{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T22:19:56Z","timestamp":1773699596324,"version":"3.50.1"},"reference-count":157,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1016\/j.mce.2008.09.020","type":"journal-article","created":{"date-parts":[[2008,10,2]],"date-time":"2008-10-02T09:11:28Z","timestamp":1222938688000},"page":"193-202","source":"Crossref","is-referenced-by-count":175,"title":["The sweeter side of ACE2: Physiological evidence for a role in diabetes"],"prefix":"10.1016","volume":"302","author":[{"given":"Sharell M.","family":"Bindom","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Lazartigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2008.09.020_bib1","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.jacc.2005.05.051","article-title":"Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers for prevention of type 2 diabetes: a meta-analysis of randomized clinical trials","volume":"46","author":"Abuissa","year":"2005","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.mce.2008.09.020_bib2","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1590\/S0100-879X2000000600012","article-title":"Angiotensin-(1\u20137) potentiates the coronary vasodilatatory effect of bradykinin in the isolated rat heart","volume":"33","author":"Almeida","year":"2000","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.mce.2008.09.020_bib3","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1136\/bmj.317.7160.713","article-title":"Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39. UK Prospective Diabetes Study Group","volume":"317","author":"Anonymous","year":"1998","journal-title":"BMJ"},{"key":"10.1016\/j.mce.2008.09.020_bib4","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0140-6736(99)12323-7","article-title":"Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Heart Outcomes Prevention Evaluation Study Investigators","volume":"355","author":"Anonymous","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.mce.2008.09.020_bib5","first-page":"1442","article-title":"Type 2 diabetes in children and adolescents. American Diabetes Association","volume":"23","author":"Anonymous","year":"2000","journal-title":"Diabetes Care"},{"key":"10.1016\/j.mce.2008.09.020_bib6","doi-asserted-by":"crossref","first-page":"E736","DOI":"10.1152\/ajpendo.1992.262.5.E736","article-title":"Increased islet blood flow in obese rats: role of the autonomic nervous system","volume":"262","author":"Atef","year":"1992","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2008.09.020_bib7","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/BF00417691","article-title":"Changes in islet blood flow in rats with NIDDM","volume":"37","author":"Atef","year":"1994","journal-title":"Diabetologia"},{"key":"10.1016\/j.mce.2008.09.020_bib8","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s001090100210","article-title":"Tissue renin\u2013angiotensin systems: new insights from experimental animal models in hypertension research","volume":"79","author":"Bader","year":"2001","journal-title":"J. Mol. Med."},{"issue":"1 Pt 2","key":"10.1016\/j.mce.2008.09.020_bib9","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1161\/01.HYP.35.1.409","article-title":"The brain renin\u2013angiotensin system modulates angiotensin II-induced hypertension and cardiac hypertrophy","volume":"35","author":"Baltatu","year":"2000","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2008.09.020_bib10","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1210\/jcem-73-3-637","article-title":"Mechanism of insulin resistance in insulin-dependent diabetes mellitus: a major role for reduced skeletal muscle blood flow","volume":"73","author":"Baron","year":"1991","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2008.09.020_bib11","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0016-5085(03)00695-4","article-title":"Activated human hepatic stellate cells express the renin\u2013angiotensin system and synthesize angiotensin II","volume":"125","author":"Bataller","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mce.2008.09.020_bib12","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.2337\/db05-1538","article-title":"Bradykinin augments insulin-stimulated glucose transport in rat adipocytes via endothelial nitric oxide synthase-mediated inhibition of Jun NH2-terminal kinase","volume":"55","author":"Beard","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2008.09.020_bib13","doi-asserted-by":"crossref","first-page":"9796","DOI":"10.1074\/jbc.M206913200","article-title":"Visualizing superoxide production in normal and diabetic rat islets of Langerhans","volume":"278","author":"Bindokas","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2008.09.020_bib14","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/S1286-4579(99)00250-6","article-title":"TGF-beta and fibrosis","volume":"1","author":"Branton","year":"1999","journal-title":"Microbes Infect."},{"key":"10.1016\/j.mce.2008.09.020_bib15","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1161\/01.HYP.27.3.523","article-title":"Angiotensin-(1\u20137) dilates canine coronary arteries through kinins and nitric oxide","volume":"27","author":"Brosnihan","year":"1996","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2008.09.020_bib16","first-page":"26","article-title":"The renin\u2013angiotensin system in the endocrine pancreas","volume":"2","author":"Carlsson","year":"2001","journal-title":"JOP"},{"key":"10.1016\/j.mce.2008.09.020_bib17","doi-asserted-by":"crossref","first-page":"E990","DOI":"10.1152\/ajpendo.1996.271.6.E990","article-title":"Pancreatic islet blood flow in normal and obese-hyperglycemic (ob\/ob) mice","volume":"271","author":"Carlsson","year":"1996","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2008.09.020_bib18","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s001250050880","article-title":"Angiotensin II and the endocrine pancreas: effects on islet blood flow and insulin secretion in rats","volume":"41","author":"Carlsson","year":"1998","journal-title":"Diabetologia"},{"key":"10.1016\/j.mce.2008.09.020_bib19","doi-asserted-by":"crossref","first-page":"947","DOI":"10.2337\/diabetes.46.6.947","article-title":"Islet capillary blood pressure increase mediated by hyperglycemia in NIDDM GK rats","volume":"46","author":"Carlsson","year":"1997","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2008.09.020_bib20","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1097\/00004872-199108000-00008","article-title":"Evidence for an intrinsic angiotensin system in the canine pancreas","volume":"9","author":"Chappell","year":"1991","journal-title":"J. Hypertens."},{"key":"10.1016\/j.mce.2008.09.020_bib21","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00125-003-1304-4","article-title":"Islet amyloid: a complication of islet dysfunction or an aetiological factor in Type 2 diabetes?","volume":"47","author":"Clark","year":"2004","journal-title":"Diabetologia"},{"key":"10.1016\/j.mce.2008.09.020_bib22","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3181\/00379727-173-41611","article-title":"The diabetic Zucker fatty rat","volume":"17","author":"Clark","year":"1983","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.mce.2008.09.020_bib23","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1210\/endo-83-3-572","article-title":"Dynamics of insulin secretion by the perfused rat pancreas","volume":"83","author":"Curry","year":"1968","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2008.09.020_bib24","doi-asserted-by":"crossref","first-page":"H2588","DOI":"10.1152\/ajpheart.00173.2007","article-title":"Evidence that the vasodilator angiotensin-(1\u20137)-Mas axis plays an important role in erectile function","volume":"293","author":"da Costa Goncalves","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.mce.2008.09.020_bib25","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1007\/s001250051006","article-title":"Increasing prevalence of Type II diabetes in American Indian children","volume":"41","author":"Dabelea","year":"1998","journal-title":"Diabetologia"},{"key":"10.1016\/j.mce.2008.09.020_bib26","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0889-8529(05)70098-0","article-title":"Type 2 diabetes mellitus in minority children and adolescents. An emerging problem","volume":"28","author":"Dabelea","year":"1999","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"10.1016\/j.mce.2008.09.020_bib27","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.2337\/diabetes.52.4.1031","article-title":"Is podocyte injury relevant in diabetic nephropathy? Studies in patients with type 2 diabetes","volume":"52","author":"Dalla Vestra","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2008.09.020_bib28","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/nature05475","article-title":"Essential role for collectrin in renal amino acid transport","volume":"444","author":"Danilczyk","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.mce.2008.09.020_bib29","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1136\/hrt.76.3_Suppl_3.28","article-title":"Is there an internal cardiac renin\u2013angiotensin system?","volume":"76","author":"Danser","year":"1996","journal-title":"Heart"},{"key":"10.1016\/j.mce.2008.09.020_bib30","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1161\/hy1101.092845","article-title":"Enalapril attenuates oxidative stress in diabetic rats","volume":"38","author":"de Cavanagh","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2008.09.020_bib31","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1152\/physiolgenomics.00312.2005","article-title":"ACE2 gene transfer attenuates hypertension-linked pathophysiological changes in the SHR","volume":"27","author":"Diez-Freire","year":"2006","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.mce.2008.09.020_bib32","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00109-003-0450-y","article-title":"Inflammatory mediators and islet \u00df-cell failure: a link between type 1 and type 2 diabetes","volume":"81","author":"Donath","year":"2003","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.mce.2008.09.020_bib33","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1161\/01.RES.87.5.e1","article-title":"A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1\u20139","volume":"87","author":"Donoghue","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.mce.2008.09.020_bib34","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1136\/adc.86.3.207","article-title":"Type 2 diabetes in obese white children","volume":"86","author":"Drake","year":"2002","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.mce.2008.09.020_bib35","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1161\/01.CIR.89.1.493","article-title":"Tissue angiotensin system in cardiovascular medicine. A paradigm shift?","volume":"89","author":"Dzau","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.mce.2008.09.020_bib36","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1046\/j.1464-5491.2000.00409.x","article-title":"Type 2 diabetes mellitus in UK children\u2014an emerging problem","volume":"17","author":"Ehtisham","year":"2000","journal-title":"Diabet. Med."},{"key":"10.1016\/j.mce.2008.09.020_bib37","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1210\/er.2001-0039","article-title":"Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes","volume":"23","author":"Evans","year":"2002","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.mce.2008.09.020_bib38","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1161\/CIRCRESAHA.107.169110","article-title":"ACE2 over-expression in the subfornical organ prevents the angiotensin-II-mediated pressor and drinking responses and is associated with AT1 receptor down-regulation","volume":"102","author":"Feng","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.mce.2008.09.020_bib39","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1161\/01.HYP.37.2.703","article-title":"Potentiation of bradykinin by angiotensin-(1\u20137) on arterioles of spontaneously hypertensive rats studied in vivo","volume":"37","author":"Fernandes","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2008.09.020_bib40","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/HCO.0b013e328303b79b","article-title":"Genomic and proteomic approaches for targeting angiotensin converting enzyme2 for cardiovascular diseases","volume":"23","author":"Ferreira","year":"2008","journal-title":"Curr. Opin. Cardiol."},{"key":"10.1016\/j.mce.2008.09.020_bib41","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1161\/01.HYP.30.5.1156","article-title":"Angiotensin II affects basal, pulsatile, and glucose-stimulated insulin secretion in humans","volume":"30","author":"Fliser","year":"1997","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2008.09.020_bib42","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1161\/01.HYP.32.5.838","article-title":"Relationship between insulin sensitivity and maximal forearm blood flow in young men","volume":"32","author":"Fossum","year":"1998","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2008.09.020_bib43","doi-asserted-by":"crossref","first-page":"H2066","DOI":"10.1152\/ajpheart.01251.2005","article-title":"Vascular adrenergic tone and structural narrowing constrain reactive hyperemia in skeletal muscle of obese Zucker rats","volume":"290","author":"Frisbee","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.mce.2008.09.020_bib44","doi-asserted-by":"crossref","first-page":"E77","DOI":"10.1152\/ajpendo.00309.2003","article-title":"Distributed control of glucose uptake by working muscles of conscious mice: roles of transport and phosphorylation","volume":"286","author":"Fueger","year":"2004","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2008.09.020_bib45","series-title":"Abstract Presented at the 57th Annual Fall Conference and Scientific sessions of the Council for High Blood Pressure Research","article-title":"ACE2 expression in brain: angiotensin II down-regulates ACE2 in astrocytes","author":"Gallagher","year":"2003"},{"key":"10.1016\/j.mce.2008.09.020_bib46","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1677\/JOE-07-0284","article-title":"Comparative expression analysis of the renin\u2013angiotensin system components between white and brown perivascular adipose tissue","volume":"197","author":"Galvez-Prieto","year":"2008","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.mce.2008.09.020_bib47","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/j.peptides.2005.01.009","article-title":"Organ-specific distribution of ACE2 mRNA and correlating peptidase activity in rodents","volume":"26","author":"Gembardt","year":"2005","journal-title":"Peptides"},{"key":"10.1016\/j.mce.2008.09.020_bib48","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.2337\/diabetes.51.2007.S117","article-title":"Is reduced first-phase insulin release the earliest detectable abnormality in individuals destined to develop type 2 diabetes?","volume":"51","author":"Gerich","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2008.09.020_bib49","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1161\/01.HYP.0000143850.73831.9d","article-title":"Angiotensin-(1\u20137) inhibitory mechanism of norepinephrine release in hypertensive rats","volume":"44","author":"Gironacci","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2008.09.020_bib50","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1042\/bj1990393","article-title":"CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse","volume":"199","author":"Grankvist","year":"1981","journal-title":"Biochem. J."},{"key":"10.1016\/j.mce.2008.09.020_bib51","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1056\/NEJM200003303421301","article-title":"Hypertension and antihypertensive therapy as risk factors for type 2 diabetes mellitus. Atherosclerosis Risk in Communities Study","volume":"342","author":"Gress","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mce.2008.09.020_bib52","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1161\/01.RES.74.6.1141","article-title":"Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells","volume":"74","author":"Griendling","year":"1994","journal-title":"Circ. Res."},{"key":"10.1016\/j.mce.2008.09.020_bib53","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1042\/CS20070160","article-title":"ACE2 overexpression inhibits hypoxia-induced collagen production by cardiac fibroblasts","volume":"113","author":"Grobe","year":"2007","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.mce.2008.09.020_bib54","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1161\/01.CIR.100.10.1134","article-title":"Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart Association","volume":"100","author":"Grundy","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.mce.2008.09.020_bib55","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1172\/JCI16980","article-title":"Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice","volume":"116","author":"Gurley","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2008.09.020_bib56","doi-asserted-by":"crossref","first-page":"13185","DOI":"10.1021\/bi035268s","article-title":"Angiotensin-converting enzyme-2 (ACE2): comparative modeling of the active site, specificity requirements, and chloride dependence","volume":"42","author":"Guy","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.mce.2008.09.020_bib57","doi-asserted-by":"crossref","first-page":"11107","DOI":"10.1074\/jbc.M410345200","article-title":"Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells","volume":"280","author":"Harmon","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2008.09.020_bib58","first-page":"30","article-title":"Oxidative stress and hypertension","volume":"1","author":"Harrison","year":"2007","journal-title":"JASH"},{"key":"10.1016\/j.mce.2008.09.020_bib59","first-page":"725","article-title":"Ultrastructural islet study of early fibrosis in the Ren2 model of hypertension. Emerging role of the islet pancreatic pericyte-stellate cell","volume":"8","author":"Hayden","year":"2007","journal-title":"JOP"},{"key":"10.1016\/j.mce.2008.09.020_bib60","first-page":"86","article-title":"Islet redox stress: the manifold toxicities of insulin resistance, metabolic syndrome and amylin derived islet amyloid in type 2 diabetes mellitus","volume":"3","author":"Hayden","year":"2002","journal-title":"JOP"},{"key":"10.1016\/j.mce.2008.09.020_bib61","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1161\/01.HYP.37.1.72","article-title":"Angiotensin-(1\u20137)-stimulated nitric oxide and superoxide release from endothelial cells","volume":"37","author":"Heitsch","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2008.09.020_bib62","doi-asserted-by":"crossref","first-page":"R332","DOI":"10.1152\/ajpregu.1999.277.1.R332","article-title":"ACE inhibition and glucose transport in insulinresistant muscle: roles of bradykinin and nitric oxide","volume":"277","author":"Henriksen","year":"1999","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.mce.2008.09.020_bib63","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.jhep.2007.03.008","article-title":"Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1\u20137) levels in experimental billiary fibrosis","volume":"47","author":"Herath","year":"2007","journal-title":"J. Hepatol."},{"key":"10.1016\/j.mce.2008.09.020_bib64","doi-asserted-by":"crossref","first-page":"15532","DOI":"10.1074\/jbc.M212934200","article-title":"Novel peptide inhibitors of angiotensin-converting enzyme 2","volume":"278","author":"Huang","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2008.09.020_bib65","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1113\/expphysiol.2005.031096","article-title":"Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats","volume":"90","author":"Huentelman","year":"2005","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.mce.2008.09.020_bib66","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1113\/expphysiol.2007.040048","article-title":"The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice","volume":"93","author":"Imai","year":"2008","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.mce.2008.09.020_bib67","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nature03712","article-title":"Angiotensin-converting enzyme 2 protects from severe acute lung failure","volume":"436","author":"Imai","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.mce.2008.09.020_bib68","first-page":"861","article-title":"Pancreatic and islet blood flow in the regenerating pancreas after a partial pancreatectomy in adult rats","volume":"106","author":"Jansson","year":"1981","journal-title":"Surgery"},{"key":"10.1016\/j.mce.2008.09.020_bib69","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1172\/JCI200316537","article-title":"Increased islet apoptosis in Pdx1\u00b1mice","volume":"111","author":"Johnson","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2008.09.020_bib70","doi-asserted-by":"crossref","first-page":"31099","DOI":"10.1074\/jbc.M104115200","article-title":"Activation of the hexosamine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress","volume":"276","author":"Kaneto","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2008.09.020_bib71","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.2337\/diacare.21.9.1414","article-title":"Global burden of diabetes, 1995\u20132025: prevalence, numerical estimates, and projections","volume":"21","author":"King","year":"1998","journal-title":"Diabetes Care"},{"key":"10.1016\/j.mce.2008.09.020_bib72","doi-asserted-by":"crossref","first-page":"550","DOI":"10.2337\/diabetes.47.4.550","article-title":"Bradykinin directly triggers GLUT4 translocation via an insulin-independent pathway","volume":"47","author":"Kishi","year":"1998","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2008.09.020_bib73","doi-asserted-by":"crossref","first-page":"848","DOI":"10.2337\/diacare.29.04.06.dc05-1873","article-title":"Tissue gene expression of renin\u2013angiotensin system in human type 2 diabetic nephropathy","volume":"4","author":"Konoshita","year":"2006","journal-title":"Diabetes Care"},{"key":"10.1016\/j.mce.2008.09.020_bib74","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1172\/JCI114644","article-title":"Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance","volume":"85","author":"Laakso","year":"1990","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2008.09.020_bib75","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1172\/JCI1065","article-title":"Insulin resistance of glucose uptake in skeletal muscle cannot be ameliorated by enhancing endothelium-dependent blood flow in obesity","volume":"101","author":"Laine","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2008.09.020_bib76","doi-asserted-by":"crossref","first-page":"30113","DOI":"10.1074\/jbc.M505111200","article-title":"Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2)","volume":"280","author":"Lambert","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2008.09.020_bib77","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/0895-7061(95)00400-9","article-title":"The hypertensive Ren-2 transgenic rat TGR (mREN2)27 in hypertension research. Characteristics and functional aspects","volume":"9","author":"Langheinrich","year":"1996","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.mce.2008.09.020_bib78","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/s00125-003-1295-1","article-title":"Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic islets","volume":"47","author":"Lau","year":"2004","journal-title":"Diabetologia"},{"key":"10.1016\/j.mce.2008.09.020_bib79","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1210\/en.2003-0150","article-title":"Minireview: overview of the renin\u2013angiotensin system\u2014an endocrine and paracrine system","volume":"144","author":"Lavoie","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2008.09.020_bib80","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1023\/A:1003210428276","article-title":"Immunohistochemical localization of angiotensin II in the mouse pancreas","volume":"30","author":"Leung","year":"1998","journal-title":"Histochem. J."},{"key":"10.1016\/j.mce.2008.09.020_bib81","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1113\/jphysiol.2006.126193","article-title":"The physiology of a local renin\u2013angiotensin system in the pancreas","volume":"580","author":"Leung","year":"2007","journal-title":"J. Physiol."},{"key":"10.1016\/j.mce.2008.09.020_bib82","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1677\/joe.0.1600013","article-title":"Expression and localization of the renin\u2013angiotensin system in the rat pancreas","volume":"160","author":"Leung","year":"1999","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.mce.2008.09.020_bib83","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nature02145","article-title":"Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus","volume":"426","author":"Li","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.mce.2008.09.020_bib84","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1161\/01.HYP.30.3.542","article-title":"Potentiation of the hypotensive effect of bradykinin by short-term infusion of angiotensin-(1\u20137) in normotensive and hypertensive rats","volume":"30","author":"Lima","year":"1997","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2008.09.020_bib85","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1530\/eje.1.02086","article-title":"The direct effects of the angiotensin-converting enzyme inhibitors, zofenoprilat and enalaprilat, on isolated human pancreatic islets","volume":"154","author":"Lupi","year":"2006","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.mce.2008.09.020_bib86","doi-asserted-by":"crossref","first-page":"27905","DOI":"10.1074\/jbc.274.39.27905","article-title":"Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells","volume":"274","author":"Maechler","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2008.09.020_bib87","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1097\/01.hjh.0000177537.91527.09","article-title":"The diabetogenic potential of thiazide-type and beta blocker combinations in patients with hypertension","volume":"23","author":"Mason","year":"2005","journal-title":"J. Hypertens."},{"key":"10.1016\/j.mce.2008.09.020_bib88","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1172\/JCI119126","article-title":"Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells","volume":"99","author":"Matsuoka","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2008.09.020_bib89","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1007\/s001250051447","article-title":"Podocyte number predicts long-term urinary albumin excretion in Pima Indians with Type II diabetes and microalbuminuria","volume":"42","author":"Meyer","year":"1999","journal-title":"Diabetologia"},{"key":"10.1016\/j.mce.2008.09.020_bib90","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1161\/hy09t1.094234","article-title":"Angiotensin II and renal fibrosis","volume":"38","author":"Mezzano","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2008.09.020_bib91","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1053\/j.ajkd.2007.11.022","article-title":"Expression of ACE and ACE2 in individuals with diabetic kidney disease and healthy controls","volume":"51","author":"Mizuiri","year":"2008","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.mce.2008.09.020_bib92","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0002-9610(99)80066-X","article-title":"Glucose-induced islet hyperemia is mediated by nitric oxide","volume":"171","author":"Moldovan","year":"1996","journal-title":"Am. J. Surg."},{"key":"10.1016\/j.mce.2008.09.020_bib93","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.bbrc.2005.05.065","article-title":"Increased expression of NAD(P)H oxidase in islets of animal models of Type 2 diabetes and its improvement by an AT1 receptor antagonist","volume":"332","author":"Nakayama","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2008.09.020_bib94","doi-asserted-by":"crossref","first-page":"80","DOI":"10.2337\/diacare.21.1.80","article-title":"Early presentation of type 2 diabetes in Mexican\u2013American youth","volume":"21","author":"Neufeld","year":"1998","journal-title":"Diabetes Care"},{"key":"10.1016\/j.mce.2008.09.020_bib95","first-page":"E28","article-title":"Development of diabetes is retarded by ACE inhibition in hypertensive patients: a sub-analysis of the Captopril Prevention Project","volume":"38","author":"Niklason","year":"2004","journal-title":"J. Hypertens."},{"key":"10.1016\/j.mce.2008.09.020_bib96","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.2337\/diabetes.52.6.1457","article-title":"Pancreatic beta-cells express phagocyte-like NAD(P)H oxidase","volume":"52","author":"Oliveira","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2008.09.020_bib97","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/S0196-9781(99)00123-0","article-title":"Synergistic effect of angiotensin-(1\u20137) on bradykinin arteriolar dilation in vivo","volume":"20","author":"Oliveira","year":"1999","journal-title":"Peptides"},{"key":"10.1016\/j.mce.2008.09.020_bib98","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/S0196-9781(02)00080-3","article-title":"Angiotensin-(1\u20137) and bradykinin interaction in diabetes mellitus: in vivo study","volume":"23","author":"Oliveira","year":"2002","journal-title":"Peptides"},{"key":"10.1016\/j.mce.2008.09.020_bib99","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1172\/JCI119163","article-title":"Podocyte loss and progressive glomerular injury in type II diabetes","volume":"99","author":"Pagtalunan","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2008.09.020_bib100","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1053\/gast.2002.36561","article-title":"Up-regulation of components of the renin\u2013angiotensin system in the bile duct-ligated rat liver","volume":"123","author":"Paizis","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mce.2008.09.020_bib101","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1136\/gut.2004.062398","article-title":"Chronic liver injury in rats and humans upregulates the novel enzyme angiotensin converting enzyme 2","volume":"54","author":"Paizis","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.mce.2008.09.020_bib102","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1152\/physrev.00036.2005","article-title":"Physiology of local renin\u2013angiotensin systems","volume":"86","author":"Paul","year":"2006","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mce.2008.09.020_bib103","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1161\/01.HYP.26.6.1154","article-title":"Angiotensin-(1\u20137) potentiates the hypotensive effect of bradykinin in conscious rats","volume":"26","author":"Paula","year":"1995","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2008.09.020_bib104","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.2337\/diabetes.50.6.1371","article-title":"Resistance to exercise-induced increase in glucose uptake during hyperinsulinemia in insulin-resistant skeletal muscle of patients with type 1 diabetes","volume":"50","author":"Peltoniemi","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2008.09.020_bib105","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.jpeds.2004.12.042","article-title":"The global spread of type 2 diabetes mellitus in children and adolescents","volume":"146","author":"Pinhas-Hamiel","year":"2005","journal-title":"J. Pediatr."},{"key":"10.1016\/j.mce.2008.09.020_bib106","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/j.1476-5381.1994.tb14787.x","article-title":"Release of nitric oxide by angiotensin-(1\u20137) from porcine coronary endothelium: implications for a novel angiotensin receptor","volume":"111","author":"Portsi","year":"1994","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mce.2008.09.020_bib107","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.peptides.2007.02.006","article-title":"Lack of potentiation of bradykinin by angiotensin-(1\u20137) in a type 2 diabetes model: role of insulin","volume":"28","author":"Rastelli","year":"2007","journal-title":"Peptides"},{"key":"10.1016\/j.mce.2008.09.020_bib108","doi-asserted-by":"crossref","first-page":"A11","DOI":"10.1016\/S0895-7061(03)00110-9","article-title":"Diabetes and cardiovascular outcomes in elderly subjects treated with ace-inhibitors or diuretics: findings from the 2ND Australian national blood pressure study","volume":"16","author":"Reid","year":"2003","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.mce.2008.09.020_bib109","doi-asserted-by":"crossref","first-page":"42351","DOI":"10.1074\/jbc.R400019200","article-title":"Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes","volume":"279","author":"Robertson","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2008.09.020_bib110","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0002-9343(88)90395-6","article-title":"Intra-islet regulation","volume":"85","author":"Samols","year":"1988","journal-title":"Am. J. Med."},{"key":"10.1016\/j.mce.2008.09.020_bib111","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1161\/01.HYP.0000251865.35728.2f","article-title":"Angiotensin-(1\u20137) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways","volume":"49","author":"Sampaio","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2008.09.020_bib112","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0361-9230(94)90104-X","article-title":"Characterization of a new angiotensin antagonist selective for angiotensin-(1\u20137): evidence that the actions of angiotensin-(1\u20137) are mediated by specific angiotensin receptors","volume":"35","author":"Santos","year":"1994","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.mce.2008.09.020_bib113","doi-asserted-by":"crossref","first-page":"8258","DOI":"10.1073\/pnas.1432869100","article-title":"Angiotensin-(1\u20137) is an endogenous ligand for the G protein-coupled receptor Mas","volume":"100","author":"Santos","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mce.2008.09.020_bib114","doi-asserted-by":"crossref","first-page":"340","DOI":"10.2337\/db07-0953","article-title":"Mas deficiency in FVB\/N mice produces marked changes in lipid and glycemic metabolism","volume":"57","author":"Santos","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2008.09.020_bib115","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1097\/01.ASN.0000090745.85482.06","article-title":"Gene expression profiles of podocyte-associated molecules as diagnostic markers in acquired proteinuric diseases","volume":"14","author":"Schmid","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.mce.2008.09.020_bib116","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/j.bbrc.2006.04.011","article-title":"Beneficial effects of candesartan, an angiotensin II type 1 receptor blocker, on [beta]-cell function and morphology in db\/db mice","volume":"344","author":"Shao","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2008.09.020_bib117","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/j.1745-7254.2008.00812.x","article-title":"Chronic angiotensin (1\u20137) injection accelerates STZ-induced diabetic renal injury","volume":"29","author":"Shao","year":"2008","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.mce.2008.09.020_bib118","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/sj.ki.5002373","article-title":"ACE2 inhibition worsens glomerular injury in association with increased ACE expression in streptozotocin-induced diabetic mice","volume":"72","author":"Soler","year":"2007","journal-title":"Kidney Int."},{"key":"10.1016\/j.mce.2008.09.020_bib119","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1172\/JCI118709","article-title":"Obesity\/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance","volume":"97","author":"Steinberg","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mce.2008.09.020_bib120","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1210\/en.130.5.2692","article-title":"A continuous 48-hour glucose infusion in rats causes both an acute and a persistent redistribution of the blood flow within the pancreas","volume":"130","author":"Styrud","year":"1992","journal-title":"Endocrinology"},{"key":"10.1016\/j.mce.2008.09.020_bib121","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2337\/diabetes.55.01.06.db05-0894","article-title":"Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy","volume":"55","author":"Susztak","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2008.09.020_bib122","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S1357-2725(02)00271-6","article-title":"Inflammation and angiotensin II","volume":"35","author":"Suzuki","year":"2003","journal-title":"Int. J. Biochem. Cell. Biol."},{"key":"10.1016\/j.mce.2008.09.020_bib123","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1677\/joe.0.1610317","article-title":"The tissue renin\u2013angiotensin system in human pancreas","volume":"161","author":"Tahmasebi","year":"1999","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.mce.2008.09.020_bib124","doi-asserted-by":"crossref","first-page":"H1560","DOI":"10.1152\/ajpheart.00941.2004","article-title":"Angiotensin-(1\u20137) inhibits growth of cardiac myocytes through activation of the mas receptor","volume":"289","author":"Tallant","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.mce.2008.09.020_bib125","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.2337\/db07-0279","article-title":"Evidence for a role of superoxide generation in glucose-induced beta cell dysfunction in vivo","volume":"56","author":"Tang","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2008.09.020_bib126","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.2337\/db07-1212","article-title":"ACE2 deficiency modifies renoprotection afforded by ACE inhibition in experimental diabetes","volume":"57","author":"Tikellis","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2008.09.020_bib127","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.biocel.2005.08.007","article-title":"Role of the renin\u2013angiotensin system in the endocrine pancreas: implications for the development of diabetes","volume":"38","author":"Tikellis","year":"2006","journal-title":"Int. J. Biochem. Cell. Biol."},{"key":"10.1016\/j.mce.2008.09.020_bib128","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1080\/02713680490517944","article-title":"Identification of angiotensin converting enzyme 2 in the rodent retina","volume":"29","author":"Tikellis","year":"2004","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.mce.2008.09.020_bib129","doi-asserted-by":"crossref","first-page":"989","DOI":"10.2337\/diabetes.53.4.989","article-title":"Improved islet morphology after blockade of the renin\u2013angiotensin system in the ZDF rat","volume":"53","author":"Tikellis","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2008.09.020_bib130","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1161\/01.HYP.0000060689.38912.CB","article-title":"Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy","volume":"41","author":"Tikellis","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2008.09.020_bib131","doi-asserted-by":"crossref","first-page":"33238","DOI":"10.1074\/jbc.M002615200","article-title":"A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase","volume":"275","author":"Tipnis","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2008.09.020_bib132","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/oby.2007.114","article-title":"ACE inhibition and AT1 receptor blockade prevent fatty liver and fibrosis in obese zucker rats","volume":"16","author":"Toblli","year":"2007","journal-title":"Obesity"},{"key":"10.1016\/j.mce.2008.09.020_bib133","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/BF00500383","article-title":"ACE-inhibition increases hepatic and extrahepatic sensitivity to insulin in patients with Type 2 (non-insulin-dependent) diabetes mellitus and arterial hypertension","volume":"34","author":"Torlone","year":"1991","journal-title":"Diabetologia"},{"key":"10.1016\/j.mce.2008.09.020_bib134","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.bbrc.2004.10.201","article-title":"Sulfonylurea as well as elevated glucose levels stimulate reactive oxygen species production in the pancreatic [beta]-cell line, MIN6\u2014a role of NAD(P)H oxidase in [beta]-cells","volume":"326","author":"Tsubouchi","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2008.09.020_bib135","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.lfs.2006.08.031","article-title":"Expression of isoforms of NADPH oxidase components in rat pancreatic islets","volume":"80","author":"Uchizono","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.mce.2008.09.020_bib136","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s001250050946","article-title":"Insulin resistance characterizes glucose uptake in skeletal muscle but not in the heart in NIDDM","volume":"41","author":"Utriainen","year":"1998","journal-title":"Diabetologia"},{"key":"10.1016\/j.mce.2008.09.020_bib137","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.placenta.2005.02.015","article-title":"Distribution of angiotensin-(1\u20137) and ACE2 in human placentas of normal and pathological pregnancies","volume":"27","author":"Vald\u00e9s","year":"2006","journal-title":"Placenta"},{"key":"10.1016\/j.mce.2008.09.020_bib138","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1161\/01.CIR.0000054611.89228.92","article-title":"Enalapril reduces the incidence of diabetes in patients with chronic heart failure: insight from the Studies Of Left Ventricular Dysfunction (SOLVD)","volume":"107","author":"Vermes","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.mce.2008.09.020_bib139","doi-asserted-by":"crossref","first-page":"14838","DOI":"10.1074\/jbc.M200581200","article-title":"Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase","volume":"277","author":"Vickers","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2008.09.020_bib140","first-page":"107","article-title":"Myocardial fibrosis: role of angiotensin II and aldosterone","volume":"88","author":"Weber","year":"1993","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.mce.2008.09.020_bib141","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1161\/01.HYP.0000037979.53963.8F","article-title":"AVE 0991, a nonpeptide mimic of the effects of angiotensin-(1\u20137) on the endothelium","volume":"40","author":"Wiemer","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2008.09.020_bib142","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/0735-1097(95)00522-6","article-title":"Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus","volume":"27","author":"Williams","year":"1996","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.mce.2008.09.020_bib143","doi-asserted-by":"crossref","first-page":"438","DOI":"10.2353\/ajpath.2007.060977","article-title":"Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury","volume":"171","author":"Wong","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.mce.2008.09.020_bib144","doi-asserted-by":"crossref","first-page":"12126","DOI":"10.1074\/jbc.M307097200","article-title":"Oxidative stress is a mediator of glucose toxicity in insulin-secreting pancreatic islet cell lines","volume":"279","author":"Wu","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2008.09.020_bib145","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.2337\/db06-0033","article-title":"ACE and ACE2 activity in diabetic mice","volume":"55","author":"Wysocki","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2008.09.020_bib146","doi-asserted-by":"crossref","first-page":"H1658","DOI":"10.1152\/ajpheart.01206.2007","article-title":"Insulin resistance and impaired functional vasodilation in obese Zucker rats","volume":"294","author":"Xiang","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.mce.2008.09.020_bib147","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1161\/01.HYP.0000205833.89478.5b","article-title":"Deletion of angiotensin-converting enzyme 2 accelerates pressure overload-induced cardiac dysfunction by increasing local angiotensin II","volume":"47","author":"Yamamoto","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2008.09.020_bib148","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1073\/pnas.90.5.1814","article-title":"Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy","volume":"90","author":"Yamamoto","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.mce.2008.09.020_bib149","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1161\/01.HYP.0000259942.38108.20","article-title":"Overexpression of angiotensin-converting enzyme 2 in the rostral ventrolateral medulla causes long-term decrease in blood pressure in the spontaneously hypertensive rats","volume":"49","author":"Yamazato","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2008.09.020_bib150","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1161\/01.HYP.0000126192.27644.76","article-title":"Increased ACE 2 and decreased ACE protein in renal tubules from diabetic mice: a renoprotective combination?","volume":"43","author":"Ye","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.mce.2008.09.020_bib151","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1681\/ASN.2006050423","article-title":"Glomerular localization and expression of angiotensin-converting enzyme 2 and angiotensin-converting enzyme: implications for albuminuria in diabetes","volume":"17","author":"Ye","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.mce.2008.09.020_bib152","doi-asserted-by":"crossref","first-page":"887","DOI":"10.2337\/diabetes.46.5.887","article-title":"A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL\/6 (Akita) mutant mice","volume":"46","author":"Yoshioka","year":"1997","journal-title":"Diabetes"},{"key":"10.1016\/j.mce.2008.09.020_bib153","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1681\/ASN.2005020159","article-title":"Urinary podocyte loss is a more specific marker of ongoing glomerular damage than proteinuria","volume":"16","author":"Yu","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.mce.2008.09.020_bib154","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1001\/jama.286.15.1882","article-title":"Ramipril and the development of diabetes","volume":"286","author":"Yusuf","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.mce.2008.09.020_bib155","doi-asserted-by":"crossref","first-page":"17132","DOI":"10.1074\/jbc.M006723200","article-title":"Collectrin, a collecting duct-specific transmembrane glycoprotein, is a novel homolog of ACE2 and is developmentally regulated in embryonic kidneys","volume":"276","author":"Zhang","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2008.09.020_bib156","doi-asserted-by":"crossref","first-page":"e414","DOI":"10.1371\/journal.pone.0000414","article-title":"The role for HNF-1\u03b2-targeted collectrin in maintenance of primary cilia and cell polarity in collecting duct cells","volume":"2","author":"Zhang","year":"2007","journal-title":"PLos ONE"},{"key":"10.1016\/j.mce.2008.09.020_bib157","article-title":"Enhanced angiotensin converting enzyme 2 regulates the insulin\/\/Akt signalling pathway by blockade of macrophage migration inhibitory factor expression","author":"Zhong","year":"2007","journal-title":"Br. J. Pharmacol."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720708004140?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720708004140?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T11:04:01Z","timestamp":1557831841000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720708004140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":157,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["S0303720708004140"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2008.09.020","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2009,4]]}}}