{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:44:51Z","timestamp":1791269091421,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2004,1]]},"DOI":"10.1016\/j.mce.2003.10.032","type":"journal-article","created":{"date-parts":[[2003,12,5]],"date-time":"2003-12-05T11:42:11Z","timestamp":1070624531000},"page":"173-179","source":"Crossref","is-referenced-by-count":51,"title":["Antiepileptic drugs inhibit cell growth in the human breast cancer cell line MCF7"],"prefix":"10.1016","volume":"213","author":[{"given":"Christel M.","family":"Olsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise T.M.","family":"Meussen-Elholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Line S.","family":"R\u00f8ste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Taub\u00f8ll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2003.10.032_BIB1","first-page":"2045","article-title":"Inhibition by anticonvulsants of prostate-specific antigen and interleukin-6 secretion by human prostate cancer cells","volume":"21","author":"Abdul","year":"2001","journal-title":"Anticancer Res."},{"key":"10.1016\/j.mce.2003.10.032_BIB2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1136\/jnnp.73.2.121","article-title":"Reproductive dysfunction in women with epilepsy: recommendations for evaluation and management","volume":"73","author":"Bauer","year":"2002","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.mce.2003.10.032_BIB3","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1210\/en.133.5.2204","article-title":"Estrogens inhibit and androgens enhance ovarian granulosa cell apoptosis","volume":"133","author":"Billig","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2003.10.032_BIB4","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/med.10017","article-title":"Anti-tumour mechanisms of valproate: a novel role for an old drug","volume":"22","author":"Blaheta","year":"2002","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.mce.2003.10.032_BIB5","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/0003-2697(88)90052-8","article-title":"An automated alkaline elution system: DNA damage induced by 1,2-dibromo-3-chloropropane in vivo and in vitro","volume":"174","author":"Brunborg","year":"1988","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.mce.2003.10.032_BIB6","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1002\/j.1460-2075.1996.tb00571.x","article-title":"Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation","volume":"15","author":"Bunone","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/j.mce.2003.10.032_BIB7","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1046\/j.1471-4159.1994.63062361.x","article-title":"Chronic sodium valproate selectively decreases protein kinase C alpha and epsilon in vitro","volume":"63","author":"Chen","year":"1994","journal-title":"J. Neurochem."},{"key":"10.1016\/j.mce.2003.10.032_BIB8","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0893-133X(95)00207-T","article-title":"Effects of valproic acid on beta-adrenergic receptors, G-proteins, and adenylyl cyclase in rat C6 glioma cells","volume":"15","author":"Chen","year":"1996","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.mce.2003.10.032_BIB9","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0169-328X(98)00303-9","article-title":"Valproate robustly enhances AP-1 mediated gene expression","volume":"64","author":"Chen","year":"1999","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.mce.2003.10.032_BIB10","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1097\/00001813-199609000-00008","article-title":"Antitumor activity of sodium valproate in cultures of human neuroblastoma cells","volume":"7","author":"Cinatl","year":"1996","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.mce.2003.10.032_BIB11","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1097\/00001813-199711000-00007","article-title":"Sodium valproate inhibits in vivo growth of human neuroblastoma cells","volume":"8","author":"Cinatl","year":"1997","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.mce.2003.10.032_BIB12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0736-5748(96)00069-X","article-title":"Correlation of in vitro anti-proliferative potential with in vivo teratogenicity in a series of valproate analogues","volume":"15","author":"Courage-Maguire","year":"1997","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.mce.2003.10.032_BIB13","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.1093\/emboj\/20.24.6969","article-title":"Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells","volume":"20","author":"G\u00f6ttlicher","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.mce.2003.10.032_BIB14","first-page":"6","article-title":"Absence of estrogenic activity in some drugs commonly used during pregnancy","volume":"7","author":"Isenhower","year":"1986","journal-title":"Biol. Res. Pregnancy Perinatol."},{"key":"10.1016\/j.mce.2003.10.032_BIB15","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1056\/NEJM199311043291904","article-title":"Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy","volume":"329","author":"Isoj\u00e4rvi","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mce.2003.10.032_BIB16","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/ana.410390506","article-title":"Obesity and endocrine disorders in women taking valproate for epilepsy","volume":"39","author":"Isoj\u00e4rvi","year":"1996","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.mce.2003.10.032_BIB17","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/S0002-9343(01)00806-3","article-title":"Altered ovarian function and cardiovascular risk factors in valproate-treated women","volume":"111","author":"Isoj\u00e4rvi","year":"2001","journal-title":"Am. J. Med."},{"key":"10.1016\/j.mce.2003.10.032_BIB18","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1289\/ehp.00108403","article-title":"Assaying estrogenicity by quantitating the expression levels of endogenous estrogen-regulated genes","volume":"108","author":"J\u00f8rgensen","year":"2000","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.mce.2003.10.032_BIB19","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/BF02967472","article-title":"Estrogen receptor-mediated cross-talk with growth factor signalling pathways","volume":"8","author":"Kato","year":"2001","journal-title":"Breast Cancer"},{"key":"10.1016\/j.mce.2003.10.032_BIB20","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/(SICI)1520-6866(1999)19:1<61::AID-TCM7>3.0.CO;2-O","article-title":"Genotoxicity of the anticonvulsant drug phenytoin (PHT): a follow-up study of PHT-untreated epileptic patients. I. Sister cromatid exchange (SCE) analysis","volume":"19","author":"Kaul","year":"1999","journal-title":"Teratog. Carcinog. Mutagen."},{"key":"10.1016\/j.mce.2003.10.032_BIB21","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/(SICI)1520-6866(1999)19:1<73::AID-TCM8>3.0.CO;2-E","article-title":"Genotoxicity of the anticonvulsant drug phenytoin (PHT): a follow-up study of PHT-untreated epileptic patients. II. Mitotic index (MI) and proliferation kinetics","volume":"19","author":"Kaul","year":"1999","journal-title":"Teratog. Carcinog. Mutagen."},{"key":"10.1016\/j.mce.2003.10.032_BIB22","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/1520-6866(2001)21:2<151::AID-TCM4>3.0.CO;2-E","article-title":"II. An altered proliferation response due to the anticonvulsant phenytoin (PHT) in epileptic patients","volume":"21","author":"Kaul","year":"2001","journal-title":"Teratog. Carcinog. Mutagen."},{"key":"10.1016\/j.mce.2003.10.032_BIB23","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0145-2126(01)00151-5","article-title":"Valproic acid induces apoptosis in human leukemia cells by stimulating both caspase-dependent and independent apoptotic signalling pathways","volume":"26","author":"Kawagoe","year":"2002","journal-title":"Leuk. Res."},{"key":"10.1016\/j.mce.2003.10.032_BIB24","first-page":"3585","article-title":"Valproic acid inhibits proliferation and changes expression of CD44 and CD56 of malignant glioma cells in vitro","volume":"18","author":"Kn\u00fcpfer","year":"1998","journal-title":"Anticancer Res."},{"key":"10.1016\/j.mce.2003.10.032_BIB25","first-page":"347","article-title":"Different effects of valproic acid on proliferation and migration of malignant glioma cells in vitro","volume":"21","author":"Kn\u00fcpfer","year":"2001","journal-title":"Anticancer Res."},{"key":"10.1016\/j.mce.2003.10.032_BIB26","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1053\/seiz.2000.0512","article-title":"Seizures, hormones and sexuality","volume":"10","author":"Lambert","year":"2001","journal-title":"Seizure"},{"key":"10.1016\/j.mce.2003.10.032_BIB27","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/256592a0","article-title":"Oestrogen-responsive human breast cancer in long term tissue culture","volume":"256","author":"Lippman","year":"1975","journal-title":"Nature"},{"key":"10.1016\/j.mce.2003.10.032_BIB28","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0006-8993(91)90193-Y","article-title":"The anticonvulsant valproate teratogen restricts the glial cell cycle at a defined point in the mid-G1 phase","volume":"554","author":"Martin","year":"1991","journal-title":"Brain Res."},{"issue":"4 (Suppl. 1)","key":"10.1016\/j.mce.2003.10.032_BIB29","first-page":"S42","article-title":"Epilepsy in women: the science of why it is special","volume":"53","author":"Morrell","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.mce.2003.10.032_BIB30","first-page":"52","article-title":"Effects of valproate, phenobarbital, and carbamazepine on sex steroid setup in women with epilepsy","volume":"21","author":"Murialdo","year":"1998","journal-title":"Clin. Neuropharmacol."},{"key":"10.1016\/j.mce.2003.10.032_BIB31","doi-asserted-by":"crossref","first-page":"322","DOI":"10.4088\/JCP.v63n0409","article-title":"Menstrual abnormalities and polycystic ovary syndrome in women taking valproate for bipolar mood disorder","volume":"63","author":"O\u2019Donovan","year":"2002","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.mce.2003.10.032_BIB32","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0960-0760(90)90423-I","article-title":"Regulation of breast cancer growth by insulin-like growth factors","volume":"37","author":"Osborne","year":"1990","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.mce.2003.10.032_BIB33","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1210\/jc.85.5.2057","article-title":"Estradiol acts as a germ cell survival factor in the human testis in vitro","volume":"85","author":"Pentik\u00e4inen","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2003.10.032_BIB34","unstructured":"Pritchard, P.B., 1997. III. Hormone changes in epilepsy. In: Engel Jr., J., Pedley, A.T. (Eds.), Epilepsy: A Comprehensive Textbook. Lippincoll-Raven, Philadelphia, pp. 1997\u20132002."},{"key":"10.1016\/j.mce.2003.10.032_BIB35","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/0006-8993(85)90207-0","article-title":"Therapeutic levels of sodium valproate inhibit mitotic indices in cells of neural origin","volume":"347","author":"Regan","year":"1985","journal-title":"Brain Res."},{"key":"10.1016\/j.mce.2003.10.032_BIB36","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0960-0760(97)00155-6","article-title":"Coronary artery and cultured aortic smooth muscle cells express mRNA for both the classical estrogen receptor and the newly described estrogen receptor beta","volume":"64","author":"Register","year":"1998","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.mce.2003.10.032_BIB37","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s002800050649","article-title":"Multienzyme-mediated stable and transient multidrug resistance and collateral sensitivity induced by xenobiotics","volume":"40","author":"Rekha","year":"1997","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.mce.2003.10.032_BIB38","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1053\/seiz.2001.0545","article-title":"Morphological changes in the testis after long-term valproate treatment in male Wistar rats","volume":"10","author":"R\u00f8ste","year":"2001","journal-title":"Seizure"},{"key":"10.1016\/j.mce.2003.10.032_BIB39","doi-asserted-by":"crossref","unstructured":"R\u00f8ste, L.S., Taub\u00f8ll, E., Isoj\u00e4rvi, J.I.T., Berner, Aa., Berg, K.A., Pakarinen, A.J., Huhtaniemi, I., Knip, M., Gjerstad, L. Gonadal morphology and sex hormones in male and female Wistar rats after long-term lamotrigine treatment. Seizure, in press.","DOI":"10.1016\/S1059-1311(03)00056-6"},{"key":"10.1016\/j.mce.2003.10.032_BIB40","first-page":"357","article-title":"Valproic acid, but not its non-teratogenic analogue 2-isopropylpentanoic acid, affects proliferation, viability and neuronal differentiation of the human teratocarcinoma cell line NTera-2","volume":"19","author":"Skladchikova","year":"1998","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.mce.2003.10.032_BIB41","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1528-1157.1987.tb04210.x","article-title":"Effects of anticonvulsants on cell growth and enzymatic and receptor binding activity in a neuroblastoma \u00d7 glioma hybrid cell culture","volume":"28","author":"Slesinger","year":"1987","journal-title":"Epilepsia"},{"issue":"Suppl 7","key":"10.1016\/j.mce.2003.10.032_BIB42","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1289\/ehp.95103s7113","article-title":"The F-SCREEN assay as a tool to identify estrogens: an update on estrogenic environmental pollutants","volume":"103","author":"Soto","year":"1995","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.mce.2003.10.032_BIB43","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1046\/j.1528-1157.2001.0420081002.x","article-title":"Hormone profiles in young adults with epilepsy treated with sodium valproate or lamotrigine monotherapy","volume":"42","author":"Stephen","year":"2001","journal-title":"Epilepsia"},{"key":"10.1016\/j.mce.2003.10.032_BIB44","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0890-6238(02)00020-5","article-title":"Valproate irreversibly alters steroid secretion patterns from porcine follicular cells in vitro","volume":"16","author":"Taub\u00f8ll","year":"2002","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.mce.2003.10.032_BIB45","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1046\/j.1528-1157.2003.60702.x","article-title":"Valproate inhibits the conversion of testosterone to estradiol and acts as an apoptotic agent in growing porcine ovarian follicular cells","volume":"44","author":"Taub\u00f8ll","year":"2003","journal-title":"Epilepsia"},{"key":"10.1016\/j.mce.2003.10.032_BIB46","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/j.1528-1157.1992.tb02354.x","article-title":"Effect of antiepileptic drugs on growth of murine lymphoid tumour cells in single-cell culture","volume":"33","author":"Tittle","year":"1992","journal-title":"Epilepsia"},{"key":"10.1016\/j.mce.2003.10.032_BIB47","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0022-4731(89)90081-2","article-title":"Comparative studies on the effects of steroidal and nonsteroidal oestrogen antagonists on the proliferation of human breast cancer cells","volume":"34","author":"Wakeling","year":"1989","journal-title":"J. Steroid Biochem."},{"key":"10.1016\/j.mce.2003.10.032_BIB48","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0300-483X(90)90038-I","article-title":"Preclinical toxicology of the anticonvulsant calcium valproate","volume":"63","author":"Walker","year":"1990","journal-title":"Toxicology"},{"key":"10.1016\/j.mce.2003.10.032_BIB49","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1124\/mol.59.5.1269","article-title":"Induction of differentiation in F9 cells and activation of peroxisome proliferator-activated receptor delta by valproic acid and its teratogenic derivatives","volume":"59","author":"Werling","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.mce.2003.10.032_BIB50","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/ijc.2910530220","article-title":"Inhibition of growth-factor-activated proliferation by anti estrogens and effects on early gene expression of MCF-7 cells","volume":"53","author":"Wosikowski","year":"1993","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.mce.2003.10.032_BIB51","doi-asserted-by":"crossref","first-page":"31674","DOI":"10.1074\/jbc.M104309200","article-title":"The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth","volume":"276","author":"Yuan","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2003.10.032_BIB52","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/0006-2952(96)00062-7","article-title":"Similarities and differences in the glucuronidation of estradiol and estrone by UDP-glucuronosyltransferase in liver microsomes from male and female rats","volume":"51","author":"Zhu","year":"1996","journal-title":"Biochem. Pharmacol."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720703004155?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720703004155?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T18:19:34Z","timestamp":1585333174000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720703004155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["S0303720703004155"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2003.10.032","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2004,1]]}}}