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Med."},{"key":"10.1016\/j.mce.2008.11.002_bib155","first-page":"1521","article-title":"Prelymphomatous B cell hyperplasia in the bone marrow of interleukin-7 transgenic mice: precursor B cell dynamics, microenvironmental organization and osteolysis","volume":"24","author":"Valenzona","year":"1996","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.mce.2008.11.002_bib156","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.4049\/jimmunol.168.5.2282","article-title":"IL-12 induces monocyte IL-18 binding protein expression via IFN-gamma","volume":"168","author":"Veenstra","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.mce.2008.11.002_bib157","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/(SICI)1096-9896(199705)182:1<92::AID-PATH813>3.0.CO;2-E","article-title":"Osteoclasts are capable of particle phagocytosis and bone resorption","volume":"182","author":"Wang","year":"1997","journal-title":"J. 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Immunol."},{"key":"10.1016\/j.mce.2008.11.002_bib160","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1359\/jbmr.2002.17.7.1200","article-title":"NF-kappaB p50 and p52 expression is not required for RANK-expressing osteoclast progenitor formation but is essential for RANK- and cytokine-mediated osteoclastogenesis","volume":"17","author":"Xing","year":"2002","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.mce.2008.11.002_bib161","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S8756-3282(02)00722-6","article-title":"Interleukin-18 and interleukin-12 synergistically inhibit osteoclastic bone-resorbing activity","volume":"30","author":"Yamada","year":"2002","journal-title":"Bone"},{"key":"10.1016\/j.mce.2008.11.002_bib162","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1182\/blood.V90.9.3516","article-title":"Development of osteoclasts from embryonic stem cells through a pathway that is c-fms but not c-kit dependent","volume":"90","author":"Yamane","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.mce.2008.11.002_bib163","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1073\/pnas.95.7.3597","article-title":"Osteoclast differentiation factor is a ligand for osteoprotegerin\/osteoclastogenesis-inhibitory factor and is identical to TRANCE\/RANKL","volume":"95","author":"Yasuda","year":"1998","journal-title":"Proc. Natl. 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