{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T18:17:55Z","timestamp":1783707475030,"version":"3.55.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1016\/j.mce.2005.12.020","type":"journal-article","created":{"date-parts":[[2006,1,20]],"date-time":"2006-01-20T12:41:51Z","timestamp":1137760911000},"page":"53-59","source":"Crossref","is-referenced-by-count":29,"title":["Extracellular matrix integrity: A possible mechanism for differential clinical effects among selective estrogen receptor modulators and estrogens?"],"prefix":"10.1016","volume":"247","author":[{"given":"David A.","family":"Cox","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah M.","family":"Helvering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2005.12.020_bib1","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1023\/A:1018458406797","article-title":"Differential influence of antiestrogens on the in vitro release of gelatinases (type IV collagenases) by invasive and non-invasive breast cancer cells","volume":"15","author":"Abbas Abidi","year":"1997","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.mce.2005.12.020_bib2","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1161\/hq0801.095083","article-title":"Raloxifene-mediated increase in matrix metalloproteinase-1 production by activated monocytes","volume":"21","author":"Ardans","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.mce.2005.12.020_bib3","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/S0002-9149(00)01116-4","article-title":"Effects of estrogen and the selective estrogen receptor modulator raloxifene on markers of inflammation in postmenopausal women","volume":"86","author":"Blum","year":"2000","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.mce.2005.12.020_bib4","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/S0002-9378(97)70091-7","article-title":"Effects of raloxifene hydrochloride on the endometrium of postmenopausal women","volume":"177","author":"Boss","year":"1997","journal-title":"Am. J. Obstet. Gynecol"},{"key":"10.1016\/j.mce.2005.12.020_bib5","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s001920200020","article-title":"Collagen metabolism and turnover in women with stress urinary incontinence and pelvic prolapse","volume":"13","author":"Chen","year":"2002","journal-title":"Int. Urogynecol. J. Pelvic Floor Dysfunct."},{"key":"10.1016\/j.mce.2005.12.020_bib6","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ygyno.2004.03.048","article-title":"Endometrial pathologies associated with postmenopausal tamoxifen treatment","volume":"94","author":"Cohen","year":"2004","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.mce.2005.12.020_bib7","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1001\/jama.281.23.2189","article-title":"The effect of raloxifene on risk of breast cancer in postmenopausal women","volume":"281","author":"Cummings","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.mce.2005.12.020_bib8","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/00016349808565820","article-title":"Paraurethral connective tissue in stress-incontinent women after menopause","volume":"77","author":"Falconer","year":"1998","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"10.1016\/j.mce.2005.12.020_bib9","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1093\/jnci\/90.18.1371","article-title":"Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study","volume":"90","author":"Fisher","year":"1998","journal-title":"J. Natl. Cancer. Inst."},{"key":"10.1016\/j.mce.2005.12.020_bib10","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1093\/jnci\/93.9.684","article-title":"Five versus more than five years of tamoxifen for lumph node-negative breast cancer: updated findings from the national surgical adjuvant breast and bowel project B-14 randomized trial","volume":"93","author":"Fisher","year":"2001","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.mce.2005.12.020_bib11","doi-asserted-by":"crossref","first-page":"503","DOI":"10.7863\/jum.1999.18.7.503","article-title":"Sonographic assessment of the endometrium in osteopenic postmenopausal women treated with idoxifene","volume":"18","author":"Fleischer","year":"1999","journal-title":"J. Ultrasound Med."},{"key":"10.1016\/j.mce.2005.12.020_bib12","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1158\/0008-5472.CAN-03-3326","article-title":"Selective estrogen receptor modulators: discrimination of agonistic versus antagonistic activities by gene expression profiling in breast cancer cells","volume":"64","author":"Frasor","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.mce.2005.12.020_bib13","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1161\/res.90.3.251","article-title":"Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly","volume":"90","author":"Galis","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.mce.2005.12.020_bib14","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0029-7844(99)00502-5","article-title":"A 12-month comparative study of raloxifene, estrogen, and placebo on the postmenopausal endometrium","volume":"95","author":"Goldstein","year":"2000","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.mce.2005.12.020_bib15","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/00042192-200512020-00010","article-title":"Incidence of urinary incontinence in postmenopausal women treated with raloxifene or estrogen","volume":"12","author":"Goldstein","year":"2005","journal-title":"Menopause"},{"key":"10.1016\/j.mce.2005.12.020_bib16","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1067\/mob.2002.123938","article-title":"Adverse events that are associated with the selective estrogen receptor modulator levormeloxifene in an aborted phase III osteoporosis treatment study","volume":"187","author":"Goldstein","year":"2002","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.mce.2005.12.020_bib17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0029-7844(01)01390-4","article-title":"Raloxifene effect on frequency of surgery for pelvic floor relaxation","volume":"98","author":"Goldstein","year":"2001","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.mce.2005.12.020_bib18","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S0029-7844(00)01115-7","article-title":"Postmenopausal hormones and incontinence: the Heart and Estrogen\/Progestin Replacement Study","volume":"97","author":"Grady","year":"2001","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.mce.2005.12.020_bib19","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/0029-7844(94)00383-O","article-title":"Hormone replacement therapy and endometrial cancer risk: a meta-analysis","volume":"85","author":"Grady","year":"1995","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.mce.2005.12.020_bib20","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1095\/biolreprod.104.034595","article-title":"Differential effects of estrogen and raloxifene on messenger RNA and matrix metalloproteinase 2 activity in the rat uterus","volume":"72","author":"Helvering","year":"2005","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2005.12.020_bib21","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1001\/jama.293.8.935","article-title":"Effects of estrogen with and without progestin on urinary incontinence","volume":"293","author":"Hendrix","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.mce.2005.12.020_bib22","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1749-6632.2001.tb04028.x","article-title":"Effect of selective estrogen receptor modulators on reproductive tissues other than endometrium","volume":"949","author":"Hendrix","year":"2001","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.mce.2005.12.020_bib23","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.steroids.2005.02.011","article-title":"Vascular cell signaling by membrane estrogen receptors","volume":"70","author":"Hisamoto","year":"2005","journal-title":"Steroids"},{"key":"10.1016\/j.mce.2005.12.020_bib24","doi-asserted-by":"crossref","unstructured":"Hu, P., Greendale, G.A., Palla, S.L., Reboussin, B.A., Herrington, D.M., Barrett-Connor, E., Reuben, D.B. The effects of hormone therapy on the markers of inflammation and endothelial function and plasma matrix metalloproteinase-9 level in postmenopausal women: the postmenopausal estrogen progestin intervention (PEPI) trial. Atherosclerosis. doi:10.1016\/j.atherosclerosis.2005.06.011 (Epub ahead of print), in press.","DOI":"10.1016\/j.atherosclerosis.2005.06.011"},{"key":"10.1016\/j.mce.2005.12.020_bib25","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.fertnstert.2003.10.027","article-title":"Matrix metalloproteinase 2 is associated with changes in steroid hormones in the sera and peritoneal fluid of patients with endometriosis","volume":"81","author":"Huang","year":"2004","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.mce.2005.12.020_bib26","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1016\/S0140-6736(96)91489-0","article-title":"Changes in metabolism of collagen in genitourinary prolapse","volume":"347","author":"Jackson","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.mce.2005.12.020_bib27","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1471-0528.2002.01052.x","article-title":"The effect of oestradiol on vaginal collagen metabolism in postmenopausal women with genuine stress incontinence","volume":"109","author":"Jackson","year":"2002","journal-title":"BJOG"},{"key":"10.1016\/j.mce.2005.12.020_bib28","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/01.GME.0000058772.59606.2A","article-title":"Prevention of osteoporosis and uterine effects in postmenopausal women taking raloxifene for 5 years","volume":"10","author":"Jolly","year":"2003","journal-title":"Menopause"},{"key":"10.1016\/j.mce.2005.12.020_bib29","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1091\/mbc.E03-06-0360","article-title":"Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta","volume":"15","author":"Kian","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.mce.2005.12.020_bib30","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1158\/1078-0432.CCR-03-0047","article-title":"A high serum matrix metalloproteinase-2 level is associated with an adverse prognosis in node-positive breast carcinoma","volume":"10","author":"Leppa","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.mce.2005.12.020_bib31","first-page":"4419","article-title":"Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor","volume":"62","author":"Levenson","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.mce.2005.12.020_bib32","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s10549-004-1200-8","article-title":"Prognostic value of matrix metalloproteinases (MMP-2 and MMP-9) in patients with lymph node-negative breast carcinoma","volume":"88","author":"Li","year":"2004","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.mce.2005.12.020_bib33","first-page":"99","article-title":"Metalloproteinases and cancer invasion","volume":"1","author":"Liotta","year":"1990","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.mce.2005.12.020_bib34","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1167\/iovs.01-1276","article-title":"Regulation of estrogen receptors and MMP-2 expression by estrogens in human retinal pigment epithelium","volume":"44","author":"Marin-Castano","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mce.2005.12.020_bib35","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1093\/jnci\/djh319","article-title":"Continuing outcomes relevant to evista: breast cancer incidence in postmenopausal osteoporotic women in a randomized trial of raloxifene","volume":"96","author":"Martino","year":"2004","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.mce.2005.12.020_bib36","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1185\/030079905X61839","article-title":"Safety assessment of raloxifene over eight years in a clinical trial setting","volume":"21","author":"Martino","year":"2005","journal-title":"Curr. Med. Res. Opin."},{"issue":"Suppl. 1","key":"10.1016\/j.mce.2005.12.020_bib37","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1016\/j.maturitas.2004.03.006","article-title":"The molecular determinants of estrogen receptor pharmacology","volume":"48","author":"McDonnell","year":"2004","journal-title":"Maturitas"},{"key":"10.1016\/j.mce.2005.12.020_bib38","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/ijc.10941","article-title":"Letrozole as a potent inhibitor of cell proliferation and expression of metalloproteinases (MMP-2 and MMP-9) by human epithelial breast cancer cells","volume":"104","author":"Mitropoulou","year":"2003","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.mce.2005.12.020_bib39","first-page":"CD001405","article-title":"Oestrogens for urinary incontinence in women","author":"Moehrer","year":"2003","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.mce.2005.12.020_bib40","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1001\/jama.275.5.370","article-title":"Effects of hormone replacement therapy on endometrial histology in postmenopausal women. The Postmenopausal Estrogen\/Progestin Interventions (PEPI) Trial. The Writing Group for the PEPI Trial","volume":"275","year":"1996","journal-title":"JAMA"},{"key":"10.1016\/j.mce.2005.12.020_bib41","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1681\/ASN.V122241","article-title":"Expression and regulation of estrogen receptors in mesangial cells: influence on matrix metalloproteinase-9","volume":"12","author":"Potier","year":"2001","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.mce.2005.12.020_bib42","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1002\/ijc.11288","article-title":"Plasma MMP-9 (92kDa-MMP) activity is useful in the follow-up and in the assessment of prognosis in breast cancer patients","volume":"106","author":"Ranuncolo","year":"2003","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.mce.2005.12.020_bib43","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/00041433-200108000-00001","article-title":"Early risk of cardiovascular events after commencing hormone replacement therapy","volume":"12","author":"Rossouw","year":"2001","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.mce.2005.12.020_bib44","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jsbmb.2004.01.004","article-title":"Nongenomic effects of 17beta-estradiol\u2014diversity of membrane binding sites","volume":"88","author":"Sak","year":"2004","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.mce.2005.12.020_bib45","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0303-7207(01)00401-4","article-title":"Suppression of estrogen-dependent MMP-9 expression by Edpm5, a genetic locus for pituitary tumor growth in rat","volume":"176","author":"Sclafani","year":"2001","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.mce.2005.12.020_bib46","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3109\/13697139909038087","article-title":"Selective estrogen receptor modulators: tissue specificity and differential uterine effects","volume":"2","author":"Silfen","year":"1999","journal-title":"Climacteric"},{"key":"10.1016\/j.mce.2005.12.020_bib47","first-page":"803","article-title":"Differential effects of estradiol and raloxifene on collagen biosynthesis in cultured human skin fibroblasts","volume":"12","author":"Surazynski","year":"2003","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.mce.2005.12.020_bib48","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1523\/JNEUROSCI.21-06-01809.2001","article-title":"Estrogen prevents the lipopolysaccharide-induced inflammatory response in microglia","volume":"21","author":"Vegeto","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mce.2005.12.020_bib49","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jsbmb.2004.02.004","article-title":"Regulation of the lipopolysaccharide signal transduction pathway by 17beta-estradiol in macrophage cells","volume":"91","author":"Vegeto","year":"2004","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.mce.2005.12.020_bib50","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/01.AOG.0000109429.67671.d1","article-title":"Effect of raloxifene on urinary incontinence: a randomized controlled trial","volume":"103","author":"Waetjen","year":"2004","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.mce.2005.12.020_bib51","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1161\/01.ATV.0000090569.11739.B9","article-title":"Different effects of oral and transdermal estrogen replacement therapy on matrix metalloproteinase and their inhibitor in postmenopausal women","volume":"23","author":"Wakatsuki","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.mce.2005.12.020_bib52","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0378-5122(02)00342-0","article-title":"Adverse effects of a SERM (Levormeloxifene). Safety parameters and bone mineral density 12 months after treatment withdrawal","volume":"44","author":"Warming","year":"2003","journal-title":"Maturitas"},{"key":"10.1016\/j.mce.2005.12.020_bib53","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/nau.20048","article-title":"Basic science and translational research in female pelvic floor disorders: proceedings of an NIH-sponsored meeting","volume":"23","author":"Weber","year":"2004","journal-title":"Neurourol. Urodyn."},{"key":"10.1016\/j.mce.2005.12.020_bib54","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0925-4439(97)00097-5","article-title":"17Beta-oestradiol enhances release of matrix metalloproteinase-2 from human vascular smooth muscle cells","volume":"1406","author":"Wingrove","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mce.2005.12.020_bib55","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/gye.15.3.225.233","article-title":"Estrogenic and antiestrogenic effects of raloxifene on collagen metabolism in breast cancer MCF-7 cells","volume":"15","author":"Wolczynski","year":"2001","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.mce.2005.12.020_bib56","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1016\/S0735-1097(00)00952-9","article-title":"Divergent effects of hormone therapy on serum markers of inflammation in postmenopausal women with coronary artery disease on appropriate medical management","volume":"36","author":"Zanger","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.mce.2005.12.020_bib57","first-page":"929","article-title":"Effects of 17beta-estradiol and progesterone on the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in rat osteoblasts","volume":"21","author":"Zhang","year":"2001","journal-title":"Di Yi. Jun. Yi. Da. Xue. Xue. Bao."},{"key":"10.1016\/j.mce.2005.12.020_bib58","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1161\/01.HYP.36.6.970","article-title":"Estrogen replacement reduces age-associated remodeling in rat mesenteric arteries","volume":"36","author":"Zhang","year":"2000","journal-title":"Hypertension"}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720705004661?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720705004661?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T22:22:58Z","timestamp":1626992578000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720705004661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":58,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S0303720705004661"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2005.12.020","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}