{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T05:42:50Z","timestamp":1777441370972,"version":"3.51.4"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11775301"],"award-info":[{"award-number":["11775301"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mathematical Biosciences"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.mbs.2017.10.004","type":"journal-article","created":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T22:19:18Z","timestamp":1507846758000},"page":"33-45","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Dynamics of DNA unwinding by helicases with frequent backward steps"],"prefix":"10.1016","volume":"294","author":[{"given":"Ping","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mbs.2017.10.004_bib0001","series-title":"DNA Helicases and DNA Motor Proteins","author":"Spies","year":"2013"},{"key":"10.1016\/j.mbs.2017.10.004_bib0002","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0092-8674(00)80716-3","article-title":"Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism","volume":"97","author":"Velankar","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.mbs.2017.10.004_bib0003","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0959-440X(99)00059-7","article-title":"DNA helicases: \u201cinching forward","volume":"10","author":"Soultanas","year":"2000","journal-title":"Curr. Opin. Struc. Biol."},{"key":"10.1016\/j.mbs.2017.10.004_bib0004","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1093\/emboj\/19.14.3799","article-title":"Uncoupling DNA translocation and helicase activity in PcrA: direct evidence for active mechanism","volume":"19","author":"Soultanas","year":"2000","journal-title":"EMBO J"},{"key":"10.1016\/j.mbs.2017.10.004_bib0005","doi-asserted-by":"crossref","first-page":"12488","DOI":"10.1074\/jbc.274.18.12488","article-title":"Escherichia coli DNA helicase II is active as a monomer","volume":"274","author":"Mechanic","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mbs.2017.10.004_bib0006","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1126\/science.256.5055.350","article-title":"Allosteric effects of nucleotide cofactors on Escherichia coli Rep helicase-DNA binding","volume":"256","author":"Wong","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.mbs.2017.10.004_bib0007","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S0969-2126(99)80090-2","article-title":"Crystal structure of the N-terminal domain of the DnaB hexameric helicase","volume":"7","author":"Fass","year":"1999","journal-title":"Structure"},{"key":"10.1016\/j.mbs.2017.10.004_bib0008","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0092-8674(00)80871-5","article-title":"Crystal structure of T7 gene 4 ring helicase indicates a mechanism for sequential hydrolysis of nucleotides","volume":"101","author":"Singleton","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.mbs.2017.10.004_bib0009","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.1093\/nar\/gkl508","article-title":"Mechanisms of a ring shaped helicase","volume":"34","author":"Donmez","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.mbs.2017.10.004_bib0010","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-1-4614-5037-5_3","article-title":"Structure and mechanisms of SF2 DNA helicases","volume":"767","author":"Beyer","year":"2013","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.mbs.2017.10.004_bib0011","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/978-1-4614-5037-5_2","article-title":"Structure and mechanisms of SF1DNA helicases","volume":"767","author":"Raney","year":"2013","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.mbs.2017.10.004_bib0012","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev.biochem.76.052305.115300","article-title":"Structure and mechanism of helicases and nucleic acid translocases","volume":"76","author":"Singleton","year":"2007","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.mbs.2017.10.004_bib0013","doi-asserted-by":"crossref","first-page":"19691","DOI":"10.1074\/jbc.M010928200","article-title":"Evidence for a functional monomeric form of the bacteriophage T4 Dda helicase","volume":"276","author":"Morris","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mbs.2017.10.004_bib0014","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nsmb920","article-title":"A Brownian motor mechanism of translocation and strand separation by hepatits C virus helicase","volume":"12","author":"Levin","year":"2005","journal-title":"Nature Struc. Mol. Biol."},{"key":"10.1016\/j.mbs.2017.10.004_bib0015","doi-asserted-by":"crossref","first-page":"12655","DOI":"10.1074\/jbc.M513089200","article-title":"E. coli RecQ is a rapid, efficient and monomeric helicase","volume":"281","author":"Zhang","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mbs.2017.10.004_bib0016","doi-asserted-by":"crossref","first-page":"14722","DOI":"10.1073\/pnas.232401899","article-title":"Pre-steady-state DNA unwinding by bacteriophage T4 Dda helicase reveals a monomeric molecular motor","volume":"99","author":"Nanduri","year":"2002","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.mbs.2017.10.004_bib0017","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature04331","article-title":"RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP","volume":"439","author":"Dumont","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.mbs.2017.10.004_bib0018","doi-asserted-by":"crossref","first-page":"5518","DOI":"10.1093\/nar\/gkq273","article-title":"Active and passive mechanisms of helicases","volume":"38","author":"Manosas","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.mbs.2017.10.004_bib0019","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jmb.2012.04.007","article-title":"Dda helicase tightly couples translocation on single-stranded DNA to unwinding of duplex DNA: Dda is an optimally active helicase","volume":"420","author":"Byrd","year":"2012","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.mbs.2017.10.004_bib0020","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1126\/science.1206023","article-title":"Single\u2013Base Pair Unwinding and Asynchronous RNA Release by the Hepatitis C Virus NS3 Helicase","volume":"333","author":"Cheng","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.mbs.2017.10.004_bib0021","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevLett.91.258103","article-title":"A motor that makes its own track: helicase unwinding of DNA","volume":"91","author":"Betterton","year":"2003","journal-title":"Phys. Rev. Lett."},{"key":"10.1016\/j.mbs.2017.10.004_bib0022","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevE.71.011904","article-title":"Opening of nucleic-acid double strands by helicase: active versus passive opening","volume":"71","author":"Betterton","year":"2005","journal-title":"Phys. Rev. E"},{"key":"10.1016\/j.mbs.2017.10.004_bib0023","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevE.77.061910","article-title":"Two-state model for helicase translocation and unwinding of nucleic acids","volume":"77","author":"Garai","year":"2008","journal-title":"Phys. Rev. E"},{"key":"10.1016\/j.mbs.2017.10.004_bib0024","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.physrep.2013.03.005","article-title":"Stochastic mechano-chemical kinetics of molecular motors: A multidisciplinary enterprise from a physicist's perspective","volume":"529","author":"Chowdhury","year":"2013","journal-title":"Physics Reports"},{"key":"10.1016\/j.mbs.2017.10.004_bib0025","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.bpj.2015.05.020","article-title":"Helicase processivity and not the unwinding velocity exhibits universal increase with force","volume":"109","author":"Pincus","year":"2015","journal-title":"Biophys. J."},{"key":"10.1016\/j.mbs.2017.10.004_bib0026","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jtbi.2015.06.011","article-title":"A unified model of nucleic acid unwinding by the ribosome and the hexameric and monomeric DNA helicases","volume":"380","author":"Xie","year":"2015","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.mbs.2017.10.004_bib0027","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.bpc.2016.02.003","article-title":"Dynamics of monomeric and hexameric helicases","volume":"211","author":"Xie","year":"2016","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.mbs.2017.10.004_bib0028","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1002\/prot.25102","article-title":"Processivity of nucleic acid unwinding and translocation by helicases","volume":"84","author":"Xie","year":"2016","journal-title":"Proteins"},{"key":"10.1016\/j.mbs.2017.10.004_bib0029","doi-asserted-by":"crossref","first-page":"e00334","DOI":"10.7554\/eLife.00334","article-title":"Sequence-dependent base pair stepping dynamics in XPD helicase unwinding","volume":"2","author":"Qi","year":"2013","journal-title":"eLife"},{"key":"10.1016\/j.mbs.2017.10.004_bib0030","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0092-8674(00)80525-5","article-title":"Major domain swiveling revealed by the crystal structures of complexes of E. coli Rep helicase bound to single-stranded DNA and ADP","volume":"90","author":"Korolev","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.mbs.2017.10.004_bib0031","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.cell.2006.10.049","article-title":"UvrD helicase unwinds DNA one base pair at a time by a two-part power stroke","volume":"127","author":"Lee","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.mbs.2017.10.004_bib0032","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1073\/pnas.0913380107","article-title":"Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism","volume":"107","author":"Gu","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.mbs.2017.10.004_bib0033","doi-asserted-by":"crossref","first-page":"4910","DOI":"10.1093\/emboj\/cdg500","article-title":"High-resolution structure of the E. coli RecQ helicase catalytic core","volume":"22","author":"Bernstein","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.mbs.2017.10.004_bib0034","doi-asserted-by":"crossref","first-page":"23311","DOI":"10.1074\/jbc.M301283200","article-title":"ATP binding modulates the nucleic acid affinity of hepatitis C virus helicase","volume":"278","author":"Levin","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mbs.2017.10.004_bib0035","doi-asserted-by":"crossref","first-page":"7596","DOI":"10.1016\/S0021-9258(18)42558-6","article-title":"DNA-induced dimerisation of the Escherichia coli Rep helicase: allosteric effects of single stranded and duplex DNA","volume":"267","author":"Wong","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mbs.2017.10.004_bib0036","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.molcel.2009.07.003","article-title":"Single-molecule analysis reveals differential effect of ssDNA-binding proteins on DNA translocation by XPD helicase","volume":"35","author":"Honda","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.mbs.2017.10.004_bib0037","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.dnarep.2014.01.013","article-title":"Two steps forward, one step back: Determining XPD helicase mechanism by single-molecule fluorescence and high-resolution optical tweezers","volume":"20","author":"Spies","year":"2014","journal-title":"DNA Repair"},{"key":"10.1016\/j.mbs.2017.10.004_bib0038","doi-asserted-by":"crossref","first-page":"19790","DOI":"10.1073\/pnas.0709793104","article-title":"Real-time observation of bacteriophage T4 gp41 helicase reveals an unwinding mechanism","volume":"104","author":"Lionnet","year":"2007","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"10.1016\/j.mbs.2017.10.004_bib0039","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jtbi.2012.09.023","article-title":"Dynamics of tRNA occupancy and dissociation during translation by the ribosome","volume":"316","author":"Xie","year":"2013","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.mbs.2017.10.004_bib0040","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevE.88.012702","article-title":"Simplified biased random walk model for RecA-protein-mediated homology recognition offers rapid and accurate self-assembly of long linear arrays of binding sites","volume":"88","author":"Kates-Harbeck","year":"2013","journal-title":"Phys. Rev. E"},{"key":"10.1016\/j.mbs.2017.10.004_bib0041","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1126\/science.271.5250.795","article-title":"Overstretching B-DNA: The elastic response of individual double-stranded and single-stranded DNA molecules","volume":"271","author":"Smith","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.mbs.2017.10.004_bib0042","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1016\/j.celrep.2016.02.008","article-title":"Structural and functional insights into the unwinding mechanism of bacteroides sp Pif1","volume":"14","author":"Zhou","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.mbs.2017.10.004_bib0043","doi-asserted-by":"crossref","first-page":"e02190","DOI":"10.7554\/eLife.02190","article-title":"Periodic DNA patrolling underlies diverse functions of Pif1 on R-loops and G-rich DNA","volume":"3","author":"Zhou","year":"2014","journal-title":"eLife"}],"container-title":["Mathematical Biosciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025556417305461?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0025556417305461?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T14:01:33Z","timestamp":1659621693000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0025556417305461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":43,"alternative-id":["S0025556417305461"],"URL":"https:\/\/doi.org\/10.1016\/j.mbs.2017.10.004","relation":{},"ISSN":["0025-5564"],"issn-type":[{"value":"0025-5564","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dynamics of DNA unwinding by helicases with frequent backward steps","name":"articletitle","label":"Article Title"},{"value":"Mathematical Biosciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mbs.2017.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}