{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T12:04:48Z","timestamp":1778587488690,"version":"3.51.4"},"reference-count":47,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2008,12,1]],"date-time":"2008-12-01T00:00:00Z","timestamp":1228089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1016\/j.mce.2008.07.019","type":"journal-article","created":{"date-parts":[[2008,8,7]],"date-time":"2008-08-07T08:59:27Z","timestamp":1218099567000},"page":"87-93","source":"Crossref","is-referenced-by-count":24,"title":["Effects of estrogens on striatal damage after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in male and female mice"],"prefix":"10.1016","volume":"296","author":[{"given":"Masanori","family":"Ookubo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sho","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Araki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2008.07.019_bib1","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0006-8993(01)02944-4","article-title":"Neuroprotective effect of riluzole in MPTP-treated mice","volume":"918","author":"Araki","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.mce.2008.07.019_bib2","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1002\/mds.1170","article-title":"Hysterectomy, menopause, and estrogen use preceding Parkinson's disease: an exploratory case-control study","volume":"16","author":"Benedetti","year":"2001","journal-title":"Mov. Disord."},{"key":"10.1016\/j.mce.2008.07.019_bib3","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s004290050236","article-title":"Estrogen and the developing mammalian brain","volume":"5","author":"Beyer","year":"1999","journal-title":"Anat. Embryol. (Berl.)"},{"key":"10.1016\/j.mce.2008.07.019_bib4","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1055\/s-2001-14841","article-title":"Estrone, but not 17 bata-estradiol, attenuates kainite-induced seizures and toxicity in male mice","volume":"109","author":"Budziszewska","year":"2001","journal-title":"Exp. Clin. Endocrinol. Dab."},{"key":"10.1016\/j.mce.2008.07.019_bib5","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/1098-2396(20000915)37:4<245::AID-SYN1>3.0.CO;2-5","article-title":"Stereospecific prevention by 17beta-estradiol of MPTP-induced dopamine depletion in mice","volume":"37","author":"Callier","year":"2000","journal-title":"Synapse"},{"key":"10.1016\/j.mce.2008.07.019_bib6","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0531-5565(96)00173-8","article-title":"Melatonin levels in Parkinson's disease: drug therapy versus electrical stimulation of the internal globus pallidus","volume":"32","author":"Catala","year":"1997","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.mce.2008.07.019_bib7","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/j.neuropharm.2004.08.020","article-title":"Effect of estrogen receptor agonists treatment in MPTP mice: evidence of neuroprotection by an ER\u03b1 agonist","volume":"47","author":"D\u2019Astous","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.mce.2008.07.019_bib8","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1212\/WNL.40.5.763","article-title":"An examination of male\u2013female differences in progression and mortality of Parkinson's disease","volume":"40","author":"Diamond","year":"1990","journal-title":"Neurology"},{"key":"10.1016\/j.mce.2008.07.019_bib9","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1515\/REVNEURO.1994.5.1.27","article-title":"Modulation of brain dopamine transmission by sex steroids","volume":"5","author":"Di Paolo","year":"1994","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.mce.2008.07.019_bib10","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0892-0362(02)00187-3","article-title":"Methamphetamine-gonadal steroid hormonal interactions: effects upon acute toxicity and striatal dopamine concentrations","volume":"24","author":"Dluzen","year":"2002","journal-title":"Neurotoxicol. Treratol."},{"key":"10.1016\/j.mce.2008.07.019_bib11","doi-asserted-by":"crossref","first-page":"4912","DOI":"10.1046\/j.1432-1327.2000.01597.x","article-title":"Gultathione metabolism in brain. Metabolic interaction between astrocytes and neurons in the defense against reactive oxygen species","volume":"267","author":"Dringen","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.mce.2008.07.019_bib12","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1073\/pnas.041483198","article-title":"Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury","volume":"98","author":"Dubal","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mce.2008.07.019_bib13","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0006-8993(03)03198-6","article-title":"Failure of estrogen to protect the substantia nigra pars compacta of female rats from lesion induced by 6-hydroxydopamine","volume":"986","author":"Ferraz","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.mce.2008.07.019_bib14","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/(SICI)1098-2396(20000615)36:4<233::AID-SYN1>3.0.CO;2-I","article-title":"Basic fibroblast growth factor (bFGF) acts on both neurons and glia to mediate the neurotrophic effects of astrocytes on LHRH neurons in culture","volume":"36","author":"Gallo","year":"2000","journal-title":"Synapse"},{"key":"10.1016\/j.mce.2008.07.019_bib15","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1212\/WNL.45.5.1028-a","article-title":"Hormones and Parkinson's disease","volume":"45","author":"Giladi","year":"1995","journal-title":"Neurology"},{"key":"10.1016\/j.mce.2008.07.019_bib16","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1046\/j.1471-4159.1996.66051836.x","article-title":"Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, amyloid beta-peptide toxicity in hippocampal neurons","volume":"66","author":"Goodman","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/j.mce.2008.07.019_bib17","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/320134a0","article-title":"Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A","volume":"320","author":"Green","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.mce.2008.07.019_bib18","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1056\/NEJMra000471","article-title":"Production and actions of estrogens","volume":"346","author":"Gruber","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mce.2008.07.019_bib19","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1126\/science.6610213","article-title":"Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyidine in mice","volume":"224","author":"Heikkila","year":"1984","journal-title":"Science"},{"key":"10.1016\/j.mce.2008.07.019_bib20","first-page":"497","article-title":"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned model of Parkinson's disease, with emphasis on mice and nonhuman primates","volume":"54","author":"Jakowec","year":"2004","journal-title":"Comp. Med."},{"key":"10.1016\/j.mce.2008.07.019_bib21","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1365-2826.2005.01337.x","article-title":"Oestrogens prevent loss of dopaminergic transporter (DAT) and vesicular monoamine transporter (VMAT2) in substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mice","volume":"17","author":"Jourdain","year":"2005","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.mce.2008.07.019_bib22","first-page":"727","article-title":"Neuroprotective effects of estrone on NMDA-induced toxicity in primary cultures of rat cortical neurons are independent of estrogen receptors","volume":"54","author":"Kajta","year":"2002","journal-title":"Pol. J. Pharmacol."},{"key":"10.1016\/j.mce.2008.07.019_bib23","doi-asserted-by":"crossref","first-page":"5925","DOI":"10.1073\/pnas.93.12.5925","article-title":"Cloning of a novel receptor expressed in rat prostate and ovary","volume":"93","author":"Kuiper","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mce.2008.07.019_bib24","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1210\/en.138.3.863","article-title":"Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptor alpha and beta","volume":"138","author":"Kuiper","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2008.07.019_bib25","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.euroneuro.2004.05.007","article-title":"Effect of angiotensin-converting enzyme inhibitor perindopril on interneurons in MPTP-treated mice","volume":"15","author":"Kurosaki","year":"2005","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.mce.2008.07.019_bib26","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1126\/science.6823561","article-title":"Chronic parkinsonism in humans due to a product of meperidine-analog synthesis","volume":"219","author":"Langston","year":"1983","journal-title":"Science"},{"issue":"Suppl. 100","key":"10.1016\/j.mce.2008.07.019_bib27","first-page":"49","article-title":"MPTP-induced parkinsonism in human and no-human primates\u2014clinical and experimental aspects","author":"Langston","year":"1984","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.mce.2008.07.019_bib28","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/ana.410240415","article-title":"Rate of cell death in parkinsonism indicates active neuropathological process","volume":"24","author":"McGeer","year":"1988","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.mce.2008.07.019_bib29","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1210\/en.2002-221069","article-title":"Immunolocalization of estrogen receptor beta in the mouse brain: comparison with estrogen receptor alpha","volume":"144","author":"Mitra","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2008.07.019_bib30","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.neuroscience.2005.07.060","article-title":"Estrogen, neuroinflammation and neuroprotection in Parkinson's disease: glia dictates resistance versus vulnerability to neurodegeneration","volume":"138","author":"Morale","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.mce.2008.07.019_bib31","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/j.neuropharm.2007.02.004","article-title":"Role of estrogen receptors in neuroprotection by estradiol against MPTP toxicity","volume":"52","author":"Morissette","year":"2007","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.mce.2008.07.019_bib32","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0306-4522(02)00578-X","article-title":"Dose- and sex-dependent effects of the neurotoxin 6-hydroxydopamine on the nigrostriatal dopaminergic pathway of adult rats: differential actions of estrogen in males and females","volume":"116","author":"Murray","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.mce.2008.07.019_bib33","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1097\/00004647-200007000-00003","article-title":"High susceptibility to cerebral ischemia in GFAP-null mice","volume":"20","author":"Nawashiro","year":"2000","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"Suppl. 3","key":"10.1016\/j.mce.2008.07.019_bib34","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1002\/ana.10566","article-title":"Neuroprotection of Parkinson's disease: prospects and promises","volume":"53","author":"Olanov","year":"2003","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.mce.2008.07.019_bib35","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/jnr.10833","article-title":"Estrogen interacts with the IGF-1 system to protect nigrostriatal dopamine and maintain motoric behavior after 6-hydroxydopamine lesions","volume":"75","author":"Quesada","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.mce.2008.07.019_bib36","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1159\/000070277","article-title":"Repeated estradiol treatment prevents MPTP-induced dopamine depletion in male mice","volume":"77","author":"Ramirez","year":"2003","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.mce.2008.07.019_bib37","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1212\/WNL.52.7.1417","article-title":"The effect of estrogen replacement on early Parkinson's disease","volume":"52","author":"Saunders-Pullman","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.mce.2008.07.019_bib38","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s10552-005-9002-9","article-title":"Circulating melatonin levels: possible link between Parkinson's disease and cancer risk?","volume":"17","author":"Schernhammer","year":"2006","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.mce.2008.07.019_bib39","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/0306-9877(94)90133-3","article-title":"Estrogens and Parkinson's disease","volume":"42","author":"Session","year":"1994","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.mce.2008.07.019_bib40","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.molbrainres.2004.09.017","article-title":"The MPTP model of Parkinson's disease","volume":"134","author":"Smeyne","year":"2005","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.mce.2008.07.019_bib41","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/00002826-199903000-00005","article-title":"Effects of female sex steroids on Parkinson's disease in postmenopausal women","volume":"22","author":"Strijks","year":"1999","journal-title":"Clin. Neuropharmacol."},{"key":"10.1016\/j.mce.2008.07.019_bib42","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1007\/s00702-007-0790-9","article-title":"Damage of oligodendrocytes in the striatum after MPTP neurotoxicity in mice","volume":"114","author":"Takagi","year":"2007","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.mce.2008.07.019_bib43","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.brainres.2006.02.029","article-title":"Estrogen down-regulates glial activation in male mice following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxication","volume":"1084","author":"Tripanichkul","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.mce.2008.07.019_bib44","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1212\/WNL.54.12.2292","article-title":"Estrogen improves motor disability in parkinsonian postmenopausal women with motor fluctuations","volume":"54","author":"Tsang","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.mce.2008.07.019_bib45","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s11011-007-9080-3","article-title":"Protective action of neuronal nitric oxide synthase inhibitor in the MPTP mouse model of Parkinson's disease","volume":"23","author":"Watanabe","year":"2008","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.mce.2008.07.019_bib46","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1006\/frne.2000.0207","article-title":"Estrogens: tropic and protective factors in the adult brain","volume":"22","author":"Wise","year":"2001","journal-title":"Front. Neuroendcrinol."},{"key":"10.1016\/j.mce.2008.07.019_bib47","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s00702-008-0019-6","article-title":"Role of reactive nitrogen and reactive oxygen species against MPTP neurotoxicity in mice","volume":"115","author":"Yokoyama","year":"2008","journal-title":"J. Neural Transm."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720708003365?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720708003365?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T17:21:00Z","timestamp":1545844860000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720708003365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12]]},"references-count":47,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["S0303720708003365"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2008.07.019","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2008,12]]}}}