{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:37:27Z","timestamp":1792442247958,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular and Cellular Endocrinology"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1016\/j.mce.2009.05.009","type":"journal-article","created":{"date-parts":[[2009,5,24]],"date-time":"2009-05-24T04:57:25Z","timestamp":1243141045000},"page":"239-243","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":78,"title":["The role of Mitogen activated protein kinase (MAPK) in sperm functions"],"prefix":"10.1016","volume":"314","author":[{"given":"Tal","family":"Almog","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zvi","family":"Naor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mce.2009.05.009_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1477-7827-6-7","article-title":"Epidermal growth factor mediates spermatogonial proliferation in newt testis","volume":"6","author":"Abe","year":"2008","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.mce.2009.05.009_bib2","doi-asserted-by":"crossref","first-page":"14479","DOI":"10.1074\/jbc.M710492200","article-title":"Identification of extracellular signal-regulated kinase 1\/2 and p38 MAPK as regulators of human sperm motility and acrosome reaction and as predictors of poor spermatozoan quality","volume":"283","author":"Almog","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2009.05.009_bib3","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1530\/REP-07-0304","article-title":"Leptin and leptin receptor in pig spermatozoa: evidence of their involvement in sperm capacitation and survival","volume":"136","author":"Aquila","year":"2008","journal-title":"Reproduction"},{"key":"10.1016\/j.mce.2009.05.009_bib4","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1093\/humrep\/deg340","article-title":"Towards a physiological role for cytochrome P450 aromatase in ejaculated human sperm","volume":"18","author":"Aquila","year":"2003","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.mce.2009.05.009_bib5","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1006\/bbrc.1997.7626","article-title":"The addition of mitogen-activated protein kinase and p34cdc2 kinase substrate peptides inhibits the flagellar motility of demembranated fowl spermatozoa","volume":"240","author":"Ashizawa","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2009.05.009_bib6","first-page":"581","article-title":"Observations on the penetration of the sperm in the mammalian egg","volume":"4","author":"Austin","year":"1951","journal-title":"Aust. J. Sci. Res. (B)"},{"key":"10.1016\/j.mce.2009.05.009_bib7","doi-asserted-by":"crossref","first-page":"14864","DOI":"10.1073\/pnas.2536658100","article-title":"CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm","volume":"100","author":"Carlson","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mce.2009.05.009_bib8","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/168697b0","article-title":"Fertilizing capacity of spermatozoa deposited into the fallopian tubes","volume":"168","author":"Chang","year":"1951","journal-title":"Nature"},{"key":"10.1016\/j.mce.2009.05.009_bib9","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/mrd.1151","article-title":"17 beta-estradiol induces spermatogonial proliferation through mitogen-activated protein kinase (extracellular signal-regulated kinase 1\/2) activity in the lizard (Podarcis s. sicula)","volume":"61","author":"Chieffi","year":"2002","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.mce.2009.05.009_bib10","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1242\/jeb.01000","article-title":"Environmental influence on testicular MAP kinase (ERK1) activity in the frog Rana esculenta","volume":"207","author":"Chieffi","year":"2004","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.mce.2009.05.009_bib11","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1385\/MB:29:1:57","article-title":"Protein-protein interactions in the regulation of the extracellular signal-regulated kinase","volume":"29","author":"Chuderland","year":"2005","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.mce.2009.05.009_bib12","doi-asserted-by":"crossref","first-page":"4696","DOI":"10.1038\/sj.onc.1204632","article-title":"The ERK-dependent signalling is stage-specifically modulated by FSH, during primary Sertoli cell maturation","volume":"20","author":"Crepieux","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.mce.2009.05.009_bib13","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/molehr\/8.2.124","article-title":"The extracellular signal-regulated kinase (ERK) pathway is involved in human sperm function and modulated by the superoxide anion","volume":"8","author":"de Lamirande","year":"2002","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.mce.2009.05.009_bib14","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1095\/biolreprod46.5.779","article-title":"Hyperactivated sperm progress in the mouse oviduct","volume":"46","author":"Demott","year":"1992","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2009.05.009_bib15","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1530\/rep.1.00184","article-title":"Meiotic progression of isolated mouse spermatocytes under simulated microgravity","volume":"128","author":"Di Agostino","year":"2004","journal-title":"Reproduction"},{"key":"10.1016\/j.mce.2009.05.009_bib16","doi-asserted-by":"crossref","first-page":"40225","DOI":"10.1074\/jbc.M105143200","article-title":"Signaling through extracellular signal-regulated kinase is required for spermatogonial proliferative response to stem cell factor","volume":"276","author":"Dolci","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2009.05.009_bib17","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1046\/j.1439-0272.2001.00449.x","article-title":"The zona pellucida-induced acrosome reaction of human spermatozoa involves extracellular signal-regulated kinase activation","volume":"33","author":"du Plessis","year":"2001","journal-title":"Andrologia"},{"key":"10.1016\/j.mce.2009.05.009_bib18","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1095\/biolreprod.103.026666","article-title":"Testicular activity of Mos in the frog, Rana esculenta: a new role in spermatogonial proliferation","volume":"70","author":"Ferrara","year":"2004","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2009.05.009_bib19","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/mrd.1080350214","article-title":"Flow cytometric studies of bicarbonate-mediated Ca2+ influx in boar sperm populations","volume":"35","author":"Harrison","year":"1993","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.mce.2009.05.009_bib20","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1007\/s11248-008-9191-6","article-title":"Ablation of the scaffold protein JLP causes reduced fertility in male mice","volume":"17","author":"Iwanaga","year":"2008","journal-title":"Transgenic Res."},{"issue":"12","key":"10.1016\/j.mce.2009.05.009_bib21","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1093\/molehr\/gal085","article-title":"Evidence for the involvement of proline-directed serine\/threonine phosphorylation in sperm capacitation","volume":"12","author":"Jha","year":"2006","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.mce.2009.05.009_bib22","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1677\/joe.1.06781","article-title":"Tumor necrosis factor {alpha} reversibly disrupts the blood-testis barrier and impairs Sertoli\u2013germ cell adhesion in the seminiferous epithelium of adult rat testes","volume":"190","author":"Li","year":"2006","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.mce.2009.05.009_bib23","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/molehr\/8.1.37","article-title":"An anti-actin monoclonal antibody inhibits the zona pellucida-induced acrosome reaction and hyperactivated motility of human sperm","volume":"8","author":"Liu","year":"2002","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.mce.2009.05.009_bib24","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.2741\/1913","article-title":"A sperm component, HSD-3.8 (SPAG1), interacts with G-protein beta 1 subunit and activates extracellular signal-regulated kinases (ERK)","volume":"11","author":"Liu","year":"2006","journal-title":"Front. Biosci."},{"key":"10.1016\/j.mce.2009.05.009_bib25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/014850199262733","article-title":"Expression and phosphorylation of mitogen-activated protein kinases during spermatogenesis and epididymal sperm maturation in mice","volume":"43","author":"Lu","year":"1999","journal-title":"Arch. Androl."},{"key":"10.1016\/j.mce.2009.05.009_bib26","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1095\/biolreprod58.6.1476","article-title":"Extracellular signal-regulated kinases modulate capacitation of human spermatozoa","volume":"58","author":"Luconi","year":"1998","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2009.05.009_bib27","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/molehr\/4.3.251","article-title":"Progesterone stimulates p42 extracellular signal-regulated kinase (p42erk) in human spermatozoa","volume":"4","author":"Luconi","year":"1998","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.mce.2009.05.009_bib28","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.bcp.2007.10.024","article-title":"Promiscuous coupling and involvement of protein kinase C and extracellular signal-regulated kinase 1\/2 in the adenosine A1 receptor signalling in mammalian spermatozoa","volume":"75","author":"Minelli","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.mce.2009.05.009_bib29","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.bbrc.2006.06.040","article-title":"Phosphorylated extracellular signal-regulated kinase 1\/2 is localized to the XY body of meiotic prophase spermatocytes","volume":"346","author":"Miura","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mce.2009.05.009_bib30","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1006\/cbir.2001.0834","article-title":"Definitive expression of c-mos in late meiotic prophase leads to phosphorylation of a 34 kDa protein in cultured rat spermatocytes","volume":"26","author":"Nagao","year":"2002","journal-title":"Cell. Biol. Int."},{"key":"10.1016\/j.mce.2009.05.009_bib31","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1471-2121-2-21","article-title":"A regulator of G protein signaling, RGS3, inhibits gonadotropin-releasing hormone (GnRH)-stimulated luteinizing hormone (LH) secretion.","volume":"2","author":"Neill","year":"2001","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.mce.2009.05.009_bib32","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0014-5793(91)81396-P","article-title":"Delayed activation of phospholipase D by gonadotropin-releasing hormone in a clonal pituitary gonadotrope cell line (alpha T3-1)","volume":"295","author":"Netiv","year":"1991","journal-title":"FEBS Lett."},{"key":"10.1016\/j.mce.2009.05.009_bib33","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1091\/mbc.e05-06-0548","article-title":"The nuclear RNA-binding protein Sam68 translocates to the cytoplasm and associates with the polysomes in mouse spermatocytes","volume":"17","author":"Paronetto","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.mce.2009.05.009_bib34","first-page":"4480","article-title":"TNFalpha down-regulates the Fas ligand and inhibits germ cell apoptosis in the human testis","volume":"86","author":"Pentikainen","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.mce.2009.05.009_bib35","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/hmg\/9.4.477","article-title":"Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA","volume":"9","author":"Prakash","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mce.2009.05.009_bib36","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.tcb.2006.08.006","article-title":"Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking","volume":"16","author":"Ridley","year":"2006","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.mce.2009.05.009_bib37","doi-asserted-by":"crossref","first-page":"33571","DOI":"10.1074\/jbc.274.47.33571","article-title":"Activation of the mitogen-activated protein kinase ERK1 during meiotic progression of mouse pachytene spermatocytes","volume":"274","author":"Sette","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mce.2009.05.009_bib38","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1242\/jcs.108.6.2525","article-title":"Sperm exocytosis reconstructed in a cell-free system: evidence for the involvement of phospholipase C and actin filaments in membrane fusion","volume":"108","author":"Spungin","year":"1995","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mce.2009.05.009_bib39","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1095\/biolreprod46.4.686","article-title":"Hyperactivation enhances mouse sperm capacity for penetrating viscoelastic media","volume":"46","author":"Suarez","year":"1992","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2009.05.009_bib40","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1095\/biolreprod.106.052399","article-title":"Growth factor-stimulated mitogen-activated kinase (MAPK) phosphorylation in the rat epididymis is limited by segmental boundaries","volume":"75","author":"Tomsig","year":"2006","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2009.05.009_bib41","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1095\/biolreprod54.3.709","article-title":"Sperm motility development in the epididymis is associated with decreased glycogen synthase kinase-3 and protein phosphatase 1 activity","volume":"54","author":"Vijayaraghavan","year":"1996","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.mce.2009.05.009_bib42","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1242\/dev.121.4.1139","article-title":"Capacitation of mouse spermatozoa. II: Protein tyrosine phosphorylation and capacitation are regulated by a cAMP-dependent pathway","volume":"121","author":"Visconti","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.mce.2009.05.009_bib43","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1093\/humrep\/deh618","article-title":"Tryptase inhibits motility of human spermatozoa mainly by activation of the mitogen-activated protein kinase pathway","volume":"20","author":"Weidinger","year":"2005","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.mce.2009.05.009_bib44","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.yexcr.2004.08.012","article-title":"Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility.","volume":"301","author":"Wheeler","year":"2004","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.mce.2009.05.009_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2005.08.001","article-title":"Mitogen-activated protein kinases, adherens junction dynamics, and spermatogenesis: a review of recent data","volume":"286","author":"Wong","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.mce.2009.05.009_bib46","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.ydbio.2004.12.036","article-title":"TGF-beta3 regulates anchoring junction dynamics in the seminiferous epithelium of the rat testis via the Ras\/ERK signaling pathway: An in vivo study","volume":"280","author":"Xia","year":"2005","journal-title":"Dev. Biol."}],"container-title":["Molecular and Cellular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720709002755?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303720709002755?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T14:02:45Z","timestamp":1759586565000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303720709002755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S0303720709002755"],"URL":"https:\/\/doi.org\/10.1016\/j.mce.2009.05.009","relation":{},"ISSN":["0303-7207"],"issn-type":[{"value":"0303-7207","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of Mitogen activated protein kinase (MAPK) in sperm functions","name":"articletitle","label":"Article Title"},{"value":"Molecular and Cellular Endocrinology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mce.2009.05.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}