346","author":"Dubail","year":"2015","journal-title":"Matrix Biology"},{"issue":"1","key":"10.1016\/j.mbplus.2025.100186_b0020","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s13059-018-1457-6","article-title":"Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6","volume":"19","author":"Prins","year":"2018","journal-title":"Genome Biology"},{"issue":"5","key":"10.1016\/j.mbplus.2025.100186_b0025","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1086\/425231","article-title":"ADAMTS10 mutations in autosomal recessive Weill-Marchesani syndrome","volume":"75","author":"Dagoneau","year":"2004","journal-title":"The American Journal of Human Genetics"},{"issue":"4","key":"10.1016\/j.mbplus.2025.100186_b0030","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.21873\/anticanres.14139","article-title":"Overexpression of AGR2 is associated with drug resistance in mutant non-small cell lung cancers","volume":"40","author":"Luu","year":"2020","journal-title":"Anticancer Research"},{"issue":"4","key":"10.1016\/j.mbplus.2025.100186_b0035","doi-asserted-by":"crossref","DOI":"10.1590\/1678-4685-gmb-2019-0266","article-title":"A metalloproteinase of the disintegrin and metalloproteinases and the ThromboSpondin Motifs 6 as a novel marker for colon cancer: functional experiments","volume":"43","author":"Wang","year":"2020","journal-title":"Genetics and Molecular Biology"},{"issue":"5","key":"10.1016\/j.mbplus.2025.100186_b0040","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/cgt.2015.20","article-title":"Identification of commonly dysregulated genes in colorectal cancer by integrating analysis of RNA-Seq data and qRT-PCR validation","volume":"22","author":"Xiao","year":"2015","journal-title":"Cancer Gene Therapy"},{"issue":"38","key":"10.1016\/j.mbplus.2025.100186_b0045","doi-asserted-by":"crossref","first-page":"61273","DOI":"10.18632\/oncotarget.11341","article-title":"ADAMTS6 suppresses tumor progression via the ERK signaling pathway and serves as a prognostic marker in human breast cancer","volume":"7","author":"Xie","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.mbplus.2025.100186_b0050","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.canlet.2021.07.017","article-title":"Calcium channel TRPV6 promotes breast cancer metastasis by NFATC2IP","volume":"519","author":"Xu","year":"2021","journal-title":"Cancer Letters"},{"key":"10.1016\/j.mbplus.2025.100186_b0055","doi-asserted-by":"crossref","unstructured":"J. Huguet Herrero et al., Loss of function variants in ADAMTS6 : Connective tissue, Heart defect, thoracic Aortic aneurysm and Neuro developmental Syndrome (CHANS). medRxiv, 2025.","DOI":"10.1101\/2025.05.02.25326573"},{"issue":"7553","key":"10.1016\/j.mbplus.2025.100186_b0060","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/nature14269","article-title":"Global genetic analysis in mice unveils central role for cilia in congenital heart disease","volume":"521","author":"Li","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.mbplus.2025.100186_b0065","doi-asserted-by":"crossref","first-page":"35956","DOI":"10.1038\/srep35956","article-title":"ADAMTS-10 and -6 differentially regulate cell-cell junctions and focal adhesions","volume":"6","author":"Cain","year":"2016","journal-title":"Scientific Reports"},{"issue":"8065","key":"10.1016\/j.mbplus.2025.100186_b0070","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/s41586-025-08771-z","article-title":"Translational genomics of osteoarthritis in 1,962,069 individuals","volume":"641","author":"Hatzikotoulas","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.mbplus.2025.100186_b0080","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/978-1-4939-9167-9_7","article-title":"Generation and culture of mouse embryonic fibroblasts","volume":"1960","author":"Tan","year":"2019","journal-title":"Methods in Molecular Biology"},{"key":"10.1016\/j.mbplus.2025.100186_b0085","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/978-1-4939-9698-8_17","article-title":"Alizarin red and alcian blue preparations to visualize the skeleton","volume":"2043","author":"Mead","year":"2020","journal-title":"Methods in Molecular Biology"},{"issue":"1","key":"10.1016\/j.mbplus.2025.100186_b0090","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/pro.3993","article-title":"The ImageJ ecosystem: open-source software for image visualization, processing, and analysis","volume":"30","author":"Schroeder","year":"2021","journal-title":"Protein Science"},{"issue":"34","key":"10.1016\/j.mbplus.2025.100186_b0095","doi-asserted-by":"crossref","first-page":"14420","DOI":"10.1073\/pnas.0902306106","article-title":"Notch pathway regulation of chondrocyte differentiation and proliferation during appendicular and axial skeleton development","volume":"106","author":"Mead","year":"2009","journal-title":"Proceedings of the National academy of Sciences of the United States of America"},{"key":"10.1016\/j.mbplus.2025.100186_b0100","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/978-1-4939-9698-8_14","article-title":"Expression analysis by RNAscope in situ hybridization","volume":"2043","author":"Mead","year":"2020","journal-title":"Methods in Molecular Biology"},{"issue":"7","key":"10.1016\/j.mbplus.2025.100186_b0105","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nature Methods"},{"issue":"4","key":"10.1016\/j.mbplus.2025.100186_b0110","doi-asserted-by":"crossref","first-page":"R124","DOI":"10.1186\/ar2013","article-title":"Expression profiling of metalloproteinases and their inhibitors in synovium and cartilage","volume":"8","author":"Davidson","year":"2006","journal-title":"Arthritis Research and Therapy"},{"issue":"1","key":"10.1016\/j.mbplus.2025.100186_b0115","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/art.11433","article-title":"Expression profiling of metalloproteinases and their inhibitors in cartilage","volume":"50","author":"Kevorkian","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"3","key":"10.1016\/j.mbplus.2025.100186_b0120","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00441-016-2545-0","article-title":"Development of the lung","volume":"367","author":"Schittny","year":"2017","journal-title":"Cell and Tissue Research"},{"key":"10.1016\/j.mbplus.2025.100186_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121464","article-title":"Soluble ECM promotes organotypic formation in lung alveolar model","volume":"283","author":"Valdoz","year":"2022","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.mbplus.2025.100186_b0130","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1083\/jcb.131.2.539","article-title":"Dual role for the latent transforming growth factor-beta binding protein in storage of latent TGF-beta in the extracellular matrix and as a structural matrix protein","volume":"131","author":"Dallas","year":"1995","journal-title":"The Journal of Cell Biology"},{"issue":"5","key":"10.1016\/j.mbplus.2025.100186_b0135","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.ceb.2009.05.005","article-title":"Extracellular microfibrils: contextual platforms for TGFbeta and BMP signaling","volume":"21","author":"Ramirez","year":"2009","journal-title":"Current Opinion in Cell Biology"},{"issue":"6","key":"10.1016\/j.mbplus.2025.100186_b0140","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1083\/jcb.201003089","article-title":"Fibrillin-1 and -2 differentially modulate endogenous TGF-beta and BMP bioavailability during bone formation","volume":"190","author":"Nistala","year":"2010","journal-title":"The Journal of Cell Biology"},{"key":"10.1016\/j.mbplus.2025.100186_b0145","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.matbio.2019.06.006","article-title":"The role of fibrillin and microfibril binding proteins in elastin and elastic fibre assembly","volume":"84","author":"Godwin","year":"2019","journal-title":"Matrix Biology"}],"container-title":["Matrix Biology Plus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590028525000195?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590028525000195?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T20:04:41Z","timestamp":1766174681000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590028525000195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":28,"alternative-id":["S2590028525000195"],"URL":"https:\/\/doi.org\/10.1016\/j.mbplus.2025.100186","relation":{},"ISSN":["2590-0285"],"issn-type":[{"value":"2590-0285","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Generation of a conditional Adamts6 mouse allele reveals roles in lung maturation in addition to cardiac and musculoskeletal development","name":"articletitle","label":"Article Title"},{"value":"Matrix Biology Plus","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mbplus.2025.100186","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100186"}}